LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Galactose oxidase - central domain/Kelch motif/Domain of unknown function (DUF4110) - putative
Species:
Leishmania infantum
UniProt:
A4HWQ7_LEIIN
TriTrypDb:
LINF_160005800
Length:
735

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HWQ7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWQ7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.302
CLV_C14_Caspase3-7 511 515 PF00656 0.524
CLV_C14_Caspase3-7 544 548 PF00656 0.636
CLV_NRD_NRD_1 372 374 PF00675 0.418
CLV_NRD_NRD_1 450 452 PF00675 0.341
CLV_NRD_NRD_1 551 553 PF00675 0.639
CLV_NRD_NRD_1 660 662 PF00675 0.228
CLV_NRD_NRD_1 7 9 PF00675 0.484
CLV_NRD_NRD_1 701 703 PF00675 0.251
CLV_NRD_NRD_1 717 719 PF00675 0.417
CLV_PCSK_FUR_1 5 9 PF00082 0.467
CLV_PCSK_FUR_1 699 703 PF00082 0.325
CLV_PCSK_KEX2_1 119 121 PF00082 0.269
CLV_PCSK_KEX2_1 19 21 PF00082 0.437
CLV_PCSK_KEX2_1 200 202 PF00082 0.312
CLV_PCSK_KEX2_1 330 332 PF00082 0.407
CLV_PCSK_KEX2_1 364 366 PF00082 0.320
CLV_PCSK_KEX2_1 372 374 PF00082 0.386
CLV_PCSK_KEX2_1 376 378 PF00082 0.455
CLV_PCSK_KEX2_1 450 452 PF00082 0.334
CLV_PCSK_KEX2_1 55 57 PF00082 0.488
CLV_PCSK_KEX2_1 551 553 PF00082 0.639
CLV_PCSK_KEX2_1 660 662 PF00082 0.216
CLV_PCSK_KEX2_1 7 9 PF00082 0.482
CLV_PCSK_KEX2_1 701 703 PF00082 0.251
CLV_PCSK_KEX2_1 717 719 PF00082 0.417
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.269
CLV_PCSK_PC1ET2_1 19 21 PF00082 0.439
CLV_PCSK_PC1ET2_1 200 202 PF00082 0.403
CLV_PCSK_PC1ET2_1 330 332 PF00082 0.403
CLV_PCSK_PC1ET2_1 364 366 PF00082 0.322
CLV_PCSK_PC1ET2_1 376 378 PF00082 0.487
CLV_PCSK_PC1ET2_1 55 57 PF00082 0.488
CLV_PCSK_PC1ET2_1 7 9 PF00082 0.508
CLV_PCSK_PC7_1 372 378 PF00082 0.534
CLV_PCSK_SKI1_1 16 20 PF00082 0.466
CLV_PCSK_SKI1_1 182 186 PF00082 0.269
CLV_PCSK_SKI1_1 195 199 PF00082 0.319
CLV_PCSK_SKI1_1 23 27 PF00082 0.468
CLV_PCSK_SKI1_1 30 34 PF00082 0.539
CLV_PCSK_SKI1_1 373 377 PF00082 0.537
CLV_PCSK_SKI1_1 475 479 PF00082 0.318
CLV_PCSK_SKI1_1 606 610 PF00082 0.391
CLV_PCSK_SKI1_1 660 664 PF00082 0.327
CLV_PCSK_SKI1_1 678 682 PF00082 0.134
DEG_APCC_DBOX_1 677 685 PF00400 0.358
DEG_APCC_KENBOX_2 33 37 PF00400 0.606
DEG_SCF_FBW7_2 625 631 PF00400 0.368
DEG_SPOP_SBC_1 134 138 PF00917 0.250
DEG_SPOP_SBC_1 639 643 PF00917 0.358
DOC_ANK_TNKS_1 649 656 PF00023 0.358
DOC_CKS1_1 625 630 PF01111 0.234
DOC_CKS1_1 75 80 PF01111 0.415
DOC_MAPK_gen_1 19 28 PF00069 0.575
DOC_MAPK_gen_1 200 206 PF00069 0.274
DOC_MAPK_gen_1 364 371 PF00069 0.331
DOC_MAPK_gen_1 450 458 PF00069 0.330
DOC_MAPK_gen_1 602 610 PF00069 0.444
DOC_PP1_RVXF_1 550 557 PF00149 0.627
DOC_USP7_MATH_1 134 138 PF00917 0.234
DOC_USP7_MATH_1 428 432 PF00917 0.669
DOC_USP7_MATH_1 639 643 PF00917 0.308
DOC_USP7_MATH_1 649 653 PF00917 0.192
DOC_USP7_UBL2_3 3 7 PF12436 0.498
DOC_USP7_UBL2_3 30 34 PF12436 0.560
DOC_USP7_UBL2_3 55 59 PF12436 0.377
DOC_USP7_UBL2_3 605 609 PF12436 0.407
DOC_WW_Pin1_4 340 345 PF00397 0.378
DOC_WW_Pin1_4 584 589 PF00397 0.452
DOC_WW_Pin1_4 624 629 PF00397 0.234
DOC_WW_Pin1_4 74 79 PF00397 0.341
LIG_14-3-3_CanoR_1 125 134 PF00244 0.323
LIG_14-3-3_CanoR_1 135 143 PF00244 0.268
LIG_14-3-3_CanoR_1 174 181 PF00244 0.368
LIG_14-3-3_CanoR_1 249 255 PF00244 0.326
LIG_14-3-3_CanoR_1 274 282 PF00244 0.380
LIG_14-3-3_CanoR_1 640 645 PF00244 0.270
LIG_APCC_ABBA_1 254 259 PF00400 0.346
LIG_APCC_ABBA_1 608 613 PF00400 0.361
LIG_APCC_ABBA_1 84 89 PF00400 0.310
LIG_BRCT_BRCA1_1 323 327 PF00533 0.366
LIG_BRCT_BRCA1_1 479 483 PF00533 0.324
LIG_deltaCOP1_diTrp_1 167 171 PF00928 0.234
LIG_eIF4E_1 675 681 PF01652 0.358
LIG_FHA_1 460 466 PF00498 0.328
LIG_FHA_1 482 488 PF00498 0.369
LIG_FHA_1 585 591 PF00498 0.483
LIG_FHA_1 75 81 PF00498 0.329
LIG_FHA_2 411 417 PF00498 0.735
LIG_FHA_2 476 482 PF00498 0.299
LIG_FHA_2 64 70 PF00498 0.377
LIG_FHA_2 646 652 PF00498 0.349
LIG_LIR_Gen_1 160 168 PF02991 0.244
LIG_LIR_Gen_1 175 184 PF02991 0.234
LIG_LIR_Gen_1 269 280 PF02991 0.380
LIG_LIR_Gen_1 350 361 PF02991 0.401
LIG_LIR_Gen_1 631 639 PF02991 0.313
LIG_LIR_Nem_3 160 165 PF02991 0.244
LIG_LIR_Nem_3 175 181 PF02991 0.299
LIG_LIR_Nem_3 269 275 PF02991 0.389
LIG_LIR_Nem_3 350 356 PF02991 0.380
LIG_LIR_Nem_3 363 369 PF02991 0.210
LIG_LIR_Nem_3 491 496 PF02991 0.323
LIG_LIR_Nem_3 631 637 PF02991 0.345
LIG_LIR_Nem_3 706 712 PF02991 0.259
LIG_LYPXL_S_1 366 370 PF13949 0.309
LIG_LYPXL_yS_3 367 370 PF13949 0.317
LIG_MYND_1 563 567 PF01753 0.612
LIG_Pex14_2 150 154 PF04695 0.299
LIG_Pex14_2 165 169 PF04695 0.155
LIG_Pex14_2 219 223 PF04695 0.286
LIG_Pex14_2 634 638 PF04695 0.368
LIG_Pex14_2 97 101 PF04695 0.368
LIG_PTB_Apo_2 351 358 PF02174 0.315
LIG_PTB_Apo_2 458 465 PF02174 0.313
LIG_PTB_Phospho_1 351 357 PF10480 0.407
LIG_PTB_Phospho_1 458 464 PF10480 0.317
LIG_REV1ctd_RIR_1 113 124 PF16727 0.368
LIG_REV1ctd_RIR_1 635 644 PF16727 0.250
LIG_REV1ctd_RIR_1 695 706 PF16727 0.234
LIG_SH2_CRK 493 497 PF00017 0.357
LIG_SH2_GRB2like 210 213 PF00017 0.299
LIG_SH2_NCK_1 210 214 PF00017 0.308
LIG_SH2_NCK_1 712 716 PF00017 0.501
LIG_SH2_SRC 210 213 PF00017 0.299
LIG_SH2_SRC 464 467 PF00017 0.407
LIG_SH2_SRC 712 715 PF00017 0.501
LIG_SH2_STAP1 529 533 PF00017 0.515
LIG_SH2_STAT3 267 270 PF00017 0.397
LIG_SH2_STAT3 466 469 PF00017 0.415
LIG_SH2_STAT5 114 117 PF00017 0.250
LIG_SH2_STAT5 146 149 PF00017 0.336
LIG_SH2_STAT5 162 165 PF00017 0.329
LIG_SH2_STAT5 218 221 PF00017 0.290
LIG_SH2_STAT5 333 336 PF00017 0.273
LIG_SH2_STAT5 357 360 PF00017 0.380
LIG_SH2_STAT5 464 467 PF00017 0.289
LIG_SH3_3 561 567 PF00018 0.589
LIG_SH3_3 622 628 PF00018 0.234
LIG_SH3_3 70 76 PF00018 0.365
LIG_SH3_3 80 86 PF00018 0.249
LIG_SUMO_SIM_par_1 337 343 PF11976 0.316
LIG_TRAF2_1 405 408 PF00917 0.653
LIG_TRAF2_1 430 433 PF00917 0.655
LIG_TRAF2_1 66 69 PF00917 0.469
LIG_UBA3_1 288 295 PF00899 0.424
LIG_UBA3_1 482 489 PF00899 0.437
LIG_WRC_WIRS_1 349 354 PF05994 0.311
MOD_CDK_SPK_2 74 79 PF00069 0.334
MOD_CDK_SPxK_1 624 630 PF00069 0.251
MOD_CDK_SPxxK_3 340 347 PF00069 0.392
MOD_CK1_1 189 195 PF00069 0.282
MOD_CK1_1 250 256 PF00069 0.307
MOD_CK1_1 278 284 PF00069 0.315
MOD_CK1_1 410 416 PF00069 0.608
MOD_CK1_1 437 443 PF00069 0.498
MOD_CK1_1 517 523 PF00069 0.445
MOD_CK2_1 173 179 PF00069 0.368
MOD_CK2_1 401 407 PF00069 0.600
MOD_CK2_1 410 416 PF00069 0.568
MOD_CK2_1 470 476 PF00069 0.493
MOD_CK2_1 63 69 PF00069 0.376
MOD_CK2_1 645 651 PF00069 0.345
MOD_Cter_Amidation 549 552 PF01082 0.646
MOD_Cter_Amidation 603 606 PF01082 0.452
MOD_GlcNHglycan 127 130 PF01048 0.444
MOD_GlcNHglycan 191 194 PF01048 0.282
MOD_GlcNHglycan 249 252 PF01048 0.299
MOD_GlcNHglycan 394 397 PF01048 0.522
MOD_GlcNHglycan 453 456 PF01048 0.410
MOD_GlcNHglycan 500 504 PF01048 0.470
MOD_GlcNHglycan 519 522 PF01048 0.451
MOD_GlcNHglycan 525 528 PF01048 0.375
MOD_GlcNHglycan 622 625 PF01048 0.258
MOD_GSK3_1 153 160 PF00069 0.234
MOD_GSK3_1 232 239 PF00069 0.339
MOD_GSK3_1 403 410 PF00069 0.570
MOD_GSK3_1 424 431 PF00069 0.607
MOD_GSK3_1 477 484 PF00069 0.321
MOD_GSK3_1 495 502 PF00069 0.282
MOD_GSK3_1 510 517 PF00069 0.456
MOD_GSK3_1 519 526 PF00069 0.375
MOD_GSK3_1 620 627 PF00069 0.275
MOD_GSK3_1 645 652 PF00069 0.290
MOD_LATS_1 449 455 PF00433 0.436
MOD_N-GLC_1 110 115 PF02516 0.368
MOD_NEK2_1 348 353 PF00069 0.385
MOD_NEK2_1 470 475 PF00069 0.489
MOD_NEK2_1 619 624 PF00069 0.322
MOD_NEK2_1 638 643 PF00069 0.106
MOD_NEK2_2 287 292 PF00069 0.364
MOD_PIKK_1 135 141 PF00454 0.251
MOD_PIKK_1 153 159 PF00454 0.234
MOD_PIKK_1 232 238 PF00454 0.430
MOD_PIKK_1 266 272 PF00454 0.369
MOD_PIKK_1 428 434 PF00454 0.672
MOD_PIKK_1 495 501 PF00454 0.368
MOD_PKA_2 124 130 PF00069 0.263
MOD_PKA_2 134 140 PF00069 0.200
MOD_PKA_2 173 179 PF00069 0.375
MOD_PKA_2 639 645 PF00069 0.260
MOD_PKA_2 649 655 PF00069 0.235
MOD_PKA_2 89 95 PF00069 0.306
MOD_Plk_1 110 116 PF00069 0.296
MOD_Plk_1 278 284 PF00069 0.359
MOD_Plk_1 475 481 PF00069 0.310
MOD_Plk_1 50 56 PF00069 0.346
MOD_Plk_1 630 636 PF00069 0.365
MOD_Plk_2-3 514 520 PF00069 0.515
MOD_Plk_4 110 116 PF00069 0.341
MOD_Plk_4 252 258 PF00069 0.321
MOD_Plk_4 348 354 PF00069 0.443
MOD_Plk_4 459 465 PF00069 0.327
MOD_Plk_4 520 526 PF00069 0.387
MOD_Plk_4 586 592 PF00069 0.366
MOD_Plk_4 640 646 PF00069 0.345
MOD_ProDKin_1 340 346 PF00069 0.384
MOD_ProDKin_1 584 590 PF00069 0.443
MOD_ProDKin_1 624 630 PF00069 0.234
MOD_ProDKin_1 74 80 PF00069 0.337
MOD_SUMO_for_1 32 35 PF00179 0.492
MOD_SUMO_for_1 662 665 PF00179 0.347
MOD_SUMO_rev_2 175 184 PF00179 0.232
MOD_SUMO_rev_2 431 437 PF00179 0.488
MOD_SUMO_rev_2 651 658 PF00179 0.350
MOD_SUMO_rev_2 688 698 PF00179 0.368
TRG_DiLeu_BaEn_1 676 681 PF01217 0.234
TRG_DiLeu_BaEn_4 179 185 PF01217 0.269
TRG_DiLeu_BaLyEn_6 492 497 PF01217 0.456
TRG_ENDOCYTIC_2 146 149 PF00928 0.325
TRG_ENDOCYTIC_2 162 165 PF00928 0.329
TRG_ENDOCYTIC_2 353 356 PF00928 0.392
TRG_ENDOCYTIC_2 367 370 PF00928 0.224
TRG_ENDOCYTIC_2 493 496 PF00928 0.358
TRG_ER_diArg_1 371 373 PF00400 0.399
TRG_ER_diArg_1 450 452 PF00400 0.322
TRG_ER_diArg_1 660 662 PF00400 0.226
TRG_ER_diArg_1 701 703 PF00400 0.325
TRG_ER_diArg_1 717 719 PF00400 0.496
TRG_Pf-PMV_PEXEL_1 660 665 PF00026 0.330
TRG_Pf-PMV_PEXEL_1 678 683 PF00026 0.187
TRG_Pf-PMV_PEXEL_1 701 706 PF00026 0.305
TRG_Pf-PMV_PEXEL_1 717 721 PF00026 0.369

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8R8 Leptomonas seymouri 75% 100%
A0A0S4JR73 Bodo saltans 50% 94%
A0A1X0NZQ9 Trypanosomatidae 59% 100%
A0A3Q8I9A1 Leishmania donovani 100% 100%
A0A422NAE1 Trypanosoma rangeli 60% 100%
A4H8D5 Leishmania braziliensis 86% 100%
C9ZPS3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 99%
E9AQG4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q08979 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
Q4QF12 Leishmania major 95% 100%
Q5R8W1 Pongo abelii 31% 100%
Q8TBB5 Homo sapiens 30% 100%
Q921I2 Mus musculus 32% 100%
V5BBA4 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS