LeishMANIAdb
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Serine/threonine-protein phosphatase 4 regulatory subunit 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Gene product:
protein phosphatase 2A regulatory subunit - putative
Species:
Leishmania infantum
UniProt:
A4HWJ0_LEIIN
TriTrypDb:
LINF_150017300
Length:
831

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000159 protein phosphatase type 2A complex 5 2
GO:0005737 cytoplasm 2 2
GO:0008287 protein serine/threonine phosphatase complex 4 2
GO:0032991 protein-containing complex 1 2
GO:0110165 cellular anatomical entity 1 2
GO:1902494 catalytic complex 2 2
GO:1903293 phosphatase complex 3 2
GO:0005815 microtubule organizing center 2 1
GO:0005929 cilium 4 1
GO:0036064 ciliary basal body 3 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0120025 plasma membrane bounded cell projection 3 1

Expansion

Sequence features

A4HWJ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWJ0

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 2
GO:0006793 phosphorus metabolic process 3 2
GO:0006796 phosphate-containing compound metabolic process 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0016311 dephosphorylation 5 2
GO:0019538 protein metabolic process 3 2
GO:0036211 protein modification process 4 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0071704 organic substance metabolic process 2 2
GO:1901564 organonitrogen compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0019208 phosphatase regulator activity 3 2
GO:0019888 protein phosphatase regulator activity 4 2
GO:0030234 enzyme regulator activity 2 2
GO:0098772 molecular function regulator activity 1 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 270 276 PF00089 0.339
CLV_NRD_NRD_1 103 105 PF00675 0.572
CLV_NRD_NRD_1 156 158 PF00675 0.390
CLV_NRD_NRD_1 168 170 PF00675 0.355
CLV_NRD_NRD_1 480 482 PF00675 0.455
CLV_NRD_NRD_1 567 569 PF00675 0.679
CLV_NRD_NRD_1 614 616 PF00675 0.525
CLV_NRD_NRD_1 745 747 PF00675 0.427
CLV_PCSK_KEX2_1 103 105 PF00082 0.570
CLV_PCSK_KEX2_1 156 158 PF00082 0.367
CLV_PCSK_KEX2_1 480 482 PF00082 0.455
CLV_PCSK_KEX2_1 567 569 PF00082 0.679
CLV_PCSK_KEX2_1 616 618 PF00082 0.439
CLV_PCSK_KEX2_1 745 747 PF00082 0.430
CLV_PCSK_PC1ET2_1 616 618 PF00082 0.492
CLV_PCSK_SKI1_1 243 247 PF00082 0.459
CLV_PCSK_SKI1_1 366 370 PF00082 0.356
CLV_PCSK_SKI1_1 387 391 PF00082 0.332
CLV_PCSK_SKI1_1 661 665 PF00082 0.434
CLV_PCSK_SKI1_1 684 688 PF00082 0.479
CLV_Separin_Metazoa 26 30 PF03568 0.525
CLV_Separin_Metazoa 496 500 PF03568 0.466
DEG_APCC_DBOX_1 341 349 PF00400 0.460
DEG_Nend_UBRbox_3 1 3 PF02207 0.776
DEG_SPOP_SBC_1 244 248 PF00917 0.354
DEG_SPOP_SBC_1 382 386 PF00917 0.383
DOC_CKS1_1 277 282 PF01111 0.243
DOC_CKS1_1 38 43 PF01111 0.589
DOC_CYCLIN_RxL_1 363 372 PF00134 0.374
DOC_CYCLIN_RxL_1 383 392 PF00134 0.196
DOC_CYCLIN_yCln2_LP_2 264 270 PF00134 0.409
DOC_MAPK_gen_1 639 647 PF00069 0.404
DOC_MAPK_MEF2A_6 115 124 PF00069 0.617
DOC_MAPK_MEF2A_6 764 772 PF00069 0.417
DOC_PP1_RVXF_1 271 277 PF00149 0.459
DOC_PP2B_LxvP_1 264 267 PF13499 0.379
DOC_USP7_MATH_1 102 106 PF00917 0.586
DOC_USP7_MATH_1 313 317 PF00917 0.399
DOC_USP7_MATH_1 51 55 PF00917 0.690
DOC_USP7_MATH_1 520 524 PF00917 0.430
DOC_USP7_MATH_1 543 547 PF00917 0.578
DOC_USP7_MATH_1 557 561 PF00917 0.612
DOC_USP7_MATH_1 571 575 PF00917 0.581
DOC_USP7_MATH_1 598 602 PF00917 0.603
DOC_USP7_MATH_1 734 738 PF00917 0.373
DOC_USP7_MATH_1 96 100 PF00917 0.727
DOC_USP7_UBL2_3 383 387 PF12436 0.456
DOC_WW_Pin1_4 110 115 PF00397 0.582
DOC_WW_Pin1_4 20 25 PF00397 0.628
DOC_WW_Pin1_4 276 281 PF00397 0.289
DOC_WW_Pin1_4 33 38 PF00397 0.652
DOC_WW_Pin1_4 4 9 PF00397 0.775
DOC_WW_Pin1_4 40 45 PF00397 0.601
DOC_WW_Pin1_4 583 588 PF00397 0.658
DOC_WW_Pin1_4 653 658 PF00397 0.442
DOC_WW_Pin1_4 737 742 PF00397 0.420
DOC_WW_Pin1_4 85 90 PF00397 0.664
LIG_14-3-3_CanoR_1 103 107 PF00244 0.534
LIG_14-3-3_CanoR_1 156 160 PF00244 0.399
LIG_14-3-3_CanoR_1 169 177 PF00244 0.324
LIG_14-3-3_CanoR_1 218 226 PF00244 0.516
LIG_14-3-3_CanoR_1 273 277 PF00244 0.433
LIG_14-3-3_CanoR_1 29 34 PF00244 0.577
LIG_14-3-3_CanoR_1 342 346 PF00244 0.473
LIG_14-3-3_CanoR_1 403 412 PF00244 0.377
LIG_14-3-3_CanoR_1 480 487 PF00244 0.444
LIG_14-3-3_CanoR_1 623 632 PF00244 0.478
LIG_14-3-3_CanoR_1 715 720 PF00244 0.512
LIG_Actin_WH2_2 671 689 PF00022 0.430
LIG_BIR_III_2 474 478 PF00653 0.408
LIG_BRCT_BRCA1_1 131 135 PF00533 0.438
LIG_EH1_1 224 232 PF00400 0.380
LIG_FHA_1 171 177 PF00498 0.371
LIG_FHA_1 218 224 PF00498 0.436
LIG_FHA_1 244 250 PF00498 0.508
LIG_FHA_1 269 275 PF00498 0.457
LIG_FHA_1 277 283 PF00498 0.435
LIG_FHA_1 30 36 PF00498 0.787
LIG_FHA_1 356 362 PF00498 0.461
LIG_FHA_1 625 631 PF00498 0.393
LIG_FHA_1 662 668 PF00498 0.406
LIG_FHA_1 701 707 PF00498 0.349
LIG_FHA_1 712 718 PF00498 0.358
LIG_FHA_1 751 757 PF00498 0.448
LIG_FHA_1 760 766 PF00498 0.417
LIG_FHA_2 114 120 PF00498 0.686
LIG_FHA_2 184 190 PF00498 0.421
LIG_FHA_2 342 348 PF00498 0.495
LIG_FHA_2 5 11 PF00498 0.740
LIG_FHA_2 683 689 PF00498 0.526
LIG_FHA_2 699 705 PF00498 0.315
LIG_FHA_2 784 790 PF00498 0.509
LIG_GBD_Chelix_1 241 249 PF00786 0.423
LIG_GBD_Chelix_1 283 291 PF00786 0.401
LIG_LIR_Apic_2 275 280 PF02991 0.332
LIG_LIR_Apic_2 46 51 PF02991 0.624
LIG_LIR_Gen_1 333 340 PF02991 0.429
LIG_LIR_Gen_1 364 374 PF02991 0.421
LIG_LIR_Nem_3 224 229 PF02991 0.376
LIG_LIR_Nem_3 263 268 PF02991 0.360
LIG_LIR_Nem_3 306 312 PF02991 0.434
LIG_LIR_Nem_3 333 337 PF02991 0.396
LIG_LIR_Nem_3 364 370 PF02991 0.422
LIG_LIR_Nem_3 658 663 PF02991 0.332
LIG_LIR_Nem_3 718 724 PF02991 0.425
LIG_LIR_Nem_3 781 785 PF02991 0.370
LIG_LYPXL_SIV_4 792 800 PF13949 0.463
LIG_PCNA_yPIPBox_3 169 181 PF02747 0.331
LIG_Pex14_1 402 406 PF04695 0.351
LIG_Pex14_1 779 783 PF04695 0.439
LIG_Pex3_1 177 188 PF04882 0.382
LIG_RPA_C_Fungi 164 176 PF08784 0.339
LIG_SH2_GRB2like 147 150 PF00017 0.344
LIG_SH2_NCK_1 406 410 PF00017 0.392
LIG_SH2_STAT5 225 228 PF00017 0.376
LIG_SH2_STAT5 290 293 PF00017 0.497
LIG_SH2_STAT5 367 370 PF00017 0.332
LIG_SH2_STAT5 388 391 PF00017 0.331
LIG_SH2_STAT5 406 409 PF00017 0.201
LIG_SH2_STAT5 760 763 PF00017 0.444
LIG_SH3_2 24 29 PF14604 0.520
LIG_SH3_3 21 27 PF00018 0.640
LIG_SH3_3 32 38 PF00018 0.702
LIG_SH3_3 41 47 PF00018 0.538
LIG_SH3_3 597 603 PF00018 0.465
LIG_SH3_3 651 657 PF00018 0.453
LIG_SH3_3 728 734 PF00018 0.420
LIG_SUMO_SIM_anti_2 423 431 PF11976 0.450
LIG_SUMO_SIM_anti_2 805 810 PF11976 0.425
LIG_SUMO_SIM_par_1 31 36 PF11976 0.614
LIG_TRAF2_1 152 155 PF00917 0.492
LIG_TRAF2_1 515 518 PF00917 0.379
LIG_TRFH_1 110 114 PF08558 0.613
LIG_TYR_ITIM 365 370 PF00017 0.327
LIG_WRC_WIRS_1 390 395 PF05994 0.324
LIG_WRC_WIRS_1 622 627 PF05994 0.400
LIG_WW_3 26 30 PF00397 0.525
MOD_CDK_SPK_2 110 115 PF00069 0.582
MOD_CDK_SPK_2 276 281 PF00069 0.274
MOD_CDK_SPK_2 737 742 PF00069 0.386
MOD_CK1_1 113 119 PF00069 0.638
MOD_CK1_1 16 22 PF00069 0.782
MOD_CK1_1 275 281 PF00069 0.329
MOD_CK1_1 3 9 PF00069 0.671
MOD_CK1_1 301 307 PF00069 0.402
MOD_CK1_1 317 323 PF00069 0.529
MOD_CK1_1 355 361 PF00069 0.447
MOD_CK1_1 36 42 PF00069 0.600
MOD_CK1_1 558 564 PF00069 0.740
MOD_CK1_1 624 630 PF00069 0.469
MOD_CK1_1 737 743 PF00069 0.361
MOD_CK1_1 816 822 PF00069 0.472
MOD_CK1_1 83 89 PF00069 0.657
MOD_CK1_1 92 98 PF00069 0.618
MOD_CK2_1 115 121 PF00069 0.696
MOD_CK2_1 149 155 PF00069 0.451
MOD_CK2_1 183 189 PF00069 0.406
MOD_CK2_1 20 26 PF00069 0.641
MOD_CK2_1 341 347 PF00069 0.392
MOD_CK2_1 4 10 PF00069 0.595
MOD_CK2_1 512 518 PF00069 0.421
MOD_CK2_1 682 688 PF00069 0.457
MOD_CK2_1 698 704 PF00069 0.311
MOD_CK2_1 737 743 PF00069 0.488
MOD_CK2_1 783 789 PF00069 0.423
MOD_CMANNOS 779 782 PF00535 0.444
MOD_GlcNHglycan 2 5 PF01048 0.636
MOD_GlcNHglycan 235 238 PF01048 0.423
MOD_GlcNHglycan 300 303 PF01048 0.412
MOD_GlcNHglycan 318 322 PF01048 0.445
MOD_GlcNHglycan 481 484 PF01048 0.443
MOD_GlcNHglycan 52 56 PF01048 0.739
MOD_GlcNHglycan 545 548 PF01048 0.562
MOD_GlcNHglycan 550 553 PF01048 0.610
MOD_GlcNHglycan 563 566 PF01048 0.617
MOD_GlcNHglycan 573 576 PF01048 0.610
MOD_GlcNHglycan 594 597 PF01048 0.725
MOD_GlcNHglycan 600 603 PF01048 0.719
MOD_GlcNHglycan 66 69 PF01048 0.715
MOD_GlcNHglycan 78 81 PF01048 0.694
MOD_GlcNHglycan 818 821 PF01048 0.559
MOD_GlcNHglycan 82 85 PF01048 0.699
MOD_GlcNHglycan 94 97 PF01048 0.590
MOD_GlcNHglycan 98 101 PF01048 0.587
MOD_GSK3_1 12 19 PF00069 0.735
MOD_GSK3_1 217 224 PF00069 0.437
MOD_GSK3_1 268 275 PF00069 0.310
MOD_GSK3_1 29 36 PF00069 0.606
MOD_GSK3_1 313 320 PF00069 0.407
MOD_GSK3_1 355 362 PF00069 0.359
MOD_GSK3_1 39 46 PF00069 0.560
MOD_GSK3_1 557 564 PF00069 0.658
MOD_GSK3_1 569 576 PF00069 0.556
MOD_GSK3_1 579 586 PF00069 0.621
MOD_GSK3_1 588 595 PF00069 0.626
MOD_GSK3_1 673 680 PF00069 0.416
MOD_GSK3_1 707 714 PF00069 0.495
MOD_GSK3_1 76 83 PF00069 0.606
MOD_GSK3_1 809 816 PF00069 0.343
MOD_GSK3_1 84 91 PF00069 0.622
MOD_GSK3_1 92 99 PF00069 0.587
MOD_N-GLC_1 221 226 PF02516 0.442
MOD_N-GLC_1 558 563 PF02516 0.745
MOD_N-GLC_1 71 76 PF02516 0.780
MOD_N-GLC_1 809 814 PF02516 0.408
MOD_N-GLC_1 89 94 PF02516 0.694
MOD_NEK2_1 268 273 PF00069 0.299
MOD_NEK2_1 298 303 PF00069 0.471
MOD_NEK2_1 352 357 PF00069 0.408
MOD_NEK2_1 361 366 PF00069 0.440
MOD_NEK2_1 389 394 PF00069 0.317
MOD_NEK2_1 58 63 PF00069 0.609
MOD_NEK2_1 632 637 PF00069 0.473
MOD_NEK2_1 749 754 PF00069 0.497
MOD_NEK2_1 809 814 PF00069 0.472
MOD_NEK2_2 674 679 PF00069 0.498
MOD_NEK2_2 682 687 PF00069 0.414
MOD_PIKK_1 170 176 PF00454 0.394
MOD_PIKK_1 469 475 PF00454 0.543
MOD_PIKK_1 677 683 PF00454 0.449
MOD_PKA_1 169 175 PF00069 0.272
