LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HWM8_LEIIN
TriTrypDb:
LINF_150022100
Length:
295

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWM8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWM8

PDB structure(s): 7ane_aq

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 287 291 PF00656 0.703
CLV_NRD_NRD_1 15 17 PF00675 0.406
CLV_NRD_NRD_1 163 165 PF00675 0.418
CLV_NRD_NRD_1 187 189 PF00675 0.441
CLV_PCSK_FUR_1 13 17 PF00082 0.414
CLV_PCSK_KEX2_1 15 17 PF00082 0.406
CLV_PCSK_KEX2_1 163 165 PF00082 0.514
CLV_PCSK_KEX2_1 187 189 PF00082 0.463
CLV_PCSK_KEX2_1 198 200 PF00082 0.476
CLV_PCSK_KEX2_1 74 76 PF00082 0.402
CLV_PCSK_PC1ET2_1 198 200 PF00082 0.565
CLV_PCSK_PC1ET2_1 74 76 PF00082 0.402
CLV_PCSK_SKI1_1 75 79 PF00082 0.431
CLV_PCSK_SKI1_1 92 96 PF00082 0.205
DEG_Nend_Nbox_1 1 3 PF02207 0.571
DOC_CYCLIN_RxL_1 121 129 PF00134 0.389
DOC_MAPK_gen_1 13 23 PF00069 0.391
DOC_MAPK_gen_1 198 204 PF00069 0.595
DOC_USP7_MATH_1 218 222 PF00917 0.575
DOC_USP7_MATH_1 223 227 PF00917 0.608
DOC_USP7_MATH_1 228 232 PF00917 0.640
DOC_USP7_MATH_1 244 248 PF00917 0.716
DOC_USP7_MATH_1 86 90 PF00917 0.543
DOC_WW_Pin1_4 197 202 PF00397 0.466
LIG_14-3-3_CanoR_1 145 153 PF00244 0.448
LIG_14-3-3_CanoR_1 245 254 PF00244 0.562
LIG_APCC_ABBA_1 151 156 PF00400 0.377
LIG_CaM_NSCaTE_8 19 26 PF13499 0.521
LIG_CtBP_PxDLS_1 125 129 PF00389 0.383
LIG_deltaCOP1_diTrp_1 96 104 PF00928 0.400
LIG_FHA_1 41 47 PF00498 0.414
LIG_FHA_2 109 115 PF00498 0.414
LIG_FHA_2 233 239 PF00498 0.655
LIG_FHA_2 264 270 PF00498 0.591
LIG_FHA_2 86 92 PF00498 0.395
LIG_LIR_Apic_2 11 17 PF02991 0.430
LIG_LIR_Apic_2 55 61 PF02991 0.407
LIG_LIR_Gen_1 117 126 PF02991 0.458
LIG_LIR_Gen_1 148 159 PF02991 0.370
LIG_LIR_Nem_3 117 122 PF02991 0.429
LIG_LIR_Nem_3 148 154 PF02991 0.376
LIG_LIR_Nem_3 176 182 PF02991 0.440
LIG_LIR_Nem_3 203 209 PF02991 0.507
LIG_LIR_Nem_3 27 32 PF02991 0.396
LIG_LIR_Nem_3 96 101 PF02991 0.521
LIG_PCNA_yPIPBox_3 24 35 PF02747 0.431
LIG_Pex14_1 97 101 PF04695 0.382
LIG_SH2_CRK 14 18 PF00017 0.431
LIG_SH2_CRK 32 36 PF00017 0.407
LIG_SH2_NCK_1 32 36 PF00017 0.423
LIG_SH2_PTP2 143 146 PF00017 0.523
LIG_SH2_PTP2 58 61 PF00017 0.505
LIG_SH2_STAP1 130 134 PF00017 0.373
LIG_SH2_STAT3 130 133 PF00017 0.380
LIG_SH2_STAT5 143 146 PF00017 0.523
LIG_SH2_STAT5 189 192 PF00017 0.435
LIG_SH2_STAT5 32 35 PF00017 0.396
LIG_SH2_STAT5 58 61 PF00017 0.397
LIG_SH2_STAT5 93 96 PF00017 0.381
LIG_SH3_3 119 125 PF00018 0.398
LIG_SUMO_SIM_anti_2 200 206 PF11976 0.595
LIG_SUMO_SIM_par_1 123 129 PF11976 0.394
LIG_TRAF2_1 208 211 PF00917 0.500
LIG_TYR_ITIM 204 209 PF00017 0.593
LIG_UBA3_1 20 24 PF00899 0.414
LIG_WRC_WIRS_1 101 106 PF05994 0.411
MOD_CK1_1 147 153 PF00069 0.517
MOD_CK1_1 247 253 PF00069 0.773
MOD_CK1_1 256 262 PF00069 0.707
MOD_CK2_1 256 262 PF00069 0.696
MOD_CK2_1 263 269 PF00069 0.626
MOD_CK2_1 85 91 PF00069 0.401
MOD_GlcNHglycan 220 223 PF01048 0.565
MOD_GlcNHglycan 225 228 PF01048 0.570
MOD_GlcNHglycan 246 249 PF01048 0.746
MOD_GlcNHglycan 250 253 PF01048 0.706
MOD_GlcNHglycan 255 258 PF01048 0.691
MOD_GSK3_1 100 107 PF00069 0.412
MOD_GSK3_1 228 235 PF00069 0.642
MOD_GSK3_1 243 250 PF00069 0.721
MOD_N-GLC_1 180 185 PF02516 0.334
MOD_N-GLC_2 136 138 PF02516 0.381
MOD_NEK2_1 1 6 PF00069 0.575
MOD_NEK2_1 126 131 PF00069 0.369
MOD_NEK2_1 8 13 PF00069 0.501
MOD_PIKK_1 2 8 PF00454 0.662
MOD_PKA_2 108 114 PF00069 0.461
MOD_PKA_2 144 150 PF00069 0.454
MOD_PKA_2 244 250 PF00069 0.664
MOD_Plk_1 126 132 PF00069 0.374
MOD_Plk_1 147 153 PF00069 0.437
MOD_Plk_1 192 198 PF00069 0.422
MOD_Plk_1 86 92 PF00069 0.542
MOD_Plk_4 192 198 PF00069 0.422
MOD_Plk_4 30 36 PF00069 0.424
MOD_ProDKin_1 197 203 PF00069 0.470
MOD_SUMO_rev_2 231 240 PF00179 0.648
TRG_ENDOCYTIC_2 143 146 PF00928 0.523
TRG_ENDOCYTIC_2 18 21 PF00928 0.387
TRG_ENDOCYTIC_2 206 209 PF00928 0.480
TRG_ENDOCYTIC_2 32 35 PF00928 0.400
TRG_ENDOCYTIC_2 98 101 PF00928 0.556
TRG_ER_diArg_1 14 16 PF00400 0.427
TRG_ER_diArg_1 187 189 PF00400 0.463
TRG_Pf-PMV_PEXEL_1 188 193 PF00026 0.457
TRG_Pf-PMV_PEXEL_1 75 79 PF00026 0.528

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILX7 Leptomonas seymouri 76% 100%
A0A0S4JNA3 Bodo saltans 64% 100%
A0A1X0NU24 Trypanosomatidae 65% 100%
A0A3S7WTN6 Leishmania donovani 100% 100%
A0A422NC20 Trypanosoma rangeli 65% 96%
A4H8A8 Leishmania braziliensis 85% 95%
C9ZXR0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9AQD5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QF40 Leishmania major 94% 100%
V5BPT4 Trypanosoma cruzi 64% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS