DRBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWG0_LEIIN

TriTrypDb:

LINF_150013600

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.559
CLV_NRD_NRD_1	221	223	PF00675	0.459
CLV_NRD_NRD_1	348	350	PF00675	0.522
CLV_NRD_NRD_1	395	397	PF00675	0.578
CLV_NRD_NRD_1	428	430	PF00675	0.504
CLV_NRD_NRD_1	77	79	PF00675	0.749
CLV_PCSK_KEX2_1	221	223	PF00082	0.477
CLV_PCSK_KEX2_1	260	262	PF00082	0.471
CLV_PCSK_KEX2_1	330	332	PF00082	0.645
CLV_PCSK_KEX2_1	348	350	PF00082	0.568
CLV_PCSK_KEX2_1	395	397	PF00082	0.670
CLV_PCSK_KEX2_1	428	430	PF00082	0.532
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.571
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.645
CLV_PCSK_SKI1_1	117	121	PF00082	0.423
CLV_PCSK_SKI1_1	159	163	PF00082	0.456
CLV_PCSK_SKI1_1	221	225	PF00082	0.452
CLV_PCSK_SKI1_1	239	243	PF00082	0.506
CLV_PCSK_SKI1_1	26	30	PF00082	0.543
CLV_PCSK_SKI1_1	323	327	PF00082	0.525
CLV_PCSK_SKI1_1	444	448	PF00082	0.551
DEG_APCC_DBOX_1	116	124	PF00400	0.501
DEG_APCC_DBOX_1	398	406	PF00400	0.465
DOC_ANK_TNKS_1	162	169	PF00023	0.578
DOC_CKS1_1	152	157	PF01111	0.405
DOC_CKS1_1	351	356	PF01111	0.495
DOC_CYCLIN_RxL_1	236	245	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.658
DOC_MAPK_gen_1	219	228	PF00069	0.460
DOC_MAPK_gen_1	329	337	PF00069	0.648
DOC_PP4_FxxP_1	150	153	PF00568	0.374
DOC_PP4_FxxP_1	419	422	PF00568	0.527
DOC_USP7_MATH_1	102	106	PF00917	0.699
DOC_USP7_MATH_1	283	287	PF00917	0.706
DOC_USP7_MATH_1	41	45	PF00917	0.729
DOC_USP7_MATH_1	442	446	PF00917	0.596
DOC_USP7_MATH_1	91	95	PF00917	0.798
DOC_USP7_UBL2_3	79	83	PF12436	0.682
DOC_WW_Pin1_4	151	156	PF00397	0.400
DOC_WW_Pin1_4	267	272	PF00397	0.528
DOC_WW_Pin1_4	28	33	PF00397	0.720
DOC_WW_Pin1_4	350	355	PF00397	0.489
DOC_WW_Pin1_4	418	423	PF00397	0.629
LIG_14-3-3_CanoR_1	221	226	PF00244	0.469
LIG_14-3-3_CterR_2	444	448	PF00244	0.562
LIG_Actin_WH2_2	219	234	PF00022	0.401
LIG_APCC_ABBA_1	210	215	PF00400	0.585
LIG_BIR_II_1	1	5	PF00653	0.770
LIG_BIR_III_2	109	113	PF00653	0.495
LIG_BRCT_BRCA1_1	244	248	PF00533	0.527
LIG_BRCT_BRCA1_1	357	361	PF00533	0.466
LIG_FHA_1	17	23	PF00498	0.631
LIG_FHA_1	402	408	PF00498	0.478
LIG_FHA_2	98	104	PF00498	0.695
LIG_LIR_Apic_2	148	153	PF02991	0.393
LIG_LIR_Gen_1	198	205	PF02991	0.602
LIG_LIR_Gen_1	224	233	PF02991	0.422
LIG_LIR_Gen_1	23	32	PF02991	0.598
LIG_LIR_Gen_1	51	61	PF02991	0.483
LIG_LIR_Nem_3	167	173	PF02991	0.608
LIG_LIR_Nem_3	197	203	PF02991	0.606
LIG_LIR_Nem_3	224	228	PF02991	0.459
LIG_LIR_Nem_3	23	27	PF02991	0.589
LIG_LIR_Nem_3	51	56	PF02991	0.477
LIG_Pex14_2	126	130	PF04695	0.391
LIG_Pex14_2	146	150	PF04695	0.210
LIG_SH2_CRK	170	174	PF00017	0.644
LIG_SH2_CRK	352	356	PF00017	0.563
LIG_SH2_NCK_1	352	356	PF00017	0.568
LIG_SH2_NCK_1	63	67	PF00017	0.490
LIG_SH2_STAT5	145	148	PF00017	0.447
LIG_SH2_STAT5	200	203	PF00017	0.480
LIG_SH2_STAT5	225	228	PF00017	0.423
LIG_SH2_STAT5	352	355	PF00017	0.606
LIG_SH2_STAT5	401	404	PF00017	0.439
LIG_SH3_1	348	354	PF00018	0.573
LIG_SH3_3	152	158	PF00018	0.394
LIG_SH3_3	170	176	PF00018	0.565
LIG_SH3_3	348	354	PF00018	0.473
LIG_SH3_3	35	41	PF00018	0.685
LIG_SH3_3	402	408	PF00018	0.421
LIG_SH3_3	6	12	PF00018	0.699
LIG_SUMO_SIM_par_1	439	445	PF11976	0.518
LIG_TRAF2_1	13	16	PF00917	0.727
LIG_TRAF2_1	325	328	PF00917	0.633
LIG_TRAF2_1	362	365	PF00917	0.480
LIG_TRFH_1	201	205	PF08558	0.642
LIG_UBA3_1	360	366	PF00899	0.517
LIG_UBA3_1	440	447	PF00899	0.576
LIG_WRC_WIRS_1	147	152	PF05994	0.392
MOD_CDK_SPK_2	151	156	PF00069	0.400
MOD_CDK_SPK_2	418	423	PF00069	0.406
MOD_CDK_SPxxK_3	350	357	PF00069	0.494
MOD_CK1_1	251	257	PF00069	0.489
MOD_CK1_1	31	37	PF00069	0.722
MOD_CK1_1	77	83	PF00069	0.781
MOD_CK1_1	85	91	PF00069	0.722
MOD_CK1_1	94	100	PF00069	0.685
MOD_CK2_1	161	167	PF00069	0.559
MOD_CK2_1	359	365	PF00069	0.428
MOD_GlcNHglycan	276	279	PF01048	0.738
MOD_GlcNHglycan	285	288	PF01048	0.732
MOD_GlcNHglycan	313	316	PF01048	0.702
MOD_GlcNHglycan	432	435	PF01048	0.522
MOD_GlcNHglycan	44	47	PF01048	0.607
MOD_GlcNHglycan	53	56	PF01048	0.393
MOD_GlcNHglycan	79	82	PF01048	0.743
MOD_GlcNHglycan	87	90	PF01048	0.711
MOD_GlcNHglycan	97	100	PF01048	0.625
MOD_GSK3_1	16	23	PF00069	0.603
MOD_GSK3_1	190	197	PF00069	0.678
MOD_GSK3_1	319	326	PF00069	0.585
MOD_GSK3_1	355	362	PF00069	0.434
MOD_GSK3_1	70	77	PF00069	0.623
MOD_GSK3_1	81	88	PF00069	0.604
MOD_GSK3_1	91	98	PF00069	0.667
MOD_N-GLC_1	195	200	PF02516	0.617
MOD_N-GLC_1	248	253	PF02516	0.602
MOD_N-GLC_1	291	296	PF02516	0.711
MOD_NEK2_1	1	6	PF00069	0.698
MOD_NEK2_1	146	151	PF00069	0.434
MOD_NEK2_1	189	194	PF00069	0.663
MOD_NEK2_1	242	247	PF00069	0.540
MOD_NEK2_1	274	279	PF00069	0.672
MOD_NEK2_2	442	447	PF00069	0.582
MOD_PKA_1	221	227	PF00069	0.459
MOD_PKA_2	221	227	PF00069	0.419
MOD_PKA_2	77	83	PF00069	0.738
MOD_PKB_1	308	316	PF00069	0.533
MOD_Plk_1	190	196	PF00069	0.671
MOD_Plk_1	436	442	PF00069	0.545
MOD_Plk_1	81	87	PF00069	0.691
MOD_Plk_4	436	442	PF00069	0.503
MOD_Plk_4	82	88	PF00069	0.584
MOD_ProDKin_1	151	157	PF00069	0.401
MOD_ProDKin_1	267	273	PF00069	0.525
MOD_ProDKin_1	28	34	PF00069	0.722
MOD_ProDKin_1	350	356	PF00069	0.491
MOD_ProDKin_1	418	424	PF00069	0.623
MOD_SUMO_rev_2	240	248	PF00179	0.427
MOD_SUMO_rev_2	322	332	PF00179	0.573
MOD_SUMO_rev_2	358	367	PF00179	0.508
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.527
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.457
TRG_ENDOCYTIC_2	170	173	PF00928	0.646
TRG_ENDOCYTIC_2	200	203	PF00928	0.580
TRG_ENDOCYTIC_2	225	228	PF00928	0.417
TRG_ENDOCYTIC_2	352	355	PF00928	0.559
TRG_ER_diArg_1	220	222	PF00400	0.460
TRG_ER_diArg_1	348	350	PF00400	0.568
TRG_NES_CRM1_1	218	229	PF08389	0.442
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I615	Leptomonas seymouri	70%	100%
A0A1X0NTS1	Trypanosomatidae	38%	100%
A0A3S5H6U7	Leishmania donovani	100%	100%
A0A422NLQ5	Trypanosoma rangeli	38%	100%
A4H835	Leishmania braziliensis	76%	100%
C9ZP02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AQ60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFC3	Leishmania major	93%	100%