MOD_PKA_2 102 108 PF00069 0.555
MOD_PKA_2 155 161 PF00069 0.442
MOD_PKA_2 217 223 PF00069 0.452
MOD_PKA_2 272 278 PF00069 0.452
MOD_PKA_2 341 347 PF00069 0.428
MOD_PKA_2 404 410 PF00069 0.331
MOD_PKA_2 479 485 PF00069 0.390
MOD_PKA_2 561 567 PF00069 0.612
MOD_PKA_2 579 585 PF00069 0.704
MOD_Plk_1 120 126 PF00069 0.569
MOD_Plk_1 128 134 PF00069 0.616
MOD_Plk_1 16 22 PF00069 0.647
MOD_Plk_1 221 227 PF00069 0.355
MOD_Plk_1 317 323 PF00069 0.453
MOD_Plk_1 71 77 PF00069 0.623
MOD_Plk_4 221 227 PF00069 0.389
MOD_Plk_4 272 278 PF00069 0.382
MOD_Plk_4 29 35 PF00069 0.539
MOD_Plk_4 389 395 PF00069 0.315
MOD_Plk_4 715 721 PF00069 0.483
MOD_Plk_4 778 784 PF00069 0.423
MOD_ProDKin_1 110 116 PF00069 0.583
MOD_ProDKin_1 20 26 PF00069 0.629
MOD_ProDKin_1 276 282 PF00069 0.285
MOD_ProDKin_1 33 39 PF00069 0.649
MOD_ProDKin_1 4 10 PF00069 0.774
MOD_ProDKin_1 40 46 PF00069 0.602
MOD_ProDKin_1 583 589 PF00069 0.649
MOD_ProDKin_1 653 659 PF00069 0.441
MOD_ProDKin_1 737 743 PF00069 0.418
MOD_ProDKin_1 85 91 PF00069 0.665
TRG_DiLeu_BaEn_1 257 262 PF01217 0.324
TRG_DiLeu_BaEn_3 154 160 PF01217 0.480
TRG_DiLeu_BaEn_4 371 377 PF01217 0.422
TRG_DiLeu_BaLyEn_6 348 353 PF01217 0.438
TRG_DiLeu_BaLyEn_6 752 757 PF01217 0.453
TRG_ENDOCYTIC_2 147 150 PF00928 0.393
TRG_ENDOCYTIC_2 290 293 PF00928 0.340
TRG_ENDOCYTIC_2 367 370 PF00928 0.314
TRG_ENDOCYTIC_2 487 490 PF00928 0.399
TRG_ENDOCYTIC_2 780 783 PF00928 0.377
TRG_ER_diArg_1 102 104 PF00400 0.590
TRG_ER_diArg_1 402 405 PF00400 0.326
TRG_ER_diArg_1 479 481 PF00400 0.451
TRG_ER_diArg_1 638 641 PF00400 0.389
TRG_ER_diArg_1 744 746 PF00400 0.430
TRG_NES_CRM1_1 250 263 PF08389 0.407
TRG_NES_CRM1_1 359 372 PF08389 0.437
TRG_Pf-PMV_PEXEL_1 366 371 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 506 510 PF00026 0.524
TRG_Pf-PMV_PEXEL_1 684 688 PF00026 0.496

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA72 Leptomonas seymouri 66% 84%
A0A3Q8IDF8 Leishmania donovani 100% 100%
A0A3R7N5C8 Trypanosoma rangeli 37% 100%
A4H865 Leishmania braziliensis 83% 100%
C9ZXV3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AQ91 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q38845 Arabidopsis thaliana 22% 100%
Q4QCX5 Leishmania major 24% 100%
Q4QF92 Leishmania major 96% 100%
Q9UT08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 100%
V5DL61 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS