Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWG7_LEIIN

TriTrypDb:

LINF_150014400

Length:

949

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.543
CLV_NRD_NRD_1	210	212	PF00675	0.614
CLV_NRD_NRD_1	214	216	PF00675	0.635
CLV_NRD_NRD_1	227	229	PF00675	0.699
CLV_NRD_NRD_1	350	352	PF00675	0.658
CLV_NRD_NRD_1	367	369	PF00675	0.644
CLV_NRD_NRD_1	420	422	PF00675	0.643
CLV_NRD_NRD_1	461	463	PF00675	0.616
CLV_NRD_NRD_1	487	489	PF00675	0.725
CLV_NRD_NRD_1	642	644	PF00675	0.421
CLV_NRD_NRD_1	846	848	PF00675	0.778
CLV_PCSK_FUR_1	348	352	PF00082	0.668
CLV_PCSK_FUR_1	458	462	PF00082	0.589
CLV_PCSK_KEX2_1	214	216	PF00082	0.632
CLV_PCSK_KEX2_1	226	228	PF00082	0.777
CLV_PCSK_KEX2_1	350	352	PF00082	0.658
CLV_PCSK_KEX2_1	367	369	PF00082	0.644
CLV_PCSK_KEX2_1	420	422	PF00082	0.576
CLV_PCSK_KEX2_1	460	462	PF00082	0.611
CLV_PCSK_KEX2_1	487	489	PF00082	0.725
CLV_PCSK_KEX2_1	642	644	PF00082	0.421
CLV_PCSK_KEX2_1	846	848	PF00082	0.778
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.730
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.574
CLV_PCSK_PC7_1	483	489	PF00082	0.641
CLV_PCSK_SKI1_1	127	131	PF00082	0.650
CLV_PCSK_SKI1_1	2	6	PF00082	0.671
CLV_PCSK_SKI1_1	223	227	PF00082	0.719
CLV_PCSK_SKI1_1	263	267	PF00082	0.670
CLV_PCSK_SKI1_1	675	679	PF00082	0.445
CLV_PCSK_SKI1_1	681	685	PF00082	0.392
CLV_PCSK_SKI1_1	779	783	PF00082	0.269
CLV_PCSK_SKI1_1	821	825	PF00082	0.640
DEG_COP1_1	431	439	PF00400	0.430
DEG_Nend_UBRbox_1	1	4	PF02207	0.446
DEG_SCF_TRCP1_1	765	771	PF00400	0.674
DEG_SIAH_1	244	252	PF03145	0.459
DEG_SIAH_1	88	96	PF03145	0.443
DEG_SPOP_SBC_1	541	545	PF00917	0.462
DEG_SPOP_SBC_1	711	715	PF00917	0.652
DEG_SPOP_SBC_1	734	738	PF00917	0.673
DOC_CKS1_1	605	610	PF01111	0.490
DOC_CKS1_1	687	692	PF01111	0.622
DOC_CKS1_1	889	894	PF01111	0.482
DOC_CYCLIN_RxL_1	176	186	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	782	788	PF00134	0.304
DOC_MAPK_gen_1	777	786	PF00069	0.469
DOC_MAPK_gen_1	809	817	PF00069	0.422
DOC_MAPK_HePTP_8	776	788	PF00069	0.447
DOC_MAPK_MEF2A_6	772	780	PF00069	0.565
DOC_MAPK_NFAT4_5	777	785	PF00069	0.476
DOC_PIKK_1	895	902	PF02985	0.474
DOC_PP1_RVXF_1	177	184	PF00149	0.444
DOC_PP1_RVXF_1	261	268	PF00149	0.520
DOC_PP2B_LxvP_1	469	472	PF13499	0.442
DOC_PP2B_LxvP_1	782	785	PF13499	0.304
DOC_PP4_FxxP_1	618	621	PF00568	0.293
DOC_USP7_MATH_1	159	163	PF00917	0.492
DOC_USP7_MATH_1	233	237	PF00917	0.525
DOC_USP7_MATH_1	298	302	PF00917	0.465
DOC_USP7_MATH_1	308	312	PF00917	0.460
DOC_USP7_MATH_1	321	325	PF00917	0.424
DOC_USP7_MATH_1	346	350	PF00917	0.474
DOC_USP7_MATH_1	402	406	PF00917	0.466
DOC_USP7_MATH_1	554	558	PF00917	0.512
DOC_USP7_MATH_1	573	577	PF00917	0.452
DOC_USP7_MATH_1	596	600	PF00917	0.533
DOC_USP7_MATH_1	606	610	PF00917	0.449
DOC_USP7_MATH_1	711	715	PF00917	0.692
DOC_USP7_MATH_1	716	720	PF00917	0.786
DOC_USP7_MATH_1	734	738	PF00917	0.751
DOC_USP7_MATH_1	745	749	PF00917	0.758
DOC_WW_Pin1_4	134	139	PF00397	0.510
DOC_WW_Pin1_4	21	26	PF00397	0.473
DOC_WW_Pin1_4	229	234	PF00397	0.539
DOC_WW_Pin1_4	241	246	PF00397	0.456
DOC_WW_Pin1_4	312	317	PF00397	0.523
DOC_WW_Pin1_4	338	343	PF00397	0.458
DOC_WW_Pin1_4	47	52	PF00397	0.527
DOC_WW_Pin1_4	500	505	PF00397	0.476
DOC_WW_Pin1_4	597	602	PF00397	0.564
DOC_WW_Pin1_4	604	609	PF00397	0.471
DOC_WW_Pin1_4	657	662	PF00397	0.561
DOC_WW_Pin1_4	686	691	PF00397	0.609
DOC_WW_Pin1_4	703	708	PF00397	0.660
DOC_WW_Pin1_4	730	735	PF00397	0.707
DOC_WW_Pin1_4	840	845	PF00397	0.473
DOC_WW_Pin1_4	888	893	PF00397	0.628
DOC_WW_Pin1_4	91	96	PF00397	0.537
DOC_WW_Pin1_4	911	916	PF00397	0.562
LIG_14-3-3_CanoR_1	127	132	PF00244	0.454
LIG_14-3-3_CanoR_1	215	224	PF00244	0.455
LIG_14-3-3_CanoR_1	250	255	PF00244	0.496
LIG_14-3-3_CanoR_1	319	327	PF00244	0.448
LIG_14-3-3_CanoR_1	460	469	PF00244	0.489
LIG_14-3-3_CanoR_1	669	675	PF00244	0.561
LIG_14-3-3_CanoR_1	812	816	PF00244	0.437
LIG_14-3-3_CanoR_1	866	876	PF00244	0.468
LIG_APCC_ABBA_1	264	269	PF00400	0.473
LIG_APCC_ABBAyCdc20_2	263	269	PF00400	0.472
LIG_BIR_III_2	501	505	PF00653	0.481
LIG_BIR_III_4	39	43	PF00653	0.488
LIG_BIR_III_4	725	729	PF00653	0.685
LIG_BRCT_BRCA1_1	447	451	PF00533	0.399
LIG_BRCT_BRCA1_1	556	560	PF00533	0.526
LIG_BRCT_BRCA1_1	813	817	PF00533	0.418
LIG_deltaCOP1_diTrp_1	55	63	PF00928	0.455
LIG_deltaCOP1_diTrp_1	753	759	PF00928	0.641
LIG_FHA_1	104	110	PF00498	0.548
LIG_FHA_1	120	126	PF00498	0.377
LIG_FHA_1	161	167	PF00498	0.485
LIG_FHA_1	269	275	PF00498	0.477
LIG_FHA_1	430	436	PF00498	0.436
LIG_FHA_1	649	655	PF00498	0.566
LIG_FHA_1	687	693	PF00498	0.671
LIG_FHA_1	822	828	PF00498	0.415
LIG_FHA_2	570	576	PF00498	0.477
LIG_FHA_2	820	826	PF00498	0.494
LIG_FHA_2	907	913	PF00498	0.515
LIG_Integrin_RGD_1	391	393	PF01839	0.652
LIG_LIR_Apic_2	607	613	PF02991	0.491
LIG_LIR_Apic_2	706	711	PF02991	0.619
LIG_LIR_Apic_2	934	940	PF02991	0.531
LIG_LIR_Gen_1	361	369	PF02991	0.409
LIG_LIR_Gen_1	822	831	PF02991	0.443
LIG_LIR_Nem_3	301	307	PF02991	0.480
LIG_LIR_Nem_3	361	365	PF02991	0.412
LIG_LIR_Nem_3	535	541	PF02991	0.488
