LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
DEAD/DEAH box helicase/Helicase conserved C-terminal domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HWQ4_LEIIN
TriTrypDb:
LINF_160005500
Length:
657

Annotations

Annotations by Jardim et al.

Helicases, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HWQ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWQ4

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016072 rRNA metabolic process 7 1
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003676 nucleic acid binding 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003824 catalytic activity 1 4
GO:0004386 helicase activity 2 4
GO:0140640 catalytic activity, acting on a nucleic acid 2 4
GO:0140657 ATP-dependent activity 1 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 12 14 PF00675 0.564
CLV_NRD_NRD_1 222 224 PF00675 0.539
CLV_NRD_NRD_1 290 292 PF00675 0.718
CLV_NRD_NRD_1 333 335 PF00675 0.318
CLV_NRD_NRD_1 449 451 PF00675 0.337
CLV_NRD_NRD_1 548 550 PF00675 0.608
CLV_NRD_NRD_1 583 585 PF00675 0.513
CLV_PCSK_FUR_1 10 14 PF00082 0.558
CLV_PCSK_KEX2_1 12 14 PF00082 0.562
CLV_PCSK_KEX2_1 222 224 PF00082 0.561
CLV_PCSK_KEX2_1 289 291 PF00082 0.664
CLV_PCSK_KEX2_1 297 299 PF00082 0.683
CLV_PCSK_KEX2_1 471 473 PF00082 0.251
CLV_PCSK_KEX2_1 583 585 PF00082 0.483
CLV_PCSK_KEX2_1 626 628 PF00082 0.529
CLV_PCSK_KEX2_1 9 11 PF00082 0.538
CLV_PCSK_PC1ET2_1 297 299 PF00082 0.718
CLV_PCSK_PC1ET2_1 471 473 PF00082 0.251
CLV_PCSK_PC1ET2_1 626 628 PF00082 0.529
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.557
CLV_PCSK_PC7_1 218 224 PF00082 0.589
CLV_PCSK_SKI1_1 113 117 PF00082 0.276
CLV_PCSK_SKI1_1 156 160 PF00082 0.241
CLV_PCSK_SKI1_1 395 399 PF00082 0.381
CLV_PCSK_SKI1_1 412 416 PF00082 0.324
CLV_PCSK_SKI1_1 453 457 PF00082 0.277
CLV_PCSK_SKI1_1 47 51 PF00082 0.407
CLV_PCSK_SKI1_1 620 624 PF00082 0.464
CLV_PCSK_SKI1_1 64 68 PF00082 0.263
CLV_PCSK_SKI1_1 652 656 PF00082 0.398
DEG_APCC_DBOX_1 112 120 PF00400 0.513
DEG_SPOP_SBC_1 606 610 PF00917 0.465
DOC_CKS1_1 176 181 PF01111 0.451
DOC_CKS1_1 193 198 PF01111 0.510
DOC_CYCLIN_RxL_1 646 657 PF00134 0.523
DOC_MAPK_DCC_7 412 422 PF00069 0.465
DOC_MAPK_gen_1 166 176 PF00069 0.512
DOC_MAPK_gen_1 385 391 PF00069 0.332
DOC_MAPK_MEF2A_6 113 120 PF00069 0.449
DOC_MAPK_MEF2A_6 642 651 PF00069 0.459
DOC_PP1_RVXF_1 393 400 PF00149 0.359
DOC_PP1_RVXF_1 45 52 PF00149 0.387
DOC_PP1_RVXF_1 81 88 PF00149 0.512
DOC_PP2B_LxvP_1 27 30 PF13499 0.477
DOC_PP2B_LxvP_1 415 418 PF13499 0.468
DOC_PP2B_LxvP_1 532 535 PF13499 0.372
DOC_PP2B_LxvP_1 569 572 PF13499 0.645
DOC_PP4_FxxP_1 505 508 PF00568 0.451
DOC_PP4_FxxP_1 87 90 PF00568 0.512
DOC_SPAK_OSR1_1 249 253 PF12202 0.458
DOC_SPAK_OSR1_1 362 366 PF12202 0.491
DOC_USP7_MATH_1 348 352 PF00917 0.546
DOC_USP7_MATH_1 542 546 PF00917 0.702
DOC_USP7_MATH_1 606 610 PF00917 0.447
DOC_USP7_MATH_1 69 73 PF00917 0.482
DOC_USP7_MATH_1 78 82 PF00917 0.442
DOC_USP7_UBL2_3 292 296 PF12436 0.763
DOC_USP7_UBL2_3 616 620 PF12436 0.420
DOC_WW_Pin1_4 118 123 PF00397 0.476
DOC_WW_Pin1_4 175 180 PF00397 0.451
DOC_WW_Pin1_4 192 197 PF00397 0.488
DOC_WW_Pin1_4 282 287 PF00397 0.728
DOC_WW_Pin1_4 323 328 PF00397 0.503
DOC_WW_Pin1_4 53 58 PF00397 0.467
DOC_WW_Pin1_4 538 543 PF00397 0.571
LIG_14-3-3_CanoR_1 10 16 PF00244 0.657
LIG_14-3-3_CanoR_1 241 251 PF00244 0.452
LIG_14-3-3_CanoR_1 267 271 PF00244 0.473
LIG_14-3-3_CanoR_1 289 299 PF00244 0.746
LIG_14-3-3_CanoR_1 402 407 PF00244 0.466
LIG_14-3-3_CanoR_1 555 560 PF00244 0.615
LIG_14-3-3_CanoR_1 627 633 PF00244 0.448
LIG_14-3-3_CanoR_1 94 103 PF00244 0.568
LIG_Actin_WH2_2 608 625 PF00022 0.473
LIG_BIR_II_1 1 5 PF00653 0.515
LIG_BRCT_BRCA1_1 238 242 PF00533 0.542
LIG_BRCT_BRCA1_1 359 363 PF00533 0.473
LIG_BRCT_BRCA1_1 552 556 PF00533 0.629
LIG_FHA_1 128 134 PF00498 0.458
LIG_FHA_1 171 177 PF00498 0.467
LIG_FHA_1 203 209 PF00498 0.548
LIG_FHA_1 344 350 PF00498 0.434
LIG_FHA_1 478 484 PF00498 0.512
LIG_FHA_1 564 570 PF00498 0.547
LIG_FHA_1 606 612 PF00498 0.436
LIG_FHA_1 69 75 PF00498 0.485
LIG_FHA_2 123 129 PF00498 0.537
LIG_FHA_2 176 182 PF00498 0.451
LIG_FHA_2 193 199 PF00498 0.513
LIG_FHA_2 226 232 PF00498 0.712
LIG_LIR_Apic_2 597 602 PF02991 0.515
LIG_LIR_Apic_2 641 647 PF02991 0.501
LIG_LIR_Apic_2 84 90 PF02991 0.512
LIG_LIR_Gen_1 181 189 PF02991 0.537
LIG_LIR_Gen_1 247 257 PF02991 0.350
LIG_LIR_Gen_1 28 38 PF02991 0.439
LIG_LIR_Gen_1 315 324 PF02991 0.458
LIG_LIR_Gen_1 434 443 PF02991 0.452
LIG_LIR_Nem_3 181 185 PF02991 0.537
LIG_LIR_Nem_3 247 253 PF02991 0.356
LIG_LIR_Nem_3 28 34 PF02991 0.445
LIG_LIR_Nem_3 315 319 PF02991 0.444
LIG_LIR_Nem_3 434 439 PF02991 0.461
LIG_LIR_Nem_3 553 559 PF02991 0.607
LIG_MYND_3 186 190 PF01753 0.556
LIG_Pex14_2 143 147 PF04695 0.537
LIG_Pex14_2 371 375 PF04695 0.496
LIG_Pex14_2 390 394 PF04695 0.253
LIG_Pex14_2 466 470 PF04695 0.512
LIG_PTB_Apo_2 45 52 PF02174 0.387
LIG_SH2_CRK 599 603 PF00017 0.462
LIG_SH2_NCK_1 599 603 PF00017 0.515
LIG_SH2_SRC 501 504 PF00017 0.451
LIG_SH2_STAP1 332 336 PF00017 0.373
LIG_SH2_STAT3 374 377 PF00017 0.489
LIG_SH2_STAT5 102 105 PF00017 0.492
LIG_SH2_STAT5 219 222 PF00017 0.560
LIG_SH2_STAT5 374 377 PF00017 0.420
LIG_SH2_STAT5 416 419 PF00017 0.361
LIG_SH2_STAT5 501 504 PF00017 0.444
LIG_SH2_STAT5 514 517 PF00017 0.450
LIG_SH2_STAT5 586 589 PF00017 0.426
LIG_SH2_STAT5 599 602 PF00017 0.424
LIG_SH3_3 151 157 PF00018 0.537
LIG_SH3_3 173 179 PF00018 0.463
LIG_SH3_3 193 199 PF00018 0.330
LIG_SH3_3 280 286 PF00018 0.707
LIG_SH3_3 600 606 PF00018 0.469
LIG_SH3_3 72 78 PF00018 0.454
LIG_SH3_4 564 571 PF00018 0.614
LIG_SUMO_SIM_anti_2 529 535 PF11976 0.371
LIG_SUMO_SIM_par_1 172 178 PF11976 0.512
LIG_SUMO_SIM_par_1 250 256 PF11976 0.408
LIG_SUMO_SIM_par_1 345 351 PF11976 0.530
LIG_TRAF2_1 595 598 PF00917 0.540
LIG_UBA3_1 185 194 PF00899 0.408
LIG_UBA3_1 378 386 PF00899 0.368
LIG_UBA3_1 414 419 PF00899 0.436
LIG_UBA3_1 43 47 PF00899 0.440
LIG_UBA3_1 621 626 PF00899 0.462
MOD_CDC14_SPxK_1 121 124 PF00782 0.338
MOD_CDC14_SPxK_1 287 290 PF00782 0.695
MOD_CDK_SPK_2 175 180 PF00069 0.389
MOD_CDK_SPK_2 284 289 PF00069 0.678
MOD_CDK_SPxK_1 118 124 PF00069 0.338
MOD_CDK_SPxK_1 284 290 PF00069 0.683
MOD_CDK_SPxxK_3 282 289 PF00069 0.666
MOD_CDK_SPxxK_3 323 330 PF00069 0.486
MOD_CK1_1 236 242 PF00069 0.536
MOD_CK1_1 357 363 PF00069 0.458
MOD_CK1_1 446 452 PF00069 0.401
MOD_CK1_1 477 483 PF00069 0.353
MOD_CK1_1 53 59 PF00069 0.332
MOD_CK1_1 575 581 PF00069 0.550
MOD_CK1_1 81 87 PF00069 0.381
MOD_CK2_1 122 128 PF00069 0.413
MOD_CK2_1 225 231 PF00069 0.701
MOD_CK2_1 241 247 PF00069 0.548
MOD_CK2_1 454 460 PF00069 0.338
MOD_CK2_1 542 548 PF00069 0.617
MOD_CK2_1 575 581 PF00069 0.527
MOD_CK2_1 591 597 PF00069 0.322
MOD_GlcNHglycan 292 295 PF01048 0.696
MOD_GlcNHglycan 429 432 PF01048 0.465
MOD_GlcNHglycan 467 470 PF01048 0.328
MOD_GlcNHglycan 574 577 PF01048 0.559
MOD_GlcNHglycan 593 596 PF01048 0.320
MOD_GlcNHglycan 71 74 PF01048 0.338
MOD_GlcNHglycan 80 83 PF01048 0.358
MOD_GSK3_1 118 125 PF00069 0.373
MOD_GSK3_1 170 177 PF00069 0.338
MOD_GSK3_1 198 205 PF00069 0.652
MOD_GSK3_1 319 326 PF00069 0.353
MOD_GSK3_1 339 346 PF00069 0.199
MOD_GSK3_1 538 545 PF00069 0.580
MOD_GSK3_1 551 558 PF00069 0.554
MOD_GSK3_1 559 566 PF00069 0.557
MOD_GSK3_1 64 71 PF00069 0.389
MOD_N-GLC_1 261 266 PF02516 0.348
MOD_N-GLC_1 446 451 PF02516 0.237
MOD_N-GLC_1 538 543 PF02516 0.549
MOD_NEK2_1 1 6 PF00069 0.595
MOD_NEK2_1 266 271 PF00069 0.430
MOD_NEK2_1 381 386 PF00069 0.376
MOD_NEK2_1 427 432 PF00069 0.424
MOD_NEK2_1 50 55 PF00069 0.403
MOD_NEK2_1 526 531 PF00069 0.400
MOD_NEK2_1 551 556 PF00069 0.635
MOD_NEK2_2 340 345 PF00069 0.524
MOD_PIKK_1 354 360 PF00454 0.455
MOD_PIKK_1 64 70 PF00454 0.451
MOD_PK_1 402 408 PF00069 0.427
MOD_PK_1 527 533 PF00069 0.386
MOD_PKA_1 290 296 PF00069 0.687
MOD_PKA_1 563 569 PF00069 0.588
MOD_PKA_2 11 17 PF00069 0.654
MOD_PKA_2 236 242 PF00069 0.555
MOD_PKA_2 266 272 PF00069 0.517
MOD_PKA_2 290 296 PF00069 0.708
MOD_Plk_1 127 133 PF00069 0.304
MOD_Plk_1 340 346 PF00069 0.413
MOD_Plk_1 551 557 PF00069 0.734
MOD_Plk_1 597 603 PF00069 0.555
MOD_Plk_2-3 198 204 PF00069 0.465
MOD_Plk_4 127 133 PF00069 0.314
MOD_Plk_4 156 162 PF00069 0.338
MOD_Plk_4 170 176 PF00069 0.308
MOD_Plk_4 39 45 PF00069 0.373
MOD_Plk_4 510 516 PF00069 0.319
MOD_Plk_4 527 533 PF00069 0.386
MOD_ProDKin_1 118 124 PF00069 0.338
MOD_ProDKin_1 175 181 PF00069 0.304
MOD_ProDKin_1 192 198 PF00069 0.498
MOD_ProDKin_1 282 288 PF00069 0.731
MOD_ProDKin_1 323 329 PF00069 0.496
MOD_ProDKin_1 53 59 PF00069 0.409
MOD_ProDKin_1 538 544 PF00069 0.577
MOD_SUMO_rev_2 16 21 PF00179 0.570
MOD_SUMO_rev_2 545 551 PF00179 0.620
MOD_SUMO_rev_2 637 643 PF00179 0.637
TRG_DiLeu_BaLyEn_6 410 415 PF01217 0.423
TRG_ENDOCYTIC_2 424 427 PF00928 0.295
TRG_ENDOCYTIC_2 436 439 PF00928 0.304
TRG_ER_diArg_1 10 13 PF00400 0.558
TRG_ER_diArg_1 216 219 PF00400 0.470
TRG_ER_diArg_1 288 291 PF00400 0.785
TRG_NLS_MonoCore_2 449 454 PF00514 0.451
TRG_NLS_MonoExtC_3 449 454 PF00514 0.424
TRG_NLS_MonoExtC_3 8 13 PF00514 0.564
TRG_Pf-PMV_PEXEL_1 124 128 PF00026 0.304
TRG_Pf-PMV_PEXEL_1 64 68 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 652 657 PF00026 0.505

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8C1 Leptomonas seymouri 72% 98%
A0A0S4JMG7 Bodo saltans 40% 87%
A0A1X0NZ55 Trypanosomatidae 54% 100%
A0A3R7LSE5 Trypanosoma rangeli 53% 100%
A0A3S7WTP8 Leishmania donovani 99% 100%
A4H8D2 Leishmania braziliensis 84% 100%
C9ZPS7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 98%
E9AQG1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QF15 Leishmania major 94% 100%
Q6C193 Yarrowia lipolytica (strain CLIB 122 / E 150) 25% 100%
V5BBA0 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS