LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative nucleolar RNA binding protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nucleolar RNA binding protein
Gene product:
Nucleolar protein 56 - putative
Species:
Leishmania infantum
UniProt:
A4HWM6_LEIIN
TriTrypDb:
LINF_100007300
Length:
445

Annotations

Annotations by Jardim et al.

Nuclear proteins, nucleolar RNA binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005732 sno(s)RNA-containing ribonucleoprotein complex 3 12
GO:0030684 preribosome 3 12
GO:0031428 box C/D RNP complex 4 12
GO:0032040 small-subunit processome 4 12
GO:0032991 protein-containing complex 1 12
GO:1990904 ribonucleoprotein complex 2 12
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HWM6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWM6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0005488 binding 1 12
GO:0030515 snoRNA binding 5 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 179 183 PF00656 0.409
CLV_C14_Caspase3-7 32 36 PF00656 0.369
CLV_C14_Caspase3-7 403 407 PF00656 0.729
CLV_NRD_NRD_1 21 23 PF00675 0.436
CLV_NRD_NRD_1 52 54 PF00675 0.382
CLV_PCSK_KEX2_1 21 23 PF00082 0.447
CLV_PCSK_KEX2_1 413 415 PF00082 0.642
CLV_PCSK_KEX2_1 436 438 PF00082 0.502
CLV_PCSK_PC1ET2_1 413 415 PF00082 0.654
CLV_PCSK_PC1ET2_1 436 438 PF00082 0.502
CLV_PCSK_SKI1_1 188 192 PF00082 0.211
CLV_PCSK_SKI1_1 22 26 PF00082 0.377
CLV_PCSK_SKI1_1 305 309 PF00082 0.209
CLV_PCSK_SKI1_1 314 318 PF00082 0.200
CLV_PCSK_SKI1_1 53 57 PF00082 0.369
CLV_PCSK_SKI1_1 75 79 PF00082 0.399
CLV_PCSK_SKI1_1 99 103 PF00082 0.458
DEG_APCC_DBOX_1 20 28 PF00400 0.498
DOC_CKS1_1 315 320 PF01111 0.411
DOC_CYCLIN_RxL_1 21 32 PF00134 0.434
DOC_CYCLIN_yCln2_LP_2 6 12 PF00134 0.305
DOC_MAPK_gen_1 21 30 PF00069 0.370
DOC_MAPK_gen_1 78 86 PF00069 0.359
DOC_PP1_RVXF_1 130 136 PF00149 0.396
DOC_PP2B_LxvP_1 6 9 PF13499 0.313
DOC_PP2B_LxvP_1 84 87 PF13499 0.384
DOC_PP4_FxxP_1 412 415 PF00568 0.675
DOC_USP7_MATH_1 220 224 PF00917 0.422
DOC_USP7_MATH_1 346 350 PF00917 0.411
DOC_USP7_MATH_1 87 91 PF00917 0.478
DOC_USP7_UBL2_3 156 160 PF12436 0.411
DOC_USP7_UBL2_3 50 54 PF12436 0.346
DOC_WW_Pin1_4 133 138 PF00397 0.407
DOC_WW_Pin1_4 314 319 PF00397 0.411
DOC_WW_Pin1_4 360 365 PF00397 0.516
LIG_Actin_WH2_2 121 136 PF00022 0.379
LIG_Clathr_ClatBox_1 14 18 PF01394 0.330
LIG_deltaCOP1_diTrp_1 167 173 PF00928 0.411
LIG_FHA_1 267 273 PF00498 0.411
LIG_FHA_1 295 301 PF00498 0.411
LIG_FHA_1 361 367 PF00498 0.516
LIG_FHA_1 38 44 PF00498 0.358
LIG_FHA_2 177 183 PF00498 0.449
LIG_GBD_Chelix_1 76 84 PF00786 0.361
LIG_LIR_Gen_1 201 208 PF02991 0.411
LIG_LIR_Nem_3 201 207 PF02991 0.411
LIG_LIR_Nem_3 317 323 PF02991 0.411
LIG_LIR_Nem_3 97 101 PF02991 0.355
LIG_NRBOX 23 29 PF00104 0.455
LIG_SH2_CRK 186 190 PF00017 0.411
LIG_SH2_CRK 320 324 PF00017 0.401
LIG_SH2_STAP1 161 165 PF00017 0.393
LIG_SH2_STAT3 249 252 PF00017 0.472
LIG_SH2_STAT5 186 189 PF00017 0.497
LIG_SH2_STAT5 256 259 PF00017 0.411
LIG_SH2_STAT5 60 63 PF00017 0.521
LIG_SH3_4 50 57 PF00018 0.337
LIG_TRAF2_1 378 381 PF00917 0.511
LIG_TYR_ITIM 184 189 PF00017 0.422
LIG_UBA3_1 150 156 PF00899 0.411
LIG_UBA3_1 287 292 PF00899 0.411
LIG_UBA3_1 307 312 PF00899 0.280
LIG_WRC_WIRS_1 354 359 PF05994 0.411
LIG_WRC_WIRS_1 95 100 PF05994 0.381
MOD_CDC14_SPxK_1 136 139 PF00782 0.401
MOD_CDK_SPK_2 314 319 PF00069 0.411
MOD_CDK_SPxK_1 133 139 PF00069 0.407
MOD_CK1_1 223 229 PF00069 0.411
MOD_CK1_1 286 292 PF00069 0.411
MOD_CK2_1 104 110 PF00069 0.426
MOD_CK2_1 146 152 PF00069 0.413
MOD_CK2_1 353 359 PF00069 0.419
MOD_CK2_1 367 373 PF00069 0.391
MOD_CK2_1 435 441 PF00069 0.610
MOD_CMANNOS 168 171 PF00535 0.211
MOD_GlcNHglycan 110 115 PF01048 0.456
MOD_GlcNHglycan 350 353 PF01048 0.211
MOD_GlcNHglycan 387 390 PF01048 0.568
MOD_GlcNHglycan 419 422 PF01048 0.693
MOD_GlcNHglycan 89 92 PF01048 0.493
MOD_GSK3_1 251 258 PF00069 0.402
MOD_GSK3_1 381 388 PF00069 0.463
MOD_GSK3_1 400 407 PF00069 0.565
MOD_GSK3_1 417 424 PF00069 0.416
MOD_GSK3_1 87 94 PF00069 0.522
MOD_N-GLC_1 117 122 PF02516 0.381
MOD_N-GLC_1 234 239 PF02516 0.297
MOD_N-GLC_1 266 271 PF02516 0.211
MOD_N-GLC_1 324 329 PF02516 0.297
MOD_N-GLC_1 417 422 PF02516 0.730
MOD_NEK2_1 117 122 PF00069 0.381
MOD_NEK2_1 176 181 PF00069 0.429
MOD_NEK2_1 37 42 PF00069 0.353
MOD_NEK2_1 417 422 PF00069 0.705
MOD_NEK2_1 435 440 PF00069 0.359
MOD_PIKK_1 404 410 PF00454 0.506
MOD_PKA_2 199 205 PF00069 0.422
MOD_PKA_2 400 406 PF00069 0.728
MOD_PKB_1 414 422 PF00069 0.733
MOD_Plk_1 117 123 PF00069 0.379
MOD_Plk_1 234 240 PF00069 0.497
MOD_Plk_1 266 272 PF00069 0.411
MOD_Plk_1 324 330 PF00069 0.497
MOD_Plk_1 91 97 PF00069 0.371
MOD_Plk_4 104 110 PF00069 0.491
MOD_Plk_4 146 152 PF00069 0.445
MOD_Plk_4 252 258 PF00069 0.467
MOD_Plk_4 267 273 PF00069 0.340
MOD_Plk_4 283 289 PF00069 0.411
MOD_Plk_4 324 330 PF00069 0.497
MOD_ProDKin_1 133 139 PF00069 0.407
MOD_ProDKin_1 314 320 PF00069 0.411
MOD_ProDKin_1 360 366 PF00069 0.516
MOD_SUMO_rev_2 67 77 PF00179 0.352
TRG_DiLeu_BaLyEn_6 276 281 PF01217 0.411
TRG_ENDOCYTIC_2 186 189 PF00928 0.411
TRG_ENDOCYTIC_2 3 6 PF00928 0.315
TRG_ENDOCYTIC_2 320 323 PF00928 0.401
TRG_ER_diArg_1 163 166 PF00400 0.422
TRG_ER_diArg_1 414 417 PF00400 0.711
TRG_ER_diArg_1 437 440 PF00400 0.506
TRG_NES_CRM1_1 141 153 PF08389 0.332
TRG_NES_CRM1_1 7 20 PF08389 0.338
TRG_NLS_MonoCore_2 412 417 PF00514 0.676
TRG_NLS_MonoExtC_3 435 440 PF00514 0.619
TRG_NLS_MonoExtN_4 21 26 PF00514 0.498
TRG_Pf-PMV_PEXEL_1 309 313 PF00026 0.211
TRG_Pf-PMV_PEXEL_1 99 103 PF00026 0.519

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD49 Leptomonas seymouri 94% 100%
A0A0N1PE54 Leptomonas seymouri 36% 94%
A0A0S4IXK2 Bodo saltans 43% 98%
A0A0S4JJS5 Bodo saltans 80% 100%
A0A1X0NRL9 Trypanosomatidae 38% 91%
A0A1X0NUB3 Trypanosomatidae 81% 100%
A0A3Q8IDJ5 Leishmania donovani 22% 100%
A0A3R7NI91 Trypanosoma rangeli 79% 100%
A0A3R7NLD9 Trypanosoma rangeli 41% 92%
A0A3S5H6F4 Leishmania donovani 37% 94%
A0A3S5H6V9 Leishmania donovani 100% 100%
A1CL70 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 49% 75%
A1D688 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 50% 75%
A2QE38 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 49% 77%
A3LUT0 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 50% 86%
A4H602 Leishmania braziliensis 37% 100%
A4H8A6 Leishmania braziliensis 95% 100%
A4HL50 Leishmania braziliensis 24% 100%
A4HUC9 Leishmania infantum 37% 100%
A4I8M9 Leishmania infantum 22% 100%
A5DHW0 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 49% 88%
A5E4V9 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 50% 86%
A6QYH8 Ajellomyces capsulatus (strain NAm1 / WU24) 49% 70%
A6RMY5 Botryotinia fuckeliana (strain B05.10) 49% 78%
A6ZPE5 Saccharomyces cerevisiae (strain YJM789) 50% 87%
A7F2R6 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 49% 78%
A7TIF5 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 50% 87%
C9ZVG2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 92%
C9ZXR1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 81% 88%
E9AN29 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AQD3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9B3J1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
O00567 Homo sapiens 42% 75%
O04656 Arabidopsis thaliana 44% 99%
O04658 Arabidopsis thaliana 51% 83%
O94514 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 42% 90%
P0CP26 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 49% 78%
P0CP27 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 49% 79%
Q0CQH1 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 51% 77%
Q12460 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 88%
Q12499 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 50% 87%
Q1E1Q5 Coccidioides immitis (strain RS) 48% 73%
Q21276 Caenorhabditis elegans 39% 92%
Q2UC04 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 49% 77%
Q3SZ63 Bos taurus 40% 75%
Q4PBF2 Ustilago maydis (strain 521 / FGSC 9021) 46% 76%
Q4Q4L0 Leishmania major 22% 100%
Q4QF42 Leishmania major 98% 100%
Q4QHJ7 Leishmania major 37% 100%
Q4R779 Macaca fascicularis 49% 84%
Q4WYK9 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 50% 75%
Q54MT2 Dictyostelium discoideum 41% 82%
Q55FI4 Dictyostelium discoideum 48% 70%
Q59S06 Candida albicans (strain SC5314 / ATCC MYA-2876) 50% 86%
Q5B8G3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 49% 76%
Q5RA29 Pongo abelii 42% 75%
Q6BIX6 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 50% 86%
Q6CG46 Yarrowia lipolytica (strain CLIB 122 / E 150) 53% 86%
Q6CKR8 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 49% 87%
Q6DFW4 Mus musculus 49% 83%
Q6FQ21 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 50% 87%
Q753I4 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 50% 87%
Q8X066 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 48% 75%
Q95K50 Macaca fascicularis 40% 75%
Q9D6Z1 Mus musculus 40% 77%
Q9MAB3 Arabidopsis thaliana 50% 83%
Q9P7S7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 52% 88%
Q9QZ86 Rattus norvegicus 50% 83%
Q9Y2X3 Homo sapiens 49% 84%
V5AU06 Trypanosoma cruzi 39% 93%
V5BK67 Trypanosoma cruzi 82% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS