Histidine protein methyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4HWH0_LEIIN

TriTrypDb:

LINF_150014700

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWH0

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.765
CLV_C14_Caspase3-7	216	220	PF00656	0.572
CLV_NRD_NRD_1	260	262	PF00675	0.528
CLV_NRD_NRD_1	322	324	PF00675	0.376
CLV_PCSK_FUR_1	258	262	PF00082	0.538
CLV_PCSK_KEX2_1	221	223	PF00082	0.440
CLV_PCSK_KEX2_1	257	259	PF00082	0.611
CLV_PCSK_KEX2_1	260	262	PF00082	0.453
CLV_PCSK_KEX2_1	322	324	PF00082	0.376
CLV_PCSK_KEX2_1	461	463	PF00082	0.566
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.440
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.611
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.586
CLV_PCSK_SKI1_1	17	21	PF00082	0.449
CLV_PCSK_SKI1_1	2	6	PF00082	0.491
CLV_PCSK_SKI1_1	200	204	PF00082	0.611
CLV_PCSK_SKI1_1	293	297	PF00082	0.444
CLV_PCSK_SKI1_1	323	327	PF00082	0.376
DEG_Nend_UBRbox_1	1	4	PF02207	0.496
DEG_SCF_FBW7_1	248	255	PF00400	0.763
DEG_SPOP_SBC_1	133	137	PF00917	0.793
DEG_SPOP_SBC_1	384	388	PF00917	0.626
DOC_ANK_TNKS_1	260	267	PF00023	0.467
DOC_CKS1_1	78	83	PF01111	0.446
DOC_CYCLIN_RxL_1	288	297	PF00134	0.501
DOC_MAPK_DCC_7	58	68	PF00069	0.459
DOC_MAPK_FxFP_2	111	114	PF00069	0.588
DOC_MAPK_JIP1_4	193	199	PF00069	0.527
DOC_MAPK_MEF2A_6	468	476	PF00069	0.480
DOC_MAPK_MEF2A_6	58	67	PF00069	0.647
DOC_PP1_RVXF_1	15	21	PF00149	0.442
DOC_PP1_RVXF_1	320	327	PF00149	0.376
DOC_PP4_FxxP_1	111	114	PF00568	0.651
DOC_PP4_FxxP_1	115	118	PF00568	0.603
DOC_PP4_FxxP_1	19	22	PF00568	0.486
DOC_PP4_FxxP_1	31	34	PF00568	0.434
DOC_PP4_FxxP_1	75	78	PF00568	0.457
DOC_USP7_MATH_1	132	136	PF00917	0.703
DOC_USP7_MATH_1	161	165	PF00917	0.533
DOC_USP7_MATH_1	214	218	PF00917	0.722
DOC_USP7_MATH_1	220	224	PF00917	0.583
DOC_USP7_MATH_1	252	256	PF00917	0.698
DOC_USP7_MATH_1	348	352	PF00917	0.514
DOC_USP7_MATH_1	384	388	PF00917	0.616
DOC_USP7_MATH_2	211	217	PF00917	0.606
DOC_WW_Pin1_4	114	119	PF00397	0.577
DOC_WW_Pin1_4	143	148	PF00397	0.640
DOC_WW_Pin1_4	20	25	PF00397	0.424
DOC_WW_Pin1_4	230	235	PF00397	0.590
DOC_WW_Pin1_4	244	249	PF00397	0.664
DOC_WW_Pin1_4	30	35	PF00397	0.422
DOC_WW_Pin1_4	359	364	PF00397	0.588
DOC_WW_Pin1_4	59	64	PF00397	0.456
DOC_WW_Pin1_4	77	82	PF00397	0.414
DOC_WW_Pin1_4	84	89	PF00397	0.431
LIG_14-3-3_CanoR_1	2	11	PF00244	0.515
LIG_14-3-3_CanoR_1	49	57	PF00244	0.464
LIG_ActinCP_TwfCPI_2	75	85	PF01115	0.452
LIG_APCC_ABBAyCdc20_2	322	328	PF00400	0.353
LIG_BRCT_BRCA1_1	222	226	PF00533	0.544
LIG_BRCT_BRCA1_1	50	54	PF00533	0.455
LIG_BRCT_BRCA1_1	86	90	PF00533	0.480
LIG_CSL_BTD_1	149	152	PF09270	0.572
LIG_deltaCOP1_diTrp_1	373	379	PF00928	0.415
LIG_EVH1_1	31	35	PF00568	0.430
LIG_FHA_1	190	196	PF00498	0.602
LIG_FHA_1	359	365	PF00498	0.564
LIG_FHA_1	425	431	PF00498	0.527
LIG_FHA_1	95	101	PF00498	0.505
LIG_FHA_2	126	132	PF00498	0.791
LIG_FHA_2	167	173	PF00498	0.500
LIG_FHA_2	230	236	PF00498	0.590
LIG_GBD_Chelix_1	413	421	PF00786	0.402
LIG_HP1_1	161	165	PF01393	0.586
LIG_LIR_Gen_1	159	170	PF02991	0.591
LIG_LIR_Gen_1	373	380	PF02991	0.427
LIG_LIR_Gen_1	392	399	PF02991	0.469
LIG_LIR_Gen_1	51	61	PF02991	0.456
LIG_LIR_Nem_3	157	163	PF02991	0.593
LIG_LIR_Nem_3	373	377	PF02991	0.413
LIG_LIR_Nem_3	392	397	PF02991	0.479
LIG_LIR_Nem_3	51	57	PF02991	0.455
LIG_LIR_Nem_3	87	93	PF02991	0.481
LIG_PCNA_yPIPBox_3	193	203	PF02747	0.368
LIG_Pex14_1	420	424	PF04695	0.460
LIG_Pex14_2	111	115	PF04695	0.638
LIG_SH2_CRK	269	273	PF00017	0.376
LIG_SH2_CRK	292	296	PF00017	0.430
LIG_SH2_STAT5	284	287	PF00017	0.385
LIG_SH2_STAT5	424	427	PF00017	0.478
LIG_SH2_STAT5	436	439	PF00017	0.414
LIG_SH2_STAT5	443	446	PF00017	0.429
LIG_SH3_3	141	147	PF00018	0.638
LIG_SH3_3	19	25	PF00018	0.640
LIG_SH3_3	29	35	PF00018	0.543
LIG_SH3_3	75	81	PF00018	0.692
MOD_CK1_1	117	123	PF00069	0.750
MOD_CK1_1	135	141	PF00069	0.675
MOD_CK1_1	156	162	PF00069	0.529
MOD_CK1_1	164	170	PF00069	0.526
MOD_CK1_1	378	384	PF00069	0.569
MOD_CK1_1	401	407	PF00069	0.461
MOD_CK1_1	52	58	PF00069	0.455
MOD_CK1_1	79	85	PF00069	0.448
MOD_CK2_1	166	172	PF00069	0.521
MOD_CK2_1	229	235	PF00069	0.490
MOD_CK2_1	291	297	PF00069	0.473
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.449
MOD_GlcNHglycan	105	109	PF01048	0.747
MOD_GlcNHglycan	205	208	PF01048	0.688
MOD_GlcNHglycan	216	219	PF01048	0.616
MOD_GlcNHglycan	254	257	PF01048	0.673
MOD_GlcNHglycan	387	390	PF01048	0.654
MOD_GlcNHglycan	448	451	PF01048	0.490
MOD_GSK3_1	114	121	PF00069	0.686
MOD_GSK3_1	132	139	PF00069	0.742
MOD_GSK3_1	2	9	PF00069	0.518
MOD_GSK3_1	220	227	PF00069	0.564
MOD_GSK3_1	238	245	PF00069	0.517
MOD_GSK3_1	248	255	PF00069	0.541
MOD_GSK3_1	348	355	PF00069	0.548
MOD_GSK3_1	48	55	PF00069	0.457
MOD_GSK3_1	73	80	PF00069	0.494
MOD_LATS_1	47	53	PF00433	0.458
MOD_N-GLC_1	188	193	PF02516	0.497
MOD_N-GLC_1	348	353	PF02516	0.521
MOD_N-GLC_2	335	337	PF02516	0.385
MOD_NEK2_1	104	109	PF00069	0.705
MOD_NEK2_1	352	357	PF00069	0.555
MOD_NEK2_1	474	479	PF00069	0.439
MOD_NEK2_1	48	53	PF00069	0.457
MOD_NEK2_1	93	98	PF00069	0.752
MOD_PIKK_1	242	248	PF00454	0.668
MOD_PIKK_1	352	358	PF00454	0.492
MOD_PIKK_1	378	384	PF00454	0.643
MOD_PIKK_1	6	12	PF00454	0.509
MOD_PIKK_1	94	100	PF00454	0.472
MOD_PKA_2	474	480	PF00069	0.499
MOD_PKA_2	48	54	PF00069	0.464
MOD_PKA_2	6	12	PF00069	0.568
MOD_PKA_2	73	79	PF00069	0.473
MOD_Plk_1	348	354	PF00069	0.533
MOD_Plk_1	375	381	PF00069	0.568
MOD_Plk_1	401	407	PF00069	0.408
MOD_Plk_2-3	166	172	PF00069	0.521
MOD_ProDKin_1	114	120	PF00069	0.578
MOD_ProDKin_1	143	149	PF00069	0.641
MOD_ProDKin_1	20	26	PF00069	0.426
MOD_ProDKin_1	230	236	PF00069	0.587
MOD_ProDKin_1	244	250	PF00069	0.669
MOD_ProDKin_1	30	36	PF00069	0.419
MOD_ProDKin_1	359	365	PF00069	0.567
MOD_ProDKin_1	59	65	PF00069	0.457
MOD_ProDKin_1	77	83	PF00069	0.414
MOD_ProDKin_1	84	90	PF00069	0.432
MOD_SUMO_for_1	256	259	PF00179	0.623
MOD_SUMO_rev_2	213	223	PF00179	0.518
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.566
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.459
TRG_ENDOCYTIC_2	269	272	PF00928	0.412
TRG_ENDOCYTIC_2	292	295	PF00928	0.430
TRG_ENDOCYTIC_2	443	446	PF00928	0.436
TRG_ER_diArg_1	322	324	PF00400	0.376
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G2	Leptomonas seymouri	57%	100%
A0A1X0NU45	Trypanosomatidae	36%	100%
A0A3S7WTG3	Leishmania donovani	99%	100%
A4H852	Leishmania braziliensis	81%	100%
E9AQ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QFB2	Leishmania major	92%	99%