LIG_LIR_Nem_3	55	61	PF02991	0.433
LIG_LIR_Nem_3	753	759	PF02991	0.641
LIG_LIR_Nem_3	822	826	PF02991	0.567
LIG_LIR_Nem_3	829	834	PF02991	0.452
LIG_LIR_Nem_3	933	939	PF02991	0.560
LIG_LYPXL_S_1	303	307	PF13949	0.686
LIG_LYPXL_yS_3	304	307	PF13949	0.489
LIG_NRBOX	180	186	PF00104	0.445
LIG_Pex14_1	295	299	PF04695	0.424
LIG_Pex14_1	362	366	PF04695	0.403
LIG_Pex14_2	451	455	PF04695	0.393
LIG_Pex14_2	624	628	PF04695	0.248
LIG_Pex14_2	679	683	PF04695	0.645
LIG_Pex14_2	755	759	PF04695	0.643
LIG_PTB_Apo_2	405	412	PF02174	0.421
LIG_SH2_CRK	610	614	PF00017	0.490
LIG_SH2_CRK	708	712	PF00017	0.623
LIG_SH2_NCK_1	538	542	PF00017	0.467
LIG_SH2_STAP1	299	303	PF00017	0.444
LIG_SH2_STAP1	425	429	PF00017	0.420
LIG_SH2_STAP1	534	538	PF00017	0.526
LIG_SH2_STAP1	636	640	PF00017	0.590
LIG_SH2_STAP1	752	756	PF00017	0.642
LIG_SH2_STAP1	819	823	PF00017	0.488
LIG_SH2_STAT3	636	639	PF00017	0.587
LIG_SH2_STAT3	717	720	PF00017	0.644
LIG_SH2_STAT5	3	6	PF00017	0.517
LIG_SH2_STAT5	708	711	PF00017	0.718
LIG_SH3_1	227	233	PF00018	0.515
LIG_SH3_2	25	30	PF14604	0.458
LIG_SH3_3	132	138	PF00018	0.547
LIG_SH3_3	22	28	PF00018	0.506
LIG_SH3_3	227	233	PF00018	0.549
LIG_SH3_3	239	245	PF00018	0.476
LIG_SH3_3	310	316	PF00018	0.516
LIG_SH3_3	32	38	PF00018	0.484
LIG_SH3_3	430	436	PF00018	0.430
LIG_SH3_3	467	473	PF00018	0.483
LIG_SH3_3	602	608	PF00018	0.507
LIG_SH3_3	613	619	PF00018	0.239
LIG_SH3_3	783	789	PF00018	0.303
LIG_SUMO_SIM_par_1	431	437	PF11976	0.432
LIG_SUMO_SIM_par_1	649	656	PF11976	0.564
LIG_SUMO_SIM_par_1	804	810	PF11976	0.304
LIG_TRAF2_1	279	282	PF00917	0.436
LIG_TRAF2_1	587	590	PF00917	0.523
LIG_UBA3_1	287	293	PF00899	0.396
LIG_WRC_WIRS_1	113	118	PF05994	0.488
LIG_WW_3	503	507	PF00397	0.482
MOD_CDC14_SPxK_1	503	506	PF00782	0.483
MOD_CDC14_SPxK_1	843	846	PF00782	0.475
MOD_CDK_SPxK_1	500	506	PF00069	0.483
MOD_CDK_SPxK_1	840	846	PF00069	0.476
MOD_CDK_SPxxK_3	241	248	PF00069	0.471
MOD_CDK_SPxxK_3	312	319	PF00069	0.505
MOD_CDK_SPxxK_3	840	847	PF00069	0.478
MOD_CDK_SPxxK_3	91	98	PF00069	0.516
MOD_CK1_1	136	142	PF00069	0.554
MOD_CK1_1	219	225	PF00069	0.514
MOD_CK1_1	232	238	PF00069	0.493
MOD_CK1_1	373	379	PF00069	0.476
MOD_CK1_1	53	59	PF00069	0.439
MOD_CK1_1	536	542	PF00069	0.534
MOD_CK1_1	546	552	PF00069	0.486
MOD_CK1_1	599	605	PF00069	0.472
MOD_CK1_1	634	640	PF00069	0.630
MOD_CK1_1	703	709	PF00069	0.683
MOD_CK1_1	710	716	PF00069	0.662
MOD_CK1_1	737	743	PF00069	0.809
MOD_CK1_1	766	772	PF00069	0.622
MOD_CK1_1	911	917	PF00069	0.496
MOD_CK1_1	928	934	PF00069	0.527
MOD_CK1_1	94	100	PF00069	0.502
MOD_CK1_1	942	948	PF00069	0.561
MOD_CK2_1	346	352	PF00069	0.507
MOD_CK2_1	428	434	PF00069	0.434
MOD_CK2_1	568	574	PF00069	0.534
MOD_CK2_1	928	934	PF00069	0.499
MOD_CMANNOS	454	457	PF00535	0.575
MOD_GlcNHglycan	139	142	PF01048	0.719
MOD_GlcNHglycan	145	148	PF01048	0.705
MOD_GlcNHglycan	185	188	PF01048	0.644
MOD_GlcNHglycan	327	330	PF01048	0.711
MOD_GlcNHglycan	373	376	PF01048	0.635
MOD_GlcNHglycan	65	68	PF01048	0.693
MOD_GlcNHglycan	664	667	PF01048	0.385
MOD_GlcNHglycan	714	717	PF01048	0.483
MOD_GlcNHglycan	722	725	PF01048	0.524
MOD_GlcNHglycan	737	740	PF01048	0.607
MOD_GlcNHglycan	765	768	PF01048	0.442
MOD_GlcNHglycan	800	803	PF01048	0.304
MOD_GlcNHglycan	869	872	PF01048	0.756
MOD_GlcNHglycan	945	948	PF01048	0.681
MOD_GSK3_1	130	137	PF00069	0.504
MOD_GSK3_1	139	146	PF00069	0.528
MOD_GSK3_1	229	236	PF00069	0.561
MOD_GSK3_1	294	301	PF00069	0.435
MOD_GSK3_1	308	315	PF00069	0.429
MOD_GSK3_1	321	328	PF00069	0.463
MOD_GSK3_1	373	380	PF00069	0.460
MOD_GSK3_1	43	50	PF00069	0.503
MOD_GSK3_1	500	507	PF00069	0.477
MOD_GSK3_1	528	535	PF00069	0.489
MOD_GSK3_1	536	543	PF00069	0.486
MOD_GSK3_1	545	552	PF00069	0.486
MOD_GSK3_1	554	561	PF00069	0.494
MOD_GSK3_1	569	576	PF00069	0.507
MOD_GSK3_1	592	599	PF00069	0.475
MOD_GSK3_1	653	660	PF00069	0.551
MOD_GSK3_1	703	710	PF00069	0.659
MOD_GSK3_1	712	719	PF00069	0.669
MOD_GSK3_1	729	736	PF00069	0.710
MOD_GSK3_1	766	773	PF00069	0.633
MOD_GSK3_1	907	914	PF00069	0.528
MOD_GSK3_1	925	932	PF00069	0.417
MOD_GSK3_1	935	942	PF00069	0.497
MOD_GSK3_1	99	106	PF00069	0.459
MOD_N-GLC_1	127	132	PF02516	0.660
MOD_N-GLC_1	308	313	PF02516	0.685
MOD_N-GLC_1	546	551	PF02516	0.700
MOD_N-GLC_1	847	852	PF02516	0.702
MOD_N-GLC_1	920	925	PF02516	0.728
MOD_NEK2_1	183	188	PF00069	0.449
MOD_NEK2_1	287	292	PF00069	0.464
MOD_NEK2_1	428	433	PF00069	0.491
MOD_NEK2_1	43	48	PF00069	0.508
MOD_NEK2_1	442	447	PF00069	0.455
MOD_NEK2_1	553	558	PF00069	0.562
MOD_NEK2_1	670	675	PF00069	0.558
MOD_NEK2_1	754	759	PF00069	0.643
MOD_NEK2_1	798	803	PF00069	0.304
MOD_NEK2_2	554	559	PF00069	0.508
MOD_PIKK_1	119	125	PF00454	0.437
MOD_PIKK_1	463	469	PF00454	0.486
MOD_PIKK_1	599	605	PF00454	0.457
MOD_PIKK_1	716	722	PF00454	0.684
MOD_PKA_1	460	466	PF00069	0.403
MOD_PKA_2	377	383	PF00069	0.588
MOD_PKA_2	460	466	PF00069	0.410
MOD_PKA_2	558	564	PF00069	0.473
MOD_PKA_2	811	817	PF00069	0.426
MOD_PKB_1	248	256	PF00069	0.542
MOD_PKB_1	368	376	PF00069	0.422
MOD_PKB_1	458	466	PF00069	0.397
MOD_Plk_1	127	133	PF00069	0.572
MOD_Plk_1	258	264	PF00069	0.465
MOD_Plk_1	528	534	PF00069	0.475
MOD_Plk_1	648	654	PF00069	0.571
MOD_Plk_1	848	854	PF00069	0.581
MOD_Plk_1	920	926	PF00069	0.495
MOD_Plk_2-3	270	276	PF00069	0.495
MOD_Plk_2-3	393	399	PF00069	0.509
MOD_Plk_2-3	574	580	PF00069	0.530
MOD_Plk_2-3	929	935	PF00069	0.447
MOD_Plk_4	127	133	PF00069	0.572
MOD_Plk_4	250	256	PF00069	0.493
MOD_Plk_4	447	453	PF00069	0.429
MOD_Plk_4	53	59	PF00069	0.481
MOD_Plk_4	631	637	PF00069	0.547
MOD_ProDKin_1	134	140	PF00069	0.511
MOD_ProDKin_1	21	27	PF00069	0.472
MOD_ProDKin_1	229	235	PF00069	0.541
MOD_ProDKin_1	241	247	PF00069	0.456
MOD_ProDKin_1	312	318	PF00069	0.523
MOD_ProDKin_1	338	344	PF00069	0.455
MOD_ProDKin_1	47	53	PF00069	0.523
MOD_ProDKin_1	500	506	PF00069	0.478
MOD_ProDKin_1	597	603	PF00069	0.563
MOD_ProDKin_1	604	610	PF00069	0.471
MOD_ProDKin_1	657	663	PF00069	0.563
MOD_ProDKin_1	686	692	PF00069	0.616
MOD_ProDKin_1	703	709	PF00069	0.662
MOD_ProDKin_1	730	736	PF00069	0.707
MOD_ProDKin_1	840	846	PF00069	0.476
MOD_ProDKin_1	888	894	PF00069	0.627
MOD_ProDKin_1	91	97	PF00069	0.537
MOD_ProDKin_1	911	917	PF00069	0.562
MOD_SUMO_rev_2	219	225	PF00179	0.502
MOD_SUMO_rev_2	66	71	PF00179	0.438
TRG_DiLeu_BaEn_1	283	288	PF01217	0.407
TRG_DiLeu_BaLyEn_6	802	807	PF01217	0.304
TRG_ENDOCYTIC_2	3	6	PF00928	0.581
TRG_ENDOCYTIC_2	304	307	PF00928	0.489
TRG_ENDOCYTIC_2	366	369	PF00928	0.405
TRG_ENDOCYTIC_2	425	428	PF00928	0.411
TRG_ENDOCYTIC_2	538	541	PF00928	0.505
TRG_ENDOCYTIC_2	626	629	PF00928	0.338
TRG_ENDOCYTIC_2	641	644	PF00928	0.681
TRG_ENDOCYTIC_2	752	755	PF00928	0.638
TRG_ENDOCYTIC_2	936	939	PF00928	0.497
TRG_ER_diArg_1	191	194	PF00400	0.547
TRG_ER_diArg_1	248	251	PF00400	0.549
TRG_ER_diArg_1	30	33	PF00400	0.491
TRG_ER_diArg_1	348	351	PF00400	0.602
TRG_ER_diArg_1	366	368	PF00400	0.362
TRG_ER_diArg_1	457	460	PF00400	0.393
TRG_ER_diArg_1	481	484	PF00400	0.491
TRG_ER_diArg_1	486	488	PF00400	0.482
TRG_ER_diArg_1	641	643	PF00400	0.617
TRG_ER_diArg_1	776	779	PF00400	0.550
TRG_NLS_Bipartite_1	211	230	PF00514	0.496
TRG_NLS_MonoExtC_3	210	215	PF00514	0.428
TRG_NLS_MonoExtC_3	225	230	PF00514	0.473
TRG_NLS_MonoExtN_4	223	230	PF00514	0.493
TRG_Pf-PMV_PEXEL_1	749	753	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X2	Leptomonas seymouri	46%	87%
A0A3Q8IA27	Leishmania donovani	100%	91%
A4H840	Leishmania braziliensis	69%	100%
E9AQ68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QFB5	Leishmania major	89%	100%