LeishMANIAdb
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Sulfhydryl oxidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Sulfhydryl oxidase
Gene product:
FAD-linked sulfhydryl oxidase - putative
Species:
Leishmania infantum
UniProt:
A4HWJ4_LEIIN
TriTrypDb:
LINF_150017700
Length:
312

Annotations

Annotations by Jardim et al.

Oxidoreductase, Sulfhydryl oxidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HWJ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWJ4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0015035 protein-disulfide reductase activity 3 9
GO:0015036 disulfide oxidoreductase activity 4 9
GO:0016491 oxidoreductase activity 2 9
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 9
GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 4 9
GO:0016971 flavin-linked sulfhydryl oxidase activity 4 9
GO:0016972 thiol oxidase activity 5 9
GO:0140096 catalytic activity, acting on a protein 2 9
GO:0000166 nucleotide binding 3 1
GO:0005488 binding 1 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 1
GO:0043168 anion binding 3 1
GO:0050660 flavin adenine dinucleotide binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 288 292 PF00656 0.611
CLV_NRD_NRD_1 116 118 PF00675 0.501
CLV_NRD_NRD_1 199 201 PF00675 0.659
CLV_PCSK_FUR_1 296 300 PF00082 0.589
CLV_PCSK_KEX2_1 116 118 PF00082 0.498
CLV_PCSK_KEX2_1 295 297 PF00082 0.569
CLV_PCSK_KEX2_1 298 300 PF00082 0.582
CLV_PCSK_PC1ET2_1 295 297 PF00082 0.569
CLV_PCSK_PC1ET2_1 298 300 PF00082 0.582
CLV_PCSK_SKI1_1 104 108 PF00082 0.560
CLV_PCSK_SKI1_1 147 151 PF00082 0.674
CLV_PCSK_SKI1_1 201 205 PF00082 0.713
CLV_PCSK_SKI1_1 295 299 PF00082 0.605
DEG_MDM2_SWIB_1 53 60 PF02201 0.325
DEG_SCF_FBW7_1 274 279 PF00400 0.657
DEG_SPOP_SBC_1 215 219 PF00917 0.721
DOC_CKS1_1 273 278 PF01111 0.714
DOC_PP2B_LxvP_1 238 241 PF13499 0.561
DOC_PP4_FxxP_1 199 202 PF00568 0.657
DOC_PP4_FxxP_1 273 276 PF00568 0.708
DOC_USP7_MATH_1 149 153 PF00917 0.453
DOC_USP7_MATH_1 208 212 PF00917 0.703
DOC_USP7_MATH_1 215 219 PF00917 0.675
DOC_USP7_MATH_1 248 252 PF00917 0.741
DOC_USP7_MATH_1 258 262 PF00917 0.713
DOC_USP7_MATH_1 269 273 PF00917 0.788
DOC_USP7_MATH_1 276 280 PF00917 0.564
DOC_USP7_UBL2_3 143 147 PF12436 0.616
DOC_WW_Pin1_4 107 112 PF00397 0.339
DOC_WW_Pin1_4 16 21 PF00397 0.491
DOC_WW_Pin1_4 218 223 PF00397 0.683
DOC_WW_Pin1_4 272 277 PF00397 0.732
LIG_14-3-3_CanoR_1 259 263 PF00244 0.672
LIG_BIR_II_1 1 5 PF00653 0.614
LIG_CtBP_PxDLS_1 20 24 PF00389 0.533
LIG_FHA_1 241 247 PF00498 0.748
LIG_FHA_2 129 135 PF00498 0.529
LIG_FHA_2 143 149 PF00498 0.539
LIG_FHA_2 17 23 PF00498 0.470
LIG_FHA_2 178 184 PF00498 0.710
LIG_FHA_2 224 230 PF00498 0.634
LIG_FHA_2 286 292 PF00498 0.583
LIG_LIR_Apic_2 272 276 PF02991 0.640
LIG_LIR_Gen_1 26 36 PF02991 0.360
LIG_LIR_Gen_1 55 62 PF02991 0.327
LIG_LIR_Nem_3 195 199 PF02991 0.619
LIG_LIR_Nem_3 26 31 PF02991 0.360
LIG_LIR_Nem_3 55 60 PF02991 0.317
LIG_LIR_Nem_3 64 68 PF02991 0.333
LIG_PCNA_yPIPBox_3 41 54 PF02747 0.360
LIG_Pex14_1 118 122 PF04695 0.451
LIG_Pex14_1 57 61 PF04695 0.301
LIG_Pex14_2 53 57 PF04695 0.301
LIG_SH2_STAP1 61 65 PF00017 0.360
LIG_SH2_STAT5 303 306 PF00017 0.587
LIG_SH2_STAT5 73 76 PF00017 0.301
LIG_SH2_STAT5 90 93 PF00017 0.301
LIG_SH3_1 117 123 PF00018 0.373
LIG_SH3_2 120 125 PF14604 0.569
LIG_SH3_3 117 123 PF00018 0.373
LIG_SH3_3 299 305 PF00018 0.545
LIG_SH3_3 36 42 PF00018 0.301
LIG_SxIP_EBH_1 9 19 PF03271 0.575
LIG_TRAF2_1 131 134 PF00917 0.513
LIG_TRAF2_1 152 155 PF00917 0.450
MOD_CDK_SPxK_1 274 280 PF00069 0.715
MOD_CK1_1 218 224 PF00069 0.752
MOD_CK1_1 231 237 PF00069 0.659
MOD_CK1_1 261 267 PF00069 0.667
MOD_CK1_1 272 278 PF00069 0.753
MOD_CK2_1 128 134 PF00069 0.500
MOD_CK2_1 136 142 PF00069 0.512
MOD_CK2_1 149 155 PF00069 0.451
MOD_CK2_1 16 22 PF00069 0.520
MOD_CK2_1 177 183 PF00069 0.713
MOD_CK2_1 223 229 PF00069 0.725
MOD_CK2_1 262 268 PF00069 0.688
MOD_GlcNHglycan 162 165 PF01048 0.524
MOD_GlcNHglycan 234 237 PF01048 0.780
MOD_GlcNHglycan 25 28 PF01048 0.406
MOD_GlcNHglycan 33 36 PF01048 0.510
MOD_GlcNHglycan 42 45 PF01048 0.478
MOD_GSK3_1 179 186 PF00069 0.712
MOD_GSK3_1 214 221 PF00069 0.699
MOD_GSK3_1 228 235 PF00069 0.780
MOD_GSK3_1 258 265 PF00069 0.743
MOD_GSK3_1 272 279 PF00069 0.690
MOD_LATS_1 7 13 PF00433 0.582
MOD_NEK2_1 160 165 PF00069 0.487
MOD_NEK2_1 23 28 PF00069 0.503
MOD_NEK2_1 31 36 PF00069 0.360
MOD_NEK2_1 53 58 PF00069 0.325
MOD_NEK2_1 85 90 PF00069 0.385
MOD_PIKK_1 149 155 PF00454 0.451
MOD_PIKK_1 223 229 PF00454 0.804
MOD_PKA_2 158 164 PF00069 0.621
MOD_PKA_2 258 264 PF00069 0.671
MOD_PKA_2 8 14 PF00069 0.700
MOD_Plk_2-3 128 134 PF00069 0.510
MOD_Plk_2-3 285 291 PF00069 0.575
MOD_Plk_4 109 115 PF00069 0.342
MOD_Plk_4 269 275 PF00069 0.787
MOD_ProDKin_1 107 113 PF00069 0.339
MOD_ProDKin_1 16 22 PF00069 0.487
MOD_ProDKin_1 218 224 PF00069 0.682
MOD_ProDKin_1 272 278 PF00069 0.734
MOD_SUMO_rev_2 142 152 PF00179 0.660
TRG_ER_diArg_1 115 117 PF00400 0.301
TRG_NLS_MonoExtC_3 294 299 PF00514 0.458

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2T9 Leptomonas seymouri 54% 99%
A0A3Q8ICB2 Leishmania donovani 99% 100%
A4H869 Leishmania braziliensis 78% 100%
C9ZXU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AQ95 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QF88 Leishmania major 90% 100%
V5DL65 Trypanosoma cruzi 38% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS