Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWI3_LEIIN

TriTrypDb:

LINF_150016600

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.703
CLV_NRD_NRD_1	161	163	PF00675	0.493
CLV_NRD_NRD_1	226	228	PF00675	0.510
CLV_NRD_NRD_1	24	26	PF00675	0.558
CLV_NRD_NRD_1	398	400	PF00675	0.612
CLV_NRD_NRD_1	451	453	PF00675	0.608
CLV_NRD_NRD_1	46	48	PF00675	0.618
CLV_NRD_NRD_1	475	477	PF00675	0.586
CLV_NRD_NRD_1	52	54	PF00675	0.575
CLV_NRD_NRD_1	595	597	PF00675	0.458
CLV_NRD_NRD_1	603	605	PF00675	0.346
CLV_NRD_NRD_1	648	650	PF00675	0.527
CLV_NRD_NRD_1	654	656	PF00675	0.500
CLV_NRD_NRD_1	657	659	PF00675	0.486
CLV_NRD_NRD_1	716	718	PF00675	0.541
CLV_NRD_NRD_1	958	960	PF00675	0.628
CLV_PCSK_FUR_1	655	659	PF00082	0.585
CLV_PCSK_KEX2_1	161	163	PF00082	0.493
CLV_PCSK_KEX2_1	226	228	PF00082	0.489
CLV_PCSK_KEX2_1	272	274	PF00082	0.514
CLV_PCSK_KEX2_1	41	43	PF00082	0.619
CLV_PCSK_KEX2_1	46	48	PF00082	0.639
CLV_PCSK_KEX2_1	51	53	PF00082	0.522
CLV_PCSK_KEX2_1	595	597	PF00082	0.458
CLV_PCSK_KEX2_1	603	605	PF00082	0.346
CLV_PCSK_KEX2_1	648	650	PF00082	0.509
CLV_PCSK_KEX2_1	654	656	PF00082	0.505
CLV_PCSK_KEX2_1	657	659	PF00082	0.505
CLV_PCSK_KEX2_1	716	718	PF00082	0.498
CLV_PCSK_KEX2_1	958	960	PF00082	0.628
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.459
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.621
CLV_PCSK_PC7_1	268	274	PF00082	0.529
CLV_PCSK_PC7_1	42	48	PF00082	0.643
CLV_PCSK_SKI1_1	164	168	PF00082	0.485
CLV_PCSK_SKI1_1	227	231	PF00082	0.612
CLV_PCSK_SKI1_1	31	35	PF00082	0.594
CLV_PCSK_SKI1_1	46	50	PF00082	0.557
CLV_PCSK_SKI1_1	632	636	PF00082	0.367
CLV_PCSK_SKI1_1	687	691	PF00082	0.489
CLV_PCSK_SKI1_1	699	703	PF00082	0.496
CLV_PCSK_SKI1_1	716	720	PF00082	0.562
CLV_PCSK_SKI1_1	834	838	PF00082	0.508
CLV_PCSK_SKI1_1	959	963	PF00082	0.568
DEG_APCC_DBOX_1	163	171	PF00400	0.687
DEG_SPOP_SBC_1	463	467	PF00917	0.775
DOC_ANK_TNKS_1	647	654	PF00023	0.624
DOC_CYCLIN_RxL_1	632	641	PF00134	0.403
DOC_CYCLIN_RxL_1	696	706	PF00134	0.715
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.636
DOC_MAPK_gen_1	603	610	PF00069	0.619
DOC_MAPK_MEF2A_6	603	612	PF00069	0.546
DOC_PP1_RVXF_1	266	272	PF00149	0.746
DOC_PP1_RVXF_1	7	13	PF00149	0.724
DOC_PP2B_LxvP_1	307	310	PF13499	0.645
DOC_PP2B_LxvP_1	907	910	PF13499	0.656
DOC_PP2B_PxIxI_1	824	830	PF00149	0.641
DOC_USP7_MATH_1	119	123	PF00917	0.790
DOC_USP7_MATH_1	133	137	PF00917	0.705
DOC_USP7_MATH_1	247	251	PF00917	0.705
DOC_USP7_MATH_1	343	347	PF00917	0.662
DOC_USP7_MATH_1	447	451	PF00917	0.702
DOC_USP7_MATH_1	507	511	PF00917	0.686
DOC_USP7_MATH_1	57	61	PF00917	0.828
DOC_USP7_MATH_1	581	585	PF00917	0.730
DOC_USP7_MATH_1	707	711	PF00917	0.715
DOC_USP7_MATH_1	77	81	PF00917	0.619
DOC_USP7_MATH_1	855	859	PF00917	0.759
DOC_USP7_MATH_1	910	914	PF00917	0.797
DOC_USP7_MATH_1	927	931	PF00917	0.652
DOC_USP7_UBL2_3	31	35	PF12436	0.822
DOC_USP7_UBL2_3	37	41	PF12436	0.798
DOC_WW_Pin1_4	135	140	PF00397	0.763
DOC_WW_Pin1_4	171	176	PF00397	0.718
DOC_WW_Pin1_4	330	335	PF00397	0.717
DOC_WW_Pin1_4	429	434	PF00397	0.768
DOC_WW_Pin1_4	510	515	PF00397	0.715
DOC_WW_Pin1_4	53	58	PF00397	0.789
DOC_WW_Pin1_4	791	796	PF00397	0.684
DOC_WW_Pin1_4	858	863	PF00397	0.710
DOC_WW_Pin1_4	951	956	PF00397	0.706
LIG_14-3-3_CanoR_1	118	128	PF00244	0.732
LIG_14-3-3_CanoR_1	161	167	PF00244	0.664
LIG_14-3-3_CanoR_1	25	33	PF00244	0.724
LIG_14-3-3_CanoR_1	282	286	PF00244	0.741
LIG_14-3-3_CanoR_1	3	10	PF00244	0.778
LIG_14-3-3_CanoR_1	461	469	PF00244	0.754
LIG_14-3-3_CanoR_1	476	485	PF00244	0.703
LIG_14-3-3_CanoR_1	583	591	PF00244	0.720
LIG_14-3-3_CanoR_1	614	619	PF00244	0.488
LIG_14-3-3_CanoR_1	620	626	PF00244	0.495
LIG_14-3-3_CanoR_1	752	760	PF00244	0.716
LIG_14-3-3_CterR_2	959	964	PF00244	0.690
LIG_Actin_WH2_2	829	844	PF00022	0.703
LIG_BRCT_BRCA1_1	180	184	PF00533	0.714
LIG_BRCT_BRCA1_1	277	281	PF00533	0.708
LIG_BRCT_BRCA1_1	321	325	PF00533	0.653
LIG_CaM_IQ_9	156	171	PF13499	0.698
LIG_DCNL_PONY_1	1	4	PF03556	0.730
LIG_deltaCOP1_diTrp_1	316	325	PF00928	0.632
LIG_FHA_1	580	586	PF00498	0.775
LIG_FHA_1	79	85	PF00498	0.825
LIG_FHA_1	814	820	PF00498	0.747
LIG_FHA_1	99	105	PF00498	0.558
LIG_FHA_2	409	415	PF00498	0.848
LIG_FHA_2	733	739	PF00498	0.730
LIG_FHA_2	792	798	PF00498	0.668
LIG_FHA_2	869	875	PF00498	0.628
LIG_LIR_Gen_1	316	325	PF02991	0.632
LIG_LIR_Gen_1	375	383	PF02991	0.641
LIG_LIR_Gen_1	420	430	PF02991	0.804
LIG_LIR_Gen_1	570	581	PF02991	0.756
LIG_LIR_Gen_1	823	832	PF02991	0.643
LIG_LIR_Gen_1	846	856	PF02991	0.652
LIG_LIR_Gen_1	892	900	PF02991	0.614
LIG_LIR_Nem_3	181	187	PF02991	0.642
LIG_LIR_Nem_3	316	321	PF02991	0.585
LIG_LIR_Nem_3	340	344	PF02991	0.713
LIG_LIR_Nem_3	375	381	PF02991	0.637
LIG_LIR_Nem_3	420	426	PF02991	0.804
LIG_LIR_Nem_3	570	576	PF02991	0.592
LIG_LIR_Nem_3	633	638	PF02991	0.390
LIG_LIR_Nem_3	697	701	PF02991	0.760
LIG_LIR_Nem_3	775	780	PF02991	0.696
LIG_LIR_Nem_3	823	829	PF02991	0.652
LIG_LIR_Nem_3	846	851	PF02991	0.631
LIG_LIR_Nem_3	892	898	PF02991	0.603
LIG_LYPXL_yS_3	341	344	PF13949	0.645
LIG_MYND_1	951	955	PF01753	0.634
LIG_PCNA_yPIPBox_3	158	167	PF02747	0.638
LIG_Pex14_1	881	885	PF04695	0.631
LIG_Pex14_1	945	949	PF04695	0.683
LIG_PROFILIN_1	139	145	PF00235	0.792
LIG_Rb_LxCxE_1	815	833	PF01857	0.596
LIG_REV1ctd_RIR_1	632	640	PF16727	0.436
LIG_SH2_PTP2	784	787	PF00017	0.561
LIG_SH2_PTP2	826	829	PF00017	0.637
LIG_SH2_SRC	209	212	PF00017	0.725
LIG_SH2_SRC	693	696	PF00017	0.687
LIG_SH2_SRC	784	787	PF00017	0.561
LIG_SH2_STAP1	365	369	PF00017	0.684
LIG_SH2_STAT3	365	368	PF00017	0.687
LIG_SH2_STAT5	392	395	PF00017	0.775
LIG_SH2_STAT5	442	445	PF00017	0.739
LIG_SH2_STAT5	784	787	PF00017	0.567
LIG_SH2_STAT5	801	804	PF00017	0.741
LIG_SH2_STAT5	826	829	PF00017	0.637
LIG_SH2_STAT5	848	851	PF00017	0.703
LIG_SH3_3	136	142	PF00018	0.824
LIG_SH3_3	174	180	PF00018	0.644
LIG_SH3_3	336	342	PF00018	0.636
LIG_SH3_3	402	408	PF00018	0.800
LIG_SH3_3	71	77	PF00018	0.736
LIG_SH3_3	757	763	PF00018	0.768
LIG_SH3_3	909	915	PF00018	0.712
LIG_SUMO_SIM_par_1	169	174	PF11976	0.706
LIG_SUMO_SIM_par_1	501	508	PF11976	0.721
LIG_TRAF2_1	412	415	PF00917	0.773
LIG_TRAF2_1	794	797	PF00917	0.672
LIG_TYR_ITIM	339	344	PF00017	0.539
LIG_TYR_ITIM	782	787	PF00017	0.440
LIG_WRC_WIRS_1	631	636	PF05994	0.513
LIG_WW_3	908	912	PF00397	0.632
MOD_CDK_SPxxK_3	951	958	PF00069	0.645
MOD_CK1_1	120	126	PF00069	0.811
MOD_CK1_1	254	260	PF00069	0.791
MOD_CK1_1	333	339	PF00069	0.552
MOD_CK1_1	394	400	PF00069	0.712
MOD_CK1_1	446	452	PF00069	0.712
MOD_CK1_1	462	468	PF00069	0.633
MOD_CK1_1	5	11	PF00069	0.726
MOD_CK1_1	502	508	PF00069	0.736
MOD_CK1_1	510	516	PF00069	0.715
MOD_CK1_1	56	62	PF00069	0.769
MOD_CK1_1	754	760	PF00069	0.753
MOD_CK1_1	858	864	PF00069	0.658
MOD_CK2_1	228	234	PF00069	0.792
MOD_CK2_1	323	329	PF00069	0.651
MOD_CK2_1	408	414	PF00069	0.753
MOD_CK2_1	462	468	PF00069	0.657
MOD_CK2_1	56	62	PF00069	0.767
MOD_CK2_1	702	708	PF00069	0.690
MOD_CK2_1	732	738	PF00069	0.679
MOD_CK2_1	791	797	PF00069	0.524
MOD_CK2_1	868	874	PF00069	0.541
MOD_Cter_Amidation	23	26	PF01082	0.780
MOD_Cter_Amidation	552	555	PF01082	0.742
MOD_Cter_Amidation	652	655	PF01082	0.681
MOD_GlcNHglycan	105	108	PF01048	0.776
MOD_GlcNHglycan	119	122	PF01048	0.581
MOD_GlcNHglycan	131	134	PF01048	0.643
MOD_GlcNHglycan	180	183	PF01048	0.548
MOD_GlcNHglycan	188	191	PF01048	0.541
MOD_GlcNHglycan	258	261	PF01048	0.738
MOD_GlcNHglycan	335	338	PF01048	0.565
MOD_GlcNHglycan	393	396	PF01048	0.728
MOD_GlcNHglycan	4	7	PF01048	0.654
MOD_GlcNHglycan	42	45	PF01048	0.852
MOD_GlcNHglycan	445	448	PF01048	0.746
MOD_GlcNHglycan	449	452	PF01048	0.702
MOD_GlcNHglycan	461	464	PF01048	0.560
MOD_GlcNHglycan	468	472	PF01048	0.592
MOD_GlcNHglycan	479	482	PF01048	0.550
MOD_GlcNHglycan	488	491	PF01048	0.499
MOD_GlcNHglycan	509	512	PF01048	0.718
MOD_GlcNHglycan	522	525	PF01048	0.752
MOD_GlcNHglycan	585	588	PF01048	0.616
MOD_GlcNHglycan	705	708	PF01048	0.688
MOD_GlcNHglycan	709	712	PF01048	0.643
MOD_GlcNHglycan	753	756	PF01048	0.707
MOD_GlcNHglycan	857	860	PF01048	0.641
MOD_GlcNHglycan	912	915	PF01048	0.766
MOD_GlcNHglycan	929	932	PF01048	0.591
MOD_GlcNHglycan	936	939	PF01048	0.694
MOD_GSK3_1	120	127	PF00069	0.751
MOD_GSK3_1	129	136	PF00069	0.738
MOD_GSK3_1	150	157	PF00069	0.699
MOD_GSK3_1	241	248	PF00069	0.812
MOD_GSK3_1	251	258	PF00069	0.702
MOD_GSK3_1	294	301	PF00069	0.718
MOD_GSK3_1	305	312	PF00069	0.529
MOD_GSK3_1	319	326	PF00069	0.586
MOD_GSK3_1	333	340	PF00069	0.419
MOD_GSK3_1	391	398	PF00069	0.692
MOD_GSK3_1	42	49	PF00069	0.784
MOD_GSK3_1	429	436	PF00069	0.662
MOD_GSK3_1	443	450	PF00069	0.620
MOD_GSK3_1	455	462	PF00069	0.740
MOD_GSK3_1	463	470	PF00069	0.753
MOD_GSK3_1	498	505	PF00069	0.665
MOD_GSK3_1	53	60	PF00069	0.662
MOD_GSK3_1	579	586	PF00069	0.654
MOD_GSK3_1	703	710	PF00069	0.632
MOD_GSK3_1	787	794	PF00069	0.537
MOD_GSK3_1	923	930	PF00069	0.825
MOD_GSK3_1	98	105	PF00069	0.656
MOD_N-GLC_1	621	626	PF02516	0.572
MOD_N-GLC_1	702	707	PF02516	0.618
MOD_N-GLC_2	419	421	PF02516	0.677
MOD_NEK2_1	103	108	PF00069	0.655
MOD_NEK2_1	2	7	PF00069	0.745
MOD_NEK2_1	281	286	PF00069	0.677
MOD_NEK2_1	288	293	PF00069	0.592
MOD_NEK2_1	319	324	PF00069	0.510
MOD_NEK2_1	33	38	PF00069	0.665
MOD_NEK2_1	381	386	PF00069	0.720
MOD_NEK2_1	393	398	PF00069	0.681
MOD_NEK2_1	443	448	PF00069	0.747
MOD_NEK2_1	455	460	PF00069	0.616
MOD_NEK2_1	475	480	PF00069	0.580
MOD_NEK2_1	485	490	PF00069	0.594
MOD_NEK2_1	498	503	PF00069	0.655
MOD_NEK2_1	572	577	PF00069	0.648
MOD_NEK2_1	623	628	PF00069	0.643
MOD_NEK2_1	638	643	PF00069	0.358
MOD_NEK2_1	701	706	PF00069	0.677
MOD_NEK2_1	773	778	PF00069	0.713
MOD_NEK2_1	849	854	PF00069	0.512
MOD_NEK2_2	630	635	PF00069	0.436
MOD_NEK2_2	868	873	PF00069	0.521
MOD_OFUCOSY	293	298	PF10250	0.577
MOD_PIKK_1	275	281	PF00454	0.605
MOD_PK_1	150	156	PF00069	0.638
MOD_PK_1	25	31	PF00069	0.791
MOD_PKA_1	25	31	PF00069	0.791
MOD_PKA_1	46	52	PF00069	0.806
MOD_PKA_1	554	560	PF00069	0.703
MOD_PKA_2	114	120	PF00069	0.777
MOD_PKA_2	2	8	PF00069	0.741
MOD_PKA_2	24	30	PF00069	0.643
MOD_PKA_2	281	287	PF00069	0.580
MOD_PKA_2	381	387	PF00069	0.621
MOD_PKA_2	46	52	PF00069	0.829
MOD_PKA_2	475	481	PF00069	0.746
MOD_PKA_2	60	66	PF00069	0.607
MOD_PKA_2	613	619	PF00069	0.404
MOD_PKA_2	751	757	PF00069	0.739
MOD_PKA_2	910	916	PF00069	0.700
MOD_Plk_1	301	307	PF00069	0.732
MOD_Plk_1	455	461	PF00069	0.739
MOD_Plk_1	621	627	PF00069	0.569
MOD_Plk_1	672	678	PF00069	0.556
MOD_Plk_2-3	228	234	PF00069	0.714
MOD_Plk_2-3	672	678	PF00069	0.556
MOD_Plk_4	124	130	PF00069	0.653
MOD_Plk_4	281	287	PF00069	0.682
MOD_Plk_4	319	325	PF00069	0.483
MOD_Plk_4	343	349	PF00069	0.652
MOD_Plk_4	499	505	PF00069	0.744
MOD_Plk_4	572	578	PF00069	0.575
MOD_Plk_4	60	66	PF00069	0.624
MOD_Plk_4	614	620	PF00069	0.349
MOD_Plk_4	732	738	PF00069	0.611
MOD_Plk_4	876	882	PF00069	0.441
MOD_ProDKin_1	135	141	PF00069	0.716
MOD_ProDKin_1	171	177	PF00069	0.653
MOD_ProDKin_1	330	336	PF00069	0.652
MOD_ProDKin_1	429	435	PF00069	0.720
MOD_ProDKin_1	510	516	PF00069	0.649
MOD_ProDKin_1	53	59	PF00069	0.750
MOD_ProDKin_1	791	797	PF00069	0.607
MOD_ProDKin_1	858	864	PF00069	0.639
MOD_ProDKin_1	951	957	PF00069	0.640
TRG_DiLeu_BaEn_1	824	829	PF01217	0.551
TRG_DiLeu_BaEn_2	315	321	PF01217	0.619
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.664
TRG_ENDOCYTIC_2	341	344	PF00928	0.550
TRG_ENDOCYTIC_2	378	381	PF00928	0.757
TRG_ENDOCYTIC_2	631	634	PF00928	0.392
TRG_ENDOCYTIC_2	784	787	PF00928	0.433
TRG_ENDOCYTIC_2	826	829	PF00928	0.538
TRG_ENDOCYTIC_2	848	851	PF00928	0.632
TRG_ER_diArg_1	161	164	PF00400	0.618
TRG_ER_diArg_1	46	48	PF00400	0.803
TRG_ER_diArg_1	51	53	PF00400	0.765
TRG_ER_diArg_1	595	597	PF00400	0.670
TRG_ER_diArg_1	602	604	PF00400	0.558
TRG_ER_diArg_1	647	649	PF00400	0.693
TRG_ER_diArg_1	654	657	PF00400	0.658
TRG_ER_diArg_1	715	717	PF00400	0.688
TRG_ER_diArg_1	840	843	PF00400	0.625
TRG_ER_diArg_1	957	959	PF00400	0.717
TRG_NLS_MonoExtN_4	31	38	PF00514	0.734
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.728
TRG_Pf-PMV_PEXEL_1	717	722	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL01	Leptomonas seymouri	36%	100%
A0A3S5H6V1	Leishmania donovani	100%	100%
A4H857	Leishmania braziliensis	73%	98%
E9AQ84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QF99	Leishmania major	87%	99%