Ribonucloprotein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribonucloprotein

Gene product:

ribosomal protein S6 - putative

Species:

Leishmania infantum

UniProt:

A4HWN5_LEIIN

TriTrypDb:

LINF_150022800

Length:

126

Annotations

Annotations by Jardim et al.

Ribosomal Protein, ribosomal S6

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 4
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 28

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005681	spliceosomal complex	3	1
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0030684	preribosome	3	1
GO:0031428	box C/D RNP complex	4	1
GO:0032040	small-subunit processome	4	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0071011	precatalytic spliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Phosphorylation

Promastigote: 109

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HWN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWN5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	10
GO:0042254	ribosome biogenesis	5	10
GO:0044085	cellular component biogenesis	3	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	32	36	PF00082	0.224
CLV_PCSK_SKI1_1	85	89	PF00082	0.214
DOC_CDC14_PxL_1	65	73	PF14671	0.420
DOC_MAPK_MEF2A_6	114	122	PF00069	0.279
DOC_MAPK_MEF2A_6	75	82	PF00069	0.399
DOC_MAPK_MEF2A_6	96	103	PF00069	0.390
DOC_PP2B_LxvP_1	66	69	PF13499	0.390
DOC_USP7_UBL2_3	32	36	PF12436	0.390
DOC_WW_Pin1_4	106	111	PF00397	0.403
LIG_14-3-3_CanoR_1	16	24	PF00244	0.340
LIG_14-3-3_CanoR_1	90	98	PF00244	0.485
LIG_FHA_1	12	18	PF00498	0.337
LIG_FHA_1	40	46	PF00498	0.390
LIG_FHA_1	57	63	PF00498	0.390
LIG_FHA_2	18	24	PF00498	0.207
LIG_PCNA_yPIPBox_3	43	53	PF02747	0.390
LIG_SH2_PTP2	79	82	PF00017	0.390
LIG_SH2_STAT5	79	82	PF00017	0.390
LIG_SH3_3	77	83	PF00018	0.415
LIG_SUMO_SIM_anti_2	20	27	PF11976	0.224
LIG_SUMO_SIM_anti_2	51	56	PF11976	0.390
LIG_TYR_ITIM	77	82	PF00017	0.390
MOD_CK1_1	92	98	PF00069	0.459
MOD_GSK3_1	11	18	PF00069	0.430
MOD_NEK2_1	17	22	PF00069	0.322
MOD_PIKK_1	15	21	PF00454	0.300
MOD_PIKK_1	89	95	PF00454	0.485
MOD_PKA_2	15	21	PF00069	0.343
MOD_PKA_2	89	95	PF00069	0.485
MOD_Plk_4	17	23	PF00069	0.328
MOD_ProDKin_1	106	112	PF00069	0.403
MOD_SUMO_for_1	118	121	PF00179	0.311
TRG_DiLeu_BaEn_1	121	126	PF01217	0.345
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.402
TRG_DiLeu_LyEn_5	121	126	PF01217	0.297
TRG_ENDOCYTIC_2	79	82	PF00928	0.390
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8X8	Leptomonas seymouri	29%	85%
A0A0N1PEF5	Leptomonas seymouri	98%	100%
A0A0S4JKB4	Bodo saltans	80%	98%
A0A0S4KMG7	Bodo saltans	33%	86%
A0A1X0NU51	Trypanosomatidae	89%	100%
A0A3Q8IDI1	Leishmania donovani	100%	100%
A0A3R7MN38	Trypanosoma rangeli	29%	85%
A0A3R7NA40	Trypanosoma rangeli	92%	100%
A0A3S7X8I5	Leishmania donovani	30%	85%
A0B601	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	43%	100%
A3DMR6	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	45%	98%
A4H8B5	Leishmania braziliensis	98%	100%
A4HBC1	Leishmania braziliensis	29%	85%
A4IAG9	Leishmania infantum	30%	85%
A4YIL9	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	42%	100%
A5UJN3	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	32%	100%
A8A912	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	47%	98%
A9A2Z3	Nitrosopumilus maritimus (strain SCM1)	49%	98%
B1Y9V4	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	43%	83%
B6YWH9	Thermococcus onnurineus (strain NA1)	43%	100%
B8D6E8	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	43%	99%
B9LPY2	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	40%	100%
C3MJN1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	46%	99%
C3MYY9	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	46%	99%
C3N038	Sulfolobus islandicus (strain M.16.27)	46%	99%
C3N8Q2	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	46%	99%
C3NMR6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	46%	99%
C4KJ77	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	46%	99%
C5A1V9	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	43%	100%
C9ZLS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	87%
C9ZXQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	90%	100%
E9AQE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E9B5J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O29494	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	45%	100%
O74690	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	65%	100%
P0CQ52	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	60%	99%
P0CQ53	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	60%	99%
P12743	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	35%	100%
P32495	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	81%
P39990	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	62%	100%
P54066	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	43%	100%
P55769	Homo sapiens	56%	98%
P55770	Rattus norvegicus	56%	98%
P55858	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	45%	99%
P62008	Pyrococcus abyssi (strain GE5 / Orsay)	43%	100%
P62009	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	43%	100%
Q0W8W9	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	37%	100%
Q18GA8	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	37%	100%
Q21568	Caenorhabditis elegans	61%	98%
Q2NGM2	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	33%	100%
Q3B8S0	Bos taurus	56%	98%
Q3IPM9	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	36%	100%
Q466D1	Methanosarcina barkeri (strain Fusaro / DSM 804)	35%	100%
Q4J8P1	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	50%	100%
Q4P0K3	Ustilago maydis (strain 521 / FGSC 9021)	65%	100%
Q4Q2E3	Leishmania major	30%	85%
Q4QF32	Leishmania major	100%	100%
Q4R5C6	Macaca fascicularis	56%	98%
Q54ST0	Dictyostelium discoideum	54%	98%
Q5ANL6	Candida albicans (strain SC5314 / ATCC MYA-2876)	60%	100%
Q5E950	Bos taurus	41%	82%
Q5JGR3	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	44%	100%
Q5RC65	Pongo abelii	41%	82%
Q5XH16	Xenopus laevis	59%	98%
Q60YI3	Caenorhabditis briggsae	33%	77%
Q6BLQ3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	62%	100%
Q6C0I0	Yarrowia lipolytica (strain CLIB 122 / E 150)	57%	100%
Q6CM69	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	65%	100%
Q6FQV5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	63%	100%
Q6NTV9	Xenopus laevis	37%	85%
Q6P8C4	Xenopus tropicalis	37%	85%
Q6P8E9	Xenopus tropicalis	60%	98%
Q6PBV6	Danio rerio	38%	84%
Q6XIP0	Drosophila yakuba	34%	79%
Q757T2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	60%	99%
Q8I7X7	Branchiostoma belcheri	35%	79%
Q8PU74	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	37%	100%
Q8TQL9	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	35%	100%
Q8U160	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	43%	100%
Q8ZTA5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	42%	83%
Q971C9	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	48%	100%
Q9CRB2	Mus musculus	42%	82%
Q9D0T1	Mus musculus	56%	98%
Q9LEY9	Arabidopsis thaliana	39%	81%
Q9NX24	Homo sapiens	41%	82%
Q9P7H0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	82%
Q9U3Z7	Drosophila melanogaster	60%	99%
Q9V3U2	Drosophila melanogaster	35%	79%
Q9XXD4	Caenorhabditis elegans	36%	77%
Q9YAX7	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	44%	99%