Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWP4_LEIIN

TriTrypDb:

LINF_150023500

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	200	202	PF00082	0.634
CLV_PCSK_KEX2_1	47	49	PF00082	0.553
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.651
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.561
CLV_PCSK_SKI1_1	47	51	PF00082	0.600
DEG_Nend_UBRbox_3	1	3	PF02207	0.651
DOC_MAPK_gen_1	142	150	PF00069	0.559
DOC_PP1_RVXF_1	13	19	PF00149	0.451
DOC_PP1_RVXF_1	22	28	PF00149	0.473
DOC_PP2B_LxvP_1	190	193	PF13499	0.697
DOC_USP7_MATH_1	123	127	PF00917	0.669
DOC_USP7_MATH_1	179	183	PF00917	0.541
DOC_USP7_MATH_1	55	59	PF00917	0.699
DOC_USP7_MATH_1	74	78	PF00917	0.428
DOC_USP7_MATH_1	94	98	PF00917	0.607
DOC_USP7_UBL2_3	196	200	PF12436	0.547
DOC_WW_Pin1_4	151	156	PF00397	0.516
DOC_WW_Pin1_4	170	175	PF00397	0.562
LIG_14-3-3_CanoR_1	158	166	PF00244	0.605
LIG_14-3-3_CanoR_1	183	193	PF00244	0.656
LIG_14-3-3_CanoR_1	209	214	PF00244	0.708
LIG_14-3-3_CanoR_1	95	99	PF00244	0.706
LIG_FHA_1	65	71	PF00498	0.570
LIG_LIR_Apic_2	117	121	PF02991	0.612
LIG_LIR_Gen_1	77	83	PF02991	0.607
LIG_LIR_Nem_3	57	63	PF02991	0.547
LIG_LIR_Nem_3	77	82	PF02991	0.395
LIG_Pex14_2	60	64	PF04695	0.599
LIG_SH2_PTP2	79	82	PF00017	0.611
LIG_SH2_STAT3	98	101	PF00017	0.574
LIG_SH2_STAT5	149	152	PF00017	0.475
LIG_SH2_STAT5	165	168	PF00017	0.505
LIG_SH2_STAT5	79	82	PF00017	0.684
LIG_SH3_1	196	202	PF00018	0.636
LIG_SH3_3	117	123	PF00018	0.622
LIG_SH3_3	192	198	PF00018	0.690
LIG_SUMO_SIM_par_1	67	73	PF11976	0.644
LIG_TRAF2_1	154	157	PF00917	0.481
MOD_CDK_SPxxK_3	151	158	PF00069	0.514
MOD_CK1_1	86	92	PF00069	0.690
MOD_CK2_1	151	157	PF00069	0.458
MOD_GlcNHglycan	190	193	PF01048	0.724
MOD_GlcNHglycan	92	95	PF01048	0.647
MOD_GSK3_1	103	110	PF00069	0.393
MOD_GSK3_1	184	191	PF00069	0.588
MOD_GSK3_1	50	57	PF00069	0.575
MOD_GSK3_1	86	93	PF00069	0.689
MOD_NEK2_1	114	119	PF00069	0.573
MOD_NEK2_1	72	77	PF00069	0.620
MOD_PIKK_1	185	191	PF00454	0.535
MOD_PK_1	209	215	PF00069	0.708
MOD_PKA_2	157	163	PF00069	0.572
MOD_PKA_2	94	100	PF00069	0.712
MOD_PKB_1	142	150	PF00069	0.436
MOD_Plk_1	9	15	PF00069	0.469
MOD_Plk_4	144	150	PF00069	0.456
MOD_ProDKin_1	151	157	PF00069	0.515
MOD_ProDKin_1	170	176	PF00069	0.555
TRG_ENDOCYTIC_2	79	82	PF00928	0.611
TRG_ER_diArg_1	181	184	PF00400	0.657
TRG_NLS_Bipartite_1	37	51	PF00514	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7M0	Leptomonas seymouri	58%	100%
A0A0S4J706	Bodo saltans	32%	94%
A0A1X0NU63	Trypanosomatidae	36%	96%
A0A3R7MDP5	Trypanosoma rangeli	36%	97%
A0A3S7WTQ3	Leishmania donovani	99%	100%
A4H8C3	Leishmania braziliensis	81%	100%
C9ZXP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E9AQF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QF24	Leishmania major	94%	100%