LeishMANIAdb
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Phosphomevalonate kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphomevalonate kinase
Gene product:
phosphomevalonate kinase protein - putative
Species:
Leishmania infantum
UniProt:
A4HWN3_LEIIN
TriTrypDb:
LINF_150022700
Length:
458

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, phosphomevalonate kinase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HWN3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWN3

Function

Biological processes
Term Name Level Count
GO:0006084 acetyl-CoA metabolic process 5 10
GO:0006139 nucleobase-containing compound metabolic process 3 10
GO:0006163 purine nucleotide metabolic process 5 10
GO:0006629 lipid metabolic process 3 10
GO:0006637 acyl-CoA metabolic process 4 10
GO:0006644 phospholipid metabolic process 4 10
GO:0006725 cellular aromatic compound metabolic process 3 10
GO:0006753 nucleoside phosphate metabolic process 4 10
GO:0006790 sulfur compound metabolic process 3 10
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 11
GO:0008610 lipid biosynthetic process 4 10
GO:0008654 phospholipid biosynthetic process 5 10
GO:0009058 biosynthetic process 2 10
GO:0009117 nucleotide metabolic process 5 10
GO:0009150 purine ribonucleotide metabolic process 6 10
GO:0009240 isopentenyl diphosphate biosynthetic process 6 10
GO:0009259 ribonucleotide metabolic process 5 10
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway 6 10
GO:0019637 organophosphate metabolic process 3 10
GO:0019693 ribose phosphate metabolic process 4 10
GO:0033865 nucleoside bisphosphate metabolic process 5 10
GO:0033875 ribonucleoside bisphosphate metabolic process 6 10
GO:0034032 purine nucleoside bisphosphate metabolic process 5 10
GO:0034641 cellular nitrogen compound metabolic process 3 10
GO:0035383 thioester metabolic process 3 10
GO:0043603 amide metabolic process 3 10
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 10
GO:0044255 cellular lipid metabolic process 3 10
GO:0044281 small molecule metabolic process 2 10
GO:0046483 heterocycle metabolic process 3 10
GO:0046490 isopentenyl diphosphate metabolic process 5 10
GO:0055086 nucleobase-containing small molecule metabolic process 3 10
GO:0071704 organic substance metabolic process 2 10
GO:0072521 purine-containing compound metabolic process 4 10
GO:0090407 organophosphate biosynthetic process 4 10
GO:1901135 carbohydrate derivative metabolic process 3 10
GO:1901360 organic cyclic compound metabolic process 3 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901576 organic substance biosynthetic process 3 10
GO:0006720 isoprenoid metabolic process 4 1
GO:0006721 terpenoid metabolic process 5 1
GO:0008299 isoprenoid biosynthetic process 4 1
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway 6 1
GO:0016114 terpenoid biosynthetic process 5 1
GO:0044249 cellular biosynthetic process 3 1
GO:0045337 farnesyl diphosphate biosynthetic process 6 1
GO:0045338 farnesyl diphosphate metabolic process 5 1
GO:1902767 isoprenoid biosynthetic process via mevalonate 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004631 phosphomevalonate kinase activity 5 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016776 phosphotransferase activity, phosphate group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 108 112 PF00656 0.476
CLV_C14_Caspase3-7 298 302 PF00656 0.425
CLV_NRD_NRD_1 221 223 PF00675 0.346
CLV_NRD_NRD_1 247 249 PF00675 0.390
CLV_NRD_NRD_1 293 295 PF00675 0.377
CLV_NRD_NRD_1 308 310 PF00675 0.380
CLV_NRD_NRD_1 319 321 PF00675 0.487
CLV_PCSK_KEX2_1 221 223 PF00082 0.310
CLV_PCSK_KEX2_1 247 249 PF00082 0.479
CLV_PCSK_KEX2_1 293 295 PF00082 0.431
CLV_PCSK_KEX2_1 308 310 PF00082 0.415
CLV_PCSK_KEX2_1 319 321 PF00082 0.474
CLV_PCSK_SKI1_1 269 273 PF00082 0.369
CLV_PCSK_SKI1_1 369 373 PF00082 0.288
CLV_PCSK_SKI1_1 39 43 PF00082 0.381
DEG_APCC_DBOX_1 368 376 PF00400 0.432
DEG_Nend_UBRbox_2 1 3 PF02207 0.451
DEG_SPOP_SBC_1 166 170 PF00917 0.445
DEG_SPOP_SBC_1 43 47 PF00917 0.375
DOC_CDC14_PxL_1 339 347 PF14671 0.400
DOC_CYCLIN_RxL_1 363 374 PF00134 0.497
DOC_CYCLIN_RxL_1 5 14 PF00134 0.309
DOC_MAPK_DCC_7 144 152 PF00069 0.487
DOC_MAPK_DCC_7 437 445 PF00069 0.329
DOC_MAPK_MEF2A_6 144 152 PF00069 0.487
DOC_MAPK_MEF2A_6 263 272 PF00069 0.380
DOC_PP1_RVXF_1 286 293 PF00149 0.305
DOC_PP4_FxxP_1 262 265 PF00568 0.343
DOC_USP7_MATH_1 102 106 PF00917 0.418
DOC_USP7_MATH_1 365 369 PF00917 0.483
DOC_USP7_MATH_1 48 52 PF00917 0.440
DOC_USP7_MATH_1 71 75 PF00917 0.442
DOC_WW_Pin1_4 19 24 PF00397 0.482
DOC_WW_Pin1_4 279 284 PF00397 0.423
DOC_WW_Pin1_4 296 301 PF00397 0.390
DOC_WW_Pin1_4 57 62 PF00397 0.390
DOC_WW_Pin1_4 86 91 PF00397 0.376
LIG_14-3-3_CanoR_1 227 231 PF00244 0.445
LIG_14-3-3_CanoR_1 293 297 PF00244 0.391
LIG_14-3-3_CanoR_1 35 41 PF00244 0.414
LIG_14-3-3_CanoR_1 64 68 PF00244 0.511
LIG_APCC_ABBA_1 428 433 PF00400 0.352
LIG_BRCT_BRCA1_1 59 63 PF00533 0.333
LIG_BRCT_BRCA1_1 65 69 PF00533 0.332
LIG_CSL_BTD_1 255 258 PF09270 0.492
LIG_CtBP_PxDLS_1 385 389 PF00389 0.513
LIG_deltaCOP1_diTrp_1 254 262 PF00928 0.389
LIG_EVH1_2 258 262 PF00568 0.393
LIG_FHA_1 166 172 PF00498 0.445
LIG_FHA_1 35 41 PF00498 0.345
LIG_FHA_1 387 393 PF00498 0.439
LIG_FHA_2 108 114 PF00498 0.397
LIG_LIR_Apic_2 254 259 PF02991 0.460
LIG_LIR_Apic_2 260 265 PF02991 0.413
LIG_LIR_Gen_1 113 120 PF02991 0.441
LIG_LIR_Gen_1 14 23 PF02991 0.361
LIG_LIR_Gen_1 209 219 PF02991 0.492
LIG_LIR_Gen_1 413 420 PF02991 0.432
LIG_LIR_Gen_1 433 443 PF02991 0.382
LIG_LIR_Gen_1 66 75 PF02991 0.367
LIG_LIR_Nem_3 113 118 PF02991 0.417
LIG_LIR_Nem_3 14 18 PF02991 0.323
LIG_LIR_Nem_3 206 211 PF02991 0.432
LIG_LIR_Nem_3 217 223 PF02991 0.295
LIG_LIR_Nem_3 301 307 PF02991 0.343
LIG_LIR_Nem_3 413 419 PF02991 0.432
LIG_LIR_Nem_3 429 435 PF02991 0.314
LIG_LIR_Nem_3 66 70 PF02991 0.368
LIG_NRBOX 387 393 PF00104 0.445
LIG_Pex14_2 63 67 PF04695 0.377
LIG_RPA_C_Fungi 358 370 PF08784 0.331
LIG_SH2_CRK 211 215 PF00017 0.399
LIG_SH2_CRK 412 416 PF00017 0.304
LIG_SH2_NCK_1 211 215 PF00017 0.399
LIG_SH2_NCK_1 412 416 PF00017 0.304
LIG_SH2_NCK_1 98 102 PF00017 0.298
LIG_SH2_SRC 130 133 PF00017 0.396
LIG_SH2_SRC 15 18 PF00017 0.344
LIG_SH2_STAP1 211 215 PF00017 0.285
LIG_SH2_STAP1 332 336 PF00017 0.392
LIG_SH2_STAP1 412 416 PF00017 0.285
LIG_SH2_STAP1 98 102 PF00017 0.357
LIG_SH2_STAT5 130 133 PF00017 0.353
LIG_SH2_STAT5 15 18 PF00017 0.320
LIG_SH2_STAT5 188 191 PF00017 0.331
LIG_SH2_STAT5 211 214 PF00017 0.285
LIG_SH2_STAT5 314 317 PF00017 0.313
LIG_SH2_STAT5 435 438 PF00017 0.478
LIG_SH3_2 258 263 PF14604 0.446
LIG_SH3_3 145 151 PF00018 0.432
LIG_SH3_3 252 258 PF00018 0.468
LIG_SH3_3 340 346 PF00018 0.398
LIG_SH3_3 401 407 PF00018 0.266
LIG_SH3_3 451 457 PF00018 0.514
LIG_SUMO_SIM_par_1 384 390 PF11976 0.424
LIG_SUMO_SIM_par_1 441 448 PF11976 0.332
LIG_SUMO_SIM_par_1 8 14 PF11976 0.312
LIG_TRFH_1 262 266 PF08558 0.464
MOD_CDK_SPxxK_3 57 64 PF00069 0.437
MOD_CK1_1 105 111 PF00069 0.507
MOD_CK1_1 226 232 PF00069 0.499
MOD_CK1_1 51 57 PF00069 0.547
MOD_CK2_1 107 113 PF00069 0.409
MOD_CK2_1 236 242 PF00069 0.490
MOD_GlcNHglycan 163 166 PF01048 0.266
MOD_GlcNHglycan 2 6 PF01048 0.319
MOD_GlcNHglycan 205 208 PF01048 0.266
MOD_GlcNHglycan 233 236 PF01048 0.634
MOD_GlcNHglycan 447 452 PF01048 0.473
MOD_GlcNHglycan 50 53 PF01048 0.640
MOD_GlcNHglycan 72 76 PF01048 0.493
MOD_GlcNHglycan 85 89 PF01048 0.374
MOD_GSK3_1 102 109 PF00069 0.383
MOD_GSK3_1 156 163 PF00069 0.266
MOD_GSK3_1 292 299 PF00069 0.435
MOD_GSK3_1 44 51 PF00069 0.639
MOD_N-GLC_2 439 441 PF02516 0.349
MOD_NEK2_1 1 6 PF00069 0.435
MOD_NEK2_1 161 166 PF00069 0.302
MOD_NEK2_1 167 172 PF00069 0.329
MOD_NEK2_1 231 236 PF00069 0.484
MOD_NEK2_1 392 397 PF00069 0.266
MOD_NEK2_1 63 68 PF00069 0.403
MOD_NEK2_2 52 57 PF00069 0.488
MOD_PIKK_1 123 129 PF00454 0.317
MOD_PIKK_1 130 136 PF00454 0.366
MOD_PIKK_1 197 203 PF00454 0.383
MOD_PKA_2 226 232 PF00069 0.478
MOD_PKA_2 292 298 PF00069 0.391
MOD_PKA_2 34 40 PF00069 0.399
MOD_PKA_2 63 69 PF00069 0.346
MOD_Plk_4 11 17 PF00069 0.314
MOD_Plk_4 167 173 PF00069 0.285
MOD_Plk_4 226 232 PF00069 0.505
MOD_ProDKin_1 19 25 PF00069 0.471
MOD_ProDKin_1 279 285 PF00069 0.414
MOD_ProDKin_1 296 302 PF00069 0.384
MOD_ProDKin_1 57 63 PF00069 0.394
MOD_ProDKin_1 86 92 PF00069 0.368
MOD_SUMO_for_1 381 384 PF00179 0.399
MOD_SUMO_for_1 41 44 PF00179 0.497
MOD_SUMO_rev_2 374 383 PF00179 0.399
TRG_DiLeu_BaEn_1 387 392 PF01217 0.345
TRG_DiLeu_BaLyEn_6 439 444 PF01217 0.337
TRG_ENDOCYTIC_2 15 18 PF00928 0.320
TRG_ENDOCYTIC_2 211 214 PF00928 0.345
TRG_ENDOCYTIC_2 220 223 PF00928 0.229
TRG_ENDOCYTIC_2 412 415 PF00928 0.285
TRG_ENDOCYTIC_2 435 438 PF00928 0.336
TRG_ER_diArg_1 220 222 PF00400 0.305
TRG_ER_diArg_1 246 248 PF00400 0.389
TRG_ER_diArg_1 292 294 PF00400 0.411
TRG_ER_diArg_1 307 309 PF00400 0.416
TRG_ER_diArg_1 318 320 PF00400 0.444
TRG_Pf-PMV_PEXEL_1 320 324 PF00026 0.542
TRG_Pf-PMV_PEXEL_1 369 374 PF00026 0.269

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P784 Leptomonas seymouri 76% 100%
A0A0S4JMH3 Bodo saltans 55% 100%
A0A1D8PLH0 Candida albicans (strain SC5314 / ATCC MYA-2876) 29% 100%
A0A1X0NVR4 Trypanosomatidae 56% 100%
A0A3S5IQX7 Trypanosoma rangeli 55% 98%
A0A3S7WTM8 Leishmania donovani 100% 100%
A4H8B3 Leishmania braziliensis 84% 100%
C9ZXQ3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 97%
E9AQE1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
I1RZD0 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 31% 100%
P24521 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
Q4QF34 Leishmania major 95% 100%
Q4WV38 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 29% 95%
Q9C6T1 Arabidopsis thaliana 34% 91%
Q9UT88 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS