Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWH2_LEIIN

TriTrypDb:

LINF_150015300

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	509	513	PF00656	0.580
CLV_C14_Caspase3-7	600	604	PF00656	0.719
CLV_C14_Caspase3-7	610	614	PF00656	0.594
CLV_C14_Caspase3-7	658	662	PF00656	0.676
CLV_NRD_NRD_1	174	176	PF00675	0.762
CLV_NRD_NRD_1	362	364	PF00675	0.573
CLV_NRD_NRD_1	421	423	PF00675	0.741
CLV_NRD_NRD_1	470	472	PF00675	0.583
CLV_NRD_NRD_1	577	579	PF00675	0.647
CLV_NRD_NRD_1	581	583	PF00675	0.693
CLV_NRD_NRD_1	589	591	PF00675	0.618
CLV_NRD_NRD_1	611	613	PF00675	0.558
CLV_PCSK_KEX2_1	174	176	PF00082	0.762
CLV_PCSK_KEX2_1	362	364	PF00082	0.573
CLV_PCSK_KEX2_1	421	423	PF00082	0.741
CLV_PCSK_KEX2_1	470	472	PF00082	0.579
CLV_PCSK_KEX2_1	577	579	PF00082	0.654
CLV_PCSK_KEX2_1	581	583	PF00082	0.686
CLV_PCSK_KEX2_1	589	591	PF00082	0.611
CLV_PCSK_KEX2_1	611	613	PF00082	0.558
CLV_PCSK_PC7_1	417	423	PF00082	0.735
CLV_PCSK_PC7_1	577	583	PF00082	0.611
CLV_PCSK_SKI1_1	478	482	PF00082	0.489
DEG_APCC_DBOX_1	497	505	PF00400	0.516
DEG_SCF_FBW7_1	229	234	PF00400	0.710
DEG_SPOP_SBC_1	165	169	PF00917	0.721
DEG_SPOP_SBC_1	187	191	PF00917	0.621
DEG_SPOP_SBC_1	204	208	PF00917	0.611
DOC_CKS1_1	309	314	PF01111	0.733
DOC_CKS1_1	465	470	PF01111	0.544
DOC_CKS1_1	92	97	PF01111	0.601
DOC_MAPK_gen_1	498	506	PF00069	0.476
DOC_PP2B_LxvP_1	163	166	PF13499	0.606
DOC_PP2B_LxvP_1	342	345	PF13499	0.594
DOC_PP2B_LxvP_1	543	546	PF13499	0.626
DOC_PP2B_LxvP_1	637	640	PF13499	0.695
DOC_PP4_FxxP_1	650	653	PF00568	0.528
DOC_SPAK_OSR1_1	338	342	PF12202	0.620
DOC_USP7_MATH_1	112	116	PF00917	0.679
DOC_USP7_MATH_1	150	154	PF00917	0.672
DOC_USP7_MATH_1	166	170	PF00917	0.575
DOC_USP7_MATH_1	187	191	PF00917	0.608
DOC_USP7_MATH_1	412	416	PF00917	0.712
DOC_USP7_MATH_1	420	424	PF00917	0.635
DOC_USP7_MATH_1	522	526	PF00917	0.704
DOC_USP7_MATH_1	546	550	PF00917	0.645
DOC_USP7_MATH_1	58	62	PF00917	0.619
DOC_USP7_MATH_1	580	584	PF00917	0.681
DOC_USP7_MATH_1	614	618	PF00917	0.681
DOC_USP7_MATH_1	653	657	PF00917	0.661
DOC_WW_Pin1_4	167	172	PF00397	0.720
DOC_WW_Pin1_4	188	193	PF00397	0.734
DOC_WW_Pin1_4	214	219	PF00397	0.776
DOC_WW_Pin1_4	227	232	PF00397	0.527
DOC_WW_Pin1_4	249	254	PF00397	0.775
DOC_WW_Pin1_4	263	268	PF00397	0.626
DOC_WW_Pin1_4	302	307	PF00397	0.647
DOC_WW_Pin1_4	308	313	PF00397	0.683
DOC_WW_Pin1_4	464	469	PF00397	0.615
DOC_WW_Pin1_4	518	523	PF00397	0.682
DOC_WW_Pin1_4	52	57	PF00397	0.739
DOC_WW_Pin1_4	91	96	PF00397	0.660
LIG_14-3-3_CanoR_1	362	370	PF00244	0.711
LIG_14-3-3_CanoR_1	411	420	PF00244	0.678
LIG_14-3-3_CanoR_1	421	430	PF00244	0.596
LIG_14-3-3_CanoR_1	632	638	PF00244	0.692
LIG_AP2alpha_2	551	553	PF02296	0.534
LIG_APCC_ABBA_1	644	649	PF00400	0.575
LIG_Clathr_ClatBox_1	645	649	PF01394	0.621
LIG_deltaCOP1_diTrp_1	482	491	PF00928	0.539
LIG_EVH1_1	342	346	PF00568	0.589
LIG_EVH1_2	344	348	PF00568	0.572
LIG_FHA_1	224	230	PF00498	0.737
LIG_FHA_1	538	544	PF00498	0.614
LIG_FHA_1	563	569	PF00498	0.489
LIG_FHA_1	632	638	PF00498	0.726
LIG_FHA_2	367	373	PF00498	0.723
LIG_FHA_2	593	599	PF00498	0.722
LIG_Integrin_RGD_1	403	405	PF01839	0.597
LIG_LIR_Apic_2	622	626	PF02991	0.629
LIG_LIR_Apic_2	649	653	PF02991	0.535
LIG_LIR_Gen_1	349	359	PF02991	0.615
LIG_LIR_Gen_1	482	492	PF02991	0.506
LIG_LIR_Nem_3	347	351	PF02991	0.582
LIG_LIR_Nem_3	425	430	PF02991	0.651
LIG_LIR_Nem_3	482	487	PF02991	0.534
LIG_PDZ_Class_2	660	665	PF00595	0.725
LIG_Pex14_2	351	355	PF04695	0.587
LIG_PTAP_UEV_1	41	46	PF05743	0.620
LIG_SH2_CRK	477	481	PF00017	0.512
LIG_SH2_CRK	487	491	PF00017	0.436
LIG_SH2_NCK_1	623	627	PF00017	0.631
LIG_SH2_STAT5	93	96	PF00017	0.652
LIG_SH3_1	340	346	PF00018	0.586
LIG_SH3_3	100	106	PF00018	0.710
LIG_SH3_3	17	23	PF00018	0.714
LIG_SH3_3	247	253	PF00018	0.730
LIG_SH3_3	298	304	PF00018	0.719
LIG_SH3_3	306	312	PF00018	0.657
LIG_SH3_3	338	344	PF00018	0.649
LIG_SH3_3	39	45	PF00018	0.646
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.556
LIG_TRAF2_1	45	48	PF00917	0.755
LIG_TRAF2_1	627	630	PF00917	0.765
MOD_CDK_SPxK_1	464	470	PF00069	0.525
MOD_CDK_SPxxK_3	167	174	PF00069	0.692
MOD_CDK_SPxxK_3	464	471	PF00069	0.519
MOD_CK1_1	11	17	PF00069	0.637
MOD_CK1_1	111	117	PF00069	0.752
MOD_CK1_1	129	135	PF00069	0.578
MOD_CK1_1	185	191	PF00069	0.682
MOD_CK1_1	208	214	PF00069	0.765
MOD_CK1_1	252	258	PF00069	0.731
MOD_CK1_1	302	308	PF00069	0.730
MOD_CK1_1	365	371	PF00069	0.760
MOD_CK1_1	375	381	PF00069	0.649
MOD_CK1_1	460	466	PF00069	0.727
MOD_CK1_1	604	610	PF00069	0.744
MOD_CK1_1	616	622	PF00069	0.635
MOD_CK1_1	654	660	PF00069	0.741
MOD_CK2_1	130	136	PF00069	0.770
MOD_CK2_1	366	372	PF00069	0.719
MOD_CK2_1	410	416	PF00069	0.707
MOD_CK2_1	428	434	PF00069	0.734
MOD_CK2_1	463	469	PF00069	0.707
MOD_CK2_1	490	496	PF00069	0.527
MOD_CK2_1	604	610	PF00069	0.773
MOD_CK2_1	624	630	PF00069	0.495
MOD_GlcNHglycan	110	113	PF01048	0.574
MOD_GlcNHglycan	151	155	PF01048	0.666
MOD_GlcNHglycan	183	187	PF01048	0.761
MOD_GlcNHglycan	208	211	PF01048	0.685
MOD_GlcNHglycan	260	263	PF01048	0.768
MOD_GlcNHglycan	364	367	PF01048	0.687
MOD_GlcNHglycan	422	425	PF01048	0.727
MOD_GlcNHglycan	430	433	PF01048	0.665
MOD_GlcNHglycan	459	462	PF01048	0.717
MOD_GlcNHglycan	524	527	PF01048	0.681
MOD_GlcNHglycan	548	551	PF01048	0.586
MOD_GlcNHglycan	606	609	PF01048	0.741
MOD_GlcNHglycan	626	629	PF01048	0.526
MOD_GlcNHglycan	653	656	PF01048	0.727
MOD_GlcNHglycan	96	99	PF01048	0.716
MOD_GSK3_1	108	115	PF00069	0.776
MOD_GSK3_1	126	133	PF00069	0.525
MOD_GSK3_1	150	157	PF00069	0.684
MOD_GSK3_1	161	168	PF00069	0.638
MOD_GSK3_1	174	181	PF00069	0.651
MOD_GSK3_1	182	189	PF00069	0.665
MOD_GSK3_1	204	211	PF00069	0.788
MOD_GSK3_1	223	230	PF00069	0.782
MOD_GSK3_1	295	302	PF00069	0.749
MOD_GSK3_1	311	318	PF00069	0.547
MOD_GSK3_1	357	364	PF00069	0.605
MOD_GSK3_1	371	378	PF00069	0.636
MOD_GSK3_1	460	467	PF00069	0.680
MOD_GSK3_1	518	525	PF00069	0.624
MOD_GSK3_1	537	544	PF00069	0.486
MOD_GSK3_1	59	66	PF00069	0.686
MOD_GSK3_1	651	658	PF00069	0.721
MOD_GSK3_1	8	15	PF00069	0.645
MOD_N-GLC_1	357	362	PF02516	0.608
MOD_N-GLC_1	59	64	PF02516	0.600
MOD_NEK2_1	161	166	PF00069	0.739
MOD_NEK2_1	203	208	PF00069	0.742
MOD_NEK2_1	213	218	PF00069	0.680
MOD_NEK2_1	223	228	PF00069	0.639
MOD_NEK2_1	294	299	PF00069	0.709
MOD_NEK2_1	354	359	PF00069	0.643
MOD_NEK2_1	410	415	PF00069	0.753
MOD_NEK2_1	633	638	PF00069	0.773
MOD_NEK2_1	648	653	PF00069	0.496
MOD_PIKK_1	377	383	PF00454	0.742
MOD_PIKK_1	43	49	PF00454	0.756
MOD_PIKK_1	655	661	PF00454	0.582
MOD_PK_1	174	180	PF00069	0.762
MOD_PKA_1	174	180	PF00069	0.762
MOD_PKA_1	362	368	PF00069	0.599
MOD_PKA_2	174	180	PF00069	0.762
MOD_PKA_2	361	367	PF00069	0.709
MOD_PKA_2	410	416	PF00069	0.766
MOD_PKA_2	420	426	PF00069	0.607
MOD_PKA_2	457	463	PF00069	0.745
MOD_PKA_2	580	586	PF00069	0.686
MOD_PKA_2	631	637	PF00069	0.695
MOD_Plk_1	454	460	PF00069	0.710
MOD_Plk_1	648	654	PF00069	0.699
MOD_Plk_4	174	180	PF00069	0.795
MOD_Plk_4	208	214	PF00069	0.742
MOD_Plk_4	318	324	PF00069	0.594
MOD_Plk_4	562	568	PF00069	0.471
MOD_Plk_4	63	69	PF00069	0.692
MOD_Plk_4	96	102	PF00069	0.715
MOD_ProDKin_1	167	173	PF00069	0.723
MOD_ProDKin_1	188	194	PF00069	0.733
MOD_ProDKin_1	214	220	PF00069	0.773
MOD_ProDKin_1	227	233	PF00069	0.526
MOD_ProDKin_1	249	255	PF00069	0.774
MOD_ProDKin_1	263	269	PF00069	0.624
MOD_ProDKin_1	302	308	PF00069	0.649
MOD_ProDKin_1	464	470	PF00069	0.608
MOD_ProDKin_1	518	524	PF00069	0.690
MOD_ProDKin_1	52	58	PF00069	0.737
MOD_ProDKin_1	91	97	PF00069	0.660
TRG_DiLeu_BaLyEn_6	78	83	PF01217	0.666
TRG_ENDOCYTIC_2	477	480	PF00928	0.547
TRG_ENDOCYTIC_2	487	490	PF00928	0.411
TRG_ER_diArg_1	174	176	PF00400	0.762
TRG_ER_diArg_1	420	422	PF00400	0.736
TRG_ER_diArg_1	497	500	PF00400	0.507
TRG_ER_diArg_1	577	579	PF00400	0.687
TRG_ER_diArg_1	580	582	PF00400	0.718
TRG_ER_diArg_1	588	590	PF00400	0.639
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTM2	Leishmania donovani	99%	100%
A4H850	Leishmania braziliensis	57%	93%
E9AQ73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	93%
Q4QFB0	Leishmania major	87%	99%