Putative nucleotide sugar transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleotide sugar transporter - putative

Species:

Leishmania infantum

UniProt:

A4HWI2_LEIIN

TriTrypDb:

LINF_150016500

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0098588	bounding membrane of organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HWI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWI2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0008643	carbohydrate transport	5	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0071702	organic substance transport	4	7

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	9
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	9
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.605
CLV_NRD_NRD_1	194	196	PF00675	0.214
CLV_NRD_NRD_1	255	257	PF00675	0.238
CLV_NRD_NRD_1	32	34	PF00675	0.409
CLV_NRD_NRD_1	60	62	PF00675	0.319
CLV_PCSK_KEX2_1	16	18	PF00082	0.406
CLV_PCSK_KEX2_1	194	196	PF00082	0.214
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.406
CLV_PCSK_SKI1_1	100	104	PF00082	0.403
CLV_PCSK_SKI1_1	237	241	PF00082	0.213
CLV_PCSK_SKI1_1	34	38	PF00082	0.486
CLV_PCSK_SKI1_1	457	461	PF00082	0.378
DEG_SPOP_SBC_1	345	349	PF00917	0.295
DOC_CDC14_PxL_1	41	49	PF14671	0.578
DOC_CYCLIN_RxL_1	234	241	PF00134	0.213
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	408	414	PF00134	0.218
DOC_MAPK_gen_1	256	264	PF00069	0.438
DOC_MAPK_gen_1	306	313	PF00069	0.396
DOC_MAPK_HePTP_8	253	265	PF00069	0.480
DOC_MAPK_MEF2A_6	168	175	PF00069	0.241
DOC_MAPK_MEF2A_6	256	265	PF00069	0.413
DOC_MAPK_MEF2A_6	370	379	PF00069	0.238
DOC_PP1_RVXF_1	235	241	PF00149	0.213
DOC_PP1_RVXF_1	98	105	PF00149	0.594
DOC_PP2B_LxvP_1	103	106	PF13499	0.599
DOC_PP2B_LxvP_1	408	411	PF13499	0.218
DOC_USP7_MATH_1	205	209	PF00917	0.263
DOC_USP7_MATH_1	32	36	PF00917	0.634
DOC_USP7_MATH_1	335	339	PF00917	0.323
DOC_USP7_MATH_1	368	372	PF00917	0.188
DOC_USP7_MATH_1	403	407	PF00917	0.230
DOC_USP7_MATH_2	106	112	PF00917	0.632
DOC_WW_Pin1_4	113	118	PF00397	0.696
DOC_WW_Pin1_4	271	276	PF00397	0.230
DOC_WW_Pin1_4	36	41	PF00397	0.608
DOC_WW_Pin1_4	9	14	PF00397	0.556
LIG_14-3-3_CanoR_1	146	154	PF00244	0.173
LIG_14-3-3_CanoR_1	199	205	PF00244	0.384
LIG_14-3-3_CanoR_1	33	37	PF00244	0.606
LIG_14-3-3_CanoR_1	86	93	PF00244	0.600
LIG_14-3-3_CterR_2	457	461	PF00244	0.578
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BIR_III_1	1	5	PF00653	0.525
