Secreted protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4HWP1_LEIIN

TriTrypDb:

Length:

109

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	17	23	PF00400	0.628
DOC_CKS1_1	17	22	PF01111	0.623
DOC_MAPK_MEF2A_6	7	15	PF00069	0.551
DOC_USP7_UBL2_3	56	60	PF12436	0.706
DOC_WW_Pin1_4	16	21	PF00397	0.626
DOC_WW_Pin1_4	95	100	PF00397	0.792
LIG_14-3-3_CanoR_1	26	36	PF00244	0.384
LIG_14-3-3_CanoR_1	7	12	PF00244	0.557
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	1	5	PF00533	0.638
LIG_BRCT_BRCA1_1	30	34	PF00533	0.608
LIG_BRCT_BRCA1_1	45	49	PF00533	0.447
LIG_FHA_1	8	14	PF00498	0.628
LIG_LIR_Gen_1	10	20	PF02991	0.540
LIG_LIR_Nem_3	10	15	PF02991	0.511
LIG_LIR_Nem_3	2	8	PF02991	0.624
LIG_NRP_CendR_1	106	109	PF00754	0.770
LIG_Pex14_2	35	39	PF04695	0.574
LIG_SH2_PTP2	14	17	PF00017	0.616
LIG_SH2_SRC	12	15	PF00017	0.542
LIG_SH2_SRC	82	85	PF00017	0.613
LIG_SH2_STAP1	9	13	PF00017	0.550
LIG_SH2_STAT5	14	17	PF00017	0.570
LIG_SH2_STAT5	9	12	PF00017	0.609
LIG_SH3_2	55	60	PF14604	0.624
LIG_SH3_3	12	18	PF00018	0.607
LIG_SH3_3	52	58	PF00018	0.616
LIG_TYR_ITSM	8	15	PF00017	0.548
LIG_WRC_WIRS_1	36	41	PF05994	0.715
MOD_CDK_SPK_2	21	26	PF00069	0.631
MOD_CK1_1	30	36	PF00069	0.554
MOD_CK2_1	82	88	PF00069	0.703
MOD_GSK3_1	16	23	PF00069	0.644
MOD_GSK3_1	30	37	PF00069	0.522
MOD_GSK3_1	39	46	PF00069	0.485
MOD_LATS_1	87	93	PF00433	0.764
MOD_N-GLC_1	43	48	PF02516	0.611
MOD_N-GLC_1	95	100	PF02516	0.792
MOD_NEK2_1	34	39	PF00069	0.644
MOD_NEK2_1	45	50	PF00069	0.498
MOD_Plk_4	30	36	PF00069	0.640
MOD_Plk_4	45	51	PF00069	0.420
MOD_Plk_4	7	13	PF00069	0.624
MOD_ProDKin_1	16	22	PF00069	0.624
MOD_ProDKin_1	95	101	PF00069	0.792
TRG_ENDOCYTIC_2	12	15	PF00928	0.553
TRG_ER_diLys_1	104	109	PF00400	0.770

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTQ4	Leishmania donovani	99%	100%
E9AQE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QF27	Leishmania major	83%	100%