LeishMANIAdb
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Putative nucleoside transporter 1

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nucleoside transporter 1
Gene product:
nucleoside transporter 1 - putative
Species:
Leishmania infantum
UniProt:
A4HWK9_LEIIN
TriTrypDb:
LINF_150020200
Length:
491

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Annotations by Jardim et al.

Transporters, nucleoside transporter 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 50
NetGPI no yes: 0, no: 50
Cellular components
Term Name Level Count
GO:0016020 membrane 2 51
GO:0110165 cellular anatomical entity 1 51
GO:0005886 plasma membrane 3 4

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HWK9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWK9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0015851 nucleobase transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 51
GO:0005337 nucleoside transmembrane transporter activity 4 51
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 51
GO:0022857 transmembrane transporter activity 2 51
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 51
GO:0015205 nucleobase transmembrane transporter activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 247 251 PF00656 0.543
CLV_C14_Caspase3-7 295 299 PF00656 0.511
CLV_MEL_PAP_1 375 381 PF00089 0.211
CLV_NRD_NRD_1 103 105 PF00675 0.278
CLV_NRD_NRD_1 16 18 PF00675 0.304
CLV_NRD_NRD_1 328 330 PF00675 0.327
CLV_PCSK_KEX2_1 103 105 PF00082 0.254
CLV_PCSK_KEX2_1 328 330 PF00082 0.264
CLV_PCSK_KEX2_1 458 460 PF00082 0.202
CLV_PCSK_PC1ET2_1 458 460 PF00082 0.202
CLV_PCSK_SKI1_1 153 157 PF00082 0.421
CLV_PCSK_SKI1_1 194 198 PF00082 0.532
CLV_PCSK_SKI1_1 328 332 PF00082 0.291
CLV_PCSK_SKI1_1 404 408 PF00082 0.270
DEG_Nend_UBRbox_2 1 3 PF02207 0.609
DOC_MAPK_DCC_7 404 413 PF00069 0.264
DOC_MAPK_FxFP_2 346 349 PF00069 0.317
DOC_MAPK_gen_1 103 111 PF00069 0.481
DOC_MAPK_gen_1 205 216 PF00069 0.277
DOC_MAPK_gen_1 328 335 PF00069 0.435
DOC_MAPK_gen_1 389 398 PF00069 0.488
DOC_MAPK_MEF2A_6 103 111 PF00069 0.483
DOC_MAPK_MEF2A_6 209 218 PF00069 0.334
DOC_MAPK_MEF2A_6 360 369 PF00069 0.333
DOC_MAPK_MEF2A_6 378 385 PF00069 0.247
DOC_MAPK_MEF2A_6 404 413 PF00069 0.293
DOC_PP1_RVXF_1 326 333 PF00149 0.532
DOC_PP1_RVXF_1 382 388 PF00149 0.491
DOC_PP1_RVXF_1 402 408 PF00149 0.364
DOC_PP2B_PxIxI_1 348 354 PF00149 0.430
DOC_PP4_FxxP_1 346 349 PF00568 0.332
DOC_PP4_FxxP_1 48 51 PF00568 0.341
DOC_USP7_MATH_1 166 170 PF00917 0.495
DOC_USP7_MATH_1 244 248 PF00917 0.537
DOC_USP7_MATH_1 291 295 PF00917 0.514
DOC_USP7_UBL2_3 205 209 PF12436 0.184
DOC_WW_Pin1_4 377 382 PF00397 0.334
LIG_14-3-3_CanoR_1 131 139 PF00244 0.319
LIG_14-3-3_CanoR_1 230 235 PF00244 0.448
LIG_14-3-3_CanoR_1 273 282 PF00244 0.367
LIG_14-3-3_CterR_2 488 491 PF00244 0.243
LIG_APCC_ABBA_1 353 358 PF00400 0.182
LIG_BRCT_BRCA1_1 358 362 PF00533 0.332
LIG_deltaCOP1_diTrp_1 358 368 PF00928 0.182
LIG_FHA_1 143 149 PF00498 0.257
LIG_FHA_1 184 190 PF00498 0.271
LIG_FHA_1 342 348 PF00498 0.260
LIG_FHA_1 362 368 PF00498 0.309
LIG_FHA_1 482 488 PF00498 0.418
LIG_FHA_1 87 93 PF00498 0.277
LIG_FHA_2 1 7 PF00498 0.604
LIG_FHA_2 21 27 PF00498 0.458
LIG_FHA_2 311 317 PF00498 0.459
LIG_GBD_Chelix_1 319 327 PF00786 0.298
LIG_LIR_Apic_2 344 349 PF02991 0.295
LIG_LIR_Gen_1 222 231 PF02991 0.372
LIG_LIR_Gen_1 25 35 PF02991 0.411
LIG_LIR_Gen_1 321 330 PF02991 0.516
LIG_LIR_Gen_1 359 370 PF02991 0.286
LIG_LIR_Gen_1 401 410 PF02991 0.271
LIG_LIR_Gen_1 415 424 PF02991 0.347
LIG_LIR_Gen_1 72 82 PF02991 0.245
LIG_LIR_Nem_3 100 105 PF02991 0.366
LIG_LIR_Nem_3 158 164 PF02991 0.443
LIG_LIR_Nem_3 199 204 PF02991 0.247
LIG_LIR_Nem_3 208 214 PF02991 0.175
LIG_LIR_Nem_3 222 226 PF02991 0.299
LIG_LIR_Nem_3 25 31 PF02991 0.422
LIG_LIR_Nem_3 321 327 PF02991 0.478
LIG_LIR_Nem_3 359 365 PF02991 0.258
LIG_LIR_Nem_3 401 405 PF02991 0.310
LIG_LIR_Nem_3 415 419 PF02991 0.308
LIG_LIR_Nem_3 422 427 PF02991 0.267
LIG_LIR_Nem_3 56 60 PF02991 0.265
LIG_LIR_Nem_3 72 78 PF02991 0.245
LIG_LIR_Nem_3 80 85 PF02991 0.232
LIG_NRBOX 184 190 PF00104 0.241
LIG_Pex14_1 387 391 PF04695 0.532
LIG_Pex14_2 147 151 PF04695 0.420
LIG_Pex14_2 167 171 PF04695 0.437
LIG_SH2_CRK 416 420 PF00017 0.238
LIG_SH2_CRK 424 428 PF00017 0.235
LIG_SH2_CRK 82 86 PF00017 0.290
LIG_SH2_GRB2like 71 74 PF00017 0.328
LIG_SH2_GRB2like 81 84 PF00017 0.247
LIG_SH2_NCK_1 82 86 PF00017 0.342
LIG_SH2_PTP2 28 31 PF00017 0.416
LIG_SH2_SRC 28 31 PF00017 0.373
LIG_SH2_SRC 418 421 PF00017 0.266
LIG_SH2_STAP1 20 24 PF00017 0.556
LIG_SH2_STAP1 71 75 PF00017 0.370
LIG_SH2_STAT3 60 63 PF00017 0.362
LIG_SH2_STAT5 238 241 PF00017 0.464
LIG_SH2_STAT5 28 31 PF00017 0.290
LIG_SH2_STAT5 418 421 PF00017 0.244
LIG_SH2_STAT5 426 429 PF00017 0.283
LIG_SH2_STAT5 438 441 PF00017 0.237
LIG_SH2_STAT5 53 56 PF00017 0.274
LIG_SH2_STAT5 71 74 PF00017 0.274
LIG_SH3_3 306 312 PF00018 0.505
LIG_SH3_3 442 448 PF00018 0.347
LIG_SUMO_SIM_anti_2 121 127 PF11976 0.267
LIG_SUMO_SIM_anti_2 222 228 PF11976 0.292
LIG_SUMO_SIM_anti_2 478 484 PF11976 0.313
LIG_SUMO_SIM_anti_2 94 100 PF11976 0.429
LIG_SUMO_SIM_par_1 115 121 PF11976 0.269
LIG_SUMO_SIM_par_1 409 415 PF11976 0.384
LIG_SUMO_SIM_par_1 478 484 PF11976 0.211
LIG_SUMO_SIM_par_1 94 100 PF11976 0.361
LIG_TRAF2_1 299 302 PF00917 0.516
LIG_TYR_ITSM 78 85 PF00017 0.235
LIG_UBA3_1 188 194 PF00899 0.335
LIG_UBA3_1 323 331 PF00899 0.515
LIG_ULM_U2AF65_1 328 333 PF00076 0.371
LIG_WRC_WIRS_1 231 236 PF05994 0.469
MOD_CDK_SPxxK_3 377 384 PF00069 0.211
MOD_CK1_1 169 175 PF00069 0.498
MOD_CK1_1 481 487 PF00069 0.372
MOD_CK2_1 151 157 PF00069 0.349
MOD_CK2_1 20 26 PF00069 0.496
MOD_CK2_1 274 280 PF00069 0.534
MOD_CK2_1 310 316 PF00069 0.464
MOD_Cter_Amidation 456 459 PF01082 0.182
MOD_GlcNHglycan 181 184 PF01048 0.276
MOD_GlcNHglycan 254 257 PF01048 0.251
MOD_GlcNHglycan 276 279 PF01048 0.314
MOD_GlcNHglycan 48 51 PF01048 0.496
MOD_GSK3_1 138 145 PF00069 0.325
MOD_GSK3_1 151 158 PF00069 0.224
MOD_GSK3_1 166 173 PF00069 0.362
MOD_GSK3_1 179 186 PF00069 0.273
MOD_GSK3_1 318 325 PF00069 0.500
MOD_GSK3_1 356 363 PF00069 0.280
MOD_GSK3_1 483 490 PF00069 0.376
MOD_GSK3_1 69 76 PF00069 0.239
MOD_N-GLC_1 273 278 PF02516 0.345
MOD_NEK2_1 151 156 PF00069 0.297
MOD_NEK2_1 171 176 PF00069 0.423
MOD_NEK2_1 318 323 PF00069 0.442
MOD_NEK2_1 341 346 PF00069 0.314
MOD_NEK2_1 412 417 PF00069 0.307
MOD_NEK2_1 432 437 PF00069 0.347
MOD_NEK2_1 466 471 PF00069 0.300
MOD_NEK2_1 483 488 PF00069 0.304
MOD_PIKK_1 481 487 PF00454 0.498
MOD_PKA_1 205 211 PF00069 0.182
MOD_PKA_2 130 136 PF00069 0.342
MOD_PKA_2 272 278 PF00069 0.359
MOD_Plk_1 156 162 PF00069 0.450
MOD_Plk_1 300 306 PF00069 0.546
MOD_Plk_4 151 157 PF00069 0.320
MOD_Plk_4 171 177 PF00069 0.453
MOD_Plk_4 184 190 PF00069 0.290
MOD_Plk_4 219 225 PF00069 0.286
MOD_Plk_4 36 42 PF00069 0.299
MOD_Plk_4 461 467 PF00069 0.454
MOD_Plk_4 475 481 PF00069 0.259
MOD_Plk_4 53 59 PF00069 0.246
MOD_Plk_4 77 83 PF00069 0.242
MOD_Plk_4 87 93 PF00069 0.280
MOD_Plk_4 94 100 PF00069 0.236
MOD_ProDKin_1 377 383 PF00069 0.334
MOD_SUMO_for_1 292 295 PF00179 0.538
MOD_SUMO_rev_2 450 460 PF00179 0.390
TRG_DiLeu_BaEn_1 121 126 PF01217 0.294
TRG_DiLeu_BaEn_1 94 99 PF01217 0.211
TRG_DiLeu_BaLyEn_6 107 112 PF01217 0.431
TRG_DiLeu_BaLyEn_6 406 411 PF01217 0.324
TRG_ENDOCYTIC_2 161 164 PF00928 0.439
TRG_ENDOCYTIC_2 201 204 PF00928 0.259
TRG_ENDOCYTIC_2 211 214 PF00928 0.222
TRG_ENDOCYTIC_2 28 31 PF00928 0.283
TRG_ENDOCYTIC_2 416 419 PF00928 0.269
TRG_ENDOCYTIC_2 424 427 PF00928 0.255
TRG_ENDOCYTIC_2 71 74 PF00928 0.300
TRG_ENDOCYTIC_2 81 84 PF00928 0.221
TRG_ER_diArg_1 102 104 PF00400 0.444
TRG_ER_diArg_1 327 329 PF00400 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 33% 100%
A0A0N0P6Z5 Leptomonas seymouri 29% 98%
A0A0N1I1J0 Leptomonas seymouri 27% 100%
A0A0N1I8E8 Leptomonas seymouri 23% 98%
A0A0N1PBQ1 Leptomonas seymouri 33% 97%
A0A0S4JBS4 Bodo saltans 31% 100%
A0A1X0NN91 Trypanosomatidae 36% 100%
A0A1X0NPL0 Trypanosomatidae 34% 100%
A0A1X0NV38 Trypanosomatidae 30% 100%
A0A1X0NWJ5 Trypanosomatidae 32% 100%
A0A3Q8ICX7 Leishmania donovani 33% 98%
A0A3R7NQR3 Trypanosoma rangeli 35% 100%
A0A3S7WTL0 Leishmania donovani 99% 100%
A0A3S7XAS5 Leishmania donovani 31% 98%
A0A422MQ08 Trypanosoma rangeli 31% 100%
A0A422N8M2 Trypanosoma rangeli 32% 100%
A0A422NHH9 Trypanosoma rangeli 31% 100%
A0A422NR81 Trypanosoma rangeli 52% 100%
A1A4N1 Bos taurus 23% 100%
A1L272 Danio rerio 24% 95%
A4H6I0 Leishmania braziliensis 29% 100%
A4H7A5 Leishmania braziliensis 33% 100%
A4HG96 Leishmania braziliensis 25% 99%
A4HP60 Leishmania braziliensis 32% 100%
A4HUW2 Leishmania infantum 28% 100%
A4HVP9 Leishmania infantum 33% 100%
A4IDG6 Leishmania infantum 31% 98%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AGM5 Leishmania infantum 99% 100%
E9AGM6 Leishmania infantum 99% 100%
E9AGM7 Leishmania infantum 99% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O54698 Rattus norvegicus 23% 100%
O54699 Rattus norvegicus 25% 100%
O76343 Leishmania donovani 100% 100%
Q14542 Homo sapiens 25% 100%
Q4Q1M9 Leishmania major 31% 100%
Q4QF58 Leishmania major 96% 100%
Q4QF59 Leishmania major 95% 100%
Q4QG33 Leishmania major 33% 100%
Q61672 Mus musculus 25% 100%
Q7RTT9 Homo sapiens 24% 93%
Q8R139 Mus musculus 26% 93%
Q8VXY7 Arabidopsis thaliana 22% 100%
Q99808 Homo sapiens 25% 100%
Q99P65 Mus musculus 22% 100%
Q9JIM1 Mus musculus 24% 100%
V5BGB1 Trypanosoma cruzi 33% 100%
V5BRM5 Trypanosoma cruzi 30% 100%
V5DSF4 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS