LeishMANIAdb
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DNA topoisomerase 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA topoisomerase 2
Gene product:
mitochondrial DNA topoisomerase II
Species:
Leishmania infantum
UniProt:
A4HWL4_LEIIN
TriTrypDb:
LINF_150020700
Length:
1236

Annotations

Annotations by Jardim et al.

Topoisomerase, DNA topoisomerase 2 TOP2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0020023 kinetoplast 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HWL4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWL4

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 6
GO:0006259 DNA metabolic process 4 6
GO:0006265 DNA topological change 5 6
GO:0006725 cellular aromatic compound metabolic process 3 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0006996 organelle organization 4 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0016043 cellular component organization 3 6
GO:0034641 cellular nitrogen compound metabolic process 3 6
GO:0043170 macromolecule metabolic process 3 6
GO:0044237 cellular metabolic process 2 6
GO:0044238 primary metabolic process 2 6
GO:0044260 obsolete cellular macromolecule metabolic process 3 6
GO:0046483 heterocycle metabolic process 3 6
GO:0051276 chromosome organization 5 6
GO:0071103 DNA conformation change 6 6
GO:0071704 organic substance metabolic process 2 6
GO:0071840 cellular component organization or biogenesis 2 6
GO:0090304 nucleic acid metabolic process 4 6
GO:1901360 organic cyclic compound metabolic process 3 6
GO:0000712 resolution of meiotic recombination intermediates 4 1
GO:0000819 sister chromatid segregation 4 1
GO:0007059 chromosome segregation 2 1
GO:0022402 cell cycle process 2 1
GO:0022414 reproductive process 1 1
GO:0061982 meiosis I cell cycle process 3 1
GO:0098813 nuclear chromosome segregation 3 1
GO:1903046 meiotic cell cycle process 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 6
GO:0003676 nucleic acid binding 3 6
GO:0003677 DNA binding 4 6
GO:0003824 catalytic activity 1 6
GO:0003916 DNA topoisomerase activity 3 6
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3 6
GO:0005488 binding 1 6
GO:0005524 ATP binding 5 6
GO:0008094 ATP-dependent activity, acting on DNA 2 6
GO:0016853 isomerase activity 2 6
GO:0017076 purine nucleotide binding 4 6
GO:0030554 adenyl nucleotide binding 5 6
GO:0032553 ribonucleotide binding 3 6
GO:0032555 purine ribonucleotide binding 4 6
GO:0032559 adenyl ribonucleotide binding 5 6
GO:0035639 purine ribonucleoside triphosphate binding 4 6
GO:0036094 small molecule binding 2 6
GO:0043167 ion binding 2 6
GO:0043168 anion binding 3 6
GO:0043169 cation binding 3 6
GO:0046872 metal ion binding 4 6
GO:0097159 organic cyclic compound binding 2 6
GO:0097367 carbohydrate derivative binding 2 6
GO:0140097 catalytic activity, acting on DNA 3 6
GO:0140640 catalytic activity, acting on a nucleic acid 2 6
GO:0140657 ATP-dependent activity 1 6
GO:1901265 nucleoside phosphate binding 3 6
GO:1901363 heterocyclic compound binding 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 309 313 PF00656 0.573
CLV_C14_Caspase3-7 426 430 PF00656 0.677
CLV_C14_Caspase3-7 439 443 PF00656 0.458
CLV_C14_Caspase3-7 516 520 PF00656 0.611
CLV_NRD_NRD_1 1017 1019 PF00675 0.206
CLV_NRD_NRD_1 1169 1171 PF00675 0.744
CLV_NRD_NRD_1 1206 1208 PF00675 0.805
CLV_NRD_NRD_1 406 408 PF00675 0.724
CLV_NRD_NRD_1 639 641 PF00675 0.411
CLV_NRD_NRD_1 696 698 PF00675 0.506
CLV_NRD_NRD_1 705 707 PF00675 0.357
CLV_NRD_NRD_1 874 876 PF00675 0.506
CLV_NRD_NRD_1 991 993 PF00675 0.506
CLV_NRD_NRD_1 999 1001 PF00675 0.473
CLV_PCSK_KEX2_1 1089 1091 PF00082 0.506
CLV_PCSK_KEX2_1 1168 1170 PF00082 0.717
CLV_PCSK_KEX2_1 1190 1192 PF00082 0.764
CLV_PCSK_KEX2_1 214 216 PF00082 0.562
CLV_PCSK_KEX2_1 219 221 PF00082 0.449
CLV_PCSK_KEX2_1 286 288 PF00082 0.411
CLV_PCSK_KEX2_1 406 408 PF00082 0.724
CLV_PCSK_KEX2_1 478 480 PF00082 0.411
CLV_PCSK_KEX2_1 705 707 PF00082 0.506
CLV_PCSK_KEX2_1 874 876 PF00082 0.506
CLV_PCSK_KEX2_1 991 993 PF00082 0.506
CLV_PCSK_KEX2_1 997 999 PF00082 0.407
CLV_PCSK_PC1ET2_1 1089 1091 PF00082 0.506
CLV_PCSK_PC1ET2_1 1168 1170 PF00082 0.717
CLV_PCSK_PC1ET2_1 1190 1192 PF00082 0.764
CLV_PCSK_PC1ET2_1 214 216 PF00082 0.562
CLV_PCSK_PC1ET2_1 219 221 PF00082 0.449
CLV_PCSK_PC1ET2_1 286 288 PF00082 0.411
CLV_PCSK_PC1ET2_1 478 480 PF00082 0.411
CLV_PCSK_PC1ET2_1 997 999 PF00082 0.506
CLV_PCSK_PC7_1 1186 1192 PF00082 0.764
CLV_PCSK_PC7_1 215 221 PF00082 0.544
CLV_PCSK_SKI1_1 1061 1065 PF00082 0.383
CLV_PCSK_SKI1_1 1149 1153 PF00082 0.686
CLV_PCSK_SKI1_1 1196 1200 PF00082 0.805
CLV_PCSK_SKI1_1 173 177 PF00082 0.640
CLV_PCSK_SKI1_1 188 192 PF00082 0.270
CLV_PCSK_SKI1_1 214 218 PF00082 0.558
CLV_PCSK_SKI1_1 243 247 PF00082 0.500
CLV_PCSK_SKI1_1 320 324 PF00082 0.411
CLV_PCSK_SKI1_1 336 340 PF00082 0.211
CLV_PCSK_SKI1_1 475 479 PF00082 0.311
CLV_PCSK_SKI1_1 661 665 PF00082 0.396
CLV_PCSK_SKI1_1 697 701 PF00082 0.506
CLV_PCSK_SKI1_1 774 778 PF00082 0.396
CLV_PCSK_SKI1_1 785 789 PF00082 0.383
CLV_PCSK_SKI1_1 8 12 PF00082 0.569
DEG_APCC_DBOX_1 1137 1145 PF00400 0.633
DEG_APCC_DBOX_1 465 473 PF00400 0.611
DEG_APCC_DBOX_1 696 704 PF00400 0.506
DOC_CDC14_PxL_1 251 259 PF14671 0.482
DOC_CKS1_1 30 35 PF01111 0.567
DOC_CKS1_1 551 556 PF01111 0.611
DOC_CYCLIN_RxL_1 779 792 PF00134 0.506
DOC_CYCLIN_yCln2_LP_2 1059 1065 PF00134 0.506
DOC_CYCLIN_yCln2_LP_2 1137 1143 PF00134 0.625
DOC_MAPK_FxFP_2 202 205 PF00069 0.588
DOC_MAPK_gen_1 105 113 PF00069 0.506
