Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWR1_LEIIN

TriTrypDb:

LINF_160006300

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	463	467	PF00656	0.587
CLV_C14_Caspase3-7	525	529	PF00656	0.523
CLV_NRD_NRD_1	195	197	PF00675	0.514
CLV_NRD_NRD_1	287	289	PF00675	0.527
CLV_NRD_NRD_1	316	318	PF00675	0.557
CLV_NRD_NRD_1	490	492	PF00675	0.599
CLV_NRD_NRD_1	496	498	PF00675	0.498
CLV_NRD_NRD_1	602	604	PF00675	0.488
CLV_NRD_NRD_1	775	777	PF00675	0.563
CLV_NRD_NRD_1	9	11	PF00675	0.579
CLV_PCSK_KEX2_1	195	197	PF00082	0.559
CLV_PCSK_KEX2_1	212	214	PF00082	0.496
CLV_PCSK_KEX2_1	287	289	PF00082	0.520
CLV_PCSK_KEX2_1	316	318	PF00082	0.557
CLV_PCSK_KEX2_1	376	378	PF00082	0.531
CLV_PCSK_KEX2_1	496	498	PF00082	0.509
CLV_PCSK_KEX2_1	602	604	PF00082	0.408
CLV_PCSK_KEX2_1	775	777	PF00082	0.563
CLV_PCSK_KEX2_1	9	11	PF00082	0.589
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.338
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.484
CLV_PCSK_PC7_1	5	11	PF00082	0.658
CLV_PCSK_SKI1_1	269	273	PF00082	0.467
CLV_PCSK_SKI1_1	287	291	PF00082	0.518
CLV_PCSK_SKI1_1	504	508	PF00082	0.455
CLV_PCSK_SKI1_1	558	562	PF00082	0.391
CLV_PCSK_SKI1_1	574	578	PF00082	0.411
CLV_PCSK_SKI1_1	579	583	PF00082	0.382
CLV_PCSK_SKI1_1	610	614	PF00082	0.455
CLV_PCSK_SKI1_1	720	724	PF00082	0.521
CLV_Separin_Metazoa	772	776	PF03568	0.592
DEG_APCC_DBOX_1	203	211	PF00400	0.355
DEG_APCC_DBOX_1	573	581	PF00400	0.406
DEG_APCC_DBOX_1	609	617	PF00400	0.495
DEG_COP1_1	126	136	PF00400	0.667
DEG_Nend_UBRbox_1	1	4	PF02207	0.628
DEG_SPOP_SBC_1	154	158	PF00917	0.704
DOC_ANK_TNKS_1	9	16	PF00023	0.736
DOC_CYCLIN_RxL_1	553	564	PF00134	0.430
DOC_CYCLIN_RxL_1	80	91	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	736	742	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	759	765	PF00134	0.361
DOC_MAPK_DCC_7	438	448	PF00069	0.634
DOC_MAPK_gen_1	215	225	PF00069	0.530
DOC_MAPK_gen_1	80	89	PF00069	0.515
DOC_PP2B_LxvP_1	363	366	PF13499	0.547
DOC_PP2B_LxvP_1	616	619	PF13499	0.545
DOC_USP7_MATH_1	153	157	PF00917	0.739
DOC_USP7_MATH_1	18	22	PF00917	0.664
DOC_USP7_MATH_1	292	296	PF00917	0.572
DOC_USP7_MATH_1	37	41	PF00917	0.403
DOC_USP7_MATH_1	461	465	PF00917	0.619
DOC_USP7_MATH_1	521	525	PF00917	0.448
DOC_USP7_MATH_1	549	553	PF00917	0.601
DOC_USP7_MATH_1	591	595	PF00917	0.581
DOC_USP7_MATH_2	692	698	PF00917	0.323
DOC_WW_Pin1_4	142	147	PF00397	0.607
DOC_WW_Pin1_4	155	160	PF00397	0.597
DOC_WW_Pin1_4	181	186	PF00397	0.508
DOC_WW_Pin1_4	33	38	PF00397	0.506
DOC_WW_Pin1_4	411	416	PF00397	0.601
DOC_WW_Pin1_4	674	679	PF00397	0.740
LIG_14-3-3_CanoR_1	177	182	PF00244	0.584
LIG_14-3-3_CanoR_1	2	8	PF00244	0.655
LIG_14-3-3_CanoR_1	204	208	PF00244	0.510
LIG_14-3-3_CanoR_1	316	324	PF00244	0.457
LIG_14-3-3_CanoR_1	504	512	PF00244	0.475
LIG_14-3-3_CanoR_1	53	60	PF00244	0.495
LIG_14-3-3_CanoR_1	565	569	PF00244	0.463
LIG_14-3-3_CanoR_1	628	636	PF00244	0.518
LIG_14-3-3_CanoR_1	720	728	PF00244	0.511
LIG_14-3-3_CanoR_1	85	90	PF00244	0.501
LIG_14-3-3_CanoR_1	92	100	PF00244	0.471
LIG_Actin_WH2_2	200	217	PF00022	0.464
LIG_BIR_III_2	440	444	PF00653	0.583
LIG_BIR_III_2	777	781	PF00653	0.592
LIG_BIR_III_4	352	356	PF00653	0.511
LIG_Clathr_ClatBox_1	532	536	PF01394	0.597
LIG_FHA_1	220	226	PF00498	0.533
LIG_FHA_1	234	240	PF00498	0.504
LIG_FHA_1	275	281	PF00498	0.466
LIG_FHA_1	402	408	PF00498	0.425
LIG_FHA_1	473	479	PF00498	0.492
LIG_FHA_1	632	638	PF00498	0.513
LIG_FHA_1	84	90	PF00498	0.633
LIG_FHA_2	156	162	PF00498	0.532
LIG_FHA_2	292	298	PF00498	0.531
LIG_FHA_2	488	494	PF00498	0.408
LIG_FHA_2	633	639	PF00498	0.420
LIG_FHA_2	74	80	PF00498	0.442
LIG_FHA_2	93	99	PF00498	0.513
LIG_GBD_Chelix_1	728	736	PF00786	0.443
LIG_LIR_Apic_2	361	365	PF02991	0.534
LIG_LIR_Gen_1	160	171	PF02991	0.644
LIG_LIR_Gen_1	270	280	PF02991	0.540
LIG_LIR_Nem_3	160	166	PF02991	0.645
LIG_LIR_Nem_3	206	211	PF02991	0.384
LIG_LIR_Nem_3	270	275	PF02991	0.511
LIG_LIR_Nem_3	567	571	PF02991	0.520
LIG_LIR_Nem_3	598	604	PF02991	0.412
LIG_LIR_Nem_3	660	665	PF02991	0.535
LIG_LIR_Nem_3	750	755	PF02991	0.541
LIG_MYND_3	618	622	PF01753	0.505
LIG_NRBOX	177	183	PF00104	0.436
LIG_NRBOX	556	562	PF00104	0.397
LIG_PDZ_Class_2	781	786	PF00595	0.713
LIG_REV1ctd_RIR_1	135	145	PF16727	0.651
LIG_RPA_C_Fungi	721	733	PF08784	0.523
LIG_SH2_CRK	211	215	PF00017	0.337
LIG_SH2_CRK	568	572	PF00017	0.546
LIG_SH2_STAP1	332	336	PF00017	0.468
LIG_SH2_STAP1	41	45	PF00017	0.639
LIG_SH2_STAT3	402	405	PF00017	0.558
LIG_SH2_STAT5	136	139	PF00017	0.549
LIG_SH2_STAT5	402	405	PF00017	0.553
LIG_SH2_STAT5	539	542	PF00017	0.629
LIG_SH2_STAT5	705	708	PF00017	0.513
LIG_SH3_3	121	127	PF00018	0.575
LIG_SH3_3	276	282	PF00018	0.471
LIG_SH3_3	454	460	PF00018	0.517
LIG_SH3_3	56	62	PF00018	0.589
LIG_SH3_3	675	681	PF00018	0.706
LIG_SH3_3	736	742	PF00018	0.558
LIG_SUMO_SIM_anti_2	730	737	PF11976	0.434
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.629
LIG_SUMO_SIM_par_1	109	115	PF11976	0.460
LIG_SUMO_SIM_par_1	221	226	PF11976	0.513
LIG_SUMO_SIM_par_1	301	308	PF11976	0.465
LIG_SUMO_SIM_par_1	559	564	PF11976	0.367
LIG_SUMO_SIM_par_1	84	91	PF11976	0.632
LIG_TRAF2_1	167	170	PF00917	0.517
LIG_TRAF2_1	358	361	PF00917	0.671
LIG_TRAF2_1	629	632	PF00917	0.588
LIG_TRAF2_1	707	710	PF00917	0.504
LIG_TRAF2_1	76	79	PF00917	0.508
LIG_TRFH_1	512	516	PF08558	0.534
LIG_TYR_ITIM	566	571	PF00017	0.538
LIG_WW_3	679	683	PF00397	0.690
MOD_CDC14_SPxK_1	36	39	PF00782	0.498
MOD_CDC14_SPxK_1	679	682	PF00782	0.747
MOD_CDK_SPK_2	181	186	PF00069	0.539
MOD_CDK_SPxK_1	33	39	PF00069	0.510
MOD_CDK_SPxK_1	676	682	PF00069	0.754
MOD_CK1_1	157	163	PF00069	0.729
MOD_CK1_1	16	22	PF00069	0.620
MOD_CK1_1	259	265	PF00069	0.622
MOD_CK1_1	308	314	PF00069	0.523
MOD_CK1_1	481	487	PF00069	0.631
MOD_CK1_1	564	570	PF00069	0.492
MOD_CK1_1	630	636	PF00069	0.527
MOD_CK1_1	676	682	PF00069	0.699
MOD_CK1_1	685	691	PF00069	0.551
MOD_CK1_1	721	727	PF00069	0.473
MOD_CK2_1	164	170	PF00069	0.622
MOD_CK2_1	291	297	PF00069	0.550
MOD_CK2_1	387	393	PF00069	0.579
MOD_CK2_1	487	493	PF00069	0.423
MOD_CK2_1	591	597	PF00069	0.558
MOD_CK2_1	632	638	PF00069	0.436
MOD_CK2_1	73	79	PF00069	0.540
MOD_CK2_1	755	761	PF00069	0.559
MOD_CK2_1	85	91	PF00069	0.468
MOD_CK2_1	92	98	PF00069	0.414
MOD_Cter_Amidation	285	288	PF01082	0.475
MOD_GlcNHglycan	20	23	PF01048	0.634
MOD_GlcNHglycan	294	297	PF01048	0.596
MOD_GlcNHglycan	336	339	PF01048	0.428
MOD_GlcNHglycan	389	392	PF01048	0.493
MOD_GlcNHglycan	463	466	PF01048	0.501
MOD_GlcNHglycan	54	57	PF01048	0.509
MOD_GlcNHglycan	553	556	PF01048	0.550
MOD_GlcNHglycan	713	716	PF01048	0.581
MOD_GlcNHglycan	747	750	PF01048	0.506
MOD_GSK3_1	13	20	PF00069	0.725
MOD_GSK3_1	153	160	PF00069	0.762
MOD_GSK3_1	177	184	PF00069	0.548
MOD_GSK3_1	255	262	PF00069	0.723
MOD_GSK3_1	292	299	PF00069	0.525
MOD_GSK3_1	33	40	PF00069	0.529
MOD_GSK3_1	481	488	PF00069	0.544
MOD_GSK3_1	545	552	PF00069	0.697
MOD_GSK3_1	591	598	PF00069	0.507
MOD_GSK3_1	627	634	PF00069	0.576
MOD_GSK3_1	64	71	PF00069	0.466
MOD_GSK3_1	669	676	PF00069	0.620
MOD_GSK3_1	81	88	PF00069	0.478
MOD_N-GLC_1	154	159	PF02516	0.701
MOD_N-GLC_1	189	194	PF02516	0.577
MOD_NEK2_1	203	208	PF00069	0.551
MOD_NEK2_1	233	238	PF00069	0.382
MOD_NEK2_1	242	247	PF00069	0.421
MOD_NEK2_1	406	411	PF00069	0.531
MOD_NEK2_1	448	453	PF00069	0.575
MOD_NEK2_1	478	483	PF00069	0.444
MOD_NEK2_1	52	57	PF00069	0.578
MOD_NEK2_1	538	543	PF00069	0.644
MOD_NEK2_1	561	566	PF00069	0.358
MOD_NEK2_1	755	760	PF00069	0.523
MOD_NEK2_2	371	376	PF00069	0.546
MOD_NEK2_2	591	596	PF00069	0.539
MOD_NEK2_2	657	662	PF00069	0.540
MOD_PIKK_1	126	132	PF00454	0.547
MOD_PIKK_1	323	329	PF00454	0.459
MOD_PIKK_1	39	45	PF00454	0.598
MOD_PIKK_1	401	407	PF00454	0.548
MOD_PIKK_1	427	433	PF00454	0.694
MOD_PKA_1	316	322	PF00069	0.410
MOD_PKA_2	203	209	PF00069	0.378
MOD_PKA_2	316	322	PF00069	0.503
MOD_PKA_2	52	58	PF00069	0.586
MOD_PKA_2	564	570	PF00069	0.488
MOD_PKA_2	627	633	PF00069	0.629
MOD_Plk_1	189	195	PF00069	0.594
MOD_Plk_1	296	302	PF00069	0.508
MOD_Plk_1	37	43	PF00069	0.611
MOD_Plk_1	631	637	PF00069	0.554
MOD_Plk_2-3	221	227	PF00069	0.434
MOD_Plk_2-3	632	638	PF00069	0.577
MOD_Plk_4	177	183	PF00069	0.520
MOD_Plk_4	203	209	PF00069	0.543
MOD_Plk_4	325	331	PF00069	0.567
MOD_Plk_4	567	573	PF00069	0.516
MOD_Plk_4	632	638	PF00069	0.492
MOD_Plk_4	649	655	PF00069	0.477
MOD_Plk_4	657	663	PF00069	0.537
MOD_Plk_4	85	91	PF00069	0.486
MOD_ProDKin_1	142	148	PF00069	0.613
MOD_ProDKin_1	155	161	PF00069	0.592
MOD_ProDKin_1	181	187	PF00069	0.508
MOD_ProDKin_1	33	39	PF00069	0.502
MOD_ProDKin_1	411	417	PF00069	0.602
MOD_ProDKin_1	674	680	PF00069	0.739
MOD_SUMO_rev_2	72	81	PF00179	0.502
TRG_DiLeu_BaEn_1	325	330	PF01217	0.529
TRG_DiLeu_BaEn_4	173	179	PF01217	0.508
TRG_DiLeu_BaEn_4	693	699	PF01217	0.464
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.485
TRG_ENDOCYTIC_2	211	214	PF00928	0.492
TRG_ENDOCYTIC_2	568	571	PF00928	0.535
TRG_ER_diArg_1	287	289	PF00400	0.523
TRG_ER_diArg_1	315	317	PF00400	0.584
TRG_ER_diArg_1	496	498	PF00400	0.509
TRG_ER_diArg_1	601	603	PF00400	0.495
TRG_ER_diArg_1	689	692	PF00400	0.490
TRG_ER_diArg_1	774	776	PF00400	0.536
TRG_ER_diArg_1	8	10	PF00400	0.578
TRG_NLS_MonoExtN_4	80	86	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y7	Leptomonas seymouri	45%	99%
A0A1X0NZ28	Trypanosomatidae	28%	100%
A0A3R7M3M3	Trypanosoma rangeli	29%	100%
A0A3S7WTS3	Leishmania donovani	100%	100%
A4H8D9	Leishmania braziliensis	72%	100%
C9ZPS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QF08	Leishmania major	91%	100%