Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWI1_LEIIN

TriTrypDb:

LINF_150016400

Length:

826

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.524
CLV_C14_Caspase3-7	570	574	PF00656	0.459
CLV_C14_Caspase3-7	647	651	PF00656	0.690
CLV_C14_Caspase3-7	798	802	PF00656	0.598
CLV_NRD_NRD_1	174	176	PF00675	0.533
CLV_NRD_NRD_1	198	200	PF00675	0.506
CLV_NRD_NRD_1	206	208	PF00675	0.442
CLV_NRD_NRD_1	214	216	PF00675	0.456
CLV_NRD_NRD_1	278	280	PF00675	0.649
CLV_NRD_NRD_1	391	393	PF00675	0.585
CLV_NRD_NRD_1	478	480	PF00675	0.614
CLV_NRD_NRD_1	53	55	PF00675	0.660
CLV_NRD_NRD_1	542	544	PF00675	0.531
CLV_PCSK_KEX2_1	174	176	PF00082	0.527
CLV_PCSK_KEX2_1	206	208	PF00082	0.461
CLV_PCSK_KEX2_1	216	218	PF00082	0.523
CLV_PCSK_KEX2_1	278	280	PF00082	0.649
CLV_PCSK_KEX2_1	478	480	PF00082	0.590
CLV_PCSK_KEX2_1	52	54	PF00082	0.657
CLV_PCSK_KEX2_1	542	544	PF00082	0.531
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.520
CLV_PCSK_SKI1_1	199	203	PF00082	0.461
CLV_PCSK_SKI1_1	338	342	PF00082	0.586
CLV_PCSK_SKI1_1	405	409	PF00082	0.529
CLV_PCSK_SKI1_1	469	473	PF00082	0.587
CLV_PCSK_SKI1_1	593	597	PF00082	0.584
CLV_PCSK_SKI1_1	610	614	PF00082	0.623
CLV_PCSK_SKI1_1	624	628	PF00082	0.658
CLV_PCSK_SKI1_1	820	824	PF00082	0.454
DEG_APCC_DBOX_1	198	206	PF00400	0.584
DEG_APCC_DBOX_1	337	345	PF00400	0.635
DEG_SCF_FBW7_1	245	251	PF00400	0.717
DEG_SPOP_SBC_1	236	240	PF00917	0.700
DEG_SPOP_SBC_1	7	11	PF00917	0.712
DOC_CKS1_1	245	250	PF01111	0.719
DOC_CKS1_1	805	810	PF01111	0.584
DOC_CYCLIN_RxL_1	196	203	PF00134	0.457
DOC_CYCLIN_RxL_1	402	412	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	403	409	PF00134	0.489
DOC_MAPK_gen_1	768	775	PF00069	0.697
DOC_PP1_RVXF_1	643	649	PF00149	0.690
DOC_PP2B_LxvP_1	30	33	PF13499	0.615
DOC_PP2B_LxvP_1	633	636	PF13499	0.682
DOC_PP2B_LxvP_1	741	744	PF13499	0.629
DOC_PP4_FxxP_1	665	668	PF00568	0.683
DOC_USP7_MATH_1	108	112	PF00917	0.619
DOC_USP7_MATH_1	190	194	PF00917	0.538
DOC_USP7_MATH_1	248	252	PF00917	0.723
DOC_USP7_MATH_1	305	309	PF00917	0.691
DOC_USP7_MATH_1	314	318	PF00917	0.577
DOC_USP7_MATH_1	409	413	PF00917	0.589
DOC_USP7_MATH_1	481	485	PF00917	0.486
DOC_USP7_MATH_1	58	62	PF00917	0.718
DOC_USP7_MATH_1	628	632	PF00917	0.643
DOC_USP7_MATH_1	637	641	PF00917	0.535
DOC_USP7_MATH_1	64	68	PF00917	0.602
DOC_USP7_MATH_1	666	670	PF00917	0.670
DOC_USP7_MATH_1	675	679	PF00917	0.606
DOC_USP7_MATH_1	683	687	PF00917	0.574
DOC_USP7_MATH_1	7	11	PF00917	0.663
DOC_USP7_MATH_1	727	731	PF00917	0.657
DOC_USP7_MATH_1	774	778	PF00917	0.558
DOC_USP7_MATH_2	113	119	PF00917	0.696
DOC_USP7_UBL2_3	200	204	PF12436	0.582
DOC_WW_Pin1_4	13	18	PF00397	0.648
DOC_WW_Pin1_4	239	244	PF00397	0.812
DOC_WW_Pin1_4	291	296	PF00397	0.708
DOC_WW_Pin1_4	394	399	PF00397	0.562
DOC_WW_Pin1_4	60	65	PF00397	0.775
DOC_WW_Pin1_4	638	643	PF00397	0.589
DOC_WW_Pin1_4	671	676	PF00397	0.630
DOC_WW_Pin1_4	679	684	PF00397	0.644
DOC_WW_Pin1_4	70	75	PF00397	0.514
DOC_WW_Pin1_4	783	788	PF00397	0.625
DOC_WW_Pin1_4	804	809	PF00397	0.546
LIG_14-3-3_CanoR_1	104	113	PF00244	0.530
LIG_14-3-3_CanoR_1	134	139	PF00244	0.568
LIG_14-3-3_CanoR_1	326	330	PF00244	0.572
LIG_14-3-3_CanoR_1	346	350	PF00244	0.367
LIG_14-3-3_CanoR_1	363	373	PF00244	0.595
LIG_14-3-3_CanoR_1	392	401	PF00244	0.721
LIG_14-3-3_CanoR_1	528	534	PF00244	0.539
LIG_14-3-3_CanoR_1	59	64	PF00244	0.703
LIG_14-3-3_CanoR_1	645	649	PF00244	0.693
LIG_14-3-3_CanoR_1	655	662	PF00244	0.578
LIG_14-3-3_CanoR_1	677	682	PF00244	0.651
LIG_14-3-3_CanoR_1	68	76	PF00244	0.530
LIG_14-3-3_CanoR_1	793	800	PF00244	0.644
LIG_APCC_ABBAyCdc20_2	469	475	PF00400	0.595
LIG_BIR_III_4	20	24	PF00653	0.754
LIG_CaM_IQ_9	470	485	PF13499	0.449
LIG_EVH1_2	32	36	PF00568	0.616
LIG_FHA_1	196	202	PF00498	0.481
LIG_FHA_1	240	246	PF00498	0.750
LIG_FHA_1	260	266	PF00498	0.700
LIG_FHA_1	269	275	PF00498	0.626
LIG_FHA_1	376	382	PF00498	0.646
LIG_FHA_1	700	706	PF00498	0.602
LIG_FHA_2	245	251	PF00498	0.721
LIG_FHA_2	318	324	PF00498	0.552
LIG_FHA_2	365	371	PF00498	0.627
LIG_FHA_2	594	600	PF00498	0.591
LIG_FHA_2	645	651	PF00498	0.692
LIG_FHA_2	796	802	PF00498	0.568
LIG_LIR_Apic_2	663	668	PF02991	0.725
LIG_LIR_Apic_2	786	791	PF02991	0.691
LIG_LIR_Gen_1	147	154	PF02991	0.492
LIG_LIR_LC3C_4	631	635	PF02991	0.574
LIG_LIR_Nem_3	147	152	PF02991	0.500
LIG_LIR_Nem_3	352	356	PF02991	0.471
LIG_LIR_Nem_3	816	822	PF02991	0.452
LIG_Pex14_1	183	187	PF04695	0.589
LIG_Pex14_1	815	819	PF04695	0.464
LIG_Pex14_2	280	284	PF04695	0.499
LIG_RPA_C_Fungi	177	189	PF08784	0.521
LIG_RPA_C_Fungi	75	87	PF08784	0.533
LIG_SH2_CRK	353	357	PF00017	0.468
LIG_SH2_STAT3	160	163	PF00017	0.466
LIG_SH3_3	26	32	PF00018	0.635
LIG_SH3_3	271	277	PF00018	0.685
LIG_SH3_3	370	376	PF00018	0.671
LIG_SH3_3	631	637	PF00018	0.558
LIG_SH3_3	719	725	PF00018	0.663
LIG_SH3_3	732	738	PF00018	0.578
LIG_SH3_3	802	808	PF00018	0.606
LIG_SUMO_SIM_anti_2	584	590	PF11976	0.508
LIG_SUMO_SIM_anti_2	730	736	PF11976	0.551
LIG_SUMO_SIM_par_1	150	156	PF11976	0.473
LIG_SUMO_SIM_par_1	406	412	PF11976	0.563
LIG_TRAF2_1	518	521	PF00917	0.500
LIG_TRAF2_1	814	817	PF00917	0.458
LIG_UBA3_1	201	210	PF00899	0.577
MOD_CDC14_SPxK_1	674	677	PF00782	0.753
MOD_CDK_SPxK_1	671	677	PF00069	0.633
MOD_CDK_SPxxK_3	638	645	PF00069	0.599
MOD_CDK_SPxxK_3	804	811	PF00069	0.534
MOD_CK1_1	107	113	PF00069	0.723
MOD_CK1_1	13	19	PF00069	0.676
MOD_CK1_1	193	199	PF00069	0.608
MOD_CK1_1	229	235	PF00069	0.699
MOD_CK1_1	238	244	PF00069	0.660
MOD_CK1_1	259	265	PF00069	0.729
MOD_CK1_1	317	323	PF00069	0.615
MOD_CK1_1	325	331	PF00069	0.550
MOD_CK1_1	345	351	PF00069	0.464
MOD_CK1_1	362	368	PF00069	0.650
MOD_CK1_1	397	403	PF00069	0.633
MOD_CK1_1	433	439	PF00069	0.687
MOD_CK1_1	6	12	PF00069	0.662
MOD_CK1_1	66	72	PF00069	0.732
MOD_CK1_1	684	690	PF00069	0.669
MOD_CK1_1	712	718	PF00069	0.635
MOD_CK2_1	317	323	PF00069	0.553
MOD_CK2_1	409	415	PF00069	0.637
MOD_CK2_1	542	548	PF00069	0.453
MOD_CK2_1	593	599	PF00069	0.579
MOD_Cter_Amidation	390	393	PF01082	0.549
MOD_GlcNHglycan	10	13	PF01048	0.747
MOD_GlcNHglycan	106	109	PF01048	0.545
MOD_GlcNHglycan	110	113	PF01048	0.593
MOD_GlcNHglycan	142	145	PF01048	0.561
MOD_GlcNHglycan	232	235	PF01048	0.748
MOD_GlcNHglycan	250	253	PF01048	0.738
MOD_GlcNHglycan	309	312	PF01048	0.773
MOD_GlcNHglycan	411	414	PF01048	0.616
MOD_GlcNHglycan	432	435	PF01048	0.640
MOD_GlcNHglycan	438	441	PF01048	0.649
MOD_GlcNHglycan	457	460	PF01048	0.731
MOD_GlcNHglycan	483	486	PF01048	0.641
MOD_GlcNHglycan	5	8	PF01048	0.695
MOD_GlcNHglycan	544	547	PF01048	0.444
MOD_GlcNHglycan	630	633	PF01048	0.652
MOD_GlcNHglycan	662	665	PF01048	0.743
MOD_GlcNHglycan	712	715	PF01048	0.724
MOD_GlcNHglycan	718	721	PF01048	0.705
MOD_GlcNHglycan	725	728	PF01048	0.732
MOD_GlcNHglycan	762	767	PF01048	0.809
MOD_GlcNHglycan	77	80	PF01048	0.781
MOD_GlcNHglycan	94	97	PF01048	0.668
MOD_GSK3_1	104	111	PF00069	0.744
MOD_GSK3_1	191	198	PF00069	0.564
MOD_GSK3_1	226	233	PF00069	0.694
MOD_GSK3_1	235	242	PF00069	0.646
MOD_GSK3_1	244	251	PF00069	0.583
MOD_GSK3_1	287	294	PF00069	0.598
MOD_GSK3_1	3	10	PF00069	0.665
MOD_GSK3_1	314	321	PF00069	0.626
MOD_GSK3_1	392	399	PF00069	0.623
MOD_GSK3_1	429	436	PF00069	0.646
MOD_GSK3_1	538	545	PF00069	0.579
MOD_GSK3_1	59	66	PF00069	0.716
MOD_GSK3_1	624	631	PF00069	0.582
MOD_GSK3_1	667	674	PF00069	0.644
MOD_GSK3_1	675	682	PF00069	0.625
MOD_GSK3_1	708	715	PF00069	0.768
MOD_GSK3_1	723	730	PF00069	0.537
MOD_GSK3_1	789	796	PF00069	0.656
MOD_LATS_1	102	108	PF00433	0.536
MOD_LATS_1	57	63	PF00433	0.718
MOD_N-GLC_1	243	248	PF02516	0.637
MOD_N-GLC_1	287	292	PF02516	0.648
MOD_N-GLC_1	305	310	PF02516	0.481
MOD_N-GLC_1	359	364	PF02516	0.634
MOD_N-GLC_1	502	507	PF02516	0.472
MOD_N-GLC_1	593	598	PF02516	0.584
MOD_N-GLC_1	92	97	PF02516	0.655
MOD_NEK2_1	344	349	PF00069	0.470
MOD_NEK2_1	386	391	PF00069	0.564
MOD_NEK2_1	430	435	PF00069	0.615
MOD_NEK2_1	526	531	PF00069	0.583
MOD_NEK2_1	581	586	PF00069	0.496
MOD_NEK2_1	710	715	PF00069	0.694
MOD_PIKK_1	502	508	PF00454	0.474
MOD_PIKK_1	581	587	PF00454	0.473
MOD_PKA_1	392	398	PF00069	0.563
MOD_PKA_1	542	548	PF00069	0.453
MOD_PKA_2	229	235	PF00069	0.690
MOD_PKA_2	325	331	PF00069	0.629
MOD_PKA_2	345	351	PF00069	0.464
MOD_PKA_2	362	368	PF00069	0.537
MOD_PKA_2	529	535	PF00069	0.536
MOD_PKA_2	542	548	PF00069	0.420
MOD_PKA_2	58	64	PF00069	0.718
MOD_PKA_2	644	650	PF00069	0.692
MOD_PKA_2	654	660	PF00069	0.577
MOD_PKA_2	67	73	PF00069	0.533
MOD_PKB_1	390	398	PF00069	0.558
MOD_Plk_1	287	293	PF00069	0.605
MOD_Plk_1	502	508	PF00069	0.474
MOD_Plk_4	287	293	PF00069	0.642
MOD_Plk_4	345	351	PF00069	0.522
MOD_Plk_4	416	422	PF00069	0.548
MOD_Plk_4	548	554	PF00069	0.541
MOD_Plk_4	728	734	PF00069	0.634
MOD_Plk_4	736	742	PF00069	0.586
MOD_ProDKin_1	13	19	PF00069	0.647
MOD_ProDKin_1	239	245	PF00069	0.812
MOD_ProDKin_1	291	297	PF00069	0.707
MOD_ProDKin_1	394	400	PF00069	0.560
MOD_ProDKin_1	60	66	PF00069	0.775
MOD_ProDKin_1	638	644	PF00069	0.589
MOD_ProDKin_1	671	677	PF00069	0.633
MOD_ProDKin_1	679	685	PF00069	0.642
MOD_ProDKin_1	70	76	PF00069	0.514
MOD_ProDKin_1	783	789	PF00069	0.627
MOD_ProDKin_1	804	810	PF00069	0.538
MOD_SUMO_for_1	507	510	PF00179	0.594
MOD_SUMO_for_1	568	571	PF00179	0.504
MOD_SUMO_rev_2	619	626	PF00179	0.685
TRG_DiLeu_BaEn_1	287	292	PF01217	0.672
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.494
TRG_ENDOCYTIC_2	149	152	PF00928	0.490
TRG_ENDOCYTIC_2	353	356	PF00928	0.469
TRG_ER_diArg_1	161	164	PF00400	0.466
TRG_ER_diArg_1	173	175	PF00400	0.480
TRG_ER_diArg_1	205	207	PF00400	0.471
TRG_ER_diArg_1	214	217	PF00400	0.512
TRG_ER_diArg_1	277	279	PF00400	0.650
TRG_ER_diArg_1	52	54	PF00400	0.648
TRG_NLS_Bipartite_1	199	219	PF00514	0.552
TRG_NLS_MonoExtN_4	214	219	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C2	Leptomonas seymouri	32%	89%
A0A3Q8IIQ6	Leishmania donovani	99%	100%
A4H856	Leishmania braziliensis	54%	97%
E9AQ82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
Q4QFA0	Leishmania major	87%	100%