LeishMANIAdb
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Rab-GAP TBC domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Rab-GAP TBC domain-containing protein
Gene product:
Rab-GTPase-TBC domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4HWM2_LEIIN
TriTrypDb:
LINF_150021500
Length:
704

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWM2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWM2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 167 171 PF00656 0.444
CLV_C14_Caspase3-7 448 452 PF00656 0.371
CLV_C14_Caspase3-7 492 496 PF00656 0.311
CLV_C14_Caspase3-7 607 611 PF00656 0.369
CLV_NRD_NRD_1 206 208 PF00675 0.487
CLV_NRD_NRD_1 366 368 PF00675 0.264
CLV_NRD_NRD_1 419 421 PF00675 0.563
CLV_NRD_NRD_1 631 633 PF00675 0.595
CLV_PCSK_KEX2_1 366 368 PF00082 0.264
CLV_PCSK_KEX2_1 418 420 PF00082 0.565
CLV_PCSK_KEX2_1 631 633 PF00082 0.595
CLV_PCSK_PC1ET2_1 418 420 PF00082 0.640
CLV_PCSK_PC7_1 414 420 PF00082 0.588
CLV_PCSK_PC7_1 627 633 PF00082 0.588
CLV_PCSK_SKI1_1 219 223 PF00082 0.518
CLV_PCSK_SKI1_1 366 370 PF00082 0.258
CLV_PCSK_SKI1_1 384 388 PF00082 0.552
CLV_PCSK_SKI1_1 404 408 PF00082 0.404
CLV_PCSK_SKI1_1 439 443 PF00082 0.579
CLV_PCSK_SKI1_1 599 603 PF00082 0.516
CLV_PCSK_SKI1_1 695 699 PF00082 0.349
DEG_APCC_DBOX_1 234 242 PF00400 0.611
DEG_APCC_DBOX_1 438 446 PF00400 0.383
DEG_APCC_DBOX_1 694 702 PF00400 0.489
DOC_ANK_TNKS_1 245 252 PF00023 0.582
DOC_ANK_TNKS_1 50 57 PF00023 0.432
DOC_CKS1_1 3 8 PF01111 0.512
DOC_CYCLIN_yCln2_LP_2 374 380 PF00134 0.346
DOC_CYCLIN_yCln2_LP_2 577 583 PF00134 0.380
DOC_MAPK_DCC_7 235 243 PF00069 0.598
DOC_MAPK_gen_1 433 442 PF00069 0.393
DOC_MAPK_gen_1 631 637 PF00069 0.351
DOC_MAPK_MEF2A_6 235 243 PF00069 0.598
DOC_MAPK_MEF2A_6 372 380 PF00069 0.321
DOC_MAPK_MEF2A_6 587 596 PF00069 0.298
DOC_MAPK_MEF2A_6 677 686 PF00069 0.599
DOC_PP2B_LxvP_1 374 377 PF13499 0.346
DOC_PP2B_LxvP_1 577 580 PF13499 0.363
DOC_PP2B_LxvP_1 635 638 PF13499 0.337
DOC_PP2B_LxvP_1 84 87 PF13499 0.460
DOC_USP7_MATH_1 150 154 PF00917 0.556
DOC_USP7_MATH_1 160 164 PF00917 0.594
DOC_USP7_MATH_1 271 275 PF00917 0.669
DOC_USP7_MATH_1 328 332 PF00917 0.643
DOC_USP7_MATH_1 493 497 PF00917 0.397
DOC_USP7_MATH_1 58 62 PF00917 0.538
DOC_WW_Pin1_4 2 7 PF00397 0.543
