Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily - putative

Species:

Leishmania infantum

UniProt:

A4HWM3_LEIIN

TriTrypDb:

LINF_150021600

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWM3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.648
CLV_NRD_NRD_1	230	232	PF00675	0.511
CLV_NRD_NRD_1	45	47	PF00675	0.635
CLV_NRD_NRD_1	53	55	PF00675	0.557
CLV_PCSK_FUR_1	228	232	PF00082	0.539
CLV_PCSK_KEX2_1	2	4	PF00082	0.517
CLV_PCSK_KEX2_1	230	232	PF00082	0.511
CLV_PCSK_KEX2_1	282	284	PF00082	0.555
CLV_PCSK_KEX2_1	44	46	PF00082	0.615
CLV_PCSK_KEX2_1	53	55	PF00082	0.559
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.517
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.555
CLV_PCSK_PC7_1	40	46	PF00082	0.533
CLV_Separin_Metazoa	236	240	PF03568	0.560
DEG_Nend_UBRbox_1	1	4	PF02207	0.510
DEG_SCF_FBW7_1	159	165	PF00400	0.538
DOC_CKS1_1	159	164	PF01111	0.577
DOC_CKS1_1	9	14	PF01111	0.501
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.494
DOC_MAPK_gen_1	50	59	PF00069	0.516
DOC_MAPK_MEF2A_6	269	276	PF00069	0.393
DOC_MAPK_MEF2A_6	53	61	PF00069	0.457
DOC_MAPK_NFAT4_5	54	62	PF00069	0.531
DOC_SPAK_OSR1_1	269	273	PF12202	0.480
DOC_USP7_MATH_1	126	130	PF00917	0.544
DOC_USP7_MATH_1	162	166	PF00917	0.660
DOC_USP7_MATH_1	293	297	PF00917	0.660
DOC_WW_Pin1_4	158	163	PF00397	0.584
DOC_WW_Pin1_4	174	179	PF00397	0.745
DOC_WW_Pin1_4	242	247	PF00397	0.708
DOC_WW_Pin1_4	296	301	PF00397	0.730
DOC_WW_Pin1_4	34	39	PF00397	0.517
DOC_WW_Pin1_4	8	13	PF00397	0.591
LIG_14-3-3_CanoR_1	100	110	PF00244	0.562
LIG_14-3-3_CanoR_1	116	120	PF00244	0.438
LIG_14-3-3_CanoR_1	283	292	PF00244	0.465
LIG_14-3-3_CanoR_1	3	12	PF00244	0.464
LIG_BRCT_BRCA1_1	264	268	PF00533	0.665
LIG_FHA_1	139	145	PF00498	0.406
LIG_FHA_1	154	160	PF00498	0.516
LIG_FHA_1	169	175	PF00498	0.653
LIG_FHA_1	4	10	PF00498	0.504
LIG_FHA_2	67	73	PF00498	0.451
LIG_FHA_2	9	15	PF00498	0.577
LIG_LIR_Gen_1	68	78	PF02991	0.468
LIG_LIR_Nem_3	68	74	PF02991	0.490
LIG_PDZ_Class_1	299	304	PF00595	0.705
LIG_SH2_STAP1	280	284	PF00017	0.428
LIG_SH2_STAP1	92	96	PF00017	0.505
LIG_SH2_STAT5	285	288	PF00017	0.437
LIG_SH3_3	156	162	PF00018	0.623
LIG_SH3_3	289	295	PF00018	0.685
LIG_SH3_3	35	41	PF00018	0.583
LIG_WW_2	292	295	PF00397	0.556
MOD_CDC14_SPxK_1	37	40	PF00782	0.501
MOD_CDK_SPxK_1	34	40	PF00069	0.542
MOD_CK1_1	176	182	PF00069	0.756
MOD_CK1_1	296	302	PF00069	0.675
MOD_CK1_1	33	39	PF00069	0.536
MOD_CK2_1	66	72	PF00069	0.456
MOD_CK2_1	8	14	PF00069	0.538
MOD_GlcNHglycan	103	106	PF01048	0.530
MOD_GlcNHglycan	128	131	PF01048	0.521
MOD_GlcNHglycan	146	149	PF01048	0.294
MOD_GlcNHglycan	217	220	PF01048	0.547
MOD_GlcNHglycan	264	267	PF01048	0.628
MOD_GlcNHglycan	288	291	PF01048	0.729
MOD_GlcNHglycan	295	298	PF01048	0.516
MOD_GlcNHglycan	32	35	PF01048	0.620
MOD_GSK3_1	158	165	PF00069	0.631
MOD_GSK3_1	168	175	PF00069	0.674
MOD_GSK3_1	258	265	PF00069	0.751
MOD_GSK3_1	295	302	PF00069	0.764
MOD_GSK3_1	30	37	PF00069	0.556
MOD_NEK2_1	144	149	PF00069	0.434
MOD_NEK2_1	151	156	PF00069	0.451
MOD_PKA_2	115	121	PF00069	0.515
MOD_PKB_1	98	106	PF00069	0.409
MOD_Plk_1	65	71	PF00069	0.457
MOD_Plk_2-3	66	72	PF00069	0.456
MOD_Plk_4	115	121	PF00069	0.515
MOD_Plk_4	25	31	PF00069	0.555
MOD_Plk_4	66	72	PF00069	0.497
MOD_ProDKin_1	158	164	PF00069	0.582
MOD_ProDKin_1	174	180	PF00069	0.743
MOD_ProDKin_1	242	248	PF00069	0.709
MOD_ProDKin_1	296	302	PF00069	0.730
MOD_ProDKin_1	34	40	PF00069	0.518
MOD_ProDKin_1	8	14	PF00069	0.591
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.473
TRG_ENDOCYTIC_2	71	74	PF00928	0.504
TRG_ER_diArg_1	228	231	PF00400	0.531
TRG_ER_diArg_1	43	46	PF00400	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL8	Leptomonas seymouri	52%	90%
A0A3R7RI28	Trypanosoma rangeli	33%	100%
A0A3S7WTT4	Leishmania donovani	100%	100%
A4H8A3	Leishmania braziliensis	75%	100%
C9ZXR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QF45	Leishmania major	91%	100%