LIG_BIR_III_3	1	5	PF00653	0.525
LIG_BRCT_BRCA1_1	137	141	PF00533	0.346
LIG_BRCT_BRCA1_1	388	392	PF00533	0.399
LIG_EH1_1	203	211	PF00400	0.218
LIG_eIF4E_1	154	160	PF01652	0.138
LIG_eIF4E_1	204	210	PF01652	0.288
LIG_FHA_1	131	137	PF00498	0.389
LIG_FHA_1	227	233	PF00498	0.188
LIG_FHA_1	234	240	PF00498	0.206
LIG_FHA_1	275	281	PF00498	0.222
LIG_FHA_1	352	358	PF00498	0.335
LIG_FHA_1	411	417	PF00498	0.288
LIG_FHA_2	424	430	PF00498	0.184
LIG_HP1_1	374	378	PF01393	0.253
LIG_LIR_Apic_2	270	275	PF02991	0.346
LIG_LIR_Gen_1	212	222	PF02991	0.281
LIG_LIR_Gen_1	229	238	PF02991	0.134
LIG_LIR_Nem_3	137	143	PF02991	0.234
LIG_LIR_Nem_3	180	186	PF02991	0.381
LIG_LIR_Nem_3	208	214	PF02991	0.281
LIG_LIR_Nem_3	229	233	PF02991	0.221
LIG_LIR_Nem_3	241	247	PF02991	0.191
LIG_LIR_Nem_3	438	444	PF02991	0.223
LIG_MLH1_MIPbox_1	137	141	PF16413	0.323
LIG_NRBOX	284	290	PF00104	0.208
LIG_Pex14_2	240	244	PF04695	0.238
LIG_Pex14_2	327	331	PF04695	0.307
LIG_Pex14_2	392	396	PF04695	0.230
LIG_PTB_Apo_2	213	220	PF02174	0.213
LIG_PTB_Apo_2	325	332	PF02174	0.307
LIG_SH2_CRK	214	218	PF00017	0.220
LIG_SH2_CRK	323	327	PF00017	0.230
LIG_SH2_NCK_1	204	208	PF00017	0.288
LIG_SH2_NCK_1	214	218	PF00017	0.288
LIG_SH2_NCK_1	323	327	PF00017	0.218
LIG_SH2_SRC	321	324	PF00017	0.230
LIG_SH2_STAP1	323	327	PF00017	0.267
LIG_SH2_STAT5	147	150	PF00017	0.285
LIG_SH2_STAT5	154	157	PF00017	0.280
LIG_SH2_STAT5	211	214	PF00017	0.260
LIG_SH2_STAT5	321	324	PF00017	0.265
LIG_SH2_STAT5	444	447	PF00017	0.456
LIG_SH3_3	111	117	PF00018	0.701
LIG_SH3_3	37	43	PF00018	0.633
LIG_SH3_3	99	105	PF00018	0.643
LIG_SUMO_SIM_par_1	45	50	PF11976	0.557
LIG_TRAF2_1	96	99	PF00917	0.665
LIG_TRFH_1	245	249	PF08558	0.253
LIG_TYR_ITSM	210	217	PF00017	0.218
LIG_UBA3_1	160	168	PF00899	0.218
LIG_UBA3_1	263	271	PF00899	0.342
LIG_Vh1_VBS_1	248	266	PF01044	0.388
MOD_CDK_SPxxK_3	9	16	PF00069	0.568
MOD_CK1_1	274	280	PF00069	0.280
MOD_CK1_1	338	344	PF00069	0.263
MOD_CK1_1	455	461	PF00069	0.620
MOD_CK1_1	60	66	PF00069	0.554
MOD_CK1_1	68	74	PF00069	0.599
MOD_CK1_1	78	84	PF00069	0.637
MOD_CK2_1	403	409	PF00069	0.230
MOD_GlcNHglycan	110	113	PF01048	0.492
MOD_GlcNHglycan	126	129	PF01048	0.168
MOD_GlcNHglycan	20	25	PF01048	0.416
MOD_GlcNHglycan	29	32	PF01048	0.384
MOD_GlcNHglycan	383	386	PF01048	0.268
MOD_GlcNHglycan	388	391	PF01048	0.243
MOD_GlcNHglycan	405	408	PF01048	0.143
MOD_GlcNHglycan	457	460	PF01048	0.343
MOD_GlcNHglycan	81	84	PF01048	0.371
MOD_GSK3_1	104	111	PF00069	0.710
MOD_GSK3_1	113	120	PF00069	0.601
MOD_GSK3_1	130	137	PF00069	0.188
MOD_GSK3_1	141	148	PF00069	0.256
MOD_GSK3_1	184	191	PF00069	0.506
MOD_GSK3_1	205	212	PF00069	0.253
MOD_GSK3_1	267	274	PF00069	0.346
MOD_GSK3_1	32	39	PF00069	0.656
MOD_GSK3_1	345	352	PF00069	0.311
MOD_GSK3_1	53	60	PF00069	0.540
MOD_GSK3_1	75	82	PF00069	0.631
MOD_N-GLC_1	79	84	PF02516	0.398
MOD_NEK2_1	124	129	PF00069	0.470
MOD_NEK2_1	130	135	PF00069	0.222
MOD_NEK2_1	141	146	PF00069	0.191
MOD_NEK2_1	169	174	PF00069	0.250
MOD_NEK2_1	188	193	PF00069	0.326
MOD_NEK2_1	209	214	PF00069	0.399
MOD_NEK2_1	233	238	PF00069	0.207
MOD_NEK2_1	27	32	PF00069	0.602
MOD_NEK2_1	292	297	PF00069	0.218
MOD_NEK2_1	344	349	PF00069	0.205
MOD_NEK2_1	381	386	PF00069	0.256
MOD_NEK2_1	442	447	PF00069	0.303
MOD_NEK2_1	47	52	PF00069	0.539
MOD_NEK2_1	85	90	PF00069	0.681
MOD_PK_1	309	315	PF00069	0.480
MOD_PKA_2	145	151	PF00069	0.198
MOD_PKA_2	32	38	PF00069	0.608
MOD_PKA_2	60	66	PF00069	0.560
MOD_PKA_2	68	74	PF00069	0.530
MOD_PKA_2	85	91	PF00069	0.520
MOD_Plk_1	118	124	PF00069	0.578
MOD_Plk_1	450	456	PF00069	0.562
MOD_Plk_1	79	85	PF00069	0.609
MOD_Plk_4	130	136	PF00069	0.276
MOD_Plk_4	184	190	PF00069	0.413
MOD_Plk_4	205	211	PF00069	0.241
MOD_Plk_4	32	38	PF00069	0.608
MOD_Plk_4	335	341	PF00069	0.262
MOD_Plk_4	436	442	PF00069	0.207
MOD_Plk_4	68	74	PF00069	0.598
MOD_ProDKin_1	113	119	PF00069	0.694
MOD_ProDKin_1	271	277	PF00069	0.230
MOD_ProDKin_1	36	42	PF00069	0.608
MOD_ProDKin_1	9	15	PF00069	0.563
MOD_SUMO_for_1	305	308	PF00179	0.413
MOD_SUMO_rev_2	9	18	PF00179	0.576
TRG_DiLeu_BaEn_2	178	184	PF01217	0.438
TRG_ENDOCYTIC_2	214	217	PF00928	0.222
TRG_ENDOCYTIC_2	230	233	PF00928	0.213
TRG_ENDOCYTIC_2	323	326	PF00928	0.244
TRG_NES_CRM1_1	165	179	PF08389	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R3	Leptomonas seymouri	62%	100%
A0A0S4JKR6	Bodo saltans	40%	100%
A0A1X0NTU7	Trypanosomatidae	44%	100%
A0A3S7WTI2	Leishmania donovani	100%	100%
A0A422NRC3	Trypanosoma rangeli	43%	100%
B8B350	Oryza sativa subsp. indica	28%	100%
E9AQ83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O77592	Canis lupus familiaris	27%	100%
P78382	Homo sapiens	26%	100%
Q02334	Caenorhabditis elegans	24%	100%
Q61420	Mus musculus	27%	100%
Q654D9	Oryza sativa subsp. japonica	28%	100%
Q6YC49	Bos taurus	27%	100%
Q8LGE9	Arabidopsis thaliana	24%	100%
Q9VMU8	Drosophila melanogaster	32%	100%
Q9Y2D2	Homo sapiens	28%	100%
V5B4K3	Trypanosoma cruzi	41%	100%