Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWG1_LEIIN

TriTrypDb:

LINF_150013700

Length:

955

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.683
CLV_C14_Caspase3-7	239	243	PF00656	0.768
CLV_C14_Caspase3-7	468	472	PF00656	0.724
CLV_NRD_NRD_1	135	137	PF00675	0.778
CLV_NRD_NRD_1	174	176	PF00675	0.772
CLV_NRD_NRD_1	308	310	PF00675	0.562
CLV_NRD_NRD_1	695	697	PF00675	0.585
CLV_NRD_NRD_1	870	872	PF00675	0.754
CLV_PCSK_FUR_1	867	871	PF00082	0.773
CLV_PCSK_KEX2_1	135	137	PF00082	0.778
CLV_PCSK_KEX2_1	174	176	PF00082	0.714
CLV_PCSK_KEX2_1	307	309	PF00082	0.552
CLV_PCSK_KEX2_1	695	697	PF00082	0.585
CLV_PCSK_KEX2_1	869	871	PF00082	0.821
CLV_PCSK_SKI1_1	231	235	PF00082	0.693
CLV_PCSK_SKI1_1	297	301	PF00082	0.617
CLV_PCSK_SKI1_1	369	373	PF00082	0.741
CLV_PCSK_SKI1_1	818	822	PF00082	0.619
CLV_PCSK_SKI1_1	937	941	PF00082	0.681
DEG_Nend_UBRbox_2	1	3	PF02207	0.809
DEG_SPOP_SBC_1	114	118	PF00917	0.603
DEG_SPOP_SBC_1	13	17	PF00917	0.738
DEG_SPOP_SBC_1	288	292	PF00917	0.819
DEG_SPOP_SBC_1	463	467	PF00917	0.768
DEG_SPOP_SBC_1	60	64	PF00917	0.696
DOC_CKS1_1	266	271	PF01111	0.646
DOC_CKS1_1	611	616	PF01111	0.713
DOC_CKS1_1	654	659	PF01111	0.685
DOC_USP7_MATH_1	114	118	PF00917	0.775
DOC_USP7_MATH_1	236	240	PF00917	0.771
DOC_USP7_MATH_1	243	247	PF00917	0.700
DOC_USP7_MATH_1	280	284	PF00917	0.733
DOC_USP7_MATH_1	286	290	PF00917	0.719
DOC_USP7_MATH_1	314	318	PF00917	0.697
DOC_USP7_MATH_1	343	347	PF00917	0.764
DOC_USP7_MATH_1	462	466	PF00917	0.848
DOC_USP7_MATH_1	48	52	PF00917	0.817
DOC_USP7_MATH_1	585	589	PF00917	0.738
DOC_USP7_MATH_1	60	64	PF00917	0.655
DOC_USP7_MATH_1	742	746	PF00917	0.624
DOC_USP7_MATH_1	822	826	PF00917	0.703
DOC_USP7_MATH_1	829	833	PF00917	0.772
DOC_USP7_MATH_1	844	848	PF00917	0.681
DOC_USP7_MATH_1	888	892	PF00917	0.717
DOC_USP7_MATH_1	9	13	PF00917	0.834
DOC_USP7_MATH_1	92	96	PF00917	0.810
DOC_USP7_MATH_1	946	950	PF00917	0.724
DOC_USP7_MATH_2	171	177	PF00917	0.618
DOC_WW_Pin1_4	100	105	PF00397	0.732
DOC_WW_Pin1_4	106	111	PF00397	0.740
DOC_WW_Pin1_4	14	19	PF00397	0.818
DOC_WW_Pin1_4	265	270	PF00397	0.646
DOC_WW_Pin1_4	282	287	PF00397	0.589
DOC_WW_Pin1_4	418	423	PF00397	0.843
DOC_WW_Pin1_4	457	462	PF00397	0.753
DOC_WW_Pin1_4	569	574	PF00397	0.647
DOC_WW_Pin1_4	588	593	PF00397	0.686
DOC_WW_Pin1_4	610	615	PF00397	0.714
DOC_WW_Pin1_4	650	655	PF00397	0.708
DOC_WW_Pin1_4	75	80	PF00397	0.704
DOC_WW_Pin1_4	914	919	PF00397	0.711
LIG_14-3-3_CanoR_1	112	120	PF00244	0.658
LIG_14-3-3_CanoR_1	174	183	PF00244	0.780
LIG_14-3-3_CanoR_1	297	304	PF00244	0.670
LIG_14-3-3_CanoR_1	307	313	PF00244	0.625
LIG_14-3-3_CanoR_1	316	325	PF00244	0.479
LIG_14-3-3_CanoR_1	351	360	PF00244	0.627
LIG_14-3-3_CanoR_1	749	759	PF00244	0.795
LIG_14-3-3_CanoR_1	818	826	PF00244	0.545
LIG_14-3-3_CanoR_1	895	900	PF00244	0.803
LIG_14-3-3_CanoR_1	911	918	PF00244	0.691
LIG_AP2alpha_2	927	929	PF02296	0.660
LIG_APCC_ABBA_1	187	192	PF00400	0.602
LIG_BIR_III_2	166	170	PF00653	0.769
LIG_BRCT_BRCA1_1	183	187	PF00533	0.658
LIG_BRCT_BRCA1_1	229	233	PF00533	0.717
LIG_BRCT_BRCA1_1	646	650	PF00533	0.636
LIG_CSL_BTD_1	582	585	PF09270	0.811
LIG_DLG_GKlike_1	644	651	PF00625	0.636
LIG_eIF4E_1	229	235	PF01652	0.695
LIG_FHA_1	34	40	PF00498	0.811
LIG_FHA_1	458	464	PF00498	0.756
LIG_FHA_1	491	497	PF00498	0.717
LIG_FHA_1	754	760	PF00498	0.679
LIG_FHA_1	79	85	PF00498	0.830
LIG_FHA_1	794	800	PF00498	0.736
LIG_FHA_1	846	852	PF00498	0.742
LIG_FHA_1	938	944	PF00498	0.783
LIG_FHA_2	266	272	PF00498	0.644
LIG_FHA_2	298	304	PF00498	0.599
LIG_FHA_2	370	376	PF00498	0.718
LIG_FHA_2	466	472	PF00498	0.727
LIG_FHA_2	857	863	PF00498	0.756
LIG_FHA_2	915	921	PF00498	0.706
LIG_GBD_Chelix_1	689	697	PF00786	0.580
LIG_LIR_Apic_2	254	258	PF02991	0.713
LIG_LIR_Apic_2	825	829	PF02991	0.543
LIG_LIR_Gen_1	26	35	PF02991	0.744
LIG_LIR_Gen_1	578	585	PF02991	0.715
LIG_LIR_Nem_3	26	32	PF02991	0.757
LIG_LIR_Nem_3	513	517	PF02991	0.685
LIG_LIR_Nem_3	578	584	PF02991	0.718
LIG_LIR_Nem_3	67	71	PF02991	0.725
LIG_LIR_Nem_3	926	932	PF02991	0.653
LIG_NRBOX	413	419	PF00104	0.727
LIG_SH2_CRK	826	830	PF00017	0.544
LIG_SH2_GRB2like	631	634	PF00017	0.736
LIG_SH2_NCK_1	698	702	PF00017	0.643
LIG_SH2_PTP2	255	258	PF00017	0.716
LIG_SH2_SRC	255	258	PF00017	0.716
LIG_SH2_STAP1	631	635	PF00017	0.734
LIG_SH2_STAP1	88	92	PF00017	0.730
LIG_SH2_STAT3	144	147	PF00017	0.762
LIG_SH2_STAT5	255	258	PF00017	0.716
LIG_SH2_STAT5	29	32	PF00017	0.735
LIG_SH2_STAT5	452	455	PF00017	0.754
LIG_SH2_STAT5	88	91	PF00017	0.731
LIG_SH2_STAT5	923	926	PF00017	0.634
LIG_SH3_1	767	773	PF00018	0.710
LIG_SH3_1	787	793	PF00018	0.506
LIG_SH3_3	322	328	PF00018	0.783
LIG_SH3_3	451	457	PF00018	0.754
LIG_SH3_3	608	614	PF00018	0.801
LIG_SH3_3	651	657	PF00018	0.762
LIG_SH3_3	73	79	PF00018	0.714
LIG_SH3_3	767	773	PF00018	0.710
LIG_SH3_3	787	793	PF00018	0.588
LIG_SH3_3	81	87	PF00018	0.733
LIG_SH3_3	834	840	PF00018	0.755
LIG_TRAF2_1	372	375	PF00917	0.609
LIG_TRAF2_1	917	920	PF00917	0.702
LIG_WRC_WIRS_1	606	611	PF05994	0.817
MOD_CDC14_SPxK_1	109	112	PF00782	0.745
MOD_CDK_SPK_2	100	105	PF00069	0.812
MOD_CDK_SPK_2	265	270	PF00069	0.646
MOD_CDK_SPK_2	588	593	PF00069	0.747
MOD_CDK_SPxK_1	106	112	PF00069	0.750
MOD_CDK_SPxxK_3	100	107	PF00069	0.788
MOD_CK1_1	103	109	PF00069	0.842
MOD_CK1_1	116	122	PF00069	0.663
MOD_CK1_1	12	18	PF00069	0.746
MOD_CK1_1	20	26	PF00069	0.684
MOD_CK1_1	278	284	PF00069	0.740
MOD_CK1_1	289	295	PF00069	0.706
MOD_CK1_1	346	352	PF00069	0.704
MOD_CK1_1	355	361	PF00069	0.640
MOD_CK1_1	41	47	PF00069	0.690
MOD_CK1_1	465	471	PF00069	0.854
MOD_CK1_1	507	513	PF00069	0.686
MOD_CK1_1	51	57	PF00069	0.809
MOD_CK1_1	588	594	PF00069	0.706
MOD_CK1_1	621	627	PF00069	0.710
MOD_CK1_1	64	70	PF00069	0.655
MOD_CK1_1	642	648	PF00069	0.792
MOD_CK1_1	653	659	PF00069	0.665
MOD_CK1_1	78	84	PF00069	0.672
MOD_CK1_1	831	837	PF00069	0.817
MOD_CK2_1	265	271	PF00069	0.646
MOD_CK2_1	297	303	PF00069	0.608
MOD_CK2_1	369	375	PF00069	0.628
MOD_CK2_1	856	862	PF00069	0.751
MOD_CK2_1	914	920	PF00069	0.710
MOD_Cter_Amidation	867	870	PF01082	0.774
MOD_GlcNHglycan	11	14	PF01048	0.722
MOD_GlcNHglycan	238	241	PF01048	0.704
MOD_GlcNHglycan	242	246	PF01048	0.665
MOD_GlcNHglycan	357	360	PF01048	0.723
MOD_GlcNHglycan	426	429	PF01048	0.761
MOD_GlcNHglycan	431	434	PF01048	0.716
MOD_GlcNHglycan	436	439	PF01048	0.696
MOD_GlcNHglycan	443	446	PF01048	0.647
MOD_GlcNHglycan	45	48	PF01048	0.780
MOD_GlcNHglycan	488	491	PF01048	0.650
MOD_GlcNHglycan	53	56	PF01048	0.739
MOD_GlcNHglycan	561	564	PF01048	0.792
MOD_GlcNHglycan	620	623	PF01048	0.730
MOD_GlcNHglycan	63	66	PF01048	0.592
MOD_GlcNHglycan	644	647	PF01048	0.780
MOD_GlcNHglycan	699	702	PF01048	0.628
MOD_GlcNHglycan	763	766	PF01048	0.656
MOD_GlcNHglycan	811	814	PF01048	0.751
MOD_GlcNHglycan	831	834	PF01048	0.825
MOD_GlcNHglycan	862	866	PF01048	0.813
MOD_GlcNHglycan	890	893	PF01048	0.766
MOD_GSK3_1	114	121	PF00069	0.682
MOD_GSK3_1	17	24	PF00069	0.712
MOD_GSK3_1	223	230	PF00069	0.800
MOD_GSK3_1	278	285	PF00069	0.798
MOD_GSK3_1	288	295	PF00069	0.644
MOD_GSK3_1	308	315	PF00069	0.494
MOD_GSK3_1	316	323	PF00069	0.612
MOD_GSK3_1	33	40	PF00069	0.798
MOD_GSK3_1	342	349	PF00069	0.720
MOD_GSK3_1	441	448	PF00069	0.780
MOD_GSK3_1	486	493	PF00069	0.646
MOD_GSK3_1	49	56	PF00069	0.780
MOD_GSK3_1	506	513	PF00069	0.568
MOD_GSK3_1	569	576	PF00069	0.714
MOD_GSK3_1	584	591	PF00069	0.716
MOD_GSK3_1	60	67	PF00069	0.662
MOD_GSK3_1	621	628	PF00069	0.791
MOD_GSK3_1	642	649	PF00069	0.715
MOD_GSK3_1	728	735	PF00069	0.718
MOD_GSK3_1	738	745	PF00069	0.760
MOD_GSK3_1	818	825	PF00069	0.695
MOD_GSK3_1	829	836	PF00069	0.801
MOD_GSK3_1	9	16	PF00069	0.757
MOD_GSK3_1	906	913	PF00069	0.807
MOD_GSK3_1	923	930	PF00069	0.630
MOD_GSK3_1	942	949	PF00069	0.594
MOD_GSK3_1	99	106	PF00069	0.719
MOD_N-GLC_1	352	357	PF02516	0.727
MOD_N-GLC_1	42	47	PF02516	0.732
MOD_N-GLC_1	424	429	PF02516	0.815
MOD_N-GLC_1	473	478	PF02516	0.660
MOD_N-GLC_1	559	564	PF02516	0.734
MOD_N-GLC_1	588	593	PF02516	0.712
MOD_N-GLC_1	856	861	PF02516	0.730
MOD_N-GLC_2	910	912	PF02516	0.738
MOD_NEK2_1	120	125	PF00069	0.689
MOD_NEK2_1	234	239	PF00069	0.700
MOD_NEK2_1	287	292	PF00069	0.782
MOD_NEK2_1	506	511	PF00069	0.818
MOD_NEK2_1	525	530	PF00069	0.505
MOD_NEK2_1	559	564	PF00069	0.739
MOD_NEK2_1	636	641	PF00069	0.765
MOD_NEK2_1	736	741	PF00069	0.702
MOD_PIKK_1	17	23	PF00454	0.814
MOD_PIKK_1	275	281	PF00454	0.796
MOD_PIKK_1	316	322	PF00454	0.802
MOD_PIKK_1	445	451	PF00454	0.696
MOD_PIKK_1	661	667	PF00454	0.720
MOD_PIKK_1	92	98	PF00454	0.742
MOD_PKA_1	174	180	PF00069	0.770
MOD_PKA_1	308	314	PF00069	0.735
MOD_PKA_2	173	179	PF00069	0.782
MOD_PKA_2	308	314	PF00069	0.735
MOD_PKA_2	520	526	PF00069	0.816
MOD_PKA_2	748	754	PF00069	0.714
MOD_PKA_2	894	900	PF00069	0.754
MOD_PKA_2	910	916	PF00069	0.734
MOD_PKB_1	869	877	PF00069	0.768
MOD_Plk_1	273	279	PF00069	0.847
MOD_Plk_1	34	40	PF00069	0.718
MOD_Plk_1	507	513	PF00069	0.689
MOD_Plk_4	224	230	PF00069	0.703
MOD_Plk_4	251	257	PF00069	0.717
MOD_Plk_4	320	326	PF00069	0.682
MOD_Plk_4	34	40	PF00069	0.710
MOD_Plk_4	413	419	PF00069	0.727
MOD_Plk_4	646	652	PF00069	0.718
MOD_Plk_4	732	738	PF00069	0.787
MOD_Plk_4	742	748	PF00069	0.658
MOD_Plk_4	833	839	PF00069	0.758
MOD_ProDKin_1	100	106	PF00069	0.731
MOD_ProDKin_1	14	20	PF00069	0.815
MOD_ProDKin_1	265	271	PF00069	0.646
MOD_ProDKin_1	282	288	PF00069	0.587
MOD_ProDKin_1	418	424	PF00069	0.841
MOD_ProDKin_1	457	463	PF00069	0.754
MOD_ProDKin_1	569	575	PF00069	0.644
MOD_ProDKin_1	588	594	PF00069	0.686
MOD_ProDKin_1	610	616	PF00069	0.718
MOD_ProDKin_1	650	656	PF00069	0.705
MOD_ProDKin_1	75	81	PF00069	0.705
MOD_ProDKin_1	914	920	PF00069	0.710
MOD_SUMO_rev_2	915	924	PF00179	0.705
TRG_DiLeu_BaEn_1	375	380	PF01217	0.572
TRG_DiLeu_BaEn_1	685	690	PF01217	0.658
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.657
TRG_ENDOCYTIC_2	29	32	PF00928	0.717
TRG_ENDOCYTIC_2	68	71	PF00928	0.720
TRG_ER_diArg_1	307	309	PF00400	0.616
TRG_ER_diArg_1	695	697	PF00400	0.685
TRG_ER_diArg_1	766	769	PF00400	0.717
TRG_ER_diArg_1	867	870	PF00400	0.836
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ58	Leptomonas seymouri	34%	100%
A0A3Q8IIP4	Leishmania donovani	99%	100%
A4H836	Leishmania braziliensis	61%	97%
E9AQ61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	96%
Q4QFC2	Leishmania major	88%	100%