Tryparedoxin peroxidase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin peroxidase

Species:

Leishmania infantum

UniProt:

A4HWK2_LEIIN

TriTrypDb:

LINF_150018600

Length:

199

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: sdsanchita@gmail.com
Publication title: A Novel Role of Secretory Cytosolic Tryparedoxin Peroxidase in Delaying Apoptosis of Leishmania-Infected Macrophages
Publication 1st author(s): Das
Publication Identifier(s): 36073913
Host organism: -1
Interaction detection method(s): anti bait coimmunoprecipitation
Interaction type: physical association
Identification method participant A: western blot
Identification method participant B: predetermined participant
ID(s) interactor A: Q9Z0X1
ID(s) interactor B: A0A3S7WTJ2
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania donovani
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Annotations by Jardim et al.

Redox homeostasis, Tryparedoxin peroxidase TRYP

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	4
GO:0005737	cytoplasm	2	4
GO:0005829	cytosol	2	4
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	yes	yes: 16

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HWK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWK2

PDB structure(s): 3tue_A , 3tue_B , 3tue_C , 3tue_D , 3tue_E , 4k1f_A , 4k1f_B , 4k1f_C , 4k1f_D , 4k1f_E

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	4
GO:0019725	cellular homeostasis	2	4
GO:0042592	homeostatic process	3	4
GO:0045454	cell redox homeostasis	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0065007	biological regulation	1	4
GO:0065008	regulation of biological quality	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0004601	peroxidase activity	2	22
GO:0016209	antioxidant activity	1	22
GO:0016491	oxidoreductase activity	2	22
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	22
GO:0051920	peroxiredoxin activity	3	22
GO:0140825	lactoperoxidase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.467
CLV_NRD_NRD_1	91	93	PF00675	0.286
CLV_PCSK_SKI1_1	128	132	PF00082	0.296
CLV_PCSK_SKI1_1	140	144	PF00082	0.369
CLV_Separin_Metazoa	155	159	PF03568	0.375
DOC_CYCLIN_RxL_1	122	134	PF00134	0.389
DOC_MAPK_FxFP_2	42	45	PF00069	0.310
DOC_MAPK_gen_1	35	43	PF00069	0.310
DOC_MAPK_MEF2A_6	35	43	PF00069	0.310
DOC_PP4_FxxP_1	42	45	PF00568	0.302
DOC_PP4_FxxP_1	50	53	PF00568	0.289
DOC_USP7_MATH_1	188	192	PF00917	0.252
DOC_USP7_MATH_1	22	26	PF00917	0.431
DOC_USP7_UBL2_3	185	189	PF12436	0.234
LIG_14-3-3_CanoR_1	140	145	PF00244	0.413
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_Clathr_ClatBox_1	130	134	PF01394	0.296
LIG_FHA_1	107	113	PF00498	0.232
LIG_FHA_1	52	58	PF00498	0.419
LIG_FHA_2	141	147	PF00498	0.368
LIG_FHA_2	86	92	PF00498	0.307
LIG_LIR_Apic_2	47	53	PF02991	0.296
LIG_LIR_Gen_1	161	167	PF02991	0.399
LIG_LIR_Gen_1	193	199	PF02991	0.260
LIG_LIR_Gen_1	47	56	PF02991	0.296
LIG_LIR_Gen_1	64	74	PF02991	0.296
LIG_LIR_Gen_1	79	89	PF02991	0.303
LIG_LIR_Nem_3	161	166	PF02991	0.399
LIG_LIR_Nem_3	193	199	PF02991	0.236
LIG_LIR_Nem_3	25	29	PF02991	0.342
LIG_LIR_Nem_3	47	51	PF02991	0.296
LIG_LIR_Nem_3	64	69	PF02991	0.296
LIG_LIR_Nem_3	79	85	PF02991	0.329
LIG_PDZ_Class_1	194	199	PF00595	0.208
LIG_Pex14_1	38	42	PF04695	0.326
LIG_PTB_Apo_2	20	27	PF02174	0.341
LIG_SH2_CRK	127	131	PF00017	0.326
LIG_SH2_STAT5	195	198	PF00017	0.281
LIG_SH3_3	8	14	PF00018	0.345
LIG_SH3_4	185	192	PF00018	0.267
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.349
LIG_TRAF2_1	14	17	PF00917	0.439
LIG_TYR_ITIM	125	130	PF00017	0.326
MOD_CK1_1	77	83	PF00069	0.296
MOD_GSK3_1	57	64	PF00069	0.366
MOD_N-GLC_1	22	27	PF02516	0.342
MOD_N-GLC_1	61	66	PF02516	0.208
MOD_NEK2_1	46	51	PF00069	0.293
MOD_NEK2_1	85	90	PF00069	0.310
MOD_NEK2_2	22	27	PF00069	0.365
MOD_PK_1	108	114	PF00069	0.309
MOD_PKA_1	27	33	PF00069	0.419
MOD_Plk_1	46	52	PF00069	0.322
MOD_Plk_1	61	67	PF00069	0.296
MOD_SUMO_for_1	184	187	PF00179	0.411
MOD_SUMO_rev_2	2	8	PF00179	0.386
TRG_DiLeu_BaEn_1	155	160	PF01217	0.348
TRG_DiLeu_BaEn_1	16	21	PF01217	0.439
TRG_DiLeu_BaEn_2	160	166	PF01217	0.445
TRG_DiLeu_LyEn_5	155	160	PF01217	0.462
TRG_ENDOCYTIC_2	116	119	PF00928	0.296
TRG_ENDOCYTIC_2	127	130	PF00928	0.326
TRG_ENDOCYTIC_2	82	85	PF00928	0.392
TRG_PTS1	196	199	PF00515	0.181

