LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HWH4_LEIIN
TriTrypDb:
LINF_150015700
Length:
655

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWH4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWH4

PDB structure(s): 7ane_ae

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 372 376 PF00656 0.584
CLV_NRD_NRD_1 169 171 PF00675 0.406
CLV_NRD_NRD_1 181 183 PF00675 0.452
CLV_NRD_NRD_1 210 212 PF00675 0.483
CLV_NRD_NRD_1 222 224 PF00675 0.372
CLV_NRD_NRD_1 454 456 PF00675 0.544
CLV_NRD_NRD_1 494 496 PF00675 0.455
CLV_PCSK_FUR_1 452 456 PF00082 0.543
CLV_PCSK_KEX2_1 169 171 PF00082 0.406
CLV_PCSK_KEX2_1 181 183 PF00082 0.452
CLV_PCSK_KEX2_1 210 212 PF00082 0.497
CLV_PCSK_KEX2_1 222 224 PF00082 0.394
CLV_PCSK_KEX2_1 454 456 PF00082 0.573
CLV_PCSK_SKI1_1 222 226 PF00082 0.422
CLV_PCSK_SKI1_1 234 238 PF00082 0.376
CLV_PCSK_SKI1_1 436 440 PF00082 0.577
DOC_CKS1_1 102 107 PF01111 0.429
DOC_CYCLIN_yCln2_LP_2 102 108 PF00134 0.432
DOC_CYCLIN_yCln2_LP_2 132 138 PF00134 0.439
DOC_MAPK_DCC_7 100 108 PF00069 0.438
DOC_MAPK_DCC_7 188 196 PF00069 0.632
DOC_MAPK_DCC_7 222 232 PF00069 0.403
DOC_MAPK_gen_1 185 194 PF00069 0.603
DOC_MAPK_gen_1 279 286 PF00069 0.408
DOC_MAPK_gen_1 312 320 PF00069 0.504
DOC_MAPK_MEF2A_6 188 196 PF00069 0.599
DOC_MAPK_MEF2A_6 223 232 PF00069 0.387
DOC_MAPK_MEF2A_6 90 97 PF00069 0.465
DOC_PP1_RVXF_1 283 289 PF00149 0.371
DOC_PP1_RVXF_1 434 440 PF00149 0.258
DOC_PP1_RVXF_1 505 511 PF00149 0.437
DOC_USP7_MATH_1 574 578 PF00917 0.627
DOC_USP7_MATH_1 589 593 PF00917 0.691
DOC_USP7_MATH_1 621 625 PF00917 0.685
DOC_USP7_MATH_1 644 648 PF00917 0.746
DOC_WW_Pin1_4 101 106 PF00397 0.425
DOC_WW_Pin1_4 562 567 PF00397 0.555
DOC_WW_Pin1_4 629 634 PF00397 0.803
LIG_14-3-3_CanoR_1 116 122 PF00244 0.420
LIG_14-3-3_CanoR_1 222 228 PF00244 0.406
LIG_14-3-3_CanoR_1 234 242 PF00244 0.365
LIG_14-3-3_CanoR_1 314 319 PF00244 0.470
LIG_Actin_WH2_2 199 217 PF00022 0.406
LIG_Actin_WH2_2 346 364 PF00022 0.562
LIG_APCC_ABBA_1 250 255 PF00400 0.381
LIG_BIR_II_1 1 5 PF00653 0.505
LIG_BIR_III_4 410 414 PF00653 0.697
LIG_BRCT_BRCA1_1 257 261 PF00533 0.484
LIG_CaM_NSCaTE_8 475 482 PF13499 0.553
LIG_CSL_BTD_1 509 512 PF09270 0.519
LIG_FHA_1 116 122 PF00498 0.493
LIG_FHA_1 364 370 PF00498 0.557
LIG_FHA_1 534 540 PF00498 0.536
LIG_FHA_1 563 569 PF00498 0.519
LIG_FHA_1 614 620 PF00498 0.726
LIG_FHA_1 632 638 PF00498 0.770
LIG_FHA_1 70 76 PF00498 0.523
LIG_FHA_1 77 83 PF00498 0.519
LIG_FHA_2 142 148 PF00498 0.470
LIG_FHA_2 332 338 PF00498 0.495
LIG_FHA_2 399 405 PF00498 0.570
LIG_FHA_2 420 426 PF00498 0.527
LIG_FHA_2 483 489 PF00498 0.608
LIG_FHA_2 72 78 PF00498 0.624
LIG_LIR_Gen_1 334 344 PF02991 0.486
LIG_LIR_Nem_3 124 128 PF02991 0.504
LIG_LIR_Nem_3 162 168 PF02991 0.487
LIG_LIR_Nem_3 219 224 PF02991 0.428
LIG_LIR_Nem_3 231 236 PF02991 0.377
LIG_LIR_Nem_3 334 339 PF02991 0.462
LIG_NRBOX 319 325 PF00104 0.365
LIG_PDZ_Class_1 650 655 PF00595 0.693
LIG_SH2_CRK 221 225 PF00017 0.432
LIG_SH2_CRK 233 237 PF00017 0.367
LIG_SH2_CRK 336 340 PF00017 0.408
LIG_SH2_CRK 531 535 PF00017 0.586
LIG_SH2_GRB2like 298 301 PF00017 0.418
LIG_SH2_SRC 298 301 PF00017 0.418
LIG_SH2_STAP1 298 302 PF00017 0.424
LIG_SH2_STAP1 336 340 PF00017 0.431
LIG_SH2_STAP1 395 399 PF00017 0.521
LIG_SH2_STAT3 554 557 PF00017 0.603
LIG_SH2_STAT5 128 131 PF00017 0.524
LIG_SH2_STAT5 179 182 PF00017 0.437
LIG_SH2_STAT5 24 27 PF00017 0.473
LIG_SH2_STAT5 262 265 PF00017 0.364
LIG_SH2_STAT5 322 325 PF00017 0.392
LIG_SH2_STAT5 338 341 PF00017 0.416
LIG_SH2_STAT5 398 401 PF00017 0.502
LIG_SH2_STAT5 468 471 PF00017 0.403
LIG_SH2_STAT5 493 496 PF00017 0.568
LIG_SH2_STAT5 554 557 PF00017 0.583
LIG_SH3_2 31 36 PF14604 0.493
LIG_SH3_3 142 148 PF00018 0.468
LIG_SH3_3 28 34 PF00018 0.472
LIG_SH3_3 382 388 PF00018 0.319
LIG_SH3_3 434 440 PF00018 0.258
LIG_SH3_3 583 589 PF00018 0.688
LIG_SUMO_SIM_anti_2 104 110 PF11976 0.439
LIG_SUMO_SIM_anti_2 306 311 PF11976 0.511
LIG_SUMO_SIM_anti_2 76 84 PF11976 0.529
LIG_SUMO_SIM_par_1 104 110 PF11976 0.435
LIG_SUMO_SIM_par_1 192 198 PF11976 0.593
LIG_TRAF2_1 217 220 PF00917 0.403
LIG_TRAF2_1 328 331 PF00917 0.508
LIG_TRAF2_1 401 404 PF00917 0.599
LIG_TRAF2_1 485 488 PF00917 0.559
MOD_CK1_1 107 113 PF00069 0.409
MOD_CK1_1 17 23 PF00069 0.559
MOD_CK1_1 497 503 PF00069 0.519
MOD_CK1_1 577 583 PF00069 0.710
MOD_CK1_1 611 617 PF00069 0.701
MOD_CK1_1 642 648 PF00069 0.697
MOD_CK1_1 65 71 PF00069 0.532
MOD_CK1_1 78 84 PF00069 0.507
MOD_CK1_1 96 102 PF00069 0.426
MOD_CK2_1 192 198 PF00069 0.602
MOD_CK2_1 398 404 PF00069 0.486
MOD_CK2_1 482 488 PF00069 0.565
MOD_GlcNHglycan 109 112 PF01048 0.441
MOD_GlcNHglycan 480 483 PF01048 0.535
MOD_GlcNHglycan 576 579 PF01048 0.610
MOD_GlcNHglycan 582 585 PF01048 0.738
MOD_GlcNHglycan 591 594 PF01048 0.587
MOD_GlcNHglycan 611 614 PF01048 0.514
MOD_GlcNHglycan 616 619 PF01048 0.646
MOD_GlcNHglycan 625 628 PF01048 0.723
MOD_GlcNHglycan 637 640 PF01048 0.576
MOD_GlcNHglycan 64 67 PF01048 0.495
MOD_GlcNHglycan 642 645 PF01048 0.590
MOD_GlcNHglycan 646 649 PF01048 0.652
MOD_GSK3_1 10 17 PF00069 0.523
MOD_GSK3_1 419 426 PF00069 0.547
MOD_GSK3_1 478 485 PF00069 0.515
MOD_GSK3_1 604 611 PF00069 0.702
MOD_GSK3_1 62 69 PF00069 0.481
MOD_GSK3_1 631 638 PF00069 0.675
MOD_GSK3_1 640 647 PF00069 0.617
MOD_GSK3_1 71 78 PF00069 0.483
MOD_N-GLC_1 141 146 PF02516 0.502
MOD_N-GLC_1 608 613 PF02516 0.641
MOD_NEK2_1 180 185 PF00069 0.458
MOD_NEK2_1 323 328 PF00069 0.461
MOD_NEK2_1 377 382 PF00069 0.466
MOD_NEK2_1 478 483 PF00069 0.461
MOD_NEK2_1 494 499 PF00069 0.336
MOD_NEK2_1 50 55 PF00069 0.556
MOD_NEK2_1 598 603 PF00069 0.652
MOD_NEK2_1 604 609 PF00069 0.658
MOD_NEK2_1 650 655 PF00069 0.748
MOD_NEK2_1 75 80 PF00069 0.552
MOD_PIKK_1 377 383 PF00454 0.557
MOD_PK_1 223 229 PF00069 0.463
MOD_PKA_1 181 187 PF00069 0.571
MOD_PKA_1 222 228 PF00069 0.396
MOD_PKA_1 454 460 PF00069 0.608
MOD_PKA_2 10 16 PF00069 0.570
MOD_PKA_2 115 121 PF00069 0.416
MOD_PKA_2 180 186 PF00069 0.477
MOD_PKA_2 222 228 PF00069 0.439
MOD_PKA_2 454 460 PF00069 0.572
MOD_PKA_2 494 500 PF00069 0.435
MOD_PKA_2 639 645 PF00069 0.775
MOD_PKB_1 312 320 PF00069 0.474
MOD_PKB_1 452 460 PF00069 0.600
MOD_Plk_1 141 147 PF00069 0.495
MOD_Plk_1 539 545 PF00069 0.505
MOD_Plk_1 546 552 PF00069 0.552
MOD_Plk_1 75 81 PF00069 0.502
MOD_Plk_1 93 99 PF00069 0.437
MOD_Plk_2-3 141 147 PF00069 0.495
MOD_Plk_2-3 331 337 PF00069 0.456
MOD_Plk_4 104 110 PF00069 0.445
MOD_Plk_4 14 20 PF00069 0.472
MOD_Plk_4 489 495 PF00069 0.535
MOD_Plk_4 598 604 PF00069 0.672
MOD_Plk_4 78 84 PF00069 0.441
MOD_ProDKin_1 101 107 PF00069 0.431
MOD_ProDKin_1 562 568 PF00069 0.552
MOD_ProDKin_1 629 635 PF00069 0.802
MOD_SUMO_for_1 84 87 PF00179 0.468
MOD_SUMO_rev_2 337 345 PF00179 0.468
TRG_DiLeu_BaEn_2 86 92 PF01217 0.560
TRG_ENDOCYTIC_2 165 168 PF00928 0.391
TRG_ENDOCYTIC_2 221 224 PF00928 0.432
TRG_ENDOCYTIC_2 233 236 PF00928 0.369
TRG_ENDOCYTIC_2 290 293 PF00928 0.391
TRG_ENDOCYTIC_2 298 301 PF00928 0.418
TRG_ENDOCYTIC_2 336 339 PF00928 0.381
TRG_ER_diArg_1 161 164 PF00400 0.392
TRG_ER_diArg_1 168 170 PF00400 0.405
TRG_ER_diArg_1 180 182 PF00400 0.388
TRG_ER_diArg_1 221 223 PF00400 0.466
TRG_ER_diArg_1 26 29 PF00400 0.474
TRG_ER_diArg_1 283 286 PF00400 0.393
TRG_ER_diArg_1 453 455 PF00400 0.547
TRG_NLS_MonoExtC_3 494 499 PF00514 0.451
TRG_Pf-PMV_PEXEL_1 553 557 PF00026 0.530
TRG_PTS1 652 655 PF00515 0.769

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I655 Leptomonas seymouri 76% 99%
A0A0S4JKP6 Bodo saltans 55% 100%
A0A1X0NU53 Trypanosomatidae 66% 95%
A0A3R7NKZ5 Trypanosoma rangeli 61% 96%
A0A3S7WTG4 Leishmania donovani 100% 100%
A4H846 Leishmania braziliensis 90% 100%
C9ZXX4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 98%
E9AQ76 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QFA7 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS