Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWI4_LEIIN

TriTrypDb:

LINF_150016700

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.560
CLV_C14_Caspase3-7	292	296	PF00656	0.640
CLV_NRD_NRD_1	319	321	PF00675	0.702
CLV_NRD_NRD_1	66	68	PF00675	0.568
CLV_PCSK_KEX2_1	66	68	PF00082	0.568
CLV_PCSK_SKI1_1	54	58	PF00082	0.514
CLV_Separin_Metazoa	51	55	PF03568	0.400
DEG_SPOP_SBC_1	221	225	PF00917	0.690
DEG_SPOP_SBC_1	60	64	PF00917	0.580
DOC_ANK_TNKS_1	66	73	PF00023	0.632
DOC_MAPK_MEF2A_6	29	38	PF00069	0.500
DOC_USP7_MATH_1	104	108	PF00917	0.471
DOC_USP7_MATH_1	192	196	PF00917	0.616
DOC_USP7_MATH_1	221	225	PF00917	0.611
DOC_USP7_MATH_1	230	234	PF00917	0.574
DOC_USP7_MATH_1	271	275	PF00917	0.625
DOC_USP7_MATH_1	60	64	PF00917	0.628
DOC_USP7_MATH_1	65	69	PF00917	0.654
DOC_USP7_MATH_2	208	214	PF00917	0.572
DOC_USP7_UBL2_3	198	202	PF12436	0.590
DOC_USP7_UBL2_3	232	236	PF12436	0.625
DOC_USP7_UBL2_3	250	254	PF12436	0.621
DOC_WW_Pin1_4	204	209	PF00397	0.666
DOC_WW_Pin1_4	272	277	PF00397	0.756
DOC_WW_Pin1_4	5	10	PF00397	0.724
DOC_WW_Pin1_4	87	92	PF00397	0.494
LIG_14-3-3_CanoR_1	112	119	PF00244	0.675
LIG_14-3-3_CanoR_1	29	38	PF00244	0.597
LIG_Actin_WH2_2	186	204	PF00022	0.477
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_BIR_III_1	1	5	PF00653	0.625
LIG_BIR_III_3	1	5	PF00653	0.625
LIG_FHA_1	147	153	PF00498	0.551
LIG_FHA_1	165	171	PF00498	0.580
LIG_FHA_1	30	36	PF00498	0.498
LIG_FHA_1	47	53	PF00498	0.393
LIG_LIR_Gen_1	213	222	PF02991	0.621
LIG_LIR_Gen_1	24	35	PF02991	0.502
LIG_LIR_Gen_1	299	310	PF02991	0.671
LIG_LIR_Gen_1	93	102	PF02991	0.405
LIG_LIR_Nem_3	213	218	PF02991	0.621
LIG_LIR_Nem_3	24	30	PF02991	0.506
LIG_LIR_Nem_3	93	98	PF02991	0.389
LIG_NRP_CendR_1	320	323	PF00754	0.632
LIG_PTAP_UEV_1	3	8	PF05743	0.592
LIG_SH2_PTP2	27	30	PF00017	0.489
LIG_SH2_STAT5	27	30	PF00017	0.489
LIG_SH3_1	241	247	PF00018	0.521
LIG_SH3_3	1	7	PF00018	0.749
LIG_SH3_3	239	245	PF00018	0.699
LIG_SH3_3	265	271	PF00018	0.687
LIG_SH3_3	273	279	PF00018	0.659
LIG_SH3_3	74	80	PF00018	0.645
LIG_SUMO_SIM_anti_2	144	159	PF11976	0.554
LIG_SUMO_SIM_anti_2	314	320	PF11976	0.530
LIG_TRAF2_1	18	21	PF00917	0.625
LIG_TRAF2_1	22	25	PF00917	0.514
LIG_TRAF2_1	260	263	PF00917	0.714
LIG_WW_2	278	281	PF00397	0.647
LIG_WW_3	245	249	PF00397	0.659
MOD_CK1_1	107	113	PF00069	0.646
MOD_CK1_1	127	133	PF00069	0.710
MOD_CK1_1	134	140	PF00069	0.687
MOD_CK1_1	197	203	PF00069	0.693
MOD_CK1_1	213	219	PF00069	0.629
MOD_CK1_1	224	230	PF00069	0.625
MOD_CK1_1	272	278	PF00069	0.690
MOD_CK2_1	134	140	PF00069	0.687
MOD_CK2_1	153	159	PF00069	0.776
MOD_CK2_1	19	25	PF00069	0.561
MOD_CK2_1	204	210	PF00069	0.580
MOD_CK2_1	257	263	PF00069	0.709
MOD_CK2_1	87	93	PF00069	0.628
MOD_GlcNHglycan	104	107	PF01048	0.591
MOD_GlcNHglycan	126	129	PF01048	0.662
MOD_GlcNHglycan	133	136	PF01048	0.711
MOD_GlcNHglycan	176	179	PF01048	0.640
MOD_GlcNHglycan	212	215	PF01048	0.723
MOD_GlcNHglycan	224	227	PF01048	0.570
MOD_GlcNHglycan	232	235	PF01048	0.522
MOD_GlcNHglycan	271	274	PF01048	0.764
MOD_GSK3_1	104	111	PF00069	0.632
MOD_GSK3_1	120	127	PF00069	0.768
MOD_GSK3_1	129	136	PF00069	0.634
MOD_GSK3_1	164	171	PF00069	0.702
MOD_GSK3_1	220	227	PF00069	0.636
MOD_GSK3_1	61	68	PF00069	0.659
MOD_N-GLC_1	257	262	PF02516	0.716
MOD_NEK2_1	102	107	PF00069	0.546
MOD_NEK2_1	61	66	PF00069	0.543
MOD_PIKK_1	29	35	PF00454	0.498
MOD_PKA_2	111	117	PF00069	0.719
MOD_PKA_2	65	71	PF00069	0.609
MOD_Plk_1	168	174	PF00069	0.673
MOD_Plk_1	257	263	PF00069	0.715
MOD_Plk_2-3	146	152	PF00069	0.649
MOD_Plk_2-3	153	159	PF00069	0.613
MOD_Plk_2-3	161	167	PF00069	0.541
MOD_Plk_4	168	174	PF00069	0.673
MOD_ProDKin_1	204	210	PF00069	0.670
MOD_ProDKin_1	272	278	PF00069	0.752
MOD_ProDKin_1	5	11	PF00069	0.724
MOD_ProDKin_1	87	93	PF00069	0.492
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.604
TRG_ENDOCYTIC_2	27	30	PF00928	0.489
TRG_ER_diArg_1	240	243	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTH2	Leishmania donovani	99%	100%
A4H858	Leishmania braziliensis	57%	96%
E9AQ85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	96%
Q4QF98	Leishmania major	87%	100%