Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWQ8_LEIIN

TriTrypDb:

LINF_160006000

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWQ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	213	215	PF00675	0.496
CLV_NRD_NRD_1	252	254	PF00675	0.413
CLV_NRD_NRD_1	286	288	PF00675	0.561
CLV_NRD_NRD_1	319	321	PF00675	0.497
CLV_PCSK_KEX2_1	213	215	PF00082	0.477
CLV_PCSK_KEX2_1	252	254	PF00082	0.413
CLV_PCSK_KEX2_1	286	288	PF00082	0.525
CLV_PCSK_KEX2_1	319	321	PF00082	0.497
CLV_PCSK_PC7_1	315	321	PF00082	0.376
CLV_PCSK_SKI1_1	319	323	PF00082	0.588
DEG_APCC_DBOX_1	319	327	PF00400	0.455
DOC_CDC14_PxL_1	262	270	PF14671	0.491
DOC_CKS1_1	65	70	PF01111	0.488
DOC_CYCLIN_RxL_1	315	327	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.535
DOC_MAPK_gen_1	223	231	PF00069	0.467
DOC_MAPK_gen_1	252	259	PF00069	0.450
DOC_MAPK_HePTP_8	249	261	PF00069	0.450
DOC_MAPK_MEF2A_6	223	231	PF00069	0.514
DOC_MAPK_MEF2A_6	252	261	PF00069	0.518
DOC_MAPK_MEF2A_6	46	53	PF00069	0.497
DOC_MAPK_NFAT4_5	252	260	PF00069	0.358
DOC_PP2B_LxvP_1	272	275	PF13499	0.588
DOC_PP2B_LxvP_1	310	313	PF13499	0.486
DOC_PP2B_LxvP_1	321	324	PF13499	0.576
DOC_PP4_FxxP_1	224	227	PF00568	0.562
DOC_PP4_FxxP_1	86	89	PF00568	0.516
DOC_USP7_MATH_1	15	19	PF00917	0.568
DOC_USP7_MATH_1	150	154	PF00917	0.352
DOC_USP7_MATH_1	202	206	PF00917	0.278
DOC_WW_Pin1_4	205	210	PF00397	0.590
DOC_WW_Pin1_4	292	297	PF00397	0.633
DOC_WW_Pin1_4	61	66	PF00397	0.597
LIG_14-3-3_CanoR_1	154	164	PF00244	0.441
LIG_14-3-3_CanoR_1	167	175	PF00244	0.443
LIG_14-3-3_CanoR_1	181	189	PF00244	0.282
LIG_14-3-3_CanoR_1	246	255	PF00244	0.432
LIG_14-3-3_CanoR_1	286	290	PF00244	0.614
LIG_14-3-3_CanoR_1	56	60	PF00244	0.534
LIG_14-3-3_CanoR_1	70	78	PF00244	0.455
LIG_ActinCP_TwfCPI_2	224	234	PF01115	0.545
LIG_BIR_II_1	1	5	PF00653	0.750
LIG_BIR_III_1	1	5	PF00653	0.656
LIG_BIR_III_2	123	127	PF00653	0.555
LIG_BIR_III_3	1	5	PF00653	0.656
LIG_BRCT_BRCA1_1	82	86	PF00533	0.526
LIG_CSL_BTD_1	47	50	PF09270	0.377
LIG_deltaCOP1_diTrp_1	161	170	PF00928	0.484
LIG_FHA_2	127	133	PF00498	0.363
LIG_FHA_2	156	162	PF00498	0.344
LIG_FHA_2	303	309	PF00498	0.665
LIG_GBD_Chelix_1	53	61	PF00786	0.361
LIG_LIR_Apic_2	83	89	PF02991	0.547
LIG_LIR_Nem_3	205	210	PF02991	0.535
LIG_LIR_Nem_3	45	51	PF02991	0.248
LIG_SH2_CRK	166	170	PF00017	0.443
LIG_SH2_CRK	215	219	PF00017	0.365
LIG_SH2_CRK	240	244	PF00017	0.567
LIG_SH2_NCK_1	196	200	PF00017	0.444
LIG_SH2_NCK_1	215	219	PF00017	0.406
LIG_SH2_SRC	215	218	PF00017	0.412
LIG_SH3_2	65	70	PF14604	0.529
LIG_SH3_3	260	266	PF00018	0.505
LIG_SH3_3	44	50	PF00018	0.406
LIG_SH3_3	62	68	PF00018	0.516
LIG_SUMO_SIM_anti_2	88	95	PF11976	0.502
LIG_TRAF2_1	137	140	PF00917	0.484
LIG_TYR_ITIM	238	243	PF00017	0.542
MOD_CDK_SPxK_1	64	70	PF00069	0.488
MOD_CK1_1	205	211	PF00069	0.517
MOD_CK1_1	64	70	PF00069	0.572
MOD_CK1_1	74	80	PF00069	0.494
MOD_CK2_1	126	132	PF00069	0.344
MOD_CK2_1	133	139	PF00069	0.344
MOD_CK2_1	155	161	PF00069	0.344
MOD_GlcNHglycan	135	138	PF01048	0.477
MOD_GlcNHglycan	26	29	PF01048	0.481
MOD_GlcNHglycan	287	290	PF01048	0.658
MOD_GSK3_1	198	205	PF00069	0.424
MOD_GSK3_1	281	288	PF00069	0.536
MOD_GSK3_1	70	77	PF00069	0.567
MOD_N-GLC_1	150	155	PF02516	0.422
MOD_N-GLC_1	74	79	PF02516	0.476
MOD_NEK2_1	115	120	PF00069	0.652
MOD_NEK2_1	257	262	PF00069	0.470
MOD_NEK2_1	71	76	PF00069	0.547
MOD_PIKK_1	115	121	PF00454	0.531
MOD_PIKK_1	15	21	PF00454	0.536
MOD_PIKK_1	247	253	PF00454	0.550
MOD_PIKK_1	81	87	PF00454	0.420
MOD_PKA_2	285	291	PF00069	0.628
MOD_PKA_2	55	61	PF00069	0.477
MOD_Plk_1	150	156	PF00069	0.464
MOD_Plk_2-3	135	141	PF00069	0.443
MOD_Plk_4	257	263	PF00069	0.510
MOD_ProDKin_1	205	211	PF00069	0.585
MOD_ProDKin_1	292	298	PF00069	0.631
MOD_ProDKin_1	61	67	PF00069	0.597
MOD_SUMO_rev_2	159	165	PF00179	0.422
TRG_DiLeu_BaEn_1	318	323	PF01217	0.581
TRG_DiLeu_BaEn_2	28	34	PF01217	0.504
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.428
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.398
TRG_ENDOCYTIC_2	215	218	PF00928	0.444
TRG_ENDOCYTIC_2	240	243	PF00928	0.457
TRG_ER_diArg_1	213	215	PF00400	0.496
TRG_ER_diArg_1	319	321	PF00400	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA4	Leptomonas seymouri	48%	99%
A0A1X0P0E9	Trypanosomatidae	31%	100%
A0A3Q8ICF1	Leishmania donovani	99%	100%
A4H8D6	Leishmania braziliensis	69%	100%
C9ZPS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AQG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QF11	Leishmania major	94%	100%
V5ARD2	Trypanosoma cruzi	35%	100%