LeishMANIAdb
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Phosphodiesterase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphodiesterase
Gene product:
cAMP specific phosphodiesterase - putative
Species:
Leishmania infantum
UniProt:
A4HWN6_LEIIN
TriTrypDb:
LINF_150022900
Length:
930

Annotations

Annotations by Jardim et al.

Phosphodiesterase, cAMP specific phosphodiesterase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 35
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HWN6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWN6

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 15
GO:0009987 cellular process 1 15
GO:0050789 regulation of biological process 2 15
GO:0050794 regulation of cellular process 3 15
GO:0065007 biological regulation 1 15
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 15
GO:0004112 cyclic-nucleotide phosphodiesterase activity 6 15
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7 15
GO:0005488 binding 1 15
GO:0008081 phosphoric diester hydrolase activity 5 15
GO:0016787 hydrolase activity 2 15
GO:0016788 hydrolase activity, acting on ester bonds 3 15
GO:0042578 phosphoric ester hydrolase activity 4 15
GO:0043167 ion binding 2 15
GO:0043169 cation binding 3 15
GO:0046872 metal ion binding 4 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 602 606 PF00656 0.437
CLV_C14_Caspase3-7 916 920 PF00656 0.560
CLV_NRD_NRD_1 362 364 PF00675 0.448
CLV_NRD_NRD_1 663 665 PF00675 0.423
CLV_NRD_NRD_1 666 668 PF00675 0.456
CLV_NRD_NRD_1 813 815 PF00675 0.492
CLV_NRD_NRD_1 921 923 PF00675 0.674
CLV_PCSK_FUR_1 37 41 PF00082 0.490
CLV_PCSK_FUR_1 664 668 PF00082 0.556
CLV_PCSK_KEX2_1 362 364 PF00082 0.325
CLV_PCSK_KEX2_1 39 41 PF00082 0.499
CLV_PCSK_KEX2_1 662 664 PF00082 0.516
CLV_PCSK_KEX2_1 666 668 PF00082 0.542
CLV_PCSK_KEX2_1 7 9 PF00082 0.623
CLV_PCSK_KEX2_1 813 815 PF00082 0.492
CLV_PCSK_KEX2_1 921 923 PF00082 0.674
CLV_PCSK_PC1ET2_1 39 41 PF00082 0.423
CLV_PCSK_PC1ET2_1 7 9 PF00082 0.623
CLV_PCSK_PC7_1 358 364 PF00082 0.325
CLV_PCSK_PC7_1 662 668 PF00082 0.523
CLV_PCSK_SKI1_1 251 255 PF00082 0.349
CLV_PCSK_SKI1_1 323 327 PF00082 0.349
CLV_PCSK_SKI1_1 418 422 PF00082 0.349
CLV_PCSK_SKI1_1 425 429 PF00082 0.349
CLV_PCSK_SKI1_1 583 587 PF00082 0.623
DOC_CYCLIN_yCln2_LP_2 326 332 PF00134 0.349
DOC_CYCLIN_yCln2_LP_2 502 508 PF00134 0.349
DOC_MAPK_gen_1 37 45 PF00069 0.468
DOC_MAPK_gen_1 392 401 PF00069 0.463
DOC_MAPK_gen_1 580 590 PF00069 0.623
DOC_MAPK_MEF2A_6 323 332 PF00069 0.461
DOC_MAPK_MEF2A_6 564 571 PF00069 0.674
DOC_MAPK_MEF2A_6 595 603 PF00069 0.544
DOC_MAPK_NFAT4_5 323 331 PF00069 0.461
DOC_MAPK_NFAT4_5 564 572 PF00069 0.678
DOC_PP1_RVXF_1 93 100 PF00149 0.370
DOC_PP2B_LxvP_1 326 329 PF13499 0.349
DOC_PP4_FxxP_1 609 612 PF00568 0.516
DOC_PP4_FxxP_1 99 102 PF00568 0.589
DOC_USP7_MATH_1 16 20 PF00917 0.670
DOC_USP7_MATH_1 224 228 PF00917 0.449
DOC_USP7_MATH_1 266 270 PF00917 0.457
DOC_USP7_MATH_1 375 379 PF00917 0.343
DOC_USP7_MATH_1 430 434 PF00917 0.349
DOC_USP7_MATH_1 597 601 PF00917 0.551
DOC_USP7_UBL2_3 390 394 PF12436 0.521
DOC_WW_Pin1_4 189 194 PF00397 0.487
DOC_WW_Pin1_4 529 534 PF00397 0.413
DOC_WW_Pin1_4 588 593 PF00397 0.579
DOC_WW_Pin1_4 608 613 PF00397 0.386
DOC_WW_Pin1_4 7 12 PF00397 0.645
DOC_WW_Pin1_4 725 730 PF00397 0.349
LIG_14-3-3_CanoR_1 309 315 PF00244 0.492
LIG_14-3-3_CanoR_1 432 436 PF00244 0.392
LIG_14-3-3_CanoR_1 485 494 PF00244 0.491
LIG_14-3-3_CanoR_1 573 582 PF00244 0.610
LIG_BIR_II_1 1 5 PF00653 0.441
LIG_BRCT_BRCA1_1 190 194 PF00533 0.391
LIG_BRCT_BRCA1_1 432 436 PF00533 0.349
LIG_BRCT_BRCA1_1 599 603 PF00533 0.560
LIG_BRCT_BRCA1_1 610 614 PF00533 0.424
LIG_BRCT_BRCA1_1 793 797 PF00533 0.288
LIG_eIF4E_1 773 779 PF01652 0.492
LIG_FHA_1 158 164 PF00498 0.484
LIG_FHA_1 320 326 PF00498 0.349
LIG_FHA_1 496 502 PF00498 0.349
LIG_FHA_1 536 542 PF00498 0.362
LIG_FHA_1 566 572 PF00498 0.691
LIG_FHA_1 705 711 PF00498 0.349
LIG_FHA_2 107 113 PF00498 0.330
LIG_FHA_2 184 190 PF00498 0.558
LIG_FHA_2 208 214 PF00498 0.577
LIG_FHA_2 234 240 PF00498 0.591
LIG_FHA_2 252 258 PF00498 0.238
LIG_FHA_2 27 33 PF00498 0.498
LIG_FHA_2 465 471 PF00498 0.492
LIG_FHA_2 530 536 PF00498 0.364
LIG_FHA_2 589 595 PF00498 0.472
LIG_FHA_2 608 614 PF00498 0.432
LIG_FHA_2 695 701 PF00498 0.325
LIG_GBD_Chelix_1 705 713 PF00786 0.370
LIG_GBD_Chelix_1 892 900 PF00786 0.413
LIG_LIR_Apic_2 608 612 PF02991 0.523
LIG_LIR_Apic_2 621 626 PF02991 0.562
LIG_LIR_Gen_1 112 122 PF02991 0.552
LIG_LIR_Gen_1 365 376 PF02991 0.349
LIG_LIR_Gen_1 444 453 PF02991 0.392
LIG_LIR_Gen_1 611 619 PF02991 0.406
LIG_LIR_Gen_1 700 710 PF02991 0.398
LIG_LIR_Gen_1 794 805 PF02991 0.438
LIG_LIR_Gen_1 88 97 PF02991 0.514
LIG_LIR_Nem_3 112 117 PF02991 0.545
LIG_LIR_Nem_3 166 171 PF02991 0.441
LIG_LIR_Nem_3 191 197 PF02991 0.538
LIG_LIR_Nem_3 365 371 PF02991 0.349
LIG_LIR_Nem_3 537 542 PF02991 0.346
LIG_LIR_Nem_3 543 548 PF02991 0.346
LIG_LIR_Nem_3 611 617 PF02991 0.411
LIG_LIR_Nem_3 700 705 PF02991 0.398
LIG_LIR_Nem_3 761 766 PF02991 0.373
LIG_LIR_Nem_3 88 92 PF02991 0.411
LIG_PCNA_yPIPBox_3 509 521 PF02747 0.392
LIG_PDZ_Class_1 925 930 PF00595 0.645
LIG_PTB_Apo_2 162 169 PF02174 0.514
LIG_PTB_Apo_2 717 724 PF02174 0.349
LIG_PTB_Phospho_1 162 168 PF10480 0.522
LIG_PTB_Phospho_1 717 723 PF10480 0.349
LIG_Rb_pABgroove_1 859 867 PF01858 0.369
LIG_REV1ctd_RIR_1 886 894 PF16727 0.369
LIG_SH2_CRK 665 669 PF00017 0.412
LIG_SH2_CRK 775 779 PF00017 0.492
LIG_SH2_CRK 89 93 PF00017 0.529
LIG_SH2_GRB2like 126 129 PF00017 0.576
LIG_SH2_GRB2like 670 673 PF00017 0.349
LIG_SH2_PTP2 168 171 PF00017 0.392
LIG_SH2_PTP2 702 705 PF00017 0.461
LIG_SH2_SRC 481 484 PF00017 0.349
LIG_SH2_STAP1 197 201 PF00017 0.385
LIG_SH2_STAP1 446 450 PF00017 0.392
LIG_SH2_STAP1 773 777 PF00017 0.413
LIG_SH2_STAP1 89 93 PF00017 0.357
LIG_SH2_STAT3 197 200 PF00017 0.367
LIG_SH2_STAT3 496 499 PF00017 0.369
LIG_SH2_STAT5 168 171 PF00017 0.407
LIG_SH2_STAT5 3 6 PF00017 0.603
LIG_SH2_STAT5 686 689 PF00017 0.378
LIG_SH2_STAT5 702 705 PF00017 0.392
LIG_SH2_STAT5 723 726 PF00017 0.349
LIG_SH3_3 115 121 PF00018 0.365
LIG_SH3_3 164 170 PF00018 0.443
LIG_SH3_3 277 283 PF00018 0.367
LIG_SH3_3 296 302 PF00018 0.231
LIG_SH3_3 826 832 PF00018 0.369
LIG_SUMO_SIM_anti_2 400 406 PF11976 0.475
LIG_SUMO_SIM_anti_2 511 517 PF11976 0.349
LIG_SUMO_SIM_par_1 159 164 PF11976 0.435
LIG_SUMO_SIM_par_1 400 406 PF11976 0.471
LIG_SUMO_SIM_par_1 586 591 PF11976 0.570
LIG_SUMO_SIM_par_1 702 707 PF11976 0.349
LIG_TRAF2_1 236 239 PF00917 0.643
LIG_TRAF2_1 591 594 PF00917 0.564
LIG_TYR_ITIM 633 638 PF00017 0.398
LIG_UBA3_1 435 440 PF00899 0.461
LIG_WRC_WIRS_1 368 373 PF05994 0.349
MOD_CDK_SPxxK_3 588 595 PF00069 0.562
MOD_CK1_1 227 233 PF00069 0.457
MOD_CK1_1 61 67 PF00069 0.693
MOD_CK1_1 734 740 PF00069 0.349
MOD_CK1_1 827 833 PF00069 0.369
MOD_CK1_1 924 930 PF00069 0.647
MOD_CK2_1 106 112 PF00069 0.294
MOD_CK2_1 233 239 PF00069 0.591
MOD_CK2_1 449 455 PF00069 0.492
MOD_CK2_1 464 470 PF00069 0.213
MOD_CK2_1 588 594 PF00069 0.472
MOD_CK2_1 694 700 PF00069 0.345
MOD_CK2_1 738 744 PF00069 0.349
MOD_Cter_Amidation 360 363 PF01082 0.325
MOD_Cter_Amidation 919 922 PF01082 0.650
MOD_GlcNHglycan 14 17 PF01048 0.648
MOD_GlcNHglycan 18 21 PF01048 0.563
MOD_GlcNHglycan 294 297 PF01048 0.468
MOD_GlcNHglycan 351 354 PF01048 0.392
MOD_GlcNHglycan 451 454 PF01048 0.483
MOD_GlcNHglycan 470 473 PF01048 0.381
MOD_GlcNHglycan 487 490 PF01048 0.392
MOD_GlcNHglycan 63 66 PF01048 0.641
MOD_GlcNHglycan 640 643 PF01048 0.459
MOD_GlcNHglycan 734 737 PF01048 0.349
MOD_GlcNHglycan 766 769 PF01048 0.465
MOD_GSK3_1 12 19 PF00069 0.688
MOD_GSK3_1 141 148 PF00069 0.624
MOD_GSK3_1 157 164 PF00069 0.546
MOD_GSK3_1 183 190 PF00069 0.460
MOD_GSK3_1 233 240 PF00069 0.531
MOD_GSK3_1 242 249 PF00069 0.328
MOD_GSK3_1 253 260 PF00069 0.164
MOD_GSK3_1 315 322 PF00069 0.349
MOD_GSK3_1 464 471 PF00069 0.369
MOD_GSK3_1 481 488 PF00069 0.369
MOD_GSK3_1 546 553 PF00069 0.341
MOD_GSK3_1 682 689 PF00069 0.448
MOD_GSK3_1 690 697 PF00069 0.448
MOD_GSK3_1 734 741 PF00069 0.349
MOD_GSK3_1 74 81 PF00069 0.687
MOD_GSK3_1 921 928 PF00069 0.583
MOD_N-GLC_1 207 212 PF02516 0.464
MOD_N-GLC_1 310 315 PF02516 0.479
MOD_N-GLC_1 384 389 PF02516 0.547
MOD_N-GLC_1 550 555 PF02516 0.432
MOD_N-GLC_1 718 723 PF02516 0.349
MOD_N-GLC_1 738 743 PF02516 0.164
MOD_N-GLC_1 827 832 PF02516 0.384
MOD_NEK2_1 12 17 PF00069 0.703
MOD_NEK2_1 145 150 PF00069 0.414
MOD_NEK2_1 237 242 PF00069 0.481
MOD_NEK2_1 332 337 PF00069 0.492
MOD_NEK2_1 367 372 PF00069 0.349
MOD_NEK2_1 449 454 PF00069 0.369
MOD_NEK2_1 637 642 PF00069 0.445
MOD_NEK2_1 704 709 PF00069 0.366
MOD_NEK2_1 833 838 PF00069 0.369
MOD_NEK2_1 865 870 PF00069 0.369
MOD_NEK2_2 375 380 PF00069 0.343
MOD_NEK2_2 526 531 PF00069 0.369
MOD_PIKK_1 216 222 PF00454 0.473
MOD_PIKK_1 347 353 PF00454 0.477
MOD_PIKK_1 495 501 PF00454 0.369
MOD_PIKK_1 74 80 PF00454 0.701
MOD_PK_1 497 503 PF00069 0.461
MOD_PK_1 59 65 PF00069 0.443
MOD_PKA_1 251 257 PF00069 0.210
MOD_PKA_1 392 398 PF00069 0.436
MOD_PKA_1 921 927 PF00069 0.685
MOD_PKA_2 233 239 PF00069 0.574
MOD_PKA_2 257 263 PF00069 0.349
MOD_PKA_2 431 437 PF00069 0.392
MOD_PKA_2 572 578 PF00069 0.609
MOD_PKA_2 58 64 PF00069 0.559
MOD_PKA_2 921 927 PF00069 0.612
MOD_Plk_1 207 213 PF00069 0.563
MOD_Plk_1 237 243 PF00069 0.491
MOD_Plk_1 310 316 PF00069 0.401
MOD_Plk_1 384 390 PF00069 0.553
MOD_Plk_1 430 436 PF00069 0.349
MOD_Plk_1 550 556 PF00069 0.437
MOD_Plk_1 650 656 PF00069 0.470
MOD_Plk_1 718 724 PF00069 0.349
MOD_Plk_1 738 744 PF00069 0.164
MOD_Plk_1 791 797 PF00069 0.266
MOD_Plk_1 833 839 PF00069 0.422
MOD_Plk_2-3 26 32 PF00069 0.502
MOD_Plk_2-3 694 700 PF00069 0.325
MOD_Plk_4 163 169 PF00069 0.482
MOD_Plk_4 237 243 PF00069 0.472
MOD_Plk_4 257 263 PF00069 0.164
MOD_Plk_4 332 338 PF00069 0.398
MOD_Plk_4 384 390 PF00069 0.534
MOD_Plk_4 412 418 PF00069 0.411
MOD_Plk_4 431 437 PF00069 0.194
MOD_Plk_4 497 503 PF00069 0.349
MOD_Plk_4 650 656 PF00069 0.440
MOD_Plk_4 682 688 PF00069 0.358
MOD_Plk_4 718 724 PF00069 0.349
MOD_Plk_4 738 744 PF00069 0.164
MOD_Plk_4 816 822 PF00069 0.492
MOD_ProDKin_1 189 195 PF00069 0.476
MOD_ProDKin_1 529 535 PF00069 0.413
MOD_ProDKin_1 588 594 PF00069 0.570
MOD_ProDKin_1 608 614 PF00069 0.381
MOD_ProDKin_1 7 13 PF00069 0.649
MOD_ProDKin_1 725 731 PF00069 0.349
MOD_SUMO_rev_2 386 395 PF00179 0.477
TRG_DiLeu_BaEn_1 113 118 PF01217 0.452
TRG_DiLeu_BaEn_1 238 243 PF01217 0.579
TRG_DiLeu_BaEn_1 700 705 PF01217 0.345
TRG_DiLeu_BaEn_1 811 816 PF01217 0.288
TRG_ENDOCYTIC_2 168 171 PF00928 0.400
TRG_ENDOCYTIC_2 446 449 PF00928 0.392
TRG_ENDOCYTIC_2 635 638 PF00928 0.404
TRG_ENDOCYTIC_2 665 668 PF00928 0.416
TRG_ENDOCYTIC_2 670 673 PF00928 0.349
TRG_ENDOCYTIC_2 674 677 PF00928 0.349
TRG_ENDOCYTIC_2 702 705 PF00928 0.413
TRG_ENDOCYTIC_2 775 778 PF00928 0.422
TRG_ENDOCYTIC_2 89 92 PF00928 0.506
TRG_ER_diArg_1 662 664 PF00400 0.523
TRG_ER_diArg_1 665 667 PF00400 0.530
TRG_ER_diArg_1 813 815 PF00400 0.492
TRG_Pf-PMV_PEXEL_1 251 255 PF00026 0.349
TRG_Pf-PMV_PEXEL_1 776 780 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 813 818 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 95 100 PF00026 0.544

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P788 Leptomonas seymouri 65% 100%
A0A1X0NUP8 Trypanosomatidae 62% 100%
A0A3Q8I987 Leishmania donovani 81% 99%
A0A3R7RI37 Trypanosoma rangeli 70% 100%
A0A3S7WTN0 Leishmania donovani 100% 100%
A4H893 Leishmania braziliensis 84% 100%
A4H8B6 Leishmania braziliensis 76% 100%
A4HWN7 Leishmania infantum 81% 99%
B3P3K2 Drosophila erecta 29% 82%
B4G4E5 Drosophila persimilis 28% 73%
B4JXX2 Drosophila grimshawi 28% 86%
B4K9L4 Drosophila mojavensis 28% 83%
B4LVU6 Drosophila virilis 28% 100%
B4NAL6 Drosophila willistoni 28% 83%
B4PSS5 Drosophila yakuba 29% 81%
B4QZU1 Drosophila simulans 29% 81%
C9ZXQ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
C9ZXQ1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9AQE4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9AQE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
O00408 Homo sapiens 30% 99%
O54735 Rattus norvegicus 28% 100%
O76074 Homo sapiens 29% 100%
O77746 Canis lupus familiaris 29% 100%
P0C1Q2 Mus musculus 32% 100%
P11541 Bos taurus 25% 100%
P14099 Bos taurus 30% 100%
P16499 Homo sapiens 26% 100%
P16586 Bos taurus 27% 100%
P23439 Bos taurus 25% 100%
P23440 Mus musculus 25% 100%
P27664 Mus musculus 26% 100%
P33726 Canis lupus familiaris 25% 100%
P35913 Homo sapiens 24% 100%
P51160 Homo sapiens 27% 100%
P52731 Gallus gallus 25% 100%
Q01062 Rattus norvegicus 30% 100%
Q1KKS3 Takifugu rubripes 32% 100%
Q28156 Bos taurus 29% 100%
Q28263 Canis lupus familiaris 26% 100%
Q298P4 Drosophila pseudoobscura pseudoobscura 28% 84%
Q4QF31 Leishmania major 82% 100%
Q8CA95 Mus musculus 30% 100%
Q8CG03 Mus musculus 28% 100%
Q8VID6 Rattus norvegicus 32% 99%
Q91ZQ1 Mus musculus 27% 100%
Q922S4 Mus musculus 30% 99%
Q9HCR9 Homo sapiens 32% 100%
Q9QYJ6 Rattus norvegicus 31% 100%
Q9VFI9 Drosophila melanogaster 29% 83%
Q9Y233 Homo sapiens 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS