SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HWL1_LEIIN

TriTrypDb:

LINF_150020400

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	398	404	PF00089	0.689
CLV_NRD_NRD_1	238	240	PF00675	0.283
CLV_NRD_NRD_1	242	244	PF00675	0.283
CLV_NRD_NRD_1	245	247	PF00675	0.283
CLV_NRD_NRD_1	3	5	PF00675	0.658
CLV_NRD_NRD_1	359	361	PF00675	0.616
CLV_NRD_NRD_1	404	406	PF00675	0.734
CLV_PCSK_FUR_1	239	243	PF00082	0.332
CLV_PCSK_KEX2_1	238	240	PF00082	0.285
CLV_PCSK_KEX2_1	241	243	PF00082	0.281
CLV_PCSK_KEX2_1	245	247	PF00082	0.279
CLV_PCSK_KEX2_1	3	5	PF00082	0.656
CLV_PCSK_KEX2_1	358	360	PF00082	0.509
CLV_PCSK_KEX2_1	404	406	PF00082	0.734
CLV_PCSK_PC7_1	234	240	PF00082	0.420
CLV_PCSK_PC7_1	241	247	PF00082	0.325
CLV_PCSK_SKI1_1	216	220	PF00082	0.393
CLV_PCSK_SKI1_1	234	238	PF00082	0.211
CLV_PCSK_SKI1_1	295	299	PF00082	0.386
CLV_PCSK_SKI1_1	344	348	PF00082	0.699
CLV_PCSK_SKI1_1	52	56	PF00082	0.399
DEG_APCC_DBOX_1	215	223	PF00400	0.406
DEG_APCC_DBOX_1	233	241	PF00400	0.237
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DOC_CYCLIN_RxL_1	47	59	PF00134	0.464
DOC_MAPK_DCC_7	87	96	PF00069	0.523
DOC_MAPK_gen_1	189	195	PF00069	0.489
DOC_MAPK_HePTP_8	84	96	PF00069	0.522
DOC_MAPK_MEF2A_6	87	96	PF00069	0.523
DOC_USP7_MATH_1	175	179	PF00917	0.516
DOC_USP7_MATH_1	375	379	PF00917	0.603
DOC_USP7_MATH_1	384	388	PF00917	0.706
DOC_USP7_UBL2_3	83	87	PF12436	0.440
DOC_WW_Pin1_4	149	154	PF00397	0.506
DOC_WW_Pin1_4	385	390	PF00397	0.792
DOC_WW_Pin1_4	59	64	PF00397	0.543
LIG_14-3-3_CanoR_1	133	140	PF00244	0.562
LIG_14-3-3_CanoR_1	181	185	PF00244	0.443
LIG_14-3-3_CanoR_1	270	279	PF00244	0.433
LIG_14-3-3_CanoR_1	28	36	PF00244	0.433
LIG_14-3-3_CanoR_1	313	320	PF00244	0.460
LIG_14-3-3_CanoR_1	47	55	PF00244	0.429
LIG_14-3-3_CanoR_1	58	63	PF00244	0.483
LIG_APCC_ABBA_1	258	263	PF00400	0.562
LIG_APCC_ABBA_1	36	41	PF00400	0.447
LIG_BRCT_BRCA1_1	23	27	PF00533	0.225
LIG_BRCT_BRCA1_1	314	318	PF00533	0.492
LIG_BRCT_BRCA1_1	7	11	PF00533	0.659
LIG_BRCT_BRCA1_2	7	13	PF00533	0.638
LIG_CaM_IQ_9	208	223	PF13499	0.493
LIG_eIF4E_1	230	236	PF01652	0.540
LIG_FHA_1	142	148	PF00498	0.437
LIG_FHA_1	213	219	PF00498	0.375
LIG_FHA_1	272	278	PF00498	0.594
LIG_FHA_1	59	65	PF00498	0.521
LIG_FHA_1	70	76	PF00498	0.302
LIG_FHA_2	291	297	PF00498	0.586
LIG_LIR_Gen_1	152	158	PF02991	0.485
LIG_LIR_Gen_1	183	191	PF02991	0.410
LIG_LIR_Gen_1	209	219	PF02991	0.478
LIG_LIR_Nem_3	166	172	PF02991	0.590
LIG_LIR_Nem_3	209	214	PF02991	0.388
LIG_LIR_Nem_3	8	14	PF02991	0.554
LIG_MLH1_MIPbox_1	23	27	PF16413	0.312
LIG_Pex14_2	163	167	PF04695	0.453
LIG_Pex14_2	318	322	PF04695	0.388
LIG_PTB_Apo_2	200	207	PF02174	0.512
LIG_REV1ctd_RIR_1	24	32	PF16727	0.318
LIG_SH2_CRK	320	324	PF00017	0.398
LIG_SH2_STAP1	154	158	PF00017	0.491
LIG_SH2_STAT5	116	119	PF00017	0.364
LIG_SH2_STAT5	261	264	PF00017	0.553
LIG_SH3_5	226	230	PF00018	0.505
LIG_SUMO_SIM_anti_2	255	260	PF11976	0.515
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.518
LIG_SUMO_SIM_par_1	290	296	PF11976	0.488
LIG_SUMO_SIM_par_1	326	332	PF11976	0.518
LIG_SUMO_SIM_par_1	76	82	PF11976	0.538
LIG_TRAF2_1	183	186	PF00917	0.461
LIG_TRAF2_1	299	302	PF00917	0.482
LIG_TYR_ITIM	259	264	PF00017	0.482
MOD_CDK_SPxxK_3	149	156	PF00069	0.504
MOD_CDK_SPxxK_3	385	392	PF00069	0.725
MOD_CK1_1	141	147	PF00069	0.586
MOD_CK1_1	312	318	PF00069	0.327
MOD_CK1_1	59	65	PF00069	0.524
MOD_CK1_1	82	88	PF00069	0.441
MOD_CK2_1	133	139	PF00069	0.570
MOD_CK2_1	180	186	PF00069	0.424
MOD_CK2_1	290	296	PF00069	0.266
MOD_CK2_1	326	332	PF00069	0.515
MOD_CK2_1	400	406	PF00069	0.683
MOD_GlcNHglycan	121	124	PF01048	0.361
MOD_GlcNHglycan	135	138	PF01048	0.424
MOD_GlcNHglycan	231	234	PF01048	0.479
MOD_GlcNHglycan	314	317	PF01048	0.494
MOD_GlcNHglycan	381	384	PF01048	0.678
MOD_GSK3_1	129	136	PF00069	0.497
MOD_GSK3_1	17	24	PF00069	0.418
MOD_GSK3_1	375	382	PF00069	0.660
MOD_GSK3_1	39	46	PF00069	0.550
MOD_GSK3_1	396	403	PF00069	0.764
MOD_GSK3_1	54	61	PF00069	0.439
MOD_GSK3_1	69	76	PF00069	0.266
MOD_GSK3_1	79	86	PF00069	0.406
MOD_N-GLC_1	265	270	PF02516	0.335
MOD_N-GLC_1	271	276	PF02516	0.335
MOD_N-GLC_1	396	401	PF02516	0.727
MOD_NEK2_1	119	124	PF00069	0.356
MOD_NEK2_1	193	198	PF00069	0.434
MOD_NEK2_1	2	7	PF00069	0.592
MOD_NEK2_1	309	314	PF00069	0.496
MOD_NEK2_1	43	48	PF00069	0.531
MOD_NEK2_1	54	59	PF00069	0.389
MOD_NEK2_1	79	84	PF00069	0.534
MOD_PIKK_1	46	52	PF00454	0.464
MOD_PKA_2	180	186	PF00069	0.424
MOD_PKA_2	2	8	PF00069	0.666
MOD_PKA_2	212	218	PF00069	0.393
MOD_PKA_2	312	318	PF00069	0.508
MOD_PKA_2	400	406	PF00069	0.744
MOD_PKA_2	46	52	PF00069	0.464
MOD_Plk_1	39	45	PF00069	0.525
MOD_Plk_2-3	326	332	PF00069	0.518
MOD_Plk_4	278	284	PF00069	0.405
MOD_Plk_4	39	45	PF00069	0.402
MOD_Plk_4	74	80	PF00069	0.362
MOD_ProDKin_1	149	155	PF00069	0.503
MOD_ProDKin_1	385	391	PF00069	0.791
MOD_ProDKin_1	59	65	PF00069	0.542
MOD_SUMO_for_1	206	209	PF00179	0.524
MOD_SUMO_rev_2	369	378	PF00179	0.615
TRG_DiLeu_BaEn_1	142	147	PF01217	0.541
TRG_DiLeu_BaEn_4	363	369	PF01217	0.577
TRG_ENDOCYTIC_2	116	119	PF00928	0.345
TRG_ENDOCYTIC_2	154	157	PF00928	0.486
TRG_ENDOCYTIC_2	184	187	PF00928	0.434
TRG_ENDOCYTIC_2	261	264	PF00928	0.434
TRG_ENDOCYTIC_2	320	323	PF00928	0.392
TRG_ER_diArg_1	2	4	PF00400	0.704
TRG_ER_diArg_1	237	239	PF00400	0.340
TRG_ER_diArg_1	240	243	PF00400	0.334
TRG_ER_diArg_1	244	246	PF00400	0.329
TRG_ER_diArg_1	358	360	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL6	Leptomonas seymouri	68%	100%
A0A0S4JNX3	Bodo saltans	50%	100%
A0A1X0P9L0	Trypanosomatidae	60%	100%
A0A3S5H6V7	Leishmania donovani	100%	100%
A4H888	Leishmania braziliensis	86%	100%
C9ZMN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AQB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QF56	Leishmania major	94%	100%
V5BKH7	Trypanosoma cruzi	62%	100%