Tryparedoxin peroxidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin peroxidase

Species:

Leishmania infantum

UniProt:

A4HWK3_LEIIN

TriTrypDb:

LINF_150018800

Length:

190

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: sdsanchita@gmail.com
Publication title: A Novel Role of Secretory Cytosolic Tryparedoxin Peroxidase in Delaying Apoptosis of Leishmania-Infected Macrophages
Publication 1st author(s): Das
Publication Identifier(s): 36073913
Host organism: -1
Interaction detection method(s): anti bait coimmunoprecipitation
Interaction type: physical association
Identification method participant A: western blot
Identification method participant B: predetermined participant
ID(s) interactor A: Q9Z0X1
ID(s) interactor B: A0A3S7WTJ2
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania donovani
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Annotations by Jardim et al.

Redox homeostasis, Tryparedoxin peroxidase TRYP

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	4
GO:0005737	cytoplasm	2	4
GO:0005829	cytosol	2	4
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

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Expansion

Sequence features

A4HWK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWK3

PDB structure(s): 3tue_A , 3tue_B , 3tue_C , 3tue_D , 3tue_E , 4k1f_A , 4k1f_B , 4k1f_C , 4k1f_D , 4k1f_E

Function

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Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	4
GO:0019725	cellular homeostasis	2	4
GO:0042592	homeostatic process	3	4
GO:0045454	cell redox homeostasis	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0065007	biological regulation	1	4
GO:0065008	regulation of biological quality	2	4

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0004601	peroxidase activity	2	21
GO:0016209	antioxidant activity	1	21
GO:0016491	oxidoreductase activity	2	21
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	21
GO:0051920	peroxiredoxin activity	3	21
GO:0140825	lactoperoxidase activity	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.522
CLV_NRD_NRD_1	91	93	PF00675	0.341
CLV_PCSK_SKI1_1	128	132	PF00082	0.341
CLV_PCSK_SKI1_1	140	144	PF00082	0.416
CLV_Separin_Metazoa	155	159	PF03568	0.462
DOC_CYCLIN_RxL_1	122	134	PF00134	0.382
DOC_MAPK_FxFP_2	42	45	PF00069	0.357
DOC_MAPK_gen_1	178	186	PF00069	0.263
DOC_MAPK_gen_1	35	43	PF00069	0.376
DOC_MAPK_MEF2A_6	178	186	PF00069	0.197

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0K3AUJ9	Caenorhabditis elegans	60%	95%
A0A0N1PB76	Leptomonas seymouri	55%	84%
A0A0S4J2M3	Bodo saltans	60%	83%
A0A1X0NCW4	Trypanosomatidae	73%	96%
A0A1X0NUK9	Trypanosomatidae	73%	95%
A0A1X0NXA0	Trypanosomatidae	56%	84%
A0A2Z5VKM8	Chattonella marina var. antiqua	49%	97%
A0A3Q8IFP4	Leishmania donovani	56%	84%
A0A3R7K6K7	Trypanosoma rangeli	56%	86%
A0A3S7WTJ2	Leishmania donovani	98%	100%

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