LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HWG3_LEIIN
TriTrypDb:
LINF_150013900
Length:
699

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWG3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWG3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 100 104 PF00656 0.665
CLV_C14_Caspase3-7 213 217 PF00656 0.565
CLV_C14_Caspase3-7 278 282 PF00656 0.588
CLV_C14_Caspase3-7 379 383 PF00656 0.552
CLV_C14_Caspase3-7 617 621 PF00656 0.646
CLV_NRD_NRD_1 513 515 PF00675 0.636
CLV_PCSK_FUR_1 511 515 PF00082 0.629
CLV_PCSK_KEX2_1 208 210 PF00082 0.659
CLV_PCSK_KEX2_1 513 515 PF00082 0.636
CLV_PCSK_PC1ET2_1 208 210 PF00082 0.621
CLV_PCSK_SKI1_1 412 416 PF00082 0.659
CLV_PCSK_SKI1_1 58 62 PF00082 0.613
DEG_SCF_FBW7_1 21 28 PF00400 0.714
DEG_SPOP_SBC_1 301 305 PF00917 0.628
DEG_SPOP_SBC_1 353 357 PF00917 0.647
DEG_SPOP_SBC_1 558 562 PF00917 0.688
DOC_ANK_TNKS_1 269 276 PF00023 0.657
DOC_CKS1_1 140 145 PF01111 0.569
DOC_CKS1_1 22 27 PF01111 0.716
DOC_CKS1_1 343 348 PF01111 0.665
DOC_CYCLIN_RxL_1 55 64 PF00134 0.611
DOC_CYCLIN_yCln2_LP_2 400 403 PF00134 0.485
DOC_PP1_RVXF_1 56 62 PF00149 0.650
DOC_PP2B_LxvP_1 246 249 PF13499 0.609
DOC_PP2B_LxvP_1 400 403 PF13499 0.485
DOC_PP2B_LxvP_1 414 417 PF13499 0.512
DOC_PP4_MxPP_1 247 250 PF00568 0.675
DOC_PP4_MxPP_1 298 301 PF00568 0.704
DOC_USP7_MATH_1 118 122 PF00917 0.675
DOC_USP7_MATH_1 195 199 PF00917 0.713
DOC_USP7_MATH_1 229 233 PF00917 0.626
DOC_USP7_MATH_1 301 305 PF00917 0.628
DOC_USP7_MATH_1 310 314 PF00917 0.612
DOC_USP7_MATH_1 319 323 PF00917 0.625
DOC_USP7_MATH_1 388 392 PF00917 0.591
DOC_USP7_MATH_1 614 618 PF00917 0.804
DOC_USP7_MATH_1 681 685 PF00917 0.607
DOC_WW_Pin1_4 139 144 PF00397 0.693
DOC_WW_Pin1_4 163 168 PF00397 0.691
DOC_WW_Pin1_4 17 22 PF00397 0.840
DOC_WW_Pin1_4 183 188 PF00397 0.720
DOC_WW_Pin1_4 198 203 PF00397 0.632
DOC_WW_Pin1_4 222 227 PF00397 0.605
DOC_WW_Pin1_4 25 30 PF00397 0.629
DOC_WW_Pin1_4 250 255 PF00397 0.625
DOC_WW_Pin1_4 257 262 PF00397 0.622
DOC_WW_Pin1_4 288 293 PF00397 0.602
DOC_WW_Pin1_4 296 301 PF00397 0.647
DOC_WW_Pin1_4 326 331 PF00397 0.689
DOC_WW_Pin1_4 342 347 PF00397 0.590
DOC_WW_Pin1_4 354 359 PF00397 0.616
DOC_WW_Pin1_4 45 50 PF00397 0.718
DOC_WW_Pin1_4 53 58 PF00397 0.599
DOC_WW_Pin1_4 69 74 PF00397 0.642
LIG_14-3-3_CanoR_1 16 20 PF00244 0.730
LIG_14-3-3_CanoR_1 302 311 PF00244 0.626
LIG_14-3-3_CanoR_1 412 417 PF00244 0.624
LIG_14-3-3_CanoR_1 426 431 PF00244 0.350
LIG_14-3-3_CanoR_1 58 64 PF00244 0.644
LIG_14-3-3_CanoR_1 67 73 PF00244 0.659
LIG_APCC_ABBA_1 645 650 PF00400 0.639
LIG_BIR_II_1 1 5 PF00653 0.637
LIG_BRCT_BRCA1_1 436 440 PF00533 0.477
LIG_BRCT_BRCA1_1 641 645 PF00533 0.633
LIG_BRCT_BRCA1_1 650 654 PF00533 0.551
LIG_CtBP_PxDLS_1 249 253 PF00389 0.617
LIG_deltaCOP1_diTrp_1 650 654 PF00928 0.671
LIG_EVH1_1 401 405 PF00568 0.466
LIG_FHA_1 106 112 PF00498 0.706
LIG_FHA_1 171 177 PF00498 0.658
LIG_FHA_1 343 349 PF00498 0.668
LIG_FHA_1 45 51 PF00498 0.827
LIG_FHA_1 486 492 PF00498 0.567
LIG_FHA_1 54 60 PF00498 0.593
LIG_FHA_1 74 80 PF00498 0.671
LIG_FHA_2 114 120 PF00498 0.671
LIG_FHA_2 463 469 PF00498 0.634
LIG_FHA_2 473 479 PF00498 0.606
LIG_IBAR_NPY_1 341 343 PF08397 0.573
LIG_IBAR_NPY_1 646 648 PF08397 0.552
LIG_IRF3_LxIS_1 148 153 PF10401 0.676
LIG_LIR_Gen_1 437 448 PF02991 0.685
LIG_LIR_Gen_1 478 486 PF02991 0.499
LIG_LIR_Nem_3 313 317 PF02991 0.584
LIG_LIR_Nem_3 437 443 PF02991 0.512
LIG_LIR_Nem_3 478 483 PF02991 0.474
LIG_LIR_Nem_3 62 66 PF02991 0.614
LIG_LIR_Nem_3 642 648 PF02991 0.568
LIG_PAM2_1 643 655 PF00658 0.581
LIG_PROFILIN_1 402 408 PF00235 0.541
LIG_SH2_CRK 314 318 PF00017 0.614
LIG_SH2_CRK 343 347 PF00017 0.665
LIG_SH2_CRK 66 70 PF00017 0.607
LIG_SH2_SRC 648 651 PF00017 0.648
LIG_SH2_STAP1 473 477 PF00017 0.527
LIG_SH2_STAP1 610 614 PF00017 0.695
LIG_SH2_STAP1 648 652 PF00017 0.579
LIG_SH2_STAT3 529 532 PF00017 0.694
LIG_SH2_STAT5 220 223 PF00017 0.623
LIG_SH2_STAT5 430 433 PF00017 0.607
LIG_SH2_STAT5 677 680 PF00017 0.648
LIG_SH3_1 399 405 PF00018 0.482
LIG_SH3_3 137 143 PF00018 0.674
LIG_SH3_3 199 205 PF00018 0.622
LIG_SH3_3 255 261 PF00018 0.638
LIG_SH3_3 327 333 PF00018 0.686
LIG_SH3_3 399 405 PF00018 0.522
LIG_SH3_3 444 450 PF00018 0.535
LIG_SH3_3 81 87 PF00018 0.595
LIG_SUMO_SIM_par_1 148 153 PF11976 0.600
LIG_SUMO_SIM_par_1 172 177 PF11976 0.607
LIG_TRAF2_1 465 468 PF00917 0.498
LIG_TRAF2_1 87 90 PF00917 0.772
LIG_WW_2 405 408 PF00397 0.534
LIG_WW_3 299 303 PF00397 0.629
MOD_CDC14_SPxK_1 299 302 PF00782 0.632
MOD_CDK_SPK_2 53 58 PF00069 0.594
MOD_CDK_SPxK_1 296 302 PF00069 0.632
MOD_CK1_1 106 112 PF00069 0.630
MOD_CK1_1 139 145 PF00069 0.671
MOD_CK1_1 170 176 PF00069 0.750
MOD_CK1_1 186 192 PF00069 0.710
MOD_CK1_1 197 203 PF00069 0.577
MOD_CK1_1 2 8 PF00069 0.667
MOD_CK1_1 227 233 PF00069 0.595
MOD_CK1_1 253 259 PF00069 0.597
MOD_CK1_1 303 309 PF00069 0.748
MOD_CK1_1 324 330 PF00069 0.696
MOD_CK1_1 357 363 PF00069 0.617
MOD_CK1_1 391 397 PF00069 0.571
MOD_CK1_1 452 458 PF00069 0.632
MOD_CK1_1 461 467 PF00069 0.609
MOD_CK1_1 509 515 PF00069 0.744
MOD_CK1_1 517 523 PF00069 0.713
MOD_CK1_1 53 59 PF00069 0.578
MOD_CK1_1 608 614 PF00069 0.646
MOD_CK1_1 655 661 PF00069 0.656
MOD_CK1_1 675 681 PF00069 0.618
MOD_CK1_1 77 83 PF00069 0.656
MOD_CK2_1 113 119 PF00069 0.786
MOD_CK2_1 461 467 PF00069 0.533
MOD_GlcNHglycan 1 4 PF01048 0.606
MOD_GlcNHglycan 119 123 PF01048 0.717
MOD_GlcNHglycan 125 128 PF01048 0.730
MOD_GlcNHglycan 152 155 PF01048 0.712
MOD_GlcNHglycan 169 172 PF01048 0.549
MOD_GlcNHglycan 202 205 PF01048 0.679
MOD_GlcNHglycan 212 215 PF01048 0.629
MOD_GlcNHglycan 231 234 PF01048 0.778
MOD_GlcNHglycan 326 329 PF01048 0.804
MOD_GlcNHglycan 334 337 PF01048 0.622
MOD_GlcNHglycan 392 396 PF01048 0.593
MOD_GlcNHglycan 508 511 PF01048 0.614
MOD_GlcNHglycan 52 55 PF01048 0.626
MOD_GlcNHglycan 520 523 PF01048 0.714
MOD_GlcNHglycan 537 540 PF01048 0.646
MOD_GlcNHglycan 603 606 PF01048 0.768
MOD_GlcNHglycan 607 610 PF01048 0.603
MOD_GlcNHglycan 616 619 PF01048 0.786
MOD_GlcNHglycan 654 657 PF01048 0.626
MOD_GlcNHglycan 76 79 PF01048 0.703
MOD_GSK3_1 103 110 PF00069 0.628
MOD_GSK3_1 113 120 PF00069 0.643
MOD_GSK3_1 125 132 PF00069 0.603
MOD_GSK3_1 135 142 PF00069 0.621
MOD_GSK3_1 163 170 PF00069 0.724
MOD_GSK3_1 17 24 PF00069 0.733
MOD_GSK3_1 194 201 PF00069 0.636
MOD_GSK3_1 25 32 PF00069 0.628
MOD_GSK3_1 250 257 PF00069 0.620
MOD_GSK3_1 279 286 PF00069 0.661
MOD_GSK3_1 296 303 PF00069 0.694
MOD_GSK3_1 349 356 PF00069 0.700
MOD_GSK3_1 450 457 PF00069 0.579
MOD_GSK3_1 458 465 PF00069 0.568
MOD_GSK3_1 514 521 PF00069 0.675
MOD_GSK3_1 601 608 PF00069 0.600
MOD_GSK3_1 648 655 PF00069 0.623
MOD_GSK3_1 69 76 PF00069 0.634
MOD_N-GLC_1 111 116 PF02516 0.648
MOD_N-GLC_1 25 30 PF02516 0.674
MOD_N-GLC_1 250 255 PF02516 0.625
MOD_N-GLC_1 284 289 PF02516 0.833
MOD_N-GLC_1 461 466 PF02516 0.709
MOD_N-GLC_1 518 523 PF02516 0.636
MOD_N-GLC_1 67 72 PF02516 0.690
MOD_N-GLC_1 74 79 PF02516 0.512
MOD_NEK2_1 1 6 PF00069 0.716
MOD_NEK2_1 150 155 PF00069 0.602
MOD_NEK2_1 169 174 PF00069 0.639
MOD_NEK2_1 349 354 PF00069 0.763
MOD_NEK2_1 535 540 PF00069 0.567
MOD_NEK2_1 654 659 PF00069 0.688
MOD_NEK2_1 673 678 PF00069 0.651
MOD_PIKK_1 174 180 PF00454 0.683
MOD_PIKK_1 264 270 PF00454 0.781
MOD_PIKK_1 29 35 PF00454 0.673
MOD_PIKK_1 357 363 PF00454 0.584
MOD_PIKK_1 514 520 PF00454 0.717
MOD_PIKK_1 681 687 PF00454 0.671
MOD_PIKK_1 8 14 PF00454 0.716
MOD_PK_1 344 350 PF00069 0.610
MOD_PKA_1 208 214 PF00069 0.570
MOD_PKA_2 128 134 PF00069 0.752
MOD_PKA_2 15 21 PF00069 0.727
MOD_PKA_2 208 214 PF00069 0.576
MOD_PKA_2 301 307 PF00069 0.821
MOD_PKA_2 601 607 PF00069 0.713
MOD_PKA_2 681 687 PF00069 0.653
MOD_Plk_1 74 80 PF00069 0.647
MOD_Plk_4 321 327 PF00069 0.648
MOD_Plk_4 344 350 PF00069 0.577
MOD_Plk_4 426 432 PF00069 0.409
MOD_ProDKin_1 139 145 PF00069 0.694
MOD_ProDKin_1 163 169 PF00069 0.693
MOD_ProDKin_1 17 23 PF00069 0.839
MOD_ProDKin_1 183 189 PF00069 0.721
MOD_ProDKin_1 198 204 PF00069 0.629
MOD_ProDKin_1 222 228 PF00069 0.603
MOD_ProDKin_1 25 31 PF00069 0.628
MOD_ProDKin_1 250 256 PF00069 0.628
MOD_ProDKin_1 257 263 PF00069 0.624
MOD_ProDKin_1 288 294 PF00069 0.604
MOD_ProDKin_1 296 302 PF00069 0.650
MOD_ProDKin_1 326 332 PF00069 0.688
MOD_ProDKin_1 342 348 PF00069 0.591
MOD_ProDKin_1 354 360 PF00069 0.619
MOD_ProDKin_1 45 51 PF00069 0.716
MOD_ProDKin_1 53 59 PF00069 0.597
MOD_ProDKin_1 69 75 PF00069 0.645
TRG_DiLeu_BaLyEn_6 396 401 PF01217 0.495
TRG_DiLeu_BaLyEn_6 55 60 PF01217 0.616
TRG_ENDOCYTIC_2 314 317 PF00928 0.720
TRG_ENDOCYTIC_2 66 69 PF00928 0.606
TRG_ENDOCYTIC_2 694 697 PF00928 0.695
TRG_ER_diArg_1 511 514 PF00400 0.628
TRG_ER_diArg_1 540 543 PF00400 0.685

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7J0 Leptomonas seymouri 40% 97%
A0A3S5H6U8 Leishmania donovani 100% 100%
E9AI50 Leishmania braziliensis 78% 99%
E9AQ63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 99%
Q4QFC0 Leishmania major 89% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS