LeishMANIAdb
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Peroxisomal membrane protein PEX16

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peroxisomal membrane protein PEX16
Gene product:
Peroxisomal membrane protein (Pex16) - putative
Species:
Leishmania infantum
UniProt:
A4HWH7_LEIIN
TriTrypDb:
LINF_150016000
Length:
563

Annotations

Annotations by Jardim et al.

Glycosome membrane, Peroxin 16

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005778 peroxisomal membrane 6 10
GO:0016020 membrane 2 10
GO:0031090 organelle membrane 3 10
GO:0031903 microbody membrane 5 10
GO:0042579 microbody 5 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0098588 bounding membrane of organelle 4 10
GO:0110165 cellular anatomical entity 1 10
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1

Expansion

Sequence features

A4HWH7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWH7

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 10
GO:0007031 peroxisome organization 5 10
GO:0009987 cellular process 1 10
GO:0016043 cellular component organization 3 10
GO:0071840 cellular component organization or biogenesis 2 10
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 461 465 PF00656 0.786
CLV_NRD_NRD_1 100 102 PF00675 0.269
CLV_NRD_NRD_1 133 135 PF00675 0.254
CLV_NRD_NRD_1 172 174 PF00675 0.390
CLV_NRD_NRD_1 185 187 PF00675 0.479
CLV_NRD_NRD_1 24 26 PF00675 0.552
CLV_NRD_NRD_1 257 259 PF00675 0.472
CLV_PCSK_KEX2_1 100 102 PF00082 0.293
CLV_PCSK_KEX2_1 133 135 PF00082 0.287
CLV_PCSK_KEX2_1 172 174 PF00082 0.398
CLV_PCSK_KEX2_1 184 186 PF00082 0.481
CLV_PCSK_KEX2_1 24 26 PF00082 0.552
CLV_PCSK_KEX2_1 257 259 PF00082 0.472
CLV_PCSK_SKI1_1 155 159 PF00082 0.394
CLV_PCSK_SKI1_1 172 176 PF00082 0.396
CLV_PCSK_SKI1_1 317 321 PF00082 0.496
CLV_PCSK_SKI1_1 326 330 PF00082 0.509
CLV_PCSK_SKI1_1 503 507 PF00082 0.354
CLV_PCSK_SKI1_1 62 66 PF00082 0.333
DEG_APCC_DBOX_1 171 179 PF00400 0.607
DEG_APCC_DBOX_1 29 37 PF00400 0.610
DEG_APCC_DBOX_1 502 510 PF00400 0.502
DEG_SPOP_SBC_1 467 471 PF00917 0.646
DOC_ANK_TNKS_1 47 54 PF00023 0.467
DOC_CDC14_PxL_1 157 165 PF14671 0.635
DOC_CYCLIN_yCln2_LP_2 315 321 PF00134 0.358
DOC_MAPK_DCC_7 422 431 PF00069 0.595
DOC_MAPK_gen_1 100 110 PF00069 0.525
DOC_MAPK_gen_1 133 141 PF00069 0.502
DOC_MAPK_gen_1 419 428 PF00069 0.547
DOC_MAPK_MEF2A_6 104 112 PF00069 0.598
DOC_MAPK_MEF2A_6 317 324 PF00069 0.325
DOC_MAPK_MEF2A_6 422 431 PF00069 0.595
DOC_MAPK_RevD_3 158 173 PF00069 0.631
DOC_PP2B_LxvP_1 248 251 PF13499 0.583
DOC_PP2B_LxvP_1 330 333 PF13499 0.407
DOC_PP2B_LxvP_1 343 346 PF13499 0.417
DOC_PP4_FxxP_1 158 161 PF00568 0.570
DOC_PP4_MxPP_1 486 489 PF00568 0.617
DOC_USP7_MATH_1 13 17 PF00917 0.744
DOC_USP7_MATH_1 199 203 PF00917 0.746
DOC_USP7_MATH_1 209 213 PF00917 0.656
DOC_USP7_MATH_1 267 271 PF00917 0.720
DOC_USP7_MATH_1 467 471 PF00917 0.664
DOC_USP7_MATH_1 476 480 PF00917 0.740
DOC_USP7_MATH_1 489 493 PF00917 0.559
DOC_USP7_UBL2_3 146 150 PF12436 0.530
DOC_WW_Pin1_4 11 16 PF00397 0.742
DOC_WW_Pin1_4 179 184 PF00397 0.662
DOC_WW_Pin1_4 368 373 PF00397 0.538
DOC_WW_Pin1_4 439 444 PF00397 0.803
LIG_14-3-3_CanoR_1 100 108 PF00244 0.507
LIG_14-3-3_CanoR_1 133 137 PF00244 0.495
LIG_14-3-3_CanoR_1 176 182 PF00244 0.620
LIG_14-3-3_CanoR_1 62 67 PF00244 0.473
LIG_Actin_RPEL_3 18 37 PF02755 0.648
LIG_Actin_WH2_2 301 319 PF00022 0.227
LIG_AP2alpha_2 512 514 PF02296 0.506
LIG_Clathr_ClatBox_1 139 143 PF01394 0.530
LIG_FHA_1 103 109 PF00498 0.477
LIG_FHA_1 244 250 PF00498 0.592
LIG_FHA_1 334 340 PF00498 0.432
LIG_FHA_1 514 520 PF00498 0.556
LIG_FHA_1 545 551 PF00498 0.411
LIG_FHA_1 70 76 PF00498 0.496
LIG_FHA_2 223 229 PF00498 0.689
LIG_FHA_2 299 305 PF00498 0.447
LIG_FHA_2 406 412 PF00498 0.378
LIG_LIR_Apic_2 219 223 PF02991 0.598
LIG_LIR_Apic_2 65 71 PF02991 0.502
LIG_LIR_Gen_1 135 144 PF02991 0.495
LIG_LIR_Gen_1 301 310 PF02991 0.320
LIG_LIR_Gen_1 311 321 PF02991 0.276
LIG_LIR_Gen_1 512 523 PF02991 0.545
LIG_LIR_Gen_1 547 557 PF02991 0.398
LIG_LIR_Gen_1 88 95 PF02991 0.519
LIG_LIR_Nem_3 135 139 PF02991 0.469
LIG_LIR_Nem_3 301 305 PF02991 0.344
LIG_LIR_Nem_3 311 316 PF02991 0.347
LIG_LIR_Nem_3 512 518 PF02991 0.505
LIG_LIR_Nem_3 551 557 PF02991 0.325
LIG_LIR_Nem_3 88 92 PF02991 0.519
LIG_NRBOX 412 418 PF00104 0.360
LIG_Pex14_2 158 162 PF04695 0.563
LIG_Pex14_2 527 531 PF04695 0.598
LIG_PTB_Apo_2 501 508 PF02174 0.544
LIG_PTB_Phospho_1 501 507 PF10480 0.587
LIG_SH2_CRK 220 224 PF00017 0.697
LIG_SH2_CRK 555 559 PF00017 0.357
LIG_SH2_STAP1 545 549 PF00017 0.383
LIG_SH2_STAP1 555 559 PF00017 0.295
LIG_SH2_STAT5 313 316 PF00017 0.400
LIG_SH2_STAT5 43 46 PF00017 0.511
LIG_SH2_STAT5 430 433 PF00017 0.667
LIG_SH2_STAT5 549 552 PF00017 0.296
LIG_SH2_STAT5 559 562 PF00017 0.321
LIG_SH3_3 237 243 PF00018 0.671
LIG_SH3_3 339 345 PF00018 0.384
LIG_SH3_3 369 375 PF00018 0.517
LIG_SUMO_SIM_anti_2 105 112 PF11976 0.470
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.295
LIG_SUMO_SIM_anti_2 442 448 PF11976 0.634
LIG_SUMO_SIM_par_1 138 143 PF11976 0.466
LIG_SUMO_SIM_par_1 442 448 PF11976 0.632
LIG_TRAF2_1 348 351 PF00917 0.400
LIG_TRAF2_1 362 365 PF00917 0.347
LIG_UBA3_1 139 146 PF00899 0.447
LIG_UBA3_1 36 45 PF00899 0.561
LIG_WRC_WIRS_1 554 559 PF05994 0.382
LIG_WRC_WIRS_1 86 91 PF05994 0.515
MOD_CDK_SPK_2 179 184 PF00069 0.662
MOD_CDK_SPxK_1 179 185 PF00069 0.668
MOD_CDK_SPxK_1 368 374 PF00069 0.482
MOD_CDK_SPxxK_3 179 186 PF00069 0.671
MOD_CK1_1 16 22 PF00069 0.758
MOD_CK1_1 230 236 PF00069 0.639
MOD_CK1_1 69 75 PF00069 0.530
MOD_CK2_1 100 106 PF00069 0.523
MOD_CK2_1 16 22 PF00069 0.681
MOD_CK2_1 345 351 PF00069 0.382
MOD_CK2_1 52 58 PF00069 0.502
MOD_CMANNOS 401 404 PF00535 0.465
MOD_Cter_Amidation 255 258 PF01082 0.378
MOD_Cter_Amidation 98 101 PF01082 0.265
MOD_GlcNHglycan 196 199 PF01048 0.585
MOD_GlcNHglycan 201 204 PF01048 0.556
MOD_GlcNHglycan 211 214 PF01048 0.414
MOD_GlcNHglycan 228 232 PF01048 0.427
MOD_GlcNHglycan 254 257 PF01048 0.436
MOD_GlcNHglycan 96 99 PF01048 0.350
MOD_GSK3_1 102 109 PF00069 0.560
MOD_GSK3_1 163 170 PF00069 0.628
MOD_GSK3_1 199 206 PF00069 0.713
MOD_GSK3_1 393 400 PF00069 0.376
MOD_GSK3_1 467 474 PF00069 0.699
MOD_GSK3_1 540 547 PF00069 0.463
MOD_GSK3_1 553 560 PF00069 0.343
MOD_GSK3_1 58 65 PF00069 0.496
MOD_GSK3_1 69 76 PF00069 0.585
MOD_GSK3_1 7 14 PF00069 0.741
MOD_NEK2_1 163 168 PF00069 0.636
MOD_NEK2_1 397 402 PF00069 0.377
MOD_NEK2_1 466 471 PF00069 0.665
MOD_NEK2_1 537 542 PF00069 0.308
MOD_NEK2_1 544 549 PF00069 0.358
MOD_NEK2_1 557 562 PF00069 0.284
MOD_NEK2_1 60 65 PF00069 0.550
MOD_NEK2_1 8 13 PF00069 0.693
MOD_PIKK_1 222 228 PF00454 0.769
MOD_PKA_1 100 106 PF00069 0.530
MOD_PKA_2 132 138 PF00069 0.530
MOD_PKA_2 99 105 PF00069 0.544
MOD_Plk_4 106 112 PF00069 0.513
MOD_Plk_4 393 399 PF00069 0.358
MOD_Plk_4 553 559 PF00069 0.313
MOD_Plk_4 62 68 PF00069 0.530
MOD_ProDKin_1 11 17 PF00069 0.742
MOD_ProDKin_1 179 185 PF00069 0.668
MOD_ProDKin_1 368 374 PF00069 0.542
MOD_ProDKin_1 439 445 PF00069 0.803
MOD_SUMO_rev_2 364 369 PF00179 0.523
TRG_DiLeu_BaEn_1 106 111 PF01217 0.571
TRG_DiLeu_BaEn_1 117 122 PF01217 0.428
TRG_DiLeu_BaEn_1 335 340 PF01217 0.303
TRG_DiLeu_BaLyEn_6 533 538 PF01217 0.400
TRG_ENDOCYTIC_2 313 316 PF00928 0.368
TRG_ENDOCYTIC_2 507 510 PF00928 0.546
TRG_ENDOCYTIC_2 524 527 PF00928 0.448
TRG_ENDOCYTIC_2 549 552 PF00928 0.293
TRG_ENDOCYTIC_2 554 557 PF00928 0.260
TRG_ER_diArg_1 171 173 PF00400 0.594
TRG_ER_diArg_1 183 186 PF00400 0.679
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.290

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4R8 Leptomonas seymouri 58% 100%
A0A1X0NUI4 Trypanosomatidae 36% 100%
A0A3Q8ICA1 Leishmania donovani 100% 100%
A4H843 Leishmania braziliensis 82% 99%
C9ZXX1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AQ78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
Q4QFA4 Leishmania major 95% 100%
V5DL46 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS