Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWQ6_LEIIN

TriTrypDb:

LINF_160005700

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.540
CLV_C14_Caspase3-7	361	365	PF00656	0.486
CLV_NRD_NRD_1	323	325	PF00675	0.423
CLV_NRD_NRD_1	372	374	PF00675	0.569
CLV_NRD_NRD_1	76	78	PF00675	0.614
CLV_PCSK_KEX2_1	187	189	PF00082	0.416
CLV_PCSK_KEX2_1	323	325	PF00082	0.472
CLV_PCSK_KEX2_1	372	374	PF00082	0.569
CLV_PCSK_KEX2_1	75	77	PF00082	0.610
CLV_PCSK_KEX2_1	89	91	PF00082	0.565
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.380
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.472
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.565
CLV_PCSK_PC7_1	85	91	PF00082	0.648
CLV_PCSK_SKI1_1	263	267	PF00082	0.528
CLV_PCSK_SKI1_1	295	299	PF00082	0.461
CLV_PCSK_SKI1_1	77	81	PF00082	0.684
DEG_Nend_UBRbox_2	1	3	PF02207	0.640
DEG_SPOP_SBC_1	191	195	PF00917	0.494
DOC_CKS1_1	203	208	PF01111	0.416
DOC_MAPK_gen_1	261	270	PF00069	0.534
DOC_MAPK_gen_1	75	81	PF00069	0.770
DOC_MAPK_gen_1	89	97	PF00069	0.470
DOC_MAPK_MEF2A_6	46	54	PF00069	0.473
DOC_PP2B_LxvP_1	255	258	PF13499	0.516
DOC_PP2B_LxvP_1	268	271	PF13499	0.456
DOC_USP7_MATH_1	191	195	PF00917	0.486
DOC_USP7_MATH_1	237	241	PF00917	0.442
DOC_USP7_MATH_1	340	344	PF00917	0.462
DOC_WW_Pin1_4	101	106	PF00397	0.717
DOC_WW_Pin1_4	11	16	PF00397	0.642
DOC_WW_Pin1_4	202	207	PF00397	0.453
DOC_WW_Pin1_4	372	377	PF00397	0.585
DOC_WW_Pin1_4	391	396	PF00397	0.529
DOC_WW_Pin1_4	70	75	PF00397	0.605
LIG_14-3-3_CanoR_1	19	25	PF00244	0.572
LIG_14-3-3_CanoR_1	199	204	PF00244	0.497
LIG_14-3-3_CanoR_1	261	266	PF00244	0.550
LIG_14-3-3_CanoR_1	372	376	PF00244	0.565
LIG_14-3-3_CanoR_1	75	80	PF00244	0.674
LIG_Actin_WH2_2	248	265	PF00022	0.413
LIG_AP2alpha_2	117	119	PF02296	0.530
LIG_APCC_ABBA_1	116	121	PF00400	0.549
LIG_CaM_NSCaTE_8	305	312	PF13499	0.508
LIG_CtBP_PxDLS_1	137	141	PF00389	0.625
LIG_eIF4E_1	273	279	PF01652	0.490
LIG_FHA_1	19	25	PF00498	0.618
LIG_FHA_1	281	287	PF00498	0.457
LIG_FHA_2	203	209	PF00498	0.489
LIG_GBD_Chelix_1	238	246	PF00786	0.459
LIG_LIR_Apic_2	149	155	PF02991	0.609
LIG_LIR_Gen_1	156	165	PF02991	0.526
LIG_LIR_Gen_1	240	250	PF02991	0.468
LIG_LIR_Gen_1	27	37	PF02991	0.444
LIG_LIR_Gen_1	329	338	PF02991	0.481
LIG_LIR_Nem_3	156	160	PF02991	0.556
LIG_LIR_Nem_3	240	246	PF02991	0.466
LIG_LIR_Nem_3	27	32	PF02991	0.429
LIG_LIR_Nem_3	329	334	PF02991	0.466
LIG_LIR_Nem_3	94	100	PF02991	0.647
LIG_NRBOX	31	37	PF00104	0.418
LIG_PCNA_yPIPBox_3	249	263	PF02747	0.412
LIG_SH2_CRK	331	335	PF00017	0.568
LIG_SH2_NCK_1	100	104	PF00017	0.580
LIG_SH2_PTP2	152	155	PF00017	0.570
LIG_SH2_PTP2	157	160	PF00017	0.520
LIG_SH2_SRC	100	103	PF00017	0.523
LIG_SH2_SRC	56	59	PF00017	0.492
LIG_SH2_STAP1	243	247	PF00017	0.396
LIG_SH2_STAP1	331	335	PF00017	0.452
LIG_SH2_STAT3	273	276	PF00017	0.509
LIG_SH2_STAT5	152	155	PF00017	0.570
LIG_SH2_STAT5	157	160	PF00017	0.520
LIG_SH2_STAT5	243	246	PF00017	0.398
LIG_SH2_STAT5	321	324	PF00017	0.503
LIG_SH2_STAT5	348	351	PF00017	0.443
LIG_SH2_STAT5	56	59	PF00017	0.552
LIG_SH3_3	200	206	PF00018	0.450
LIG_SH3_3	76	82	PF00018	0.618
LIG_SUMO_SIM_par_1	136	141	PF11976	0.629
LIG_SUMO_SIM_par_1	348	354	PF11976	0.468
LIG_TRAF2_1	146	149	PF00917	0.485
LIG_TRAF2_1	91	94	PF00917	0.560
MOD_CDC14_SPxK_1	73	76	PF00782	0.626
MOD_CDK_SPK_2	101	106	PF00069	0.597
MOD_CDK_SPK_2	70	75	PF00069	0.605
MOD_CDK_SPxK_1	70	76	PF00069	0.612
MOD_CDK_SPxxK_3	101	108	PF00069	0.598
MOD_CDK_SPxxK_3	70	77	PF00069	0.612
MOD_CK1_1	13	19	PF00069	0.614
MOD_CK1_1	156	162	PF00069	0.495
MOD_CK1_1	193	199	PF00069	0.572
MOD_CK1_1	202	208	PF00069	0.446
MOD_CK1_1	339	345	PF00069	0.475
MOD_CK1_1	70	76	PF00069	0.629
MOD_CK2_1	11	17	PF00069	0.709
MOD_CK2_1	138	144	PF00069	0.551
MOD_CK2_1	88	94	PF00069	0.580
MOD_Cter_Amidation	87	90	PF01082	0.593
MOD_GlcNHglycan	195	198	PF01048	0.556
MOD_GlcNHglycan	28	32	PF01048	0.540
MOD_GlcNHglycan	310	313	PF01048	0.516
MOD_GlcNHglycan	338	341	PF01048	0.445
MOD_GSK3_1	20	27	PF00069	0.481
MOD_GSK3_1	237	244	PF00069	0.462
MOD_GSK3_1	336	343	PF00069	0.544
MOD_GSK3_1	63	70	PF00069	0.578
MOD_GSK3_1	7	14	PF00069	0.619
MOD_N-GLC_1	24	29	PF02516	0.450
MOD_NEK2_1	124	129	PF00069	0.583
MOD_NEK2_1	176	181	PF00069	0.481
MOD_NEK2_1	190	195	PF00069	0.477
MOD_NEK2_1	279	284	PF00069	0.475
MOD_NEK2_2	340	345	PF00069	0.461
MOD_PIKK_1	329	335	PF00454	0.399
MOD_PK_1	199	205	PF00069	0.549
MOD_PK_1	261	267	PF00069	0.477
MOD_PK_1	75	81	PF00069	0.674
MOD_PKA_1	75	81	PF00069	0.764
MOD_PKA_2	18	24	PF00069	0.534
MOD_PKA_2	228	234	PF00069	0.531
MOD_PKA_2	371	377	PF00069	0.589
MOD_PKA_2	75	81	PF00069	0.698
MOD_PKB_1	293	301	PF00069	0.476
MOD_PKB_1	75	83	PF00069	0.805
MOD_Plk_1	27	33	PF00069	0.429
MOD_Plk_1	279	285	PF00069	0.507
MOD_Plk_1	298	304	PF00069	0.322
MOD_Plk_1	388	394	PF00069	0.514
MOD_Plk_4	153	159	PF00069	0.624
MOD_ProDKin_1	101	107	PF00069	0.716
MOD_ProDKin_1	11	17	PF00069	0.641
MOD_ProDKin_1	202	208	PF00069	0.451
MOD_ProDKin_1	372	378	PF00069	0.590
MOD_ProDKin_1	391	397	PF00069	0.528
MOD_ProDKin_1	70	76	PF00069	0.612
MOD_SUMO_rev_2	139	146	PF00179	0.564
TRG_DiLeu_BaEn_1	28	33	PF01217	0.478
TRG_DiLeu_BaEn_2	92	98	PF01217	0.575
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.419
TRG_ENDOCYTIC_2	157	160	PF00928	0.556
TRG_ENDOCYTIC_2	243	246	PF00928	0.398
TRG_ENDOCYTIC_2	331	334	PF00928	0.461
TRG_ER_diArg_1	105	108	PF00400	0.733
TRG_ER_diArg_1	260	263	PF00400	0.513
TRG_ER_diArg_1	74	77	PF00400	0.676
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDJ0	Leishmania donovani	99%	100%
A4H8D4	Leishmania braziliensis	69%	100%
E9AQG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QF13	Leishmania major	90%	100%
Q8IS09	Leptomonas seymouri	32%	100%