LeishMANIAdb
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TLC domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TLC domain-containing protein
Gene product:
TMEM164 family - putative
Species:
Leishmania infantum
UniProt:
A4HWM7_LEIIN
TriTrypDb:
LINF_150022000
Length:
299

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4HWM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWM7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 292 294 PF00675 0.373
CLV_PCSK_SKI1_1 255 259 PF00082 0.568
CLV_PCSK_SKI1_1 260 264 PF00082 0.524
CLV_PCSK_SKI1_1 287 291 PF00082 0.344
CLV_PCSK_SKI1_1 293 297 PF00082 0.384
CLV_PCSK_SKI1_1 84 88 PF00082 0.366
DEG_APCC_DBOX_1 259 267 PF00400 0.364
DEG_MDM2_SWIB_1 129 136 PF02201 0.360
DEG_Nend_UBRbox_2 1 3 PF02207 0.332
DEG_ODPH_VHL_1 226 237 PF01847 0.409
DOC_CYCLIN_yCln2_LP_2 191 197 PF00134 0.332
DOC_CYCLIN_yCln2_LP_2 258 264 PF00134 0.341
DOC_MAPK_DCC_7 260 268 PF00069 0.328
DOC_MAPK_gen_1 109 119 PF00069 0.297
DOC_MAPK_MEF2A_6 112 119 PF00069 0.284
DOC_MAPK_MEF2A_6 260 268 PF00069 0.293
DOC_PP2B_LxvP_1 122 125 PF13499 0.360
DOC_PP2B_LxvP_1 191 194 PF13499 0.332
DOC_PP2B_LxvP_1 241 244 PF13499 0.248
DOC_PP4_FxxP_1 225 228 PF00568 0.350
DOC_PP4_FxxP_1 42 45 PF00568 0.282
DOC_USP7_UBL2_3 283 287 PF12436 0.548
DOC_WW_Pin1_4 158 163 PF00397 0.366
LIG_14-3-3_CanoR_1 245 251 PF00244 0.400
LIG_14-3-3_CanoR_1 27 33 PF00244 0.270
LIG_14-3-3_CanoR_1 67 77 PF00244 0.520
LIG_BRCT_BRCA1_1 65 69 PF00533 0.567
LIG_CSL_BTD_1 159 162 PF09270 0.326
LIG_CSL_BTD_1 215 218 PF09270 0.379
LIG_deltaCOP1_diTrp_1 157 160 PF00928 0.388
LIG_deltaCOP1_diTrp_1 170 178 PF00928 0.254
LIG_EH1_1 185 193 PF00400 0.374
LIG_eIF4E_1 150 156 PF01652 0.409
LIG_FHA_1 201 207 PF00498 0.500
LIG_FHA_1 77 83 PF00498 0.575
LIG_GBD_Chelix_1 272 280 PF00786 0.423
LIG_GBD_Chelix_1 94 102 PF00786 0.399
LIG_HCF-1_HBM_1 173 176 PF13415 0.269
LIG_LIR_Apic_2 10 14 PF02991 0.376
LIG_LIR_Gen_1 130 138 PF02991 0.299
LIG_LIR_Gen_1 15 24 PF02991 0.327
LIG_LIR_Gen_1 179 189 PF02991 0.373
LIG_LIR_Gen_1 207 214 PF02991 0.544
LIG_LIR_Gen_1 219 228 PF02991 0.339
LIG_LIR_Nem_3 130 136 PF02991 0.282
LIG_LIR_Nem_3 15 20 PF02991 0.330
LIG_LIR_Nem_3 157 163 PF02991 0.406
LIG_LIR_Nem_3 179 184 PF02991 0.293
LIG_LIR_Nem_3 207 211 PF02991 0.494
LIG_LIR_Nem_3 219 223 PF02991 0.315
LIG_MYND_1 261 265 PF01753 0.409
LIG_NRBOX 118 124 PF00104 0.290
LIG_NRBOX 150 156 PF00104 0.409
LIG_Pex14_1 133 137 PF04695 0.390
LIG_Pex14_1 208 212 PF04695 0.512
LIG_Pex14_1 216 220 PF04695 0.396
LIG_Pex14_2 129 133 PF04695 0.360
LIG_PTB_Apo_2 219 226 PF02174 0.350
LIG_SH2_CRK 201 205 PF00017 0.469
LIG_SH2_PTP2 11 14 PF00017 0.374
LIG_SH2_STAP1 96 100 PF00017 0.309
LIG_SH2_STAT3 40 43 PF00017 0.350
LIG_SH2_STAT5 11 14 PF00017 0.374
LIG_SH2_STAT5 135 138 PF00017 0.376
LIG_SH2_STAT5 150 153 PF00017 0.170
LIG_SH2_STAT5 176 179 PF00017 0.286
LIG_SH2_STAT5 181 184 PF00017 0.295
LIG_SH2_STAT5 196 199 PF00017 0.126
LIG_SH2_STAT5 96 99 PF00017 0.440
LIG_SH3_3 156 162 PF00018 0.326
LIG_SH3_4 114 121 PF00018 0.366
LIG_Sin3_3 250 257 PF02671 0.305
LIG_SUMO_SIM_anti_2 19 26 PF11976 0.397
LIG_SUMO_SIM_anti_2 52 58 PF11976 0.226
LIG_TRFH_1 239 243 PF08558 0.238
LIG_WRC_WIRS_1 217 222 PF05994 0.259
LIG_WW_3 242 246 PF00397 0.376
MOD_CK2_1 293 299 PF00069 0.594
MOD_GlcNHglycan 146 149 PF01048 0.306
MOD_GlcNHglycan 248 251 PF01048 0.612
MOD_GlcNHglycan 290 293 PF01048 0.383
MOD_GlcNHglycan 51 54 PF01048 0.235
MOD_GlcNHglycan 70 73 PF01048 0.318
MOD_GSK3_1 212 219 PF00069 0.471
MOD_NEK2_1 246 251 PF00069 0.350
MOD_NEK2_1 288 293 PF00069 0.645
MOD_NEK2_1 57 62 PF00069 0.253
MOD_PKA_1 293 299 PF00069 0.534
MOD_PKA_2 244 250 PF00069 0.396
MOD_PKA_2 63 69 PF00069 0.507
MOD_Plk_4 150 156 PF00069 0.325
MOD_Plk_4 19 25 PF00069 0.374
MOD_Plk_4 212 218 PF00069 0.451
MOD_Plk_4 268 274 PF00069 0.337
MOD_Plk_4 57 63 PF00069 0.226
MOD_Plk_4 94 100 PF00069 0.335
MOD_ProDKin_1 158 164 PF00069 0.366
TRG_DiLeu_BaLyEn_6 89 94 PF01217 0.523
TRG_ENDOCYTIC_2 135 138 PF00928 0.406
TRG_ENDOCYTIC_2 181 184 PF00928 0.351
TRG_ENDOCYTIC_2 201 204 PF00928 0.326
TRG_ENDOCYTIC_2 96 99 PF00928 0.409

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P785 Leptomonas seymouri 55% 100%
A0A0S4JGE0 Bodo saltans 37% 100%
A0A1X0NUN8 Trypanosomatidae 36% 96%
A0A3Q8IIU5 Leishmania donovani 100% 100%
A0A422NBZ1 Trypanosoma rangeli 37% 97%
A4H8A7 Leishmania braziliensis 82% 100%
E9AQD4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QF41 Leishmania major 91% 100%
Q54KD4 Dictyostelium discoideum 24% 100%
V5DL97 Trypanosoma cruzi 41% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS