Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWL2_LEIIN

TriTrypDb:

LINF_150020500

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.350
CLV_C14_Caspase3-7	299	303	PF00656	0.515
CLV_C14_Caspase3-7	448	452	PF00656	0.450
CLV_NRD_NRD_1	101	103	PF00675	0.396
CLV_NRD_NRD_1	120	122	PF00675	0.370
CLV_NRD_NRD_1	14	16	PF00675	0.586
CLV_NRD_NRD_1	338	340	PF00675	0.349
CLV_NRD_NRD_1	409	411	PF00675	0.561
CLV_NRD_NRD_1	519	521	PF00675	0.599
CLV_NRD_NRD_1	530	532	PF00675	0.548
CLV_NRD_NRD_1	535	537	PF00675	0.510
CLV_PCSK_KEX2_1	120	122	PF00082	0.463
CLV_PCSK_KEX2_1	14	16	PF00082	0.594
CLV_PCSK_KEX2_1	409	411	PF00082	0.625
CLV_PCSK_KEX2_1	530	532	PF00082	0.576
CLV_PCSK_KEX2_1	535	537	PF00082	0.545
CLV_PCSK_KEX2_1	75	77	PF00082	0.391
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.405
CLV_PCSK_PC7_1	531	537	PF00082	0.549
CLV_PCSK_SKI1_1	246	250	PF00082	0.370
CLV_PCSK_SKI1_1	324	328	PF00082	0.496
CLV_PCSK_SKI1_1	340	344	PF00082	0.292
CLV_PCSK_SKI1_1	345	349	PF00082	0.347
CLV_PCSK_SKI1_1	352	356	PF00082	0.399
CLV_PCSK_SKI1_1	410	414	PF00082	0.579
CLV_PCSK_SKI1_1	480	484	PF00082	0.785
CLV_Separin_Metazoa	527	531	PF03568	0.534
DEG_APCC_DBOX_1	154	162	PF00400	0.429
DEG_APCC_DBOX_1	344	352	PF00400	0.362
DEG_SPOP_SBC_1	27	31	PF00917	0.482
DOC_CYCLIN_RxL_1	349	358	PF00134	0.364
DOC_CYCLIN_yClb1_LxF_4	220	226	PF00134	0.324
DOC_MAPK_FxFP_2	365	368	PF00069	0.531
DOC_MAPK_gen_1	102	110	PF00069	0.455
DOC_MAPK_gen_1	14	20	PF00069	0.504
DOC_MAPK_MEF2A_6	397	405	PF00069	0.403
DOC_PP2B_LxvP_1	354	357	PF13499	0.386
DOC_PP2B_LxvP_1	52	55	PF13499	0.541
DOC_PP4_FxxP_1	365	368	PF00568	0.531
DOC_PP4_FxxP_1	80	83	PF00568	0.427
DOC_USP7_MATH_1	2	6	PF00917	0.510
DOC_USP7_MATH_1	267	271	PF00917	0.468
DOC_USP7_MATH_1	296	300	PF00917	0.724
DOC_USP7_MATH_1	488	492	PF00917	0.618
DOC_USP7_MATH_1	503	507	PF00917	0.504
DOC_USP7_MATH_2	57	63	PF00917	0.447
DOC_USP7_UBL2_3	327	331	PF12436	0.421
DOC_USP7_UBL2_3	467	471	PF12436	0.630
DOC_WW_Pin1_4	254	259	PF00397	0.433
DOC_WW_Pin1_4	492	497	PF00397	0.729
DOC_WW_Pin1_4	8	13	PF00397	0.508
LIG_14-3-3_CanoR_1	26	32	PF00244	0.661
LIG_14-3-3_CanoR_1	339	347	PF00244	0.480
LIG_14-3-3_CanoR_1	35	41	PF00244	0.749
LIG_Actin_WH2_2	400	415	PF00022	0.434
LIG_Clathr_ClatBox_1	162	166	PF01394	0.327
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.574
LIG_deltaCOP1_diTrp_1	399	405	PF00928	0.499
LIG_FHA_1	20	26	PF00498	0.777
LIG_FHA_1	339	345	PF00498	0.296
LIG_FHA_1	47	53	PF00498	0.771
LIG_FHA_2	128	134	PF00498	0.380
LIG_FHA_2	232	238	PF00498	0.270
LIG_FHA_2	371	377	PF00498	0.511
LIG_GBD_Chelix_1	383	391	PF00786	0.352
LIG_LIR_Gen_1	109	119	PF02991	0.381
LIG_LIR_Gen_1	141	150	PF02991	0.581
LIG_LIR_Gen_1	156	165	PF02991	0.237
LIG_LIR_Gen_1	218	226	PF02991	0.317
LIG_LIR_Gen_1	399	407	PF02991	0.454
LIG_LIR_Nem_3	109	115	PF02991	0.476
LIG_LIR_Nem_3	141	146	PF02991	0.476
LIG_LIR_Nem_3	156	162	PF02991	0.247
LIG_LIR_Nem_3	218	222	PF02991	0.330
LIG_LIR_Nem_3	399	405	PF02991	0.434
LIG_NRBOX	350	356	PF00104	0.476
LIG_PCNA_yPIPBox_3	90	103	PF02747	0.396
LIG_Pex14_2	207	211	PF04695	0.494
LIG_SH2_CRK	112	116	PF00017	0.433
LIG_SH2_CRK	143	147	PF00017	0.414
LIG_SH2_CRK	159	163	PF00017	0.220
LIG_SH2_CRK	219	223	PF00017	0.345
LIG_SH2_GRB2like	219	222	PF00017	0.347
LIG_SH2_GRB2like	276	279	PF00017	0.522
LIG_SH2_STAP1	112	116	PF00017	0.371
LIG_SH2_STAP1	159	163	PF00017	0.319
LIG_SH2_STAP1	219	223	PF00017	0.345
LIG_SH2_STAP1	276	280	PF00017	0.522
LIG_SH2_STAT3	443	446	PF00017	0.505
LIG_SH2_STAT5	180	183	PF00017	0.417
LIG_SH2_STAT5	242	245	PF00017	0.341
LIG_SH3_1	252	258	PF00018	0.373
LIG_SH3_3	252	258	PF00018	0.422
LIG_SH3_3	421	427	PF00018	0.560
LIG_SH3_3	48	54	PF00018	0.682
LIG_SH3_3	505	511	PF00018	0.536
LIG_SUMO_SIM_par_1	370	376	PF11976	0.387
LIG_SUMO_SIM_par_1	382	388	PF11976	0.371
LIG_TRAF2_1	332	335	PF00917	0.560
LIG_TRAF2_1	357	360	PF00917	0.458
LIG_TYR_ITIM	110	115	PF00017	0.516
LIG_WRC_WIRS_1	128	133	PF05994	0.552
MOD_CDC14_SPxK_1	11	14	PF00782	0.479
MOD_CDK_SPxK_1	8	14	PF00069	0.508
MOD_CDK_SPxxK_3	8	15	PF00069	0.490
MOD_CK1_1	176	182	PF00069	0.508
MOD_CK1_1	270	276	PF00069	0.486
MOD_CK1_1	283	289	PF00069	0.490
MOD_CK1_1	290	296	PF00069	0.442
MOD_CK1_1	31	37	PF00069	0.737
MOD_CK1_1	338	344	PF00069	0.515
MOD_CK1_1	492	498	PF00069	0.602
MOD_CK2_1	127	133	PF00069	0.602
MOD_CK2_1	329	335	PF00069	0.613
MOD_CK2_1	370	376	PF00069	0.515
MOD_CK2_1	488	494	PF00069	0.577
MOD_Cter_Amidation	100	103	PF01082	0.407
MOD_GlcNHglycan	270	273	PF01048	0.468
MOD_GlcNHglycan	293	296	PF01048	0.741
MOD_GlcNHglycan	298	301	PF01048	0.528
MOD_GlcNHglycan	304	307	PF01048	0.489
MOD_GlcNHglycan	310	313	PF01048	0.634
MOD_GlcNHglycan	41	44	PF01048	0.611
MOD_GlcNHglycan	414	417	PF01048	0.512
MOD_GlcNHglycan	447	450	PF01048	0.649
MOD_GlcNHglycan	475	478	PF01048	0.727
MOD_GlcNHglycan	497	500	PF01048	0.631
MOD_GSK3_1	145	152	PF00069	0.537
MOD_GSK3_1	172	179	PF00069	0.475
MOD_GSK3_1	26	33	PF00069	0.705
MOD_GSK3_1	280	287	PF00069	0.593
MOD_GSK3_1	290	297	PF00069	0.653
MOD_GSK3_1	308	315	PF00069	0.485
MOD_GSK3_1	441	448	PF00069	0.688
MOD_GSK3_1	488	495	PF00069	0.597
MOD_GSK3_1	55	62	PF00069	0.536
MOD_N-GLC_1	46	51	PF02516	0.493
MOD_NEK2_1	110	115	PF00069	0.397
MOD_NEK2_1	25	30	PF00069	0.737
MOD_NEK2_1	280	285	PF00069	0.504
MOD_NEK2_1	412	417	PF00069	0.723
MOD_NEK2_1	442	447	PF00069	0.551
MOD_PIKK_1	110	116	PF00454	0.361
MOD_PIKK_1	442	448	PF00454	0.637
MOD_PKA_2	176	182	PF00069	0.408
MOD_PKA_2	25	31	PF00069	0.641
MOD_PKA_2	338	344	PF00069	0.335
MOD_PKA_2	36	42	PF00069	0.691
MOD_Plk_4	127	133	PF00069	0.464
MOD_Plk_4	176	182	PF00069	0.385
MOD_Plk_4	231	237	PF00069	0.284
MOD_Plk_4	3	9	PF00069	0.670
MOD_Plk_4	64	70	PF00069	0.578
MOD_ProDKin_1	254	260	PF00069	0.432
MOD_ProDKin_1	492	498	PF00069	0.728
MOD_ProDKin_1	8	14	PF00069	0.508
MOD_SUMO_for_1	163	166	PF00179	0.404
TRG_ENDOCYTIC_2	112	115	PF00928	0.359
TRG_ENDOCYTIC_2	143	146	PF00928	0.615
TRG_ENDOCYTIC_2	159	162	PF00928	0.293
TRG_ENDOCYTIC_2	219	222	PF00928	0.347
TRG_ENDOCYTIC_2	432	435	PF00928	0.514
TRG_ENDOCYTIC_2	66	69	PF00928	0.547
TRG_ER_diArg_1	119	121	PF00400	0.438
TRG_ER_diArg_1	13	15	PF00400	0.595
TRG_ER_diArg_1	35	38	PF00400	0.696
TRG_ER_diArg_1	529	531	PF00400	0.536
TRG_NES_CRM1_1	346	360	PF08389	0.359
TRG_NLS_MonoExtC_3	459	464	PF00514	0.449
TRG_NLS_MonoExtN_4	409	414	PF00514	0.477
TRG_Pf-PMV_PEXEL_1	345	350	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX4	Leptomonas seymouri	60%	100%
A0A0S4JKE9	Bodo saltans	51%	100%
A0A1X0NTZ8	Trypanosomatidae	54%	100%
A0A3Q8IAB6	Leishmania donovani	99%	100%
A0A3S5IRP3	Trypanosoma rangeli	54%	100%
A0A3S7X2J5	Leishmania donovani	26%	100%
A4H889	Leishmania braziliensis	85%	100%
A4HHF5	Leishmania braziliensis	25%	100%
A4I4K3	Leishmania infantum	25%	100%
C9ZL87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZXS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AE02	Leishmania major	25%	100%
E9ALT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AQB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QF55	Leishmania major	96%	100%
V5B4N1	Trypanosoma cruzi	55%	100%
V5D9T1	Trypanosoma cruzi	25%	100%