DOC_WW_Pin1_4 214 219 PF00397 0.806
DOC_WW_Pin1_4 37 42 PF00397 0.558
DOC_WW_Pin1_4 557 562 PF00397 0.270
DOC_WW_Pin1_4 630 635 PF00397 0.367
DOC_WW_Pin1_4 648 653 PF00397 0.413
LIG_14-3-3_CanoR_1 195 203 PF00244 0.537
LIG_14-3-3_CanoR_1 51 57 PF00244 0.504
LIG_14-3-3_CanoR_1 632 638 PF00244 0.346
LIG_14-3-3_CanoR_1 693 698 PF00244 0.569
LIG_APCC_ABBAyCdc20_2 454 460 PF00400 0.295
LIG_BIR_II_1 1 5 PF00653 0.503
LIG_BRCT_BRCA1_1 197 201 PF00533 0.583
LIG_BRCT_BRCA1_1 241 245 PF00533 0.529
LIG_deltaCOP1_diTrp_1 66 71 PF00928 0.476
LIG_DLG_GKlike_1 693 701 PF00625 0.585
LIG_eIF4E_1 503 509 PF01652 0.426
LIG_FHA_1 220 226 PF00498 0.779
LIG_FHA_1 261 267 PF00498 0.549
LIG_FHA_1 330 336 PF00498 0.646
LIG_FHA_1 393 399 PF00498 0.478
LIG_FHA_1 457 463 PF00498 0.290
LIG_FHA_1 465 471 PF00498 0.284
LIG_FHA_1 523 529 PF00498 0.309
LIG_FHA_1 558 564 PF00498 0.268
LIG_FHA_1 584 590 PF00498 0.308
LIG_FHA_1 67 73 PF00498 0.430
LIG_FHA_1 692 698 PF00498 0.570
LIG_FHA_1 77 83 PF00498 0.458
LIG_FHA_2 142 148 PF00498 0.466
LIG_FHA_2 154 160 PF00498 0.541
LIG_FHA_2 284 290 PF00498 0.554
LIG_FHA_2 676 682 PF00498 0.505
LIG_GBD_Chelix_1 115 123 PF00786 0.619
LIG_GBD_Chelix_1 544 552 PF00786 0.514
LIG_LIR_Gen_1 310 320 PF02991 0.581
LIG_LIR_Gen_1 341 349 PF02991 0.555
LIG_LIR_Gen_1 443 453 PF02991 0.385
LIG_LIR_Gen_1 522 531 PF02991 0.389
LIG_LIR_Gen_1 603 612 PF02991 0.288
LIG_LIR_Gen_1 616 626 PF02991 0.249
LIG_LIR_Gen_1 8 15 PF02991 0.537
LIG_LIR_Nem_3 242 248 PF02991 0.533
LIG_LIR_Nem_3 297 301 PF02991 0.623
LIG_LIR_Nem_3 310 315 PF02991 0.504
LIG_LIR_Nem_3 341 346 PF02991 0.554
LIG_LIR_Nem_3 443 449 PF02991 0.325
LIG_LIR_Nem_3 452 458 PF02991 0.276
LIG_LIR_Nem_3 495 500 PF02991 0.308
LIG_LIR_Nem_3 522 527 PF02991 0.312
LIG_LIR_Nem_3 588 594 PF02991 0.323
LIG_LIR_Nem_3 603 608 PF02991 0.256
LIG_LIR_Nem_3 610 615 PF02991 0.284
LIG_LIR_Nem_3 616 621 PF02991 0.267
LIG_LIR_Nem_3 66 71 PF02991 0.476
LIG_LIR_Nem_3 8 12 PF02991 0.558
LIG_LYPXL_yS_3 591 594 PF13949 0.297
LIG_MYND_3 302 306 PF01753 0.593
LIG_NRBOX 181 187 PF00104 0.323
LIG_NRBOX 697 703 PF00104 0.487
LIG_PCNA_yPIPBox_3 281 290 PF02747 0.626
LIG_SH2_CRK 9 13 PF00017 0.562
LIG_SH2_NCK_1 158 162 PF00017 0.425
LIG_SH2_NCK_1 542 546 PF00017 0.285
LIG_SH2_STAP1 158 162 PF00017 0.425
LIG_SH2_STAP1 370 374 PF00017 0.302
LIG_SH2_STAP1 458 462 PF00017 0.363
LIG_SH2_STAP1 542 546 PF00017 0.361
LIG_SH2_STAP1 661 665 PF00017 0.427
LIG_SH2_STAT5 311 314 PF00017 0.541
LIG_SH2_STAT5 405 408 PF00017 0.377
LIG_SH2_STAT5 455 458 PF00017 0.295
LIG_SH2_STAT5 497 500 PF00017 0.300
LIG_SH2_STAT5 52 55 PF00017 0.513
LIG_SH3_3 233 239 PF00018 0.637
LIG_SH3_3 89 95 PF00018 0.492
LIG_SUMO_SIM_anti_2 459 467 PF11976 0.360
LIG_SUMO_SIM_anti_2 681 686 PF11976 0.593
LIG_SUMO_SIM_par_1 283 289 PF11976 0.560
LIG_SUMO_SIM_par_1 330 337 PF11976 0.637
LIG_SUMO_SIM_par_1 376 382 PF11976 0.348
LIG_SUMO_SIM_par_1 633 639 PF11976 0.362
LIG_TRAF2_1 128 131 PF00917 0.436
LIG_TRAF2_1 428 431 PF00917 0.404
LIG_TYR_ITIM 589 594 PF00017 0.370
LIG_TYR_ITIM 7 12 PF00017 0.731
LIG_WRC_WIRS_1 614 619 PF05994 0.367
MOD_CDC14_SPxK_1 217 220 PF00782 0.733
MOD_CDK_SPK_2 214 219 PF00069 0.668
MOD_CDK_SPxK_1 214 220 PF00069 0.733
MOD_CK1_1 104 110 PF00069 0.446
MOD_CK1_1 13 19 PF00069 0.620
MOD_CK1_1 141 147 PF00069 0.651
MOD_CK1_1 153 159 PF00069 0.773
MOD_CK1_1 2 8 PF00069 0.738
MOD_CK1_1 496 502 PF00069 0.481
MOD_CK1_1 61 67 PF00069 0.638
MOD_CK1_1 633 639 PF00069 0.446
MOD_CK2_1 141 147 PF00069 0.603
MOD_CK2_1 153 159 PF00069 0.696
MOD_CK2_1 168 174 PF00069 0.504
MOD_CK2_1 283 289 PF00069 0.570
MOD_CK2_1 328 334 PF00069 0.588
MOD_CK2_1 424 430 PF00069 0.554
MOD_CK2_1 675 681 PF00069 0.376
MOD_GlcNHglycan 144 147 PF01048 0.713
MOD_GlcNHglycan 170 173 PF01048 0.505
MOD_GlcNHglycan 18 21 PF01048 0.676
MOD_GlcNHglycan 210 213 PF01048 0.544
MOD_GlcNHglycan 24 27 PF01048 0.582
MOD_GlcNHglycan 269 272 PF01048 0.517
MOD_GlcNHglycan 273 276 PF01048 0.593
MOD_GlcNHglycan 29 32 PF01048 0.552
MOD_GlcNHglycan 325 328 PF01048 0.561
MOD_GlcNHglycan 88 91 PF01048 0.627
MOD_GlcNHglycan 96 99 PF01048 0.545
MOD_GSK3_1 1 8 PF00069 0.608
MOD_GSK3_1 100 107 PF00069 0.476
MOD_GSK3_1 138 145 PF00069 0.689
MOD_GSK3_1 149 156 PF00069 0.668
MOD_GSK3_1 160 167 PF00069 0.575
MOD_GSK3_1 18 25 PF00069 0.608
MOD_GSK3_1 208 215 PF00069 0.689
MOD_GSK3_1 267 274 PF00069 0.483
MOD_GSK3_1 445 452 PF00069 0.441
MOD_GSK3_1 60 67 PF00069 0.570
MOD_N-GLC_1 212 217 PF02516 0.654
MOD_N-GLC_1 532 537 PF02516 0.446
MOD_NEK2_1 1 6 PF00069 0.706
MOD_NEK2_1 101 106 PF00069 0.511
MOD_NEK2_1 140 145 PF00069 0.665
MOD_NEK2_1 406 411 PF00069 0.474
MOD_NEK2_1 445 450 PF00069 0.528
MOD_NEK2_1 620 625 PF00069 0.312
MOD_NEK2_1 71 76 PF00069 0.554
MOD_NEK2_2 283 288 PF00069 0.390
MOD_NEK2_2 76 81 PF00069 0.609
MOD_PIKK_1 138 144 PF00454 0.620
MOD_PIKK_1 173 179 PF00454 0.474
MOD_PIKK_1 195 201 PF00454 0.489
MOD_PIKK_1 71 77 PF00454 0.604
MOD_PKA_1 207 213 PF00069 0.644
MOD_PKA_1 219 225 PF00069 0.662
MOD_PKA_2 13 19 PF00069 0.650
MOD_PKA_2 206 212 PF00069 0.599
MOD_PKA_2 27 33 PF00069 0.566
MOD_PKA_2 44 50 PF00069 0.695
MOD_Plk_1 164 170 PF00069 0.666
MOD_Plk_1 173 179 PF00069 0.481
MOD_Plk_1 329 335 PF00069 0.580
MOD_Plk_1 471 477 PF00069 0.400
MOD_Plk_2-3 613 619 PF00069 0.360
MOD_Plk_4 104 110 PF00069 0.398
MOD_Plk_4 283 289 PF00069 0.378
MOD_Plk_4 493 499 PF00069 0.374
MOD_Plk_4 569 575 PF00069 0.400
MOD_Plk_4 613 619 PF00069 0.360
MOD_ProDKin_1 2 8 PF00069 0.704
MOD_ProDKin_1 214 220 PF00069 0.790
MOD_ProDKin_1 37 43 PF00069 0.723
MOD_ProDKin_1 557 563 PF00069 0.317
MOD_ProDKin_1 630 636 PF00069 0.454
MOD_ProDKin_1 648 654 PF00069 0.507
MOD_SUMO_for_1 128 131 PF00179 0.519
MOD_SUMO_rev_2 472 481 PF00179 0.463
TRG_DiLeu_BaEn_1 522 527 PF01217 0.407
TRG_DiLeu_BaEn_2 186 192 PF01217 0.494
TRG_DiLeu_BaEn_4 233 239 PF01217 0.552
TRG_DiLeu_BaLyEn_6 364 369 PF01217 0.328
TRG_DiLeu_BaLyEn_6 432 437 PF01217 0.510
TRG_ENDOCYTIC_2 591 594 PF00928 0.355
TRG_ENDOCYTIC_2 9 12 PF00928 0.728
TRG_ER_diArg_1 365 367 PF00400 0.349
TRG_ER_diArg_1 419 421 PF00400 0.462
TRG_ER_diArg_1 433 436 PF00400 0.418
TRG_ER_diArg_1 692 695 PF00400 0.348
TRG_NLS_MonoExtN_4 416 422 PF00514 0.537
TRG_Pf-PMV_PEXEL_1 246 250 PF00026 0.483
TRG_Pf-PMV_PEXEL_1 473 477 PF00026 0.409
TRG_Pf-PMV_PEXEL_1 695 699 PF00026 0.351

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZA9 Leptomonas seymouri 66% 99%
A0A1X0NU07 Trypanosomatidae 41% 94%
A0A3Q8I980 Leishmania donovani 100% 100%
A0A3R7NA24 Trypanosoma rangeli 41% 100%
A4H8A0 Leishmania braziliensis 79% 100%
C9ZXR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 95%
E9AQC9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QF46 Leishmania major 93% 100%
V5B4P0 Trypanosoma cruzi 39% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS