DUF4220 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWN9_LEIIN

TriTrypDb:

LINF_150023200

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.525
CLV_NRD_NRD_1	256	258	PF00675	0.425
CLV_NRD_NRD_1	34	36	PF00675	0.536
CLV_PCSK_FUR_1	32	36	PF00082	0.508
CLV_PCSK_KEX2_1	103	105	PF00082	0.585
CLV_PCSK_KEX2_1	256	258	PF00082	0.408
CLV_PCSK_KEX2_1	34	36	PF00082	0.536
CLV_PCSK_SKI1_1	103	107	PF00082	0.514
CLV_PCSK_SKI1_1	21	25	PF00082	0.392
CLV_PCSK_SKI1_1	34	38	PF00082	0.461
CLV_PCSK_SKI1_1	81	85	PF00082	0.508
DEG_Nend_UBRbox_1	1	4	PF02207	0.620
DOC_CKS1_1	131	136	PF01111	0.589
DOC_CYCLIN_RxL_1	256	270	PF00134	0.421
DOC_CYCLIN_RxL_1	280	291	PF00134	0.504
DOC_CYCLIN_RxL_1	76	85	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.588
DOC_MAPK_gen_1	202	211	PF00069	0.609
DOC_MAPK_gen_1	32	41	PF00069	0.570
DOC_MAPK_HePTP_8	29	41	PF00069	0.505
DOC_MAPK_HePTP_8	83	95	PF00069	0.443
DOC_MAPK_MEF2A_6	32	41	PF00069	0.514
DOC_MAPK_MEF2A_6	86	95	PF00069	0.399
DOC_PP2B_LxvP_1	37	40	PF13499	0.533
DOC_USP7_MATH_1	155	159	PF00917	0.666
DOC_USP7_MATH_1	251	255	PF00917	0.489
DOC_WW_Pin1_4	1	6	PF00397	0.664
DOC_WW_Pin1_4	130	135	PF00397	0.540
DOC_WW_Pin1_4	158	163	PF00397	0.724
LIG_14-3-3_CanoR_1	156	162	PF00244	0.778
LIG_14-3-3_CanoR_1	177	186	PF00244	0.587
LIG_14-3-3_CanoR_1	202	211	PF00244	0.527
LIG_14-3-3_CanoR_1	256	260	PF00244	0.400
LIG_14-3-3_CanoR_1	268	272	PF00244	0.399
LIG_14-3-3_CanoR_1	278	284	PF00244	0.421
LIG_14-3-3_CanoR_1	47	53	PF00244	0.519
LIG_14-3-3_CanoR_1	78	84	PF00244	0.443
LIG_14-3-3_CanoR_1	86	92	PF00244	0.406
LIG_Actin_WH2_2	88	105	PF00022	0.402
LIG_BRCT_BRCA1_1	143	147	PF00533	0.676
LIG_BRCT_BRCA1_1	192	196	PF00533	0.603
LIG_BRCT_BRCA1_1	217	221	PF00533	0.518
LIG_deltaCOP1_diTrp_1	173	176	PF00928	0.467
LIG_FHA_1	210	216	PF00498	0.414
LIG_FHA_1	61	67	PF00498	0.535
LIG_LIR_Gen_1	112	120	PF02991	0.425
LIG_LIR_Gen_1	279	289	PF02991	0.496
LIG_LIR_Nem_3	112	117	PF02991	0.415
LIG_LIR_Nem_3	144	150	PF02991	0.732
LIG_LIR_Nem_3	173	179	PF02991	0.531
LIG_LIR_Nem_3	20	26	PF02991	0.362
LIG_LIR_Nem_3	279	284	PF02991	0.518
LIG_LIR_Nem_3	90	95	PF02991	0.519
LIG_MLH1_MIPbox_1	217	221	PF16413	0.460
LIG_PCNA_yPIPBox_3	202	215	PF02747	0.581
LIG_Pex14_1	174	178	PF04695	0.562
LIG_Pex14_1	245	249	PF04695	0.539
LIG_Pex14_1	88	92	PF04695	0.505
LIG_Pex14_2	65	69	PF04695	0.372
LIG_PTB_Apo_2	214	221	PF02174	0.431
LIG_REV1ctd_RIR_1	21	29	PF16727	0.486
LIG_REV1ctd_RIR_1	218	228	PF16727	0.441
LIG_SH2_GRB2like	113	116	PF00017	0.458
LIG_SH2_NCK_1	138	142	PF00017	0.649
LIG_SH2_STAP1	98	102	PF00017	0.421
LIG_SH2_STAT5	178	181	PF00017	0.493
LIG_SH2_STAT5	28	31	PF00017	0.400
LIG_SH2_STAT5	73	76	PF00017	0.511
LIG_SH2_STAT5	92	95	PF00017	0.239
LIG_SH3_3	147	153	PF00018	0.682
LIG_SH3_CIN85_PxpxPR_1	151	156	PF14604	0.610
LIG_WRC_WIRS_1	246	251	PF05994	0.525
LIG_WW_2	152	155	PF00397	0.643
MOD_CDK_SPxK_1	130	136	PF00069	0.593
MOD_CK1_1	116	122	PF00069	0.504
MOD_CK1_1	158	164	PF00069	0.700
MOD_CK1_1	4	10	PF00069	0.627
MOD_CK2_1	4	10	PF00069	0.580
MOD_GlcNHglycan	147	150	PF01048	0.724
MOD_GSK3_1	141	148	PF00069	0.658
MOD_GSK3_1	156	163	PF00069	0.620
MOD_GSK3_1	177	184	PF00069	0.498
MOD_GSK3_1	186	193	PF00069	0.460
MOD_GSK3_1	245	252	PF00069	0.557
MOD_GSK3_1	6	13	PF00069	0.587
MOD_N-GLC_1	239	244	PF02516	0.548
MOD_NEK2_1	187	192	PF00069	0.537
MOD_NEK2_1	196	201	PF00069	0.510
MOD_NEK2_1	255	260	PF00069	0.424
MOD_NEK2_1	266	271	PF00069	0.390
MOD_NEK2_1	67	72	PF00069	0.442
MOD_NEK2_1	87	92	PF00069	0.229
MOD_NEK2_2	239	244	PF00069	0.558
MOD_NEK2_2	251	256	PF00069	0.487
MOD_PIKK_1	10	16	PF00454	0.534
MOD_PK_1	35	41	PF00069	0.523
MOD_PKA_1	103	109	PF00069	0.518
MOD_PKA_2	103	109	PF00069	0.417
MOD_PKA_2	155	161	PF00069	0.778
MOD_PKA_2	203	209	PF00069	0.586
MOD_PKA_2	255	261	PF00069	0.363
MOD_PKA_2	267	273	PF00069	0.352
MOD_PKA_2	46	52	PF00069	0.474
MOD_Plk_1	209	215	PF00069	0.477
MOD_Plk_1	239	245	PF00069	0.533
MOD_Plk_1	266	272	PF00069	0.461
MOD_Plk_4	182	188	PF00069	0.537
MOD_ProDKin_1	1	7	PF00069	0.655
MOD_ProDKin_1	130	136	PF00069	0.552
MOD_ProDKin_1	158	164	PF00069	0.719
TRG_DiLeu_BaEn_1	210	215	PF01217	0.536
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.469
TRG_ENDOCYTIC_2	92	95	PF00928	0.369
TRG_ER_diArg_1	102	104	PF00400	0.533
TRG_ER_diArg_1	201	204	PF00400	0.634
TRG_ER_diArg_1	255	257	PF00400	0.359
TRG_ER_diArg_1	32	35	PF00400	0.403
TRG_ER_diArg_1	75	78	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM1	Leptomonas seymouri	64%	100%
A0A1X0NU20	Trypanosomatidae	41%	100%
A0A3S7WTP0	Leishmania donovani	100%	100%
A0A422N5B2	Trypanosoma rangeli	39%	100%
A4H8B8	Leishmania braziliensis	90%	100%
C9ZXP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QF29	Leishmania major	98%	100%
V5BFJ3	Trypanosoma cruzi	38%	100%