LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
protein kinase - putativeGeneDB:LmjF.15.0770
Species:
Leishmania infantum
UniProt:
A4HWH3_LEIIN
TriTrypDb:
LINF_150015500
Length:
660

Annotations

Annotations by Jardim et al.

Protein kinase, kinase, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 482, 483
Promastigote/Amastigote: 474

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HWH3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWH3

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 8
GO:0006793 phosphorus metabolic process 3 8
GO:0006796 phosphate-containing compound metabolic process 4 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0009987 cellular process 1 8
GO:0016310 phosphorylation 5 8
GO:0019538 protein metabolic process 3 8
GO:0036211 protein modification process 4 8
GO:0043170 macromolecule metabolic process 3 8
GO:0043412 macromolecule modification 4 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0071704 organic substance metabolic process 2 8
GO:1901564 organonitrogen compound metabolic process 3 8
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004713 protein tyrosine kinase activity 4 4
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 389 393 PF00656 0.549
CLV_NRD_NRD_1 15 17 PF00675 0.607
CLV_NRD_NRD_1 151 153 PF00675 0.243
CLV_NRD_NRD_1 463 465 PF00675 0.578
CLV_PCSK_KEX2_1 15 17 PF00082 0.555
CLV_PCSK_KEX2_1 151 153 PF00082 0.243
CLV_PCSK_KEX2_1 261 263 PF00082 0.229
CLV_PCSK_KEX2_1 463 465 PF00082 0.506
CLV_PCSK_KEX2_1 651 653 PF00082 0.542
CLV_PCSK_KEX2_1 94 96 PF00082 0.229
CLV_PCSK_PC1ET2_1 261 263 PF00082 0.229
CLV_PCSK_PC1ET2_1 651 653 PF00082 0.542
CLV_PCSK_PC1ET2_1 94 96 PF00082 0.229
CLV_PCSK_PC7_1 647 653 PF00082 0.556
CLV_PCSK_SKI1_1 463 467 PF00082 0.495
CLV_PCSK_SKI1_1 497 501 PF00082 0.653
CLV_PCSK_SKI1_1 535 539 PF00082 0.658
CLV_PCSK_SKI1_1 95 99 PF00082 0.229
DEG_APCC_KENBOX_2 293 297 PF00400 0.210
DEG_Nend_UBRbox_3 1 3 PF02207 0.578
DOC_CYCLIN_RxL_1 83 96 PF00134 0.260
DOC_CYCLIN_yCln2_LP_2 282 288 PF00134 0.325
DOC_MAPK_gen_1 194 203 PF00069 0.360
DOC_MAPK_MEF2A_6 131 140 PF00069 0.248
DOC_PP2B_LxvP_1 282 285 PF13499 0.219
DOC_PP4_FxxP_1 249 252 PF00568 0.273
DOC_PP4_FxxP_1 625 628 PF00568 0.672
DOC_USP7_MATH_1 176 180 PF00917 0.251
DOC_USP7_MATH_1 305 309 PF00917 0.222
DOC_USP7_MATH_1 479 483 PF00917 0.638
DOC_USP7_MATH_1 556 560 PF00917 0.632
DOC_USP7_MATH_1 638 642 PF00917 0.562
DOC_WW_Pin1_4 471 476 PF00397 0.639
DOC_WW_Pin1_4 505 510 PF00397 0.611
DOC_WW_Pin1_4 519 524 PF00397 0.635
LIG_14-3-3_CanoR_1 151 161 PF00244 0.326
LIG_14-3-3_CanoR_1 164 170 PF00244 0.360
LIG_14-3-3_CanoR_1 647 655 PF00244 0.568
LIG_AP2alpha_1 500 504 PF02296 0.527
LIG_AP2alpha_1 655 659 PF02296 0.569
LIG_AP2alpha_2 256 258 PF02296 0.360
LIG_AP2alpha_2 653 655 PF02296 0.517
LIG_BRCT_BRCA1_1 540 544 PF00533 0.757
LIG_deltaCOP1_diTrp_1 295 301 PF00928 0.340
LIG_deltaCOP1_diTrp_1 357 362 PF00928 0.451
LIG_FHA_1 176 182 PF00498 0.246
LIG_FHA_1 308 314 PF00498 0.255
LIG_FHA_1 621 627 PF00498 0.684
LIG_FHA_1 79 85 PF00498 0.342
LIG_FHA_2 164 170 PF00498 0.360
LIG_FHA_2 190 196 PF00498 0.342
LIG_FHA_2 228 234 PF00498 0.360
LIG_FHA_2 352 358 PF00498 0.470
LIG_Integrin_isoDGR_2 417 419 PF01839 0.571
LIG_LIR_Apic_2 382 386 PF02991 0.638
LIG_LIR_Apic_2 623 628 PF02991 0.678
LIG_LIR_Gen_1 327 337 PF02991 0.294
LIG_LIR_Gen_1 498 507 PF02991 0.591
LIG_LIR_Gen_1 653 659 PF02991 0.523
LIG_LIR_Gen_1 72 78 PF02991 0.233
LIG_LIR_Nem_3 327 332 PF02991 0.300
LIG_LIR_Nem_3 335 340 PF02991 0.304
LIG_LIR_Nem_3 400 406 PF02991 0.529
LIG_LIR_Nem_3 498 503 PF02991 0.590
LIG_LIR_Nem_3 653 658 PF02991 0.519
LIG_LIR_Nem_3 72 77 PF02991 0.249
LIG_LIR_Nem_3 96 100 PF02991 0.248
LIG_LYPXL_yS_3 555 558 PF13949 0.571
LIG_MAD2 368 376 PF02301 0.566
LIG_MYND_1 549 553 PF01753 0.526
LIG_Pex14_1 297 301 PF04695 0.360
LIG_Pex14_2 500 504 PF04695 0.527
LIG_Pex14_2 655 659 PF04695 0.525
LIG_PTAP_UEV_1 522 527 PF05743 0.599
LIG_PTB_Apo_2 243 250 PF02174 0.342
LIG_SH2_CRK 150 154 PF00017 0.273
LIG_SH2_CRK 608 612 PF00017 0.618
LIG_SH2_NCK_1 383 387 PF00017 0.652
LIG_SH2_NCK_1 608 612 PF00017 0.677
LIG_SH2_PTP2 74 77 PF00017 0.248
LIG_SH2_SRC 183 186 PF00017 0.235
LIG_SH2_SRC 608 611 PF00017 0.621
LIG_SH2_STAP1 309 313 PF00017 0.303
LIG_SH2_STAT3 585 588 PF00017 0.641
LIG_SH2_STAT5 144 147 PF00017 0.229
LIG_SH2_STAT5 183 186 PF00017 0.229
LIG_SH2_STAT5 281 284 PF00017 0.243
LIG_SH2_STAT5 309 312 PF00017 0.229
LIG_SH2_STAT5 74 77 PF00017 0.248
LIG_SH3_1 608 614 PF00018 0.564
LIG_SH3_3 282 288 PF00018 0.377
LIG_SH3_3 296 302 PF00018 0.402
LIG_SH3_3 37 43 PF00018 0.450
LIG_SH3_3 373 379 PF00018 0.574
LIG_SH3_3 473 479 PF00018 0.676
LIG_SH3_3 50 56 PF00018 0.434
LIG_SH3_3 517 523 PF00018 0.616
LIG_SH3_3 550 556 PF00018 0.609
LIG_SH3_3 607 613 PF00018 0.625
LIG_SH3_3 82 88 PF00018 0.316
LIG_SUMO_SIM_anti_2 109 114 PF11976 0.273
LIG_SUMO_SIM_anti_2 34 41 PF11976 0.315
LIG_TRAF2_1 230 233 PF00917 0.360
LIG_TRAF2_1 397 400 PF00917 0.583
LIG_TRAF2_1 428 431 PF00917 0.664
LIG_WRC_WIRS_1 348 353 PF05994 0.394
LIG_WW_1 54 57 PF00397 0.509
MOD_CK1_1 127 133 PF00069 0.272
MOD_CK1_1 156 162 PF00069 0.325
MOD_CK1_1 308 314 PF00069 0.368
MOD_CK1_1 7 13 PF00069 0.557
MOD_CK2_1 111 117 PF00069 0.421
MOD_CK2_1 127 133 PF00069 0.286
MOD_CK2_1 163 169 PF00069 0.360
MOD_CK2_1 227 233 PF00069 0.393
MOD_CK2_1 351 357 PF00069 0.447
MOD_CK2_1 379 385 PF00069 0.596
MOD_CK2_1 394 400 PF00069 0.459
MOD_GlcNHglycan 155 158 PF01048 0.351
MOD_GlcNHglycan 178 181 PF01048 0.309
MOD_GlcNHglycan 20 23 PF01048 0.593
MOD_GlcNHglycan 396 399 PF01048 0.531
MOD_GlcNHglycan 481 485 PF01048 0.689
MOD_GlcNHglycan 505 508 PF01048 0.627
MOD_GlcNHglycan 523 526 PF01048 0.741
MOD_GlcNHglycan 538 541 PF01048 0.622
MOD_GlcNHglycan 546 549 PF01048 0.594
MOD_GlcNHglycan 574 577 PF01048 0.597
MOD_GlcNHglycan 9 12 PF01048 0.559
MOD_GSK3_1 152 159 PF00069 0.313
MOD_GSK3_1 300 307 PF00069 0.377
MOD_GSK3_1 347 354 PF00069 0.419
MOD_GSK3_1 390 397 PF00069 0.519
MOD_GSK3_1 503 510 PF00069 0.634
MOD_GSK3_1 538 545 PF00069 0.692
MOD_GSK3_1 638 645 PF00069 0.627
MOD_N-GLC_1 219 224 PF02516 0.351
MOD_NEK2_1 136 141 PF00069 0.229
MOD_NEK2_1 175 180 PF00069 0.294
MOD_NEK2_1 332 337 PF00069 0.282
MOD_NEK2_1 351 356 PF00069 0.473
MOD_NEK2_1 4 9 PF00069 0.590
MOD_NEK2_1 503 508 PF00069 0.622
MOD_NEK2_1 543 548 PF00069 0.655
MOD_NEK2_1 557 562 PF00069 0.407
MOD_NEK2_1 93 98 PF00069 0.273
MOD_NEK2_2 309 314 PF00069 0.202
MOD_PIKK_1 300 306 PF00454 0.197
MOD_PIKK_1 512 518 PF00454 0.608
MOD_PIKK_1 632 638 PF00454 0.749
MOD_PKA_2 153 159 PF00069 0.310
MOD_PKA_2 163 169 PF00069 0.365
MOD_PKA_2 62 68 PF00069 0.423
MOD_PKA_2 646 652 PF00069 0.711
MOD_Plk_4 33 39 PF00069 0.336
MOD_Plk_4 507 513 PF00069 0.536
MOD_Plk_4 70 76 PF00069 0.297
MOD_ProDKin_1 471 477 PF00069 0.645
MOD_ProDKin_1 505 511 PF00069 0.612
MOD_ProDKin_1 519 525 PF00069 0.636
MOD_SUMO_rev_2 111 121 PF00179 0.366
MOD_SUMO_rev_2 360 370 PF00179 0.459
TRG_DiLeu_BaEn_1 35 40 PF01217 0.281
TRG_ENDOCYTIC_2 150 153 PF00928 0.273
TRG_ENDOCYTIC_2 277 280 PF00928 0.229
TRG_ENDOCYTIC_2 281 284 PF00928 0.229
TRG_ENDOCYTIC_2 337 340 PF00928 0.382
TRG_ENDOCYTIC_2 403 406 PF00928 0.492
TRG_ENDOCYTIC_2 555 558 PF00928 0.633
TRG_ENDOCYTIC_2 74 77 PF00928 0.270
TRG_ER_diArg_1 150 152 PF00400 0.243
TRG_ER_diArg_1 462 464 PF00400 0.634
TRG_NLS_MonoExtC_3 259 265 PF00514 0.360
TRG_NLS_MonoExtN_4 257 264 PF00514 0.360
TRG_Pf-PMV_PEXEL_1 394 399 PF00026 0.724

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I7R8 Leptomonas seymouri 63% 94%
A0A1X0NUC1 Trypanosomatidae 44% 87%
A0A3S7WTG9 Leishmania donovani 100% 100%
A0A422NRC0 Trypanosoma rangeli 41% 97%
A4H848 Leishmania braziliensis 67% 99%
C9ZXX7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9AQ75 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 99%
Q4QFA8 Leishmania major 90% 100%
V5BK24 Trypanosoma cruzi 41% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS