Putative solanesyl-diphosphate synthase

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

solanesyl-diphosphate synthase - putative

Species:

Leishmania infantum

UniProt:

A4HWK0_LEIIN

TriTrypDb:

LINF_150018400

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0032991	protein-containing complex	1	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HWK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWK0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006720	isoprenoid metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008299	isoprenoid biosynthetic process	4	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016740	transferase activity	2	11
GO:0004659	prenyltransferase activity	4	2
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	2
GO:0052924	all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.262
CLV_NRD_NRD_1	136	138	PF00675	0.273
CLV_NRD_NRD_1	285	287	PF00675	0.322
CLV_NRD_NRD_1	296	298	PF00675	0.235
CLV_NRD_NRD_1	356	358	PF00675	0.575
CLV_PCSK_KEX2_1	136	138	PF00082	0.273
CLV_PCSK_KEX2_1	149	151	PF00082	0.273
CLV_PCSK_KEX2_1	285	287	PF00082	0.298
CLV_PCSK_KEX2_1	296	298	PF00082	0.238
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.293
CLV_PCSK_SKI1_1	139	143	PF00082	0.319
CLV_PCSK_SKI1_1	150	154	PF00082	0.251
CLV_PCSK_SKI1_1	286	290	PF00082	0.307
CLV_PCSK_SKI1_1	33	37	PF00082	0.340
CLV_PCSK_SKI1_1	344	348	PF00082	0.466
CLV_PCSK_SKI1_1	59	63	PF00082	0.293
CLV_PCSK_SKI1_1	70	74	PF00082	0.293
CLV_TASPASE1	192	198	PF01112	0.293
DEG_APCC_DBOX_1	138	146	PF00400	0.385
DEG_APCC_DBOX_1	328	336	PF00400	0.421
DEG_APCC_DBOX_1	69	77	PF00400	0.273
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DOC_CDC14_PxL_1	275	283	PF14671	0.293
DOC_CYCLIN_yCln2_LP_2	68	74	PF00134	0.333
DOC_MAPK_gen_1	67	76	PF00069	0.385
DOC_MAPK_MEF2A_6	67	75	PF00069	0.340
DOC_PP2B_LxvP_1	169	172	PF13499	0.293
DOC_PP2B_PxIxI_1	171	177	PF00149	0.316
DOC_PP4_FxxP_1	197	200	PF00568	0.385
DOC_PP4_FxxP_1	298	301	PF00568	0.250
DOC_USP7_MATH_1	160	164	PF00917	0.273
DOC_USP7_MATH_1	346	350	PF00917	0.464
DOC_USP7_MATH_1	94	98	PF00917	0.306
DOC_USP7_UBL2_3	205	209	PF12436	0.273
DOC_USP7_UBL2_3	261	265	PF12436	0.273
DOC_WW_Pin1_4	338	343	PF00397	0.383
DOC_WW_Pin1_4	99	104	PF00397	0.316
LIG_14-3-3_CanoR_1	161	165	PF00244	0.293
LIG_14-3-3_CterR_2	357	359	PF00244	0.598
LIG_Clathr_ClatBox_1	190	194	PF01394	0.346
LIG_FHA_1	114	120	PF00498	0.273
LIG_FHA_1	166	172	PF00498	0.319
LIG_FHA_1	177	183	PF00498	0.251
LIG_FHA_1	208	214	PF00498	0.273
LIG_FHA_1	219	225	PF00498	0.273
LIG_FHA_1	275	281	PF00498	0.293
LIG_FHA_2	178	184	PF00498	0.273
LIG_FHA_2	233	239	PF00498	0.394
LIG_FHA_2	255	261	PF00498	0.273
LIG_FHA_2	47	53	PF00498	0.533
LIG_LIR_Apic_2	194	200	PF02991	0.385
LIG_LIR_Gen_1	27	35	PF02991	0.411
LIG_LIR_Nem_3	27	31	PF02991	0.422
LIG_PCNA_yPIPBox_3	285	294	PF02747	0.412
LIG_SH2_STAT5	165	168	PF00017	0.355
LIG_SH2_STAT5	60	63	PF00017	0.294
LIG_SUMO_SIM_par_1	173	180	PF11976	0.274
LIG_SUMO_SIM_par_1	82	87	PF11976	0.418
LIG_TRAF2_1	181	184	PF00917	0.385
LIG_TRAF2_1	37	40	PF00917	0.275
MOD_CDC14_SPxK_1	341	344	PF00782	0.369
MOD_CDK_SPxK_1	338	344	PF00069	0.378
MOD_CK1_1	132	138	PF00069	0.204
MOD_CK1_1	217	223	PF00069	0.318
MOD_CK1_1	349	355	PF00069	0.447
MOD_CK1_1	44	50	PF00069	0.515
MOD_CK2_1	177	183	PF00069	0.273
MOD_CK2_1	254	260	PF00069	0.293
MOD_CK2_1	46	52	PF00069	0.528
MOD_CK2_1	94	100	PF00069	0.337
MOD_GlcNHglycan	348	351	PF01048	0.488
MOD_GlcNHglycan	85	89	PF01048	0.366
MOD_GSK3_1	203	210	PF00069	0.284
MOD_GSK3_1	214	221	PF00069	0.250
MOD_NEK2_1	118	123	PF00069	0.273
MOD_NEK2_1	177	182	PF00069	0.280
MOD_NEK2_1	2	7	PF00069	0.612
MOD_NEK2_1	207	212	PF00069	0.300
MOD_NEK2_1	218	223	PF00069	0.217
MOD_NEK2_1	232	237	PF00069	0.253
MOD_NEK2_1	84	89	PF00069	0.399
MOD_NEK2_2	160	165	PF00069	0.385
MOD_NEK2_2	331	336	PF00069	0.438
MOD_PKA_2	160	166	PF00069	0.273
MOD_Plk_1	232	238	PF00069	0.398
MOD_Plk_1	33	39	PF00069	0.434
MOD_Plk_4	102	108	PF00069	0.372
MOD_Plk_4	120	126	PF00069	0.141
MOD_Plk_4	160	166	PF00069	0.273
MOD_Plk_4	209	215	PF00069	0.273
MOD_Plk_4	349	355	PF00069	0.468
MOD_Plk_4	41	47	PF00069	0.459
MOD_ProDKin_1	338	344	PF00069	0.378
MOD_ProDKin_1	99	105	PF00069	0.316
MOD_SUMO_rev_2	198	207	PF00179	0.273
MOD_SUMO_rev_2	255	263	PF00179	0.273
TRG_DiLeu_BaEn_1	114	119	PF01217	0.273
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.321
TRG_ER_diArg_1	136	139	PF00400	0.347
TRG_ER_diArg_1	296	298	PF00400	0.280
TRG_NES_CRM1_1	189	203	PF08389	0.273
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0A7GEY4	Geoglobus acetivorans	28%	100%
A0A0N1IHA0	Leptomonas seymouri	84%	100%
A0A0U3BRC5	Leucosceptrum canum	27%	99%
A0A1X0NU81	Trypanosomatidae	67%	100%
A0A2I6PJ05	Hypoxylon pulicicidum	26%	93%
A0A343W970	Murgantia histrionica	28%	89%
A0A3Q8IA74	Leishmania donovani	100%	100%
A0A422N164	Trypanosoma rangeli	68%	100%
A0A7D0AGU9	Matsumurasca onukii	24%	100%
A4H875	Leishmania braziliensis	87%	100%
B1XJV9	Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6)	32%	100%
C9ZXT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AQA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O05572	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
O06428	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
O22043	Arabidopsis thaliana	27%	100%
O24743	Rhodobacter capsulatus	32%	100%
O26156	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	30%	100%
O43091	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	95%
O50410	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
O66126	Micrococcus luteus	29%	100%
O66129	Micrococcus luteus	30%	100%
O66952	Aquifex aeolicus (strain VF5)	27%	100%
P0A5H9	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	29%	100%
P0AD57	Escherichia coli (strain K12)	29%	100%
P0AD58	Shigella flexneri	29%	100%
P18900	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	76%
P22873	Pseudescherichia vulneris	26%	100%
P22939	Escherichia coli (strain K12)	29%	100%
P31114	Bacillus subtilis (strain 168)	28%	100%
P31171	Cyanophora paradoxa	35%	100%
P34802	Arabidopsis thaliana	29%	97%
P39464	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	28%	100%
P44916	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P45204	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	31%	100%
P48368	Cyanophora paradoxa	31%	100%
P51268	Porphyra purpurea	35%	100%
P54383	Bacillus subtilis (strain 168)	33%	100%
P55785	Geobacillus stearothermophilus	31%	100%
P72580	Synechocystis sp. (strain PCC 6803 / Kazusa)	35%	100%
P80042	Capsicum annuum	31%	97%
P95999	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	30%	100%
P9WKH0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WKH1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
Q08291	Geobacillus stearothermophilus	32%	100%
Q0INZ4	Oryza sativa subsp. japonica	35%	87%
Q1XDL8	Neopyropia yezoensis	35%	100%
Q33DR2	Mus musculus	34%	88%
Q33DR3	Mus musculus	28%	90%
Q3IPL1	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	29%	100%
Q42698	Catharanthus roseus	31%	100%
Q43133	Sinapis alba	29%	98%
Q4QF82	Leishmania major	97%	100%
Q53479	Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)	30%	100%
Q54VJ9	Dictyostelium discoideum	37%	79%
Q56RZ3	Epichloe festucae (strain Fl1)	22%	100%
Q56RZ7	Epichloe festucae var. lolii	22%	100%
Q58270	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	33%	100%
Q5HZ00	Arabidopsis thaliana	34%	85%
Q5T2R2	Homo sapiens	34%	87%
Q5U2R1	Rattus norvegicus	28%	90%
Q653T6	Oryza sativa subsp. japonica	37%	83%
Q6CBH3	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	79%
Q75HZ9	Oryza sativa subsp. japonica	35%	89%
Q76FS5	Arabidopsis thaliana	35%	86%
Q7S565	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	35%	80%
Q86YH6	Homo sapiens	28%	90%
Q8K9A0	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	25%	100%
Q8PW34	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	27%	100%
Q8S948	Arabidopsis thaliana	37%	88%
Q92236	Gibberella fujikuroi	23%	86%
Q94ID7	Hevea brasiliensis	31%	97%
Q9LHR4	Arabidopsis thaliana	27%	100%
Q9LIA0	Arabidopsis thaliana	26%	100%
Q9LRR0	Arabidopsis thaliana	28%	99%
Q9LUD9	Arabidopsis thaliana	29%	100%
Q9LUE1	Arabidopsis thaliana	29%	100%
Q9SLG2	Arabidopsis thaliana	27%	97%
Q9TLS1	Cyanidium caldarium	33%	100%
Q9UWR6	Aeropyrum pernix	30%	100%
Q9ZU77	Arabidopsis thaliana	28%	100%
V5DL68	Trypanosoma cruzi	63%	99%