Putative succinate dehydrogenase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinate dehydrogenase - putative

Species:

Leishmania infantum

UniProt:

A4HWJ7_LEIIN

TriTrypDb:

LINF_150018000

Length:

197

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, succinate dehydrogenase (SDH2C)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HWJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051540	metal cluster binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.497
CLV_C14_Caspase3-7	66	70	PF00656	0.498
CLV_NRD_NRD_1	50	52	PF00675	0.563
CLV_PCSK_KEX2_1	163	165	PF00082	0.348
CLV_PCSK_KEX2_1	171	173	PF00082	0.412
CLV_PCSK_KEX2_1	190	192	PF00082	0.558
CLV_PCSK_KEX2_1	50	52	PF00082	0.563
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.348
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.412
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.558
CLV_PCSK_SKI1_1	160	164	PF00082	0.341
DEG_APCC_DBOX_1	72	80	PF00400	0.324
DOC_MAPK_MEF2A_6	171	179	PF00069	0.554
DOC_PP4_FxxP_1	102	105	PF00568	0.242
DOC_PP4_FxxP_1	152	155	PF00568	0.327
DOC_USP7_MATH_1	181	185	PF00917	0.547
DOC_USP7_UBL2_3	186	190	PF12436	0.593
DOC_USP7_UBL2_3	38	42	PF12436	0.487
DOC_WW_Pin1_4	12	17	PF00397	0.396
DOC_WW_Pin1_4	164	169	PF00397	0.372
DOC_WW_Pin1_4	28	33	PF00397	0.446
LIG_14-3-3_CanoR_1	164	168	PF00244	0.440
LIG_eIF4E_1	18	24	PF01652	0.509
LIG_FHA_1	130	136	PF00498	0.367
LIG_FHA_1	29	35	PF00498	0.507
LIG_FHA_2	34	40	PF00498	0.475
LIG_LIR_Apic_2	100	105	PF02991	0.242
LIG_LIR_Gen_1	77	86	PF02991	0.246
LIG_LIR_Nem_3	111	115	PF02991	0.263
LIG_LIR_Nem_3	77	83	PF02991	0.318
LIG_PCNA_yPIPBox_3	50	63	PF02747	0.548
LIG_PTAP_UEV_1	1	6	PF05743	0.493
LIG_SH2_CRK	13	17	PF00017	0.417
LIG_SH2_STAP1	80	84	PF00017	0.248
LIG_SH2_STAT5	35	38	PF00017	0.513
LIG_SH2_STAT5	57	60	PF00017	0.427
LIG_SH2_STAT5	63	66	PF00017	0.417
MOD_CDK_SPxxK_3	164	171	PF00069	0.503
MOD_CK1_1	166	172	PF00069	0.407
MOD_CK2_1	181	187	PF00069	0.551
MOD_Cter_Amidation	188	191	PF01082	0.563
MOD_GlcNHglycan	168	171	PF01048	0.360
MOD_GlcNHglycan	183	186	PF01048	0.503
MOD_GlcNHglycan	2	5	PF01048	0.501
MOD_GSK3_1	24	31	PF00069	0.538
MOD_GSK3_1	84	91	PF00069	0.261
MOD_N-GLC_1	11	16	PF02516	0.547
MOD_N-GLC_1	143	148	PF02516	0.242
MOD_N-GLC_1	25	30	PF02516	0.393
MOD_N-GLC_1	55	60	PF02516	0.540
MOD_N-GLC_2	137	139	PF02516	0.255
MOD_NEK2_1	108	113	PF00069	0.263
MOD_NEK2_1	129	134	PF00069	0.338
MOD_NEK2_1	143	148	PF00069	0.188
MOD_NEK2_1	84	89	PF00069	0.248
MOD_OFUCOSY	82	88	PF10250	0.242
MOD_PKA_1	163	169	PF00069	0.445
MOD_PKA_2	163	169	PF00069	0.449
MOD_Plk_1	143	149	PF00069	0.242
MOD_Plk_1	55	61	PF00069	0.538
MOD_ProDKin_1	12	18	PF00069	0.393
MOD_ProDKin_1	164	170	PF00069	0.370
MOD_ProDKin_1	28	34	PF00069	0.445
MOD_SUMO_rev_2	159	165	PF00179	0.351
TRG_DiLeu_BaEn_1	131	136	PF01217	0.320
TRG_ENDOCYTIC_2	112	115	PF00928	0.255
TRG_ENDOCYTIC_2	20	23	PF00928	0.409
TRG_ENDOCYTIC_2	80	83	PF00928	0.242
TRG_ER_diArg_1	126	129	PF00400	0.367
TRG_ER_diArg_1	73	76	PF00400	0.335
TRG_NES_CRM1_1	117	131	PF08389	0.286
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAW5	Leptomonas seymouri	90%	100%
A0A0S4JJX0	Bodo saltans	72%	100%
A0A1X0NUF3	Trypanosomatidae	71%	100%
A0A3S5H6V4	Leishmania donovani	100%	100%
A0A422N147	Trypanosoma rangeli	72%	100%
A4H872	Leishmania braziliensis	92%	100%
A5PL98	Danio rerio	41%	70%
B0BM36	Xenopus tropicalis	40%	69%
C9ZXU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AQ98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P48932	Chondrus crispus	42%	79%
P80477	Porphyra purpurea	41%	82%
Q3B8J8	Xenopus laevis	40%	70%
Q4QF85	Leishmania major	98%	100%
Q55CC2	Dictyostelium discoideum	39%	69%
Q59662	Paracoccus denitrificans	39%	76%
Q70KF8	Uromyces fabae	40%	70%
Q9YHT2	Gallus gallus	39%	68%