DOC_MAPK_gen_1 1207 1215 PF00069 0.797
DOC_MAPK_gen_1 186 195 PF00069 0.604
DOC_MAPK_gen_1 333 343 PF00069 0.611
DOC_MAPK_gen_1 481 491 PF00069 0.515
DOC_MAPK_gen_1 563 570 PF00069 0.611
DOC_MAPK_gen_1 658 665 PF00069 0.611
DOC_MAPK_gen_1 779 788 PF00069 0.506
DOC_MAPK_gen_1 997 1006 PF00069 0.506
DOC_MAPK_MEF2A_6 1041 1048 PF00069 0.506
DOC_MAPK_MEF2A_6 1207 1215 PF00069 0.723
DOC_MAPK_MEF2A_6 1229 1236 PF00069 0.669
DOC_MAPK_MEF2A_6 336 344 PF00069 0.611
DOC_MAPK_MEF2A_6 484 493 PF00069 0.528
DOC_MAPK_MEF2A_6 613 620 PF00069 0.611
DOC_MAPK_MEF2A_6 78 86 PF00069 0.506
DOC_MAPK_NFAT4_5 613 621 PF00069 0.611
DOC_MAPK_RevD_3 207 220 PF00069 0.566
DOC_PIKK_1 391 398 PF02985 0.516
DOC_PP1_RVXF_1 1059 1066 PF00149 0.370
DOC_PP1_RVXF_1 190 196 PF00149 0.572
DOC_PP1_RVXF_1 695 702 PF00149 0.506
DOC_PP1_RVXF_1 783 789 PF00149 0.506
DOC_PP2B_LxvP_1 663 666 PF13499 0.611
DOC_PP2B_LxvP_1 753 756 PF13499 0.506
DOC_PP4_FxxP_1 202 205 PF00568 0.428
DOC_PP4_FxxP_1 551 554 PF00568 0.611
DOC_PP4_FxxP_1 805 808 PF00568 0.428
DOC_SPAK_OSR1_1 894 898 PF12202 0.506
DOC_USP7_MATH_1 1171 1175 PF00917 0.754
DOC_USP7_MATH_1 1178 1182 PF00917 0.731
DOC_USP7_MATH_1 205 209 PF00917 0.610
DOC_USP7_MATH_1 271 275 PF00917 0.499
DOC_USP7_MATH_1 423 427 PF00917 0.476
DOC_USP7_MATH_1 448 452 PF00917 0.611
DOC_USP7_MATH_1 520 524 PF00917 0.611
DOC_USP7_MATH_1 532 536 PF00917 0.611
DOC_USP7_MATH_1 569 573 PF00917 0.611
DOC_USP7_MATH_1 582 586 PF00917 0.458
DOC_USP7_MATH_1 976 980 PF00917 0.506
DOC_USP7_UBL2_3 1041 1045 PF12436 0.506
DOC_USP7_UBL2_3 1208 1212 PF12436 0.812
DOC_USP7_UBL2_3 320 324 PF12436 0.603
DOC_USP7_UBL2_3 559 563 PF12436 0.611
DOC_WW_Pin1_4 1089 1094 PF00397 0.506
DOC_WW_Pin1_4 267 272 PF00397 0.442
DOC_WW_Pin1_4 281 286 PF00397 0.474
DOC_WW_Pin1_4 29 34 PF00397 0.571
DOC_WW_Pin1_4 500 505 PF00397 0.584
DOC_WW_Pin1_4 550 555 PF00397 0.506
DOC_WW_Pin1_4 8 13 PF00397 0.636
DOC_WW_Pin1_4 966 971 PF00397 0.506
DOC_WW_Pin1_4 972 977 PF00397 0.407
DOC_WW_Pin1_4 979 984 PF00397 0.279
LIG_14-3-3_CanoR_1 1013 1021 PF00244 0.506
LIG_14-3-3_CanoR_1 1068 1074 PF00244 0.506
LIG_14-3-3_CanoR_1 1124 1132 PF00244 0.661
LIG_14-3-3_CanoR_1 173 178 PF00244 0.637
LIG_14-3-3_CanoR_1 243 252 PF00244 0.534
LIG_14-3-3_CanoR_1 336 341 PF00244 0.611
LIG_14-3-3_CanoR_1 358 364 PF00244 0.497
LIG_14-3-3_CanoR_1 406 414 PF00244 0.677
LIG_14-3-3_CanoR_1 431 437 PF00244 0.552
LIG_14-3-3_CanoR_1 479 486 PF00244 0.556
LIG_14-3-3_CanoR_1 587 593 PF00244 0.611
LIG_14-3-3_CanoR_1 658 664 PF00244 0.584
LIG_14-3-3_CanoR_1 705 714 PF00244 0.404
LIG_14-3-3_CanoR_1 78 82 PF00244 0.506
LIG_14-3-3_CanoR_1 894 903 PF00244 0.506
LIG_Actin_WH2_2 42 59 PF00022 0.569
LIG_BIR_III_4 519 523 PF00653 0.611
LIG_BRCT_BRCA1_1 149 153 PF00533 0.506
LIG_BRCT_BRCA1_1 318 322 PF00533 0.591
LIG_BRCT_BRCA1_2 318 324 PF00533 0.611
LIG_CaM_IQ_9 1011 1027 PF13499 0.428
LIG_Clathr_ClatBox_1 1006 1010 PF01394 0.506
LIG_Clathr_ClatBox_1 1048 1052 PF01394 0.506
LIG_Clathr_ClatBox_1 1141 1145 PF01394 0.658
LIG_CNOT1_NIM_1 242 251 PF04054 0.562
LIG_CtBP_PxDLS_1 494 499 PF00389 0.611
LIG_deltaCOP1_diTrp_1 636 643 PF00928 0.611
LIG_deltaCOP1_diTrp_1 899 909 PF00928 0.506
LIG_EVH1_2 262 266 PF00568 0.595
LIG_FHA_1 1069 1075 PF00498 0.506
LIG_FHA_1 1089 1095 PF00498 0.175
LIG_FHA_1 1127 1133 PF00498 0.659
LIG_FHA_1 144 150 PF00498 0.421
LIG_FHA_1 329 335 PF00498 0.573
LIG_FHA_1 337 343 PF00498 0.492
LIG_FHA_1 416 422 PF00498 0.613
LIG_FHA_1 433 439 PF00498 0.225
LIG_FHA_1 46 52 PF00498 0.582
LIG_FHA_1 551 557 PF00498 0.497
LIG_FHA_1 660 666 PF00498 0.501
LIG_FHA_1 87 93 PF00498 0.506
LIG_FHA_1 969 975 PF00498 0.409
LIG_FHA_1 999 1005 PF00498 0.506
LIG_FHA_2 1067 1073 PF00498 0.370
LIG_FHA_2 1097 1103 PF00498 0.383
LIG_FHA_2 1105 1111 PF00498 0.374
LIG_FHA_2 242 248 PF00498 0.526
LIG_FHA_2 437 443 PF00498 0.611
LIG_FHA_2 480 486 PF00498 0.556
LIG_FHA_2 514 520 PF00498 0.557
LIG_FHA_2 598 604 PF00498 0.611
LIG_FHA_2 662 668 PF00498 0.597
LIG_FHA_2 802 808 PF00498 0.412
LIG_FHA_2 9 15 PF00498 0.541
LIG_FHA_2 902 908 PF00498 0.506
LIG_FHA_2 945 951 PF00498 0.506
LIG_Integrin_isoDGR_2 892 894 PF01839 0.506
LIG_IRF3_LxIS_1 909 914 PF10401 0.506
LIG_LIR_Apic_2 500 504 PF02991 0.584
LIG_LIR_Apic_2 549 554 PF02991 0.506
LIG_LIR_Apic_2 802 808 PF02991 0.428
LIG_LIR_Gen_1 1052 1063 PF02991 0.506
LIG_LIR_Gen_1 1110 1119 PF02991 0.440
LIG_LIR_Gen_1 150 160 PF02991 0.411
LIG_LIR_Gen_1 198 207 PF02991 0.590
LIG_LIR_Gen_1 246 255 PF02991 0.463
LIG_LIR_Gen_1 488 497 PF02991 0.611
LIG_LIR_Gen_1 506 515 PF02991 0.399
LIG_LIR_Gen_1 606 616 PF02991 0.611
LIG_LIR_Gen_1 781 789 PF02991 0.506
LIG_LIR_Gen_1 80 86 PF02991 0.506
LIG_LIR_Gen_1 878 889 PF02991 0.506
LIG_LIR_Nem_3 1052 1058 PF02991 0.506
LIG_LIR_Nem_3 1105 1111 PF02991 0.439
LIG_LIR_Nem_3 115 121 PF02991 0.506
LIG_LIR_Nem_3 150 156 PF02991 0.350
LIG_LIR_Nem_3 198 202 PF02991 0.413
LIG_LIR_Nem_3 244 248 PF02991 0.551
LIG_LIR_Nem_3 488 493 PF02991 0.515
LIG_LIR_Nem_3 5 10 PF02991 0.664
LIG_LIR_Nem_3 506 512 PF02991 0.428
LIG_LIR_Nem_3 534 540 PF02991 0.611
LIG_LIR_Nem_3 572 576 PF02991 0.556
LIG_LIR_Nem_3 781 786 PF02991 0.506
LIG_LIR_Nem_3 80 84 PF02991 0.506
LIG_LIR_Nem_3 836 840 PF02991 0.389
LIG_LIR_Nem_3 878 884 PF02991 0.506
LIG_MYND_3 380 384 PF01753 0.601
LIG_PCNA_TLS_4 370 377 PF02747 0.611
LIG_Pex14_1 865 869 PF04695 0.506
LIG_Pex14_2 1020 1024 PF04695 0.345
LIG_Pex14_2 1104 1108 PF04695 0.557
LIG_Pex14_2 164 168 PF04695 0.569
LIG_Pex14_2 533 537 PF04695 0.611
LIG_PTB_Apo_2 234 241 PF02174 0.591
LIG_PTB_Apo_2 541 548 PF02174 0.556
LIG_PTB_Phospho_1 541 547 PF10480 0.560
LIG_REV1ctd_RIR_1 1063 1072 PF16727 0.506
LIG_SH2_CRK 248 252 PF00017 0.545
LIG_SH2_CRK 268 272 PF00017 0.506
LIG_SH2_CRK 459 463 PF00017 0.611
LIG_SH2_CRK 501 505 PF00017 0.589
LIG_SH2_CRK 509 513 PF00017 0.539
LIG_SH2_CRK 593 597 PF00017 0.611
LIG_SH2_CRK 7 11 PF00017 0.654
LIG_SH2_GRB2like 962 965 PF00017 0.428
LIG_SH2_NCK_1 1161 1165 PF00017 0.603
LIG_SH2_NCK_1 252 256 PF00017 0.535
LIG_SH2_NCK_1 268 272 PF00017 0.336
LIG_SH2_PTP2 547 550 PF00017 0.529
LIG_SH2_PTP2 81 84 PF00017 0.506
LIG_SH2_PTP2 811 814 PF00017 0.506
LIG_SH2_SRC 811 814 PF00017 0.506
LIG_SH2_SRC 962 965 PF00017 0.428
LIG_SH2_STAP1 1111 1115 PF00017 0.595
LIG_SH2_STAP1 248 252 PF00017 0.447
LIG_SH2_STAP1 588 592 PF00017 0.611
LIG_SH2_STAP1 989 993 PF00017 0.506
LIG_SH2_STAT3 277 280 PF00017 0.561
LIG_SH2_STAT5 1057 1060 PF00017 0.345
LIG_SH2_STAT5 112 115 PF00017 0.508
LIG_SH2_STAT5 23 26 PF00017 0.597
LIG_SH2_STAT5 268 271 PF00017 0.586
LIG_SH2_STAT5 277 280 PF00017 0.447
LIG_SH2_STAT5 35 38 PF00017 0.374
LIG_SH2_STAT5 376 379 PF00017 0.611
LIG_SH2_STAT5 459 462 PF00017 0.611
LIG_SH2_STAT5 547 550 PF00017 0.529
LIG_SH2_STAT5 588 591 PF00017 0.611
LIG_SH2_STAT5 607 610 PF00017 0.387
LIG_SH2_STAT5 720 723 PF00017 0.506
LIG_SH2_STAT5 775 778 PF00017 0.506
LIG_SH2_STAT5 81 84 PF00017 0.506
LIG_SH2_STAT5 811 814 PF00017 0.345
LIG_SH2_STAT5 887 890 PF00017 0.506
LIG_SH2_STAT5 962 965 PF00017 0.428
LIG_SH3_3 1129 1135 PF00018 0.648
LIG_SH3_3 259 265 PF00018 0.611
LIG_SH3_3 360 366 PF00018 0.507
LIG_SH3_3 810 816 PF00018 0.367
LIG_SH3_3 964 970 PF00018 0.506
LIG_SH3_5 794 798 PF00018 0.506
LIG_SUMO_SIM_anti_2 935 940 PF11976 0.506
LIG_SUMO_SIM_par_1 1140 1145 PF11976 0.644
LIG_SUMO_SIM_par_1 434 440 PF11976 0.506
LIG_SUMO_SIM_par_1 661 667 PF11976 0.556
LIG_SUMO_SIM_par_1 838 843 PF11976 0.506
LIG_SxIP_EBH_1 894 906 PF03271 0.506
LIG_TRAF2_1 1107 1110 PF00917 0.570
LIG_TRAF2_1 733 736 PF00917 0.506
LIG_TYR_ITIM 507 512 PF00017 0.558
LIG_UBA3_1 1115 1121 PF00899 0.540
LIG_UBA3_1 1141 1149 PF00899 0.680
LIG_UBA3_1 413 419 PF00899 0.623
LIG_WRC_WIRS_1 242 247 PF05994 0.572
LIG_WRC_WIRS_1 570 575 PF05994 0.556
LIG_WRC_WIRS_1 834 839 PF05994 0.389
MOD_CDC14_SPxK_1 284 287 PF00782 0.611
MOD_CDK_SPK_2 281 286 PF00069 0.624
MOD_CDK_SPxK_1 1089 1095 PF00069 0.506
MOD_CDK_SPxK_1 281 287 PF00069 0.506
MOD_CDK_SPxxK_3 550 557 PF00069 0.506
MOD_CK1_1 1126 1132 PF00069 0.568
MOD_CK1_1 1214 1220 PF00069 0.698
MOD_CK1_1 131 137 PF00069 0.389
MOD_CK1_1 26 32 PF00069 0.612
MOD_CK1_1 361 367 PF00069 0.611
MOD_CK1_1 409 415 PF00069 0.655
MOD_CK1_1 451 457 PF00069 0.611
MOD_CK1_1 549 555 PF00069 0.477
MOD_CK1_1 561 567 PF00069 0.438
MOD_CK1_1 659 665 PF00069 0.584
MOD_CK1_1 709 715 PF00069 0.431
MOD_CK1_1 722 728 PF00069 0.291
MOD_CK1_1 73 79 PF00069 0.506
MOD_CK1_1 915 921 PF00069 0.428
MOD_CK1_1 944 950 PF00069 0.428
MOD_CK1_1 979 985 PF00069 0.428
MOD_CK2_1 1066 1072 PF00069 0.370
MOD_CK2_1 1104 1110 PF00069 0.504
MOD_CK2_1 226 232 PF00069 0.578
MOD_CK2_1 479 485 PF00069 0.556
MOD_CK2_1 500 506 PF00069 0.611
MOD_CK2_1 597 603 PF00069 0.611
MOD_CK2_1 661 667 PF00069 0.611
MOD_CK2_1 730 736 PF00069 0.506
MOD_CK2_1 801 807 PF00069 0.506
MOD_CK2_1 901 907 PF00069 0.506
MOD_CK2_1 944 950 PF00069 0.506
MOD_Cter_Amidation 1188 1191 PF01082 0.769
MOD_Cter_Amidation 404 407 PF01082 0.713
MOD_GlcNHglycan 1145 1149 PF01048 0.601
MOD_GlcNHglycan 1182 1185 PF01048 0.702
MOD_GlcNHglycan 414 417 PF01048 0.409
MOD_GlcNHglycan 442 445 PF01048 0.411
MOD_GlcNHglycan 560 563 PF01048 0.384
MOD_GlcNHglycan 584 587 PF01048 0.356
MOD_GlcNHglycan 717 720 PF01048 0.506
MOD_GlcNHglycan 723 727 PF01048 0.407
MOD_GlcNHglycan 841 845 PF01048 0.506
MOD_GlcNHglycan 853 856 PF01048 0.307
MOD_GlcNHglycan 917 920 PF01048 0.467
MOD_GlcNHglycan 927 931 PF01048 0.379
MOD_GSK3_1 1035 1042 PF00069 0.355
MOD_GSK3_1 1064 1071 PF00069 0.506
MOD_GSK3_1 1122 1129 PF00069 0.651
MOD_GSK3_1 1180 1187 PF00069 0.598
MOD_GSK3_1 128 135 PF00069 0.421
MOD_GSK3_1 143 150 PF00069 0.208
MOD_GSK3_1 267 274 PF00069 0.605
MOD_GSK3_1 310 317 PF00069 0.542
MOD_GSK3_1 432 439 PF00069 0.426
MOD_GSK3_1 546 553 PF00069 0.488
MOD_GSK3_1 582 589 PF00069 0.601
MOD_GSK3_1 715 722 PF00069 0.447
MOD_GSK3_1 73 80 PF00069 0.396
MOD_GSK3_1 730 737 PF00069 0.287
MOD_GSK3_1 829 836 PF00069 0.389
MOD_GSK3_1 86 93 PF00069 0.291
MOD_GSK3_1 911 918 PF00069 0.502
MOD_GSK3_1 966 973 PF00069 0.506
MOD_LATS_1 171 177 PF00433 0.622
MOD_N-GLC_1 1032 1037 PF02516 0.506
MOD_N-GLC_1 128 133 PF02516 0.506
MOD_N-GLC_1 188 193 PF02516 0.593
MOD_N-GLC_1 205 210 PF02516 0.468
MOD_N-GLC_1 271 276 PF02516 0.530
MOD_N-GLC_1 70 75 PF02516 0.463
MOD_N-GLC_1 743 748 PF02516 0.506
MOD_N-GLC_1 963 968 PF02516 0.506
MOD_NEK2_1 1014 1019 PF00069 0.508
MOD_NEK2_1 1039 1044 PF00069 0.396
MOD_NEK2_1 1066 1071 PF00069 0.506
MOD_NEK2_1 1088 1093 PF00069 0.506
MOD_NEK2_1 1104 1109 PF00069 0.368
MOD_NEK2_1 1115 1120 PF00069 0.395
MOD_NEK2_1 1144 1149 PF00069 0.692
MOD_NEK2_1 1192 1197 PF00069 0.771
MOD_NEK2_1 121 126 PF00069 0.350
MOD_NEK2_1 164 169 PF00069 0.577
MOD_NEK2_1 257 262 PF00069 0.594
MOD_NEK2_1 266 271 PF00069 0.495
MOD_NEK2_1 344 349 PF00069 0.512
MOD_NEK2_1 359 364 PF00069 0.549
MOD_NEK2_1 489 494 PF00069 0.556
MOD_NEK2_1 596 601 PF00069 0.611
MOD_NEK2_1 627 632 PF00069 0.497
MOD_NEK2_1 734 739 PF00069 0.506
MOD_NEK2_1 830 835 PF00069 0.506
MOD_NEK2_1 840 845 PF00069 0.341
MOD_NEK2_1 869 874 PF00069 0.506
MOD_NEK2_1 911 916 PF00069 0.506
MOD_NEK2_2 1194 1199 PF00069 0.584
MOD_NEK2_2 546 551 PF00069 0.533
MOD_NEK2_2 569 574 PF00069 0.611
MOD_PIKK_1 1078 1084 PF00454 0.506
MOD_PIKK_1 26 32 PF00454 0.612
MOD_PIKK_1 279 285 PF00454 0.607
MOD_PIKK_1 344 350 PF00454 0.505
MOD_PIKK_1 692 698 PF00454 0.506
MOD_PK_1 1124 1130 PF00069 0.657
MOD_PKA_1 406 412 PF00069 0.699
MOD_PKA_1 998 1004 PF00069 0.506
MOD_PKA_2 1067 1073 PF00069 0.506
MOD_PKA_2 1123 1129 PF00069 0.490
MOD_PKA_2 1178 1184 PF00069 0.726
MOD_PKA_2 406 412 PF00069 0.699
MOD_PKA_2 586 592 PF00069 0.611
MOD_PKA_2 77 83 PF00069 0.506
MOD_PKA_2 998 1004 PF00069 0.506
MOD_Plk_1 1035 1041 PF00069 0.506
MOD_Plk_1 1051 1057 PF00069 0.506
MOD_Plk_1 1104 1110 PF00069 0.569
MOD_Plk_1 188 194 PF00069 0.593
MOD_Plk_1 205 211 PF00069 0.471
MOD_Plk_1 722 728 PF00069 0.506
MOD_Plk_1 730 736 PF00069 0.374
MOD_Plk_1 90 96 PF00069 0.365
MOD_Plk_2-3 801 807 PF00069 0.428
MOD_Plk_4 409 415 PF00069 0.655
MOD_Plk_4 532 538 PF00069 0.611
MOD_Plk_4 627 633 PF00069 0.497
MOD_Plk_4 734 740 PF00069 0.506
MOD_Plk_4 77 83 PF00069 0.506
MOD_Plk_4 801 807 PF00069 0.353
MOD_Plk_4 963 969 PF00069 0.506
MOD_ProDKin_1 1089 1095 PF00069 0.506
MOD_ProDKin_1 267 273 PF00069 0.435
MOD_ProDKin_1 281 287 PF00069 0.356
MOD_ProDKin_1 29 35 PF00069 0.565
MOD_ProDKin_1 500 506 PF00069 0.584
MOD_ProDKin_1 550 556 PF00069 0.506
MOD_ProDKin_1 8 14 PF00069 0.630
MOD_ProDKin_1 966 972 PF00069 0.506
MOD_ProDKin_1 979 985 PF00069 0.279
MOD_SUMO_rev_2 106 111 PF00179 0.506
MOD_SUMO_rev_2 1086 1091 PF00179 0.506
MOD_SUMO_rev_2 208 216 PF00179 0.420
TRG_DiLeu_BaEn_2 377 383 PF01217 0.611
TRG_DiLeu_BaEn_2 800 806 PF01217 0.449
TRG_DiLeu_BaLyEn_6 1137 1142 PF01217 0.616
TRG_DiLeu_BaLyEn_6 1226 1231 PF01217 0.731
TRG_DiLeu_BaLyEn_6 508 513 PF01217 0.611
TRG_DiLeu_BaLyEn_6 782 787 PF01217 0.506
TRG_DiLeu_LyEn_5 791 796 PF01217 0.506
TRG_ENDOCYTIC_2 1111 1114 PF00928 0.598
TRG_ENDOCYTIC_2 199 202 PF00928 0.565
TRG_ENDOCYTIC_2 248 251 PF00928 0.547
TRG_ENDOCYTIC_2 459 462 PF00928 0.611
TRG_ENDOCYTIC_2 509 512 PF00928 0.525
TRG_ENDOCYTIC_2 547 550 PF00928 0.529
TRG_ENDOCYTIC_2 593 596 PF00928 0.611
TRG_ENDOCYTIC_2 7 10 PF00928 0.661
TRG_ENDOCYTIC_2 81 84 PF00928 0.506
TRG_ENDOCYTIC_2 811 814 PF00928 0.506
TRG_ER_diArg_1 104 107 PF00400 0.506
TRG_ER_diArg_1 1169 1171 PF00400 0.744
TRG_ER_diArg_1 406 408 PF00400 0.724
TRG_ER_diArg_1 704 706 PF00400 0.506
TRG_ER_diArg_1 873 875 PF00400 0.506
TRG_ER_diArg_1 991 993 PF00400 0.506
TRG_ER_diArg_1 998 1000 PF00400 0.390
TRG_NES_CRM1_1 485 496 PF08389 0.611
TRG_NES_CRM1_1 610 624 PF08389 0.611
TRG_NLS_MonoCore_2 996 1001 PF00514 0.506
TRG_NLS_MonoExtC_3 1167 1173 PF00514 0.745
TRG_NLS_MonoExtN_4 1165 1172 PF00514 0.728
TRG_NLS_MonoExtN_4 475 482 PF00514 0.611
TRG_Pf-PMV_PEXEL_1 785 790 PF00026 0.506

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P778 Leptomonas seymouri 85% 100%
A0A0N1HUJ9 Leptomonas seymouri 36% 82%
A0A0S4IZ11 Bodo saltans 35% 83%
A0A0S4JGE3 Bodo saltans 51% 99%
A0A1X0NR68 Trypanosomatidae 36% 82%
A0A1X0NUH3 Trypanosomatidae 70% 100%
A0A3Q8II93 Leishmania donovani 35% 83%
A0A3R7MTQ1 Trypanosoma rangeli 70% 100%
A0A3S7WTK8 Leishmania donovani 100% 100%
A0A422N9B0 Trypanosoma rangeli 36% 85%
A4H891 Leishmania braziliensis 94% 100%
A4HGT2 Leishmania braziliensis 35% 100%
A4I3V9 Leishmania infantum 35% 99%
C9ZXS6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
D0A926 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 85%
D0A927 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 84%
E9AQC1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9B049 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
O16140 Bombyx mori 34% 80%
O24308 Pisum sativum 33% 85%
O42130 Gallus gallus 33% 80%
O42131 Gallus gallus 32% 76%
O46374 Sus scrofa 32% 81%
O61078 Leishmania chagasi 99% 100%
O93794 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 32% 88%
P06786 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 87%
P08096 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 83%
P0C9C0 African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) 24% 100%
P0C9C1 African swine fever virus (isolate Warthog/Namibia/Wart80/1980) 24% 100%
P0C9C2 African swine fever virus (isolate Pig/Kenya/KEN-50/1950) 26% 100%
P11388 Homo sapiens 32% 81%
P12531 Trypanosoma brucei brucei 70% 100%
P15348 Drosophila melanogaster 36% 85%
P27570 Crithidia fasciculata 86% 100%
P30182 Arabidopsis thaliana 35% 84%
P30190 Trypanosoma cruzi 70% 100%
P34203 African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) 25% 100%
P34534 Caenorhabditis elegans 32% 100%
P41001 Plasmodium falciparum (isolate K1 / Thailand) 33% 88%
P41515 Cricetulus griseus 32% 81%
P41516 Rattus norvegicus 32% 81%
P87078 Candida albicans 34% 85%
P90520 Dictyostelium discoideum 33% 96%
Q00942 African swine fever virus (strain Badajoz 1971 Vero-adapted) 25% 100%
Q01320 Mus musculus 32% 81%
Q01879 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 33% 88%
Q02880 Homo sapiens 32% 76%
Q196X4 Invertebrate iridescent virus 3 30% 100%
Q23670 Caenorhabditis elegans 34% 81%
Q4Q836 Leishmania major 33% 100%
Q4QF53 Leishmania major 98% 100%
Q55BP5 Dictyostelium discoideum 37% 81%
Q5UQE6 Acanthamoeba polyphaga mimivirus 31% 98%
Q64399 Cricetulus longicaudatus 33% 77%
Q64511 Mus musculus 33% 77%
Q9QSK1 Invertebrate iridescent virus 6 29% 100%
Q9Y8G8 Penicillium chrysogenum 32% 78%
V5B5B2 Trypanosoma cruzi 33% 85%
V5BUD4 Trypanosoma cruzi 71% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS