Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWK6_LEIIN

TriTrypDb:

LINF_150019100

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000126	transcription factor TFIIIB complex	4	1
GO:0005634	nucleus	5	1
GO:0005667	transcription regulator complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0032993	protein-DNA complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0090576	RNA polymerase III transcription regulator complex	3	1
GO:0097550	transcription preinitiation complex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWK6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006351	DNA-templated transcription	7	1
GO:0006352	DNA-templated transcription initiation	6	1
GO:0006383	transcription by RNA polymerase III	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0097659	nucleic acid-templated transcription	6	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0000987	cis-regulatory region sequence-specific DNA binding	6	1
GO:0000992	RNA polymerase III cis-regulatory region sequence-specific DNA binding	7	1
GO:0000995	RNA polymerase III general transcription initiation factor activity	2	1
GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	8	1
GO:0001016	RNA polymerase III transcription regulatory region sequence-specific DNA binding	6	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140223	general transcription initiation factor activity	1	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.469
CLV_NRD_NRD_1	141	143	PF00675	0.348
CLV_NRD_NRD_1	162	164	PF00675	0.253
CLV_NRD_NRD_1	209	211	PF00675	0.233
CLV_NRD_NRD_1	406	408	PF00675	0.709
CLV_PCSK_KEX2_1	141	143	PF00082	0.328
CLV_PCSK_KEX2_1	162	164	PF00082	0.246
CLV_PCSK_KEX2_1	209	211	PF00082	0.233
CLV_PCSK_KEX2_1	408	410	PF00082	0.573
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.573
CLV_PCSK_SKI1_1	119	123	PF00082	0.417
CLV_PCSK_SKI1_1	53	57	PF00082	0.460
DOC_CKS1_1	354	359	PF01111	0.364
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.363
DOC_MAPK_gen_1	162	169	PF00069	0.432
DOC_MAPK_MEF2A_6	128	137	PF00069	0.421
DOC_MAPK_MEF2A_6	248	256	PF00069	0.275
DOC_MAPK_MEF2A_6	282	289	PF00069	0.269
DOC_PP1_RVXF_1	293	299	PF00149	0.389
DOC_PP2B_LxvP_1	242	245	PF13499	0.327
DOC_USP7_MATH_1	104	108	PF00917	0.493
DOC_USP7_MATH_1	127	131	PF00917	0.337
DOC_USP7_MATH_1	17	21	PF00917	0.340
DOC_USP7_MATH_1	176	180	PF00917	0.259
DOC_USP7_MATH_1	269	273	PF00917	0.508
DOC_USP7_MATH_1	306	310	PF00917	0.507
DOC_USP7_MATH_1	370	374	PF00917	0.667
DOC_USP7_MATH_1	386	390	PF00917	0.647
DOC_WW_Pin1_4	353	358	PF00397	0.466
DOC_WW_Pin1_4	413	418	PF00397	0.727
LIG_14-3-3_CanoR_1	128	136	PF00244	0.259
LIG_14-3-3_CanoR_1	314	318	PF00244	0.349
LIG_14-3-3_CanoR_1	411	417	PF00244	0.701
LIG_14-3-3_CanoR_1	78	86	PF00244	0.536
LIG_Actin_WH2_2	189	206	PF00022	0.320
LIG_APCC_ABBA_1	274	279	PF00400	0.344
LIG_BIR_II_1	1	5	PF00653	0.376
LIG_BIR_III_3	1	5	PF00653	0.403
LIG_FHA_1	414	420	PF00498	0.656
LIG_FHA_2	1	7	PF00498	0.364
LIG_FHA_2	200	206	PF00498	0.415
LIG_FHA_2	364	370	PF00498	0.573
LIG_FHA_2	47	53	PF00498	0.459
LIG_FHA_2	54	60	PF00498	0.424
LIG_FHA_2	85	91	PF00498	0.567
LIG_LIR_Gen_1	349	357	PF02991	0.383
LIG_LIR_Gen_1	54	61	PF02991	0.428
LIG_LIR_Nem_3	134	139	PF02991	0.259
LIG_LIR_Nem_3	316	321	PF02991	0.329
LIG_LIR_Nem_3	349	353	PF02991	0.364
LIG_LIR_Nem_3	381	387	PF02991	0.516
LIG_LIR_Nem_3	54	60	PF02991	0.428
LIG_PCNA_PIPBox_1	223	232	PF02747	0.282
LIG_PTAP_UEV_1	396	401	PF05743	0.558
LIG_REV1ctd_RIR_1	134	142	PF16727	0.259
LIG_SH2_CRK	384	388	PF00017	0.521
LIG_SH2_NCK_1	57	61	PF00017	0.447
LIG_SH2_PTP2	238	241	PF00017	0.303
LIG_SH2_SRC	384	387	PF00017	0.532
LIG_SH2_SRC	57	60	PF00017	0.441
LIG_SH2_STAT5	14	17	PF00017	0.405
LIG_SH2_STAT5	238	241	PF00017	0.281
LIG_SH2_STAT5	7	10	PF00017	0.428
LIG_SH3_3	296	302	PF00018	0.594
LIG_SH3_3	394	400	PF00018	0.736
LIG_SH3_3	414	420	PF00018	0.462
LIG_TRAF2_1	424	427	PF00917	0.534
LIG_TRAF2_1	87	90	PF00917	0.554
MOD_CK1_1	107	113	PF00069	0.509
MOD_CK1_1	20	26	PF00069	0.387
MOD_CK1_1	313	319	PF00069	0.523
MOD_CK1_1	395	401	PF00069	0.589
MOD_CK1_1	412	418	PF00069	0.531
MOD_CK1_1	422	428	PF00069	0.762
MOD_CK2_1	363	369	PF00069	0.539
MOD_CK2_1	46	52	PF00069	0.567
MOD_CK2_1	84	90	PF00069	0.665
MOD_DYRK1A_RPxSP_1	413	417	PF00069	0.692
MOD_GlcNHglycan	106	109	PF01048	0.502
MOD_GlcNHglycan	129	132	PF01048	0.428
MOD_GlcNHglycan	307	311	PF01048	0.544
MOD_GlcNHglycan	318	321	PF01048	0.422
MOD_GlcNHglycan	323	326	PF01048	0.446
MOD_GlcNHglycan	394	397	PF01048	0.742
MOD_GlcNHglycan	422	425	PF01048	0.540
MOD_GSK3_1	306	313	PF00069	0.578
MOD_GSK3_1	316	323	PF00069	0.442
MOD_GSK3_1	391	398	PF00069	0.668
MOD_GSK3_1	407	414	PF00069	0.650
MOD_NEK2_1	114	119	PF00069	0.475
MOD_NEK2_1	137	142	PF00069	0.363
MOD_NEK2_1	199	204	PF00069	0.303
MOD_NEK2_1	214	219	PF00069	0.303
MOD_NEK2_1	321	326	PF00069	0.453
MOD_PIKK_1	422	428	PF00454	0.532
MOD_PKA_1	407	413	PF00069	0.674
MOD_PKA_2	127	133	PF00069	0.363
MOD_PKA_2	137	143	PF00069	0.363
MOD_PKA_2	313	319	PF00069	0.354
MOD_PKA_2	412	418	PF00069	0.670
MOD_PKA_2	77	83	PF00069	0.550
MOD_PKB_1	407	415	PF00069	0.582
MOD_Plk_1	53	59	PF00069	0.441
MOD_Plk_4	176	182	PF00069	0.259
MOD_Plk_4	313	319	PF00069	0.370
MOD_Plk_4	34	40	PF00069	0.470
MOD_ProDKin_1	353	359	PF00069	0.462
MOD_ProDKin_1	413	419	PF00069	0.725
MOD_SUMO_for_1	376	379	PF00179	0.519
MOD_SUMO_for_1	387	390	PF00179	0.463
MOD_SUMO_rev_2	379	383	PF00179	0.545
TRG_DiLeu_BaEn_1	349	354	PF01217	0.454
TRG_DiLeu_BaEn_2	272	278	PF01217	0.359
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.457
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.447
TRG_ENDOCYTIC_2	238	241	PF00928	0.407
TRG_ENDOCYTIC_2	318	321	PF00928	0.335
TRG_ENDOCYTIC_2	384	387	PF00928	0.519
TRG_ENDOCYTIC_2	57	60	PF00928	0.441
TRG_ER_diArg_1	161	163	PF00400	0.236
TRG_ER_diArg_1	294	297	PF00400	0.336
TRG_NLS_MonoExtC_3	406	411	PF00514	0.601
TRG_NLS_MonoExtN_4	407	412	PF00514	0.692
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I166	Leptomonas seymouri	68%	100%
A0A1X0NU06	Trypanosomatidae	37%	100%
A0A3R7MLE9	Trypanosoma rangeli	40%	100%
A0A3S5H6V5	Leishmania donovani	100%	100%
A4H880	Leishmania braziliensis	84%	100%
C9ZXT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QF67	Leishmania major	95%	100%
V5BK49	Trypanosoma cruzi	38%	100%