Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SKIP/SNW domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HWK1_LEIIN

TriTrypDb:

LINF_150018500

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0140513	nuclear protein-containing complex	2	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

A4HWK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWK1

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	10
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	10
GO:0000398	mRNA splicing, via spliceosome	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.749
CLV_C14_Caspase3-7	51	55	PF00656	0.765
CLV_C14_Caspase3-7	87	91	PF00656	0.593
CLV_NRD_NRD_1	137	139	PF00675	0.409
CLV_NRD_NRD_1	151	153	PF00675	0.262
CLV_NRD_NRD_1	212	214	PF00675	0.358
CLV_NRD_NRD_1	242	244	PF00675	0.581
CLV_NRD_NRD_1	352	354	PF00675	0.640
CLV_PCSK_KEX2_1	212	214	PF00082	0.358
CLV_PCSK_KEX2_1	242	244	PF00082	0.690
CLV_PCSK_SKI1_1	226	230	PF00082	0.489
CLV_PCSK_SKI1_1	264	268	PF00082	0.553
CLV_PCSK_SKI1_1	275	279	PF00082	0.463
CLV_PCSK_SKI1_1	419	423	PF00082	0.670
CLV_PCSK_SKI1_1	72	76	PF00082	0.693
DEG_Nend_Nbox_1	1	3	PF02207	0.743
DOC_CYCLIN_RxL_1	223	230	PF00134	0.368
DOC_CYCLIN_RxL_1	69	77	PF00134	0.562
DOC_MAPK_gen_1	138	144	PF00069	0.392
DOC_MAPK_gen_1	152	159	PF00069	0.266
DOC_MAPK_gen_1	246	255	PF00069	0.534
DOC_MAPK_gen_1	273	282	PF00069	0.541
DOC_MAPK_HePTP_8	272	284	PF00069	0.581
DOC_MAPK_MEF2A_6	152	159	PF00069	0.350
DOC_MAPK_MEF2A_6	275	284	PF00069	0.540
DOC_PP2B_LxvP_1	155	158	PF13499	0.368
DOC_USP7_MATH_1	108	112	PF00917	0.760
DOC_USP7_MATH_1	118	122	PF00917	0.622
DOC_USP7_MATH_1	131	135	PF00917	0.546
DOC_USP7_MATH_1	22	26	PF00917	0.616
DOC_USP7_MATH_1	318	322	PF00917	0.670
DOC_USP7_MATH_1	46	50	PF00917	0.737
DOC_USP7_UBL2_3	202	206	PF12436	0.443
DOC_USP7_UBL2_3	419	423	PF12436	0.670
DOC_WW_Pin1_4	63	68	PF00397	0.602
LIG_14-3-3_CanoR_1	10	16	PF00244	0.721
LIG_14-3-3_CanoR_1	109	117	PF00244	0.572
LIG_14-3-3_CanoR_1	279	285	PF00244	0.496
LIG_Actin_WH2_2	280	297	PF00022	0.505
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.685
LIG_FHA_1	10	16	PF00498	0.681
LIG_FHA_1	74	80	PF00498	0.655
LIG_FHA_2	281	287	PF00498	0.549
LIG_FHA_2	49	55	PF00498	0.748
LIG_LIR_Nem_3	327	332	PF02991	0.731
LIG_SH3_3	137	143	PF00018	0.399
LIG_SH3_3	310	316	PF00018	0.617
LIG_SH3_3	61	67	PF00018	0.599
LIG_TRAF2_1	207	210	PF00917	0.403
LIG_TRAF2_1	296	299	PF00917	0.563
MOD_CDK_SPxxK_3	63	70	PF00069	0.565
MOD_CK1_1	111	117	PF00069	0.703
MOD_CK1_1	121	127	PF00069	0.619
MOD_CK1_1	31	37	PF00069	0.743
MOD_CK1_1	66	72	PF00069	0.686
MOD_CK1_1	73	79	PF00069	0.641
MOD_CK1_1	9	15	PF00069	0.692
MOD_CK2_1	293	299	PF00069	0.572
MOD_CK2_1	318	324	PF00069	0.724
MOD_GlcNHglycan	100	103	PF01048	0.652
MOD_GlcNHglycan	110	113	PF01048	0.729
MOD_GlcNHglycan	122	126	PF01048	0.614
MOD_GlcNHglycan	133	136	PF01048	0.541
MOD_GlcNHglycan	28	31	PF01048	0.701
MOD_GlcNHglycan	305	308	PF01048	0.655
MOD_GlcNHglycan	363	366	PF01048	0.570
MOD_GlcNHglycan	82	85	PF01048	0.736
MOD_GSK3_1	107	114	PF00069	0.712
MOD_GSK3_1	2	9	PF00069	0.543
MOD_GSK3_1	22	29	PF00069	0.727
MOD_GSK3_1	314	321	PF00069	0.697
MOD_GSK3_1	345	352	PF00069	0.707
MOD_GSK3_1	361	368	PF00069	0.537
MOD_GSK3_1	66	73	PF00069	0.677
MOD_GSK3_1	80	87	PF00069	0.728
MOD_N-GLC_1	280	285	PF02516	0.592
MOD_N-GLC_1	31	36	PF02516	0.620
MOD_NEK2_1	144	149	PF00069	0.399
MOD_NEK2_1	2	7	PF00069	0.721
MOD_NEK2_1	39	44	PF00069	0.666
MOD_NEK2_1	80	85	PF00069	0.758
MOD_PIKK_1	33	39	PF00454	0.741
MOD_PKA_1	242	248	PF00069	0.569
MOD_PKA_1	70	76	PF00069	0.649
MOD_PKA_2	108	114	PF00069	0.574
MOD_PKA_2	242	248	PF00069	0.669
MOD_PKA_2	85	91	PF00069	0.716
MOD_PKA_2	9	15	PF00069	0.715
MOD_PKB_1	26	34	PF00069	0.741
MOD_PKB_1	273	281	PF00069	0.582
MOD_Plk_1	280	286	PF00069	0.591
MOD_Plk_1	298	304	PF00069	0.607
MOD_Plk_1	400	406	PF00069	0.627
MOD_Plk_2-3	400	406	PF00069	0.658
MOD_Plk_4	111	117	PF00069	0.741
MOD_Plk_4	298	304	PF00069	0.644
MOD_Plk_4	70	76	PF00069	0.662
MOD_ProDKin_1	63	69	PF00069	0.604
MOD_SUMO_for_1	205	208	PF00179	0.443
TRG_ER_diArg_1	252	255	PF00400	0.521
TRG_ER_diArg_1	394	397	PF00400	0.740
TRG_ER_diLys_1	422	427	PF00400	0.647
TRG_NLS_Bipartite_1	138	156	PF00514	0.443
TRG_NLS_MonoExtC_3	421	426	PF00514	0.608
TRG_NLS_MonoExtN_4	419	426	PF00514	0.643
TRG_NLS_MonoExtN_4	67	74	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0X6	Leptomonas seymouri	62%	77%
A0A1X0NU15	Trypanosomatidae	39%	93%
A0A3S7WTI8	Leishmania donovani	100%	100%
A0A422N165	Trypanosoma rangeli	43%	90%
A4H876	Leishmania braziliensis	83%	99%
C9ZXT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
E9AQA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QF81	Leishmania major	94%	100%