Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4HWI8_LEIIN

TriTrypDb:

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	446	450	PF00656	0.337
CLV_NRD_NRD_1	188	190	PF00675	0.373
CLV_NRD_NRD_1	196	198	PF00675	0.464
CLV_NRD_NRD_1	342	344	PF00675	0.387
CLV_NRD_NRD_1	414	416	PF00675	0.422
CLV_NRD_NRD_1	451	453	PF00675	0.369
CLV_NRD_NRD_1	572	574	PF00675	0.408
CLV_PCSK_FUR_1	412	416	PF00082	0.436
CLV_PCSK_KEX2_1	161	163	PF00082	0.579
CLV_PCSK_KEX2_1	195	197	PF00082	0.484
CLV_PCSK_KEX2_1	341	343	PF00082	0.390
CLV_PCSK_KEX2_1	412	414	PF00082	0.428
CLV_PCSK_KEX2_1	572	574	PF00082	0.468
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.437
CLV_PCSK_SKI1_1	197	201	PF00082	0.375
CLV_PCSK_SKI1_1	215	219	PF00082	0.283
CLV_PCSK_SKI1_1	23	27	PF00082	0.421
CLV_PCSK_SKI1_1	302	306	PF00082	0.449
CLV_PCSK_SKI1_1	434	438	PF00082	0.382
DEG_APCC_DBOX_1	340	348	PF00400	0.431
DEG_ODPH_VHL_1	220	231	PF01847	0.439
DEG_SCF_FBW7_1	363	370	PF00400	0.368
DEG_SCF_FBW7_1	505	510	PF00400	0.457
DEG_SCF_FBW7_1	76	82	PF00400	0.449
DEG_SPOP_SBC_1	252	256	PF00917	0.690
DEG_SPOP_SBC_1	93	97	PF00917	0.541
DOC_CDC14_PxL_1	218	226	PF14671	0.435
DOC_CDC14_PxL_1	77	85	PF14671	0.450
DOC_CKS1_1	29	34	PF01111	0.414
DOC_CKS1_1	76	81	PF01111	0.456
DOC_CYCLIN_RxL_1	299	308	PF00134	0.483
DOC_CYCLIN_RxL_1	313	324	PF00134	0.329
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.358
DOC_MAPK_FxFP_2	496	499	PF00069	0.411
DOC_MAPK_gen_1	452	460	PF00069	0.349
DOC_PP1_RVXF_1	124	130	PF00149	0.443
DOC_PP1_RVXF_1	290	296	PF00149	0.417
DOC_PP1_RVXF_1	383	389	PF00149	0.299
DOC_PP1_RVXF_1	565	572	PF00149	0.386
DOC_PP2B_LxvP_1	224	227	PF13499	0.499
DOC_PP2B_LxvP_1	25	28	PF13499	0.421
DOC_PP2B_LxvP_1	553	556	PF13499	0.366
DOC_PP4_FxxP_1	496	499	PF00568	0.411
DOC_USP7_MATH_1	251	255	PF00917	0.689
DOC_USP7_MATH_1	350	354	PF00917	0.473
DOC_USP7_MATH_1	361	365	PF00917	0.543
DOC_USP7_MATH_1	492	496	PF00917	0.390
DOC_USP7_MATH_1	535	539	PF00917	0.536
DOC_USP7_MATH_1	589	593	PF00917	0.606
DOC_USP7_MATH_1	68	72	PF00917	0.473
DOC_USP7_MATH_1	79	83	PF00917	0.652
DOC_USP7_MATH_1	92	96	PF00917	0.601
DOC_USP7_MATH_2	441	447	PF00917	0.365
DOC_WW_Pin1_4	231	236	PF00397	0.757
DOC_WW_Pin1_4	239	244	PF00397	0.691
DOC_WW_Pin1_4	28	33	PF00397	0.456
DOC_WW_Pin1_4	285	290	PF00397	0.423
DOC_WW_Pin1_4	359	364	PF00397	0.489
DOC_WW_Pin1_4	372	377	PF00397	0.501
DOC_WW_Pin1_4	39	44	PF00397	0.459
DOC_WW_Pin1_4	487	492	PF00397	0.384
DOC_WW_Pin1_4	503	508	PF00397	0.438
DOC_WW_Pin1_4	75	80	PF00397	0.456
LIG_14-3-3_CanoR_1	114	122	PF00244	0.376
LIG_14-3-3_CanoR_1	181	185	PF00244	0.430
LIG_14-3-3_CanoR_1	201	209	PF00244	0.373
LIG_14-3-3_CanoR_1	23	28	PF00244	0.421
LIG_14-3-3_CanoR_1	292	301	PF00244	0.409
LIG_14-3-3_CanoR_1	316	321	PF00244	0.339
LIG_14-3-3_CanoR_1	474	480	PF00244	0.357
LIG_14-3-3_CanoR_1	69	73	PF00244	0.552
LIG_14-3-3_CanoR_1	84	92	PF00244	0.438
LIG_APCC_ABBA_1	318	323	PF00400	0.425
LIG_APCC_ABBA_1	461	466	PF00400	0.396
LIG_APCC_ABBAyCdc20_2	302	308	PF00400	0.348
LIG_BRCT_BRCA1_1	46	50	PF00533	0.333
LIG_CtBP_PxDLS_1	43	47	PF00389	0.345
LIG_EVH1_1	224	228	PF00568	0.512
LIG_FHA_1	129	135	PF00498	0.368
LIG_FHA_1	24	30	PF00498	0.419
LIG_FHA_1	327	333	PF00498	0.440
LIG_FHA_1	415	421	PF00498	0.462
LIG_FHA_1	442	448	PF00498	0.404
LIG_FHA_2	201	207	PF00498	0.384
LIG_FHA_2	305	311	PF00498	0.352
LIG_FXI_DFP_1	306	310	PF00024	0.476
LIG_GBD_Chelix_1	336	344	PF00786	0.392
LIG_Integrin_isoDGR_2	383	385	PF01839	0.300
LIG_LIR_Apic_2	495	499	PF02991	0.407
LIG_LIR_Gen_1	155	163	PF02991	0.437
LIG_LIR_Gen_1	275	286	PF02991	0.483
LIG_LIR_Gen_1	307	317	PF02991	0.400
LIG_LIR_Gen_1	435	441	PF02991	0.398
LIG_LIR_Nem_3	155	160	PF02991	0.422
LIG_LIR_Nem_3	275	281	PF02991	0.480
LIG_LIR_Nem_3	296	301	PF02991	0.337
LIG_LIR_Nem_3	435	439	PF02991	0.393
LIG_LIR_Nem_3	47	53	PF02991	0.355
LIG_LIR_Nem_3	495	501	PF02991	0.411
LIG_LIR_Nem_3	510	515	PF02991	0.448
LIG_LYPXL_yS_3	498	501	PF13949	0.467
LIG_MLH1_MIPbox_1	46	50	PF16413	0.333
LIG_MYND_1	222	226	PF01753	0.481
LIG_MYND_1	577	581	PF01753	0.656
LIG_PAM2_1	42	54	PF00658	0.341
LIG_PCNA_PIPBox_1	470	479	PF02747	0.371
LIG_PDZ_Class_3	599	604	PF00595	0.492
LIG_Pex14_1	129	133	PF04695	0.347
LIG_Pex14_2	432	436	PF04695	0.372
LIG_Pex14_2	496	500	PF04695	0.432
LIG_PTAP_UEV_1	72	77	PF05743	0.438
LIG_SH2_CRK	278	282	PF00017	0.466
LIG_SH2_NCK_1	356	360	PF00017	0.310
LIG_SH2_SRC	133	136	PF00017	0.341
LIG_SH2_SRC	223	226	PF00017	0.455
LIG_SH2_SRC	552	555	PF00017	0.375
LIG_SH2_STAP1	328	332	PF00017	0.418
LIG_SH2_STAP1	541	545	PF00017	0.465
LIG_SH2_STAT3	267	270	PF00017	0.594
LIG_SH2_STAT5	133	136	PF00017	0.341
LIG_SH2_STAT5	176	179	PF00017	0.342
LIG_SH2_STAT5	223	226	PF00017	0.548
LIG_SH2_STAT5	321	324	PF00017	0.475
LIG_SH2_STAT5	328	331	PF00017	0.451
LIG_SH2_STAT5	339	342	PF00017	0.329
LIG_SH2_STAT5	545	548	PF00017	0.423
LIG_SH2_STAT5	552	555	PF00017	0.393
LIG_SH3_2	18	23	PF14604	0.402
LIG_SH3_3	15	21	PF00018	0.396
LIG_SH3_3	219	225	PF00018	0.512
LIG_SH3_3	238	244	PF00018	0.709
LIG_SH3_3	283	289	PF00018	0.447
LIG_SH3_3	400	406	PF00018	0.368
LIG_SH3_3	571	577	PF00018	0.478
LIG_SH3_3	70	76	PF00018	0.564
LIG_SUMO_SIM_par_1	227	234	PF11976	0.532
LIG_SUMO_SIM_par_1	42	47	PF11976	0.436
LIG_SUMO_SIM_par_1	443	449	PF11976	0.459
LIG_SxIP_EBH_1	73	86	PF03271	0.456
LIG_TRAF2_1	259	262	PF00917	0.544
LIG_TRAF2_1	274	277	PF00917	0.504
LIG_TRFH_1	218	222	PF08558	0.446
LIG_WRC_WIRS_1	368	373	PF05994	0.534
LIG_WRC_WIRS_1	493	498	PF05994	0.396
LIG_WRC_WIRS_1	500	505	PF05994	0.447
MOD_CDK_SPxxK_3	231	238	PF00069	0.507
MOD_CDK_SPxxK_3	285	292	PF00069	0.418
MOD_CK1_1	13	19	PF00069	0.401
MOD_CK1_1	174	180	PF00069	0.451
MOD_CK1_1	234	240	PF00069	0.636
MOD_CK1_1	254	260	PF00069	0.735
MOD_CK1_1	372	378	PF00069	0.400
MOD_CK1_1	42	48	PF00069	0.349
MOD_CK1_1	593	599	PF00069	0.564
MOD_CK1_1	71	77	PF00069	0.615
MOD_CK1_1	87	93	PF00069	0.433
MOD_CK2_1	256	262	PF00069	0.737
MOD_CK2_1	475	481	PF00069	0.340
MOD_CK2_1	589	595	PF00069	0.676
MOD_CK2_1	596	602	PF00069	0.697
MOD_GlcNHglycan	136	139	PF01048	0.461
MOD_GlcNHglycan	247	250	PF01048	0.761
MOD_GlcNHglycan	256	259	PF01048	0.648
MOD_GlcNHglycan	3	6	PF01048	0.415
MOD_GlcNHglycan	372	375	PF01048	0.411
MOD_GlcNHglycan	392	395	PF01048	0.395
MOD_GlcNHglycan	46	49	PF01048	0.340
MOD_GlcNHglycan	547	552	PF01048	0.366
MOD_GlcNHglycan	582	585	PF01048	0.589
MOD_GlcNHglycan	70	73	PF01048	0.478
MOD_GSK3_1	229	236	PF00069	0.592
MOD_GSK3_1	252	259	PF00069	0.682
MOD_GSK3_1	304	311	PF00069	0.430
MOD_GSK3_1	359	366	PF00069	0.375
MOD_GSK3_1	499	506	PF00069	0.461
MOD_GSK3_1	585	592	PF00069	0.678
MOD_GSK3_1	71	78	PF00069	0.476
MOD_N-GLC_1	390	395	PF02516	0.327
MOD_N-GLC_2	180	182	PF02516	0.428
MOD_N-GLC_2	557	559	PF02516	0.354
MOD_NEK2_1	245	250	PF00069	0.691
MOD_NEK2_1	390	395	PF00069	0.405
MOD_NEK2_1	432	437	PF00069	0.538
MOD_NEK2_1	44	49	PF00069	0.342
MOD_NEK2_2	475	480	PF00069	0.368
MOD_PIKK_1	272	278	PF00454	0.457
MOD_PIKK_1	535	541	PF00454	0.518
MOD_PKA_1	414	420	PF00069	0.530
MOD_PKA_2	113	119	PF00069	0.401
MOD_PKA_2	180	186	PF00069	0.427
MOD_PKA_2	200	206	PF00069	0.422
MOD_PKA_2	293	299	PF00069	0.369
MOD_PKA_2	414	420	PF00069	0.530
MOD_PKA_2	68	74	PF00069	0.530
MOD_PKB_1	195	203	PF00069	0.433
MOD_PKB_1	292	300	PF00069	0.334
MOD_PKB_1	412	420	PF00069	0.528
MOD_Plk_1	174	180	PF00069	0.340
MOD_Plk_1	350	356	PF00069	0.431
MOD_Plk_1	547	553	PF00069	0.359
MOD_Plk_2-3	443	449	PF00069	0.343
MOD_Plk_4	174	180	PF00069	0.340
MOD_Plk_4	3	9	PF00069	0.393
MOD_Plk_4	316	322	PF00069	0.339
MOD_Plk_4	350	356	PF00069	0.529
MOD_Plk_4	508	514	PF00069	0.469
MOD_ProDKin_1	231	237	PF00069	0.757
MOD_ProDKin_1	239	245	PF00069	0.690
MOD_ProDKin_1	28	34	PF00069	0.456
MOD_ProDKin_1	285	291	PF00069	0.419
MOD_ProDKin_1	359	365	PF00069	0.491
MOD_ProDKin_1	372	378	PF00069	0.486
MOD_ProDKin_1	39	45	PF00069	0.452
MOD_ProDKin_1	487	493	PF00069	0.380
MOD_ProDKin_1	503	509	PF00069	0.437
MOD_ProDKin_1	75	81	PF00069	0.448
MOD_SUMO_for_1	579	582	PF00179	0.397
TRG_ENDOCYTIC_2	157	160	PF00928	0.386
TRG_ENDOCYTIC_2	266	269	PF00928	0.553
TRG_ENDOCYTIC_2	278	281	PF00928	0.384
TRG_ENDOCYTIC_2	476	479	PF00928	0.453
TRG_ENDOCYTIC_2	498	501	PF00928	0.467
TRG_ER_diArg_1	195	197	PF00400	0.489
TRG_ER_diArg_1	238	241	PF00400	0.542
TRG_ER_diArg_1	292	295	PF00400	0.346
TRG_ER_diArg_1	340	343	PF00400	0.328
TRG_ER_diArg_1	412	415	PF00400	0.476
TRG_ER_diArg_1	571	573	PF00400	0.444
TRG_ER_diArg_1	83	86	PF00400	0.454
TRG_NES_CRM1_1	310	324	PF08389	0.377
TRG_NLS_MonoExtC_3	451	456	PF00514	0.363
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J4	Leptomonas seymouri	71%	100%
A0A1X0NTX1	Trypanosomatidae	48%	100%
A0A3Q8IA36	Leishmania donovani	99%	100%
A4H863	Leishmania braziliensis	86%	98%
C9ZXV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AQ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QF94	Leishmania major	96%	100%
V5AMI4	Trypanosoma cruzi	50%	100%