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0K3AUJ9	Caenorhabditis elegans	61%	99%
A0A0N1PB76	Leptomonas seymouri	54%	88%
A0A0S4J2M3	Bodo saltans	63%	87%
A0A1X0NCW4	Trypanosomatidae	72%	100%
A0A1X0NUK9	Trypanosomatidae	72%	100%
A0A1X0NXA0	Trypanosomatidae	59%	88%
A0A2Z5VKM8	Chattonella marina var. antiqua	51%	100%
A0A3Q8IFP4	Leishmania donovani	57%	88%
A0A3R7K6K7	Trypanosoma rangeli	59%	90%
A0A3S7WTJ2	Leishmania donovani	96%	100%
A0A3S7WTK5	Leishmania donovani	100%	100%
A0A422N179	Trypanosoma rangeli	71%	100%
A0A422NRB2	Trypanosoma rangeli	70%	100%
A0A6L0X3Y6	Leishmania infantum	99%	100%
A0A6L0XFC6	Leishmania infantum	57%	100%
A0R1V9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	43%	100%
A2BJD9	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	39%	86%
A2SZW8	Zea mays	29%	87%
A3DKL1	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	40%	85%
A4FWZ9	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	37%	92%
A4H877	Leishmania braziliensis	83%	100%
A4H879	Leishmania braziliensis	84%	100%
A4HCL7	Leishmania braziliensis	56%	100%
A4HWK3	Leishmania infantum	97%	100%
A5IIX7	Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)	38%	93%
A6UPH7	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	35%	92%
A8A9P0	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	42%	85%
B6DTL8	Bodo saltans	65%	76%
C9ZUX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	88%
C9ZXT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AQA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AQA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AW04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
K0J4Q8	Amphibacillus xylanus (strain ATCC 51415 / DSM 6626 / JCM 7361 / LMG 17667 / NBRC 15112 / Ep01)	36%	100%
O04005	Arabidopsis thaliana	29%	92%
O08709	Mus musculus	30%	89%
O08807	Mus musculus	53%	73%
O17433	Dirofilaria immitis	26%	85%
O24364	Spinacia oleracea	52%	75%
O26262	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	34%	95%
O29969	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	35%	93%
O33665	Sulfuracidifex metallicus	36%	93%
O34564	Bacillus subtilis (strain 168)	48%	100%
O35244	Rattus norvegicus	28%	89%
O58966	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	92%
O67024	Aquifex aeolicus (strain VF5)	35%	90%
O74887	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	60%	100%
O77834	Bos taurus	29%	89%
P0A0B5	Staphylococcus aureus (strain Mu50 / ATCC 700699)	36%	100%
P0A0B6	Staphylococcus aureus (strain MW2)	36%	100%
P0A0B7	Staphylococcus aureus (strain NCTC 8325 / PS 47)	36%	100%
P0A251	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	100%
P0A252	Salmonella typhi	35%	100%
P0AE08	Escherichia coli (strain K12)	36%	100%
P0AE09	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	36%	100%
P0AE10	Escherichia coli O157:H7	36%	100%
P0AE11	Shigella flexneri	36%	100%
P0C5C8	Oryza sativa subsp. indica	26%	90%
P0C5C9	Oryza sativa subsp. japonica	27%	90%
P0C5D0	Oryza sativa subsp. indica	25%	90%
P0C5D1	Oryza sativa subsp. japonica	26%	90%
P0C5D4	Oryza sativa subsp. indica	25%	92%
P0C5D5	Oryza sativa subsp. japonica	25%	92%
P0CB50	Gallus gallus	59%	100%
P0CU34	Candida albicans (strain SC5314 / ATCC MYA-2876)	58%	100%
P19476	Entamoeba histolytica	48%	85%
P20108	Mus musculus	62%	77%
P21762	Helicobacter pylori (strain ATCC 700392 / 26695)	46%	100%
P23161	Clostridium pasteurianum	48%	100%
P26830	Ferdinandcohnia aciditolerans (strain JCM 32973 / CCTCC AB 2017280 / YN-1)	39%	100%
P30041	Homo sapiens	27%	89%
P30048	Homo sapiens	59%	78%
P32119	Homo sapiens	59%	100%
P34227	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	76%
P34760	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	57%	100%
P35700	Mus musculus	59%	100%
P35704	Rattus norvegicus	60%	100%
P35705	Bos taurus	62%	77%
P48822	Brugia malayi	59%	87%
P49537	Trieres chinensis	43%	98%
P51272	Porphyra purpurea	55%	100%
P52570	Onchocerca volvulus	28%	86%
P52571	Bromus secalinus	29%	99%
P52572	Hordeum vulgare	29%	91%
P52574	Syntrichia ruralis	30%	91%
P56876	Helicobacter pylori (strain J99 / ATCC 700824)	47%	100%
P57279	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	41%	100%
P80239	Bacillus subtilis (strain 168)	37%	100%
P80602	Triticum aestivum	50%	95%
P91883	Fasciola hepatica	61%	100%
P95895	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	36%	93%
P99074	Staphylococcus aureus (strain N315)	36%	100%
P9WIE0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WIE1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
P9WQB6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	44%	100%
P9WQB7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	44%	100%
Q02UU0	Pseudomonas aeruginosa (strain UCBPP-PA14)	36%	100%
Q04120	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	55%	100%
Q06830	Homo sapiens	60%	100%
Q13162	Homo sapiens	53%	73%
Q17172	Brugia malayi	60%	100%
Q1XDL4	Neopyropia yezoensis	53%	100%
Q21824	Caenorhabditis elegans	57%	88%
Q26695	Trypanosoma brucei rhodesiense	72%	100%
Q2FJN4	Staphylococcus aureus (strain USA300)	36%	100%
Q2PFL9	Macaca fascicularis	27%	89%
Q2PFZ3	Macaca fascicularis	59%	100%
Q2YVK2	Staphylococcus aureus (strain bovine RF122 / ET3-1)	36%	100%
Q49UT8	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	36%	100%
Q4L376	Staphylococcus haemolyticus (strain JCSC1435)	35%	100%
Q4QBH2	Leishmania major	56%	100%
Q4QF68	Leishmania major	91%	100%
Q4QF74	Leishmania major	90%	100%
Q4QF76	Leishmania major	92%	100%
Q4QF80	Leishmania major	91%	100%
Q54SE2	Dictyostelium discoideum	31%	83%
Q55060	Sulfuracidifex metallicus	34%	93%
Q555L5	Dictyostelium discoideum	54%	77%
Q55624	Synechocystis sp. (strain PCC 6803 / Kazusa)	48%	100%
Q57109	Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)	34%	94%
Q58146	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	34%	92%
Q5E947	Bos taurus	60%	100%
Q5HIR5	Staphylococcus aureus (strain COL)	36%	100%
Q5HRY1	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	35%	100%
Q5JF30	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	34%	92%
Q5R7E0	Pongo abelii	26%	89%
Q5RC63	Pongo abelii	58%	100%
Q5REY3	Pongo abelii	61%	78%
Q5S1S6	Triticum aestivum	26%	92%
Q5ZJF4	Gallus gallus	29%	89%
Q61171	Mus musculus	59%	100%
Q63716	Rattus norvegicus	60%	100%
Q6B4U9	Myotis lucifugus	60%	100%
Q6DV14	Gekko japonicus	59%	100%
Q6E2Z6	Medicago truncatula	30%	91%
Q6ER94	Oryza sativa subsp. japonica	50%	76%
Q6GC91	Staphylococcus aureus (strain MSSA476)	36%	100%
Q6GJR7	Staphylococcus aureus (strain MRSA252)	36%	100%
Q6L140	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	41%	99%
Q6L240	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	36%	88%
Q6LY19	Methanococcus maripaludis (strain S2 / LL)	37%	92%
Q6QPJ6	Populus jackii	28%	93%
Q6UBI3	Suaeda salsa	27%	93%
Q6W8Q2	Triticum aestivum	28%	91%
Q73RS4	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	38%	96%
Q74NC6	Nanoarchaeum equitans (strain Kin4-M)	37%	90%
Q75SY5	Gentiana triflora	29%	92%
Q796Y8	Bacillus subtilis (strain 168)	30%	100%
Q89AS1	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	39%	100%
Q8CMQ2	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	35%	100%
Q8K3U7	Cricetulus griseus	59%	100%
Q8K9W0	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	40%	100%
Q8KBN8	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	33%	94%
Q8P9V9	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	29%	100%
Q8PYP6	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	35%	91%
Q8R844	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	38%	90%
Q8RCY5	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	35%	93%
Q8SS85	Encephalitozoon cuniculi (strain GB-M1)	42%	100%
Q8T6C4	Echinococcus granulosus	60%	100%
Q8U218	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	33%	92%
Q90384	Cynops pyrrhogaster	59%	100%
Q91191	Oncorhynchus mykiss	56%	100%
Q96291	Arabidopsis thaliana	52%	75%
Q96468	Hordeum vulgare	50%	95%
Q96XS5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	37%	94%
Q974S8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	38%	93%
Q979N7	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	40%	98%
Q9BGI2	Bos taurus	54%	73%
Q9BGI3	Bos taurus	57%	100%
Q9C5R8	Arabidopsis thaliana	52%	73%
Q9HJL3	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	40%	100%
Q9HKX0	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	34%	85%
Q9JKY1	Cricetulus griseus	58%	100%
Q9L3Q5	Peptoclostridium acidaminophilum	45%	98%
Q9LU86	Arabidopsis thaliana	29%	92%
Q9MB35	Sedum lineare	26%	100%
Q9NL98	Ascaris suum	63%	100%
Q9TSX9	Sus scrofa	29%	89%
Q9UZV4	Pyrococcus abyssi (strain GE5 / Orsay)	31%	92%
Q9V3P0	Drosophila melanogaster	61%	100%
Q9WZR4	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	38%	93%
Q9Y7F0	Candida albicans (strain SC5314 / ATCC MYA-2876)	58%	100%
Q9Y9L0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	33%	80%
Q9Z0V5	Rattus norvegicus	53%	73%
Q9Z0V6	Rattus norvegicus	61%	77%
Q9ZHF0	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	28%	100%
R4QWJ8	Leishmania donovani	100%	100%