Proliferating cell nuclear antigen

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proliferative cell nuclear antigen (PCNA) - putative

Species:

Leishmania infantum

UniProt:

A4HWN2_LEIIN

TriTrypDb:

LINF_150022600

Length:

293

Annotations

Annotations by Jardim et al.

DNA replication, Proliferating cell nuclear antigen

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043626	PCNA complex	3	1
GO:0044796	DNA polymerase processivity factor complex	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0150005	enzyme activator complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HWN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWN2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	11
GO:0006275	regulation of DNA replication	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051052	regulation of DNA metabolic process	5	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0071704	organic substance metabolic process	2	12
GO:0080090	regulation of primary metabolic process	4	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006272	leading strand elongation	7	1
GO:0006281	DNA repair	5	1
GO:0006298	mismatch repair	6	1
GO:0006301	postreplication repair	6	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0022616	DNA strand elongation	5	1
GO:0033554	cellular response to stress	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0005488	binding	1	12
GO:0008047	enzyme activator activity	3	12
GO:0030234	enzyme regulator activity	2	12
GO:0030337	DNA polymerase processivity factor activity	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.243
CLV_NRD_NRD_1	109	111	PF00675	0.243
CLV_NRD_NRD_1	215	217	PF00675	0.707
CLV_PCSK_KEX2_1	13	15	PF00082	0.228
CLV_PCSK_KEX2_1	215	217	PF00082	0.538
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.234
CLV_PCSK_SKI1_1	190	194	PF00082	0.337
CLV_PCSK_SKI1_1	262	266	PF00082	0.327
CLV_PCSK_SKI1_1	77	81	PF00082	0.228
DEG_Nend_Nbox_1	1	3	PF02207	0.213
DOC_MAPK_gen_1	108	118	PF00069	0.243
DOC_MAPK_MEF2A_6	64	72	PF00069	0.258
DOC_USP7_MATH_1	185	189	PF00917	0.333
DOC_USP7_MATH_1	250	254	PF00917	0.287
DOC_USP7_MATH_1	39	43	PF00917	0.373
DOC_USP7_UBL2_3	164	168	PF12436	0.262
DOC_USP7_UBL2_3	193	197	PF12436	0.577
DOC_WW_Pin1_4	264	269	PF00397	0.228
LIG_14-3-3_CanoR_1	134	140	PF00244	0.392
LIG_14-3-3_CanoR_1	190	200	PF00244	0.527
LIG_14-3-3_CanoR_1	258	262	PF00244	0.228
LIG_Actin_WH2_2	65	82	PF00022	0.228
LIG_APCC_ABBA_1	151	156	PF00400	0.228
LIG_BRCT_BRCA1_1	140	144	PF00533	0.228
LIG_BRCT_BRCA1_2	140	146	PF00533	0.228
LIG_Clathr_ClatBox_1	118	122	PF01394	0.228
LIG_FHA_1	134	140	PF00498	0.311
LIG_FHA_1	155	161	PF00498	0.228
LIG_FHA_2	252	258	PF00498	0.243
LIG_LIR_Gen_1	141	151	PF02991	0.228
LIG_LIR_Nem_3	10	15	PF02991	0.336
LIG_LIR_Nem_3	141	147	PF02991	0.238
LIG_LIR_Nem_3	54	60	PF02991	0.229
LIG_Pex14_2	241	245	PF04695	0.228
LIG_PTB_Apo_2	274	281	PF02174	0.373
LIG_PTB_Phospho_1	274	280	PF10480	0.373
LIG_SH2_CRK	179	183	PF00017	0.243
LIG_SH2_NCK_1	217	221	PF00017	0.557
LIG_SH2_STAP1	8	12	PF00017	0.293
LIG_SH2_STAT5	179	182	PF00017	0.373
LIG_SH2_STAT5	280	283	PF00017	0.276
LIG_SH2_STAT5	284	287	PF00017	0.276
LIG_SH3_5	129	133	PF00018	0.287
LIG_SUMO_SIM_anti_2	41	49	PF11976	0.228
LIG_SUMO_SIM_par_1	117	122	PF11976	0.284
LIG_SUMO_SIM_par_1	135	141	PF11976	0.172
LIG_SUMO_SIM_par_1	156	163	PF11976	0.243
LIG_SUMO_SIM_par_1	234	240	PF11976	0.230
LIG_SUMO_SIM_par_1	93	104	PF11976	0.240
LIG_TRAF2_1	232	235	PF00917	0.373
LIG_TRFH_1	283	287	PF08558	0.228
LIG_TYR_ITIM	6	11	PF00017	0.293
MOD_CK1_1	135	141	PF00069	0.262
MOD_CK1_1	188	194	PF00069	0.337
MOD_CK1_1	253	259	PF00069	0.287
MOD_CK2_1	251	257	PF00069	0.373
MOD_GlcNHglycan	140	143	PF01048	0.299
MOD_GlcNHglycan	171	174	PF01048	0.296
MOD_GlcNHglycan	189	193	PF01048	0.262
MOD_GSK3_1	156	163	PF00069	0.345
MOD_GSK3_1	191	198	PF00069	0.629
MOD_GSK3_1	253	260	PF00069	0.250
MOD_GSK3_1	93	100	PF00069	0.269
MOD_N-GLC_1	84	89	PF02516	0.373
MOD_NEK2_1	154	159	PF00069	0.248
MOD_NEK2_1	40	45	PF00069	0.228
MOD_PKA_2	133	139	PF00069	0.373
MOD_PKA_2	257	263	PF00069	0.228
MOD_Plk_1	40	46	PF00069	0.228
MOD_Plk_1	84	90	PF00069	0.404
MOD_Plk_4	177	183	PF00069	0.373
MOD_Plk_4	7	13	PF00069	0.333
MOD_ProDKin_1	264	270	PF00069	0.228
MOD_SUMO_for_1	192	195	PF00179	0.585
MOD_SUMO_for_1	196	199	PF00179	0.470
MOD_SUMO_for_1	200	203	PF00179	0.443
MOD_SUMO_rev_2	189	198	PF00179	0.589
TRG_DiLeu_BaEn_4	234	240	PF01217	0.322
TRG_ENDOCYTIC_2	179	182	PF00928	0.243
TRG_ENDOCYTIC_2	8	11	PF00928	0.357
TRG_ER_diArg_1	215	217	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.243

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I656	Leptomonas seymouri	94%	100%
A0A0S4JJ69	Bodo saltans	60%	95%
A0A1X0NVI3	Trypanosomatidae	75%	100%
A0A3R7LTI5	Trypanosoma rangeli	74%	100%
A0B7Y8	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	24%	100%
A0RXH7	Cenarchaeum symbiosum (strain A)	27%	100%
A1RXU8	Thermofilum pendens (strain DSM 2475 / Hrk 5)	22%	100%
A2SSW6	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	21%	100%
A4H8B2	Leishmania braziliensis	95%	100%
A6UQZ4	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	23%	100%
A6UUW0	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	23%	100%
A6VHX7	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	23%	100%
A9A2X4	Nitrosopumilus maritimus (strain SCM1)	26%	100%
A9A8V2	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	22%	100%
B0R7F7	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	24%	100%
B6YVZ1	Thermococcus onnurineus (strain NA1)	25%	100%
C5A5N6	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	24%	100%
C6A1Y5	Thermococcus sibiricus (strain DSM 12597 / MM 739)	24%	100%
C9D8Q5	Leishmania donovani	100%	100%
C9ZXQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AQE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
G0SF70	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	40%	100%
O01377	Bombyx mori	37%	100%
O02115	Caenorhabditis elegans	35%	100%
O10308	Orgyia pseudotsugata multicapsid polyhedrosis virus	24%	100%
O16852	Sarcophaga crassipalpis	38%	100%
O41056	Paramecium bursaria Chlorella virus 1	27%	100%
O58398	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	24%	100%
O73947	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	23%	100%
O82134	Pisum sativum	40%	100%
O82797	Nicotiana tabacum	40%	100%
P04961	Rattus norvegicus	39%	100%
P11038	Autographa californica nuclear polyhedrosis virus	34%	100%
P12004	Homo sapiens	39%	100%
P15873	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P17070	Oryza sativa subsp. japonica	40%	100%
P17917	Drosophila melanogaster	38%	100%
P17918	Mus musculus	39%	100%
P18248	Xenopus laevis	37%	100%
P22177	Glycine max	38%	100%
P24314	Catharanthus roseus	38%	100%
P31008	Plasmodium falciparum (isolate K1 / Thailand)	32%	100%
P53358	Styela clava	36%	100%
P57761	Cricetulus griseus	39%	100%
P57762	Sulfurisphaera ohwakuensis	21%	100%
P61074	Plasmodium falciparum (isolate 3D7)	32%	100%
P61258	Macaca fascicularis	39%	100%
Q00265	Daucus carota	38%	80%
Q00268	Daucus carota	40%	100%
Q03392	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
Q12U18	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	23%	100%
Q2FNX1	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	20%	100%
Q2NE55	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	24%	100%
Q3ZBW4	Bos taurus	39%	100%
Q43124	Brassica napus	41%	100%
Q43266	Zea mays	39%	100%
Q46E39	Methanosarcina barkeri (strain Fusaro / DSM 804)	23%	100%
Q4J9A8	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	24%	100%
Q4JAI6	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	20%	100%
Q4QF35	Leishmania major	100%	100%
Q54K47	Dictyostelium discoideum	39%	100%
Q57697	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q5JF32	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	26%	100%
Q5JFD3	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	22%	100%
Q6B6N4	Haplochromis burtoni	37%	100%
Q6LWJ8	Methanococcus maripaludis (strain S2 / LL)	22%	100%
Q74MV1	Nanoarchaeum equitans (strain Kin4-M)	21%	100%
Q7KQJ9	Plasmodium falciparum (isolate 3D7)	22%	100%
Q84513	Paramecium bursaria Chlorella virus 1	22%	100%
Q8PX25	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	23%	100%
Q8TUF7	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	23%	100%
Q8TWK3	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	21%	100%
Q8ZTY0	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	24%	100%
Q973F5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	21%	100%
Q975N2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	20%	100%
Q97Z84	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	20%	100%
Q9DDF1	Coturnix japonica	39%	100%
Q9DEA3	Gallus gallus	39%	100%
Q9HN45	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	24%	100%
Q9M7Q7	Arabidopsis thaliana	41%	100%
Q9MAY3	Populus nigra	39%	100%
Q9PTP1	Danio rerio	37%	100%
Q9UWR9	Thermococcus fumicolans	26%	100%
Q9UYX8	Pyrococcus abyssi (strain GE5 / Orsay)	26%	100%
Q9VIT0	Drosophila melanogaster	35%	100%
Q9W644	Anguilla japonica	37%	100%
Q9YFT8	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	23%	100%
Q9ZW35	Arabidopsis thaliana	41%	100%
V5DL99	Trypanosoma cruzi	75%	100%