Signal peptidase complex subunit 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Signal peptidase subunit - putative

Species:

Leishmania infantum

UniProt:

A4HWF6_LEIIN

TriTrypDb:

LINF_150013100

Length:

325

Annotations

Annotations by Jardim et al.

Translation, signal peptidase subunit, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005787	signal peptidase complex	3	7
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	7
GO:0098796	membrane protein complex	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1905368	peptidase complex	3	7

Expansion

Sequence features

A4HWF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWF6

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	7
GO:0006508	proteolysis	4	7
GO:0006518	peptide metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0016485	protein processing	5	7
GO:0019538	protein metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043603	amide metabolic process	3	7
GO:0044238	primary metabolic process	2	7
GO:0051604	protein maturation	4	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0006605	protein targeting	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.556
CLV_C14_Caspase3-7	78	82	PF00656	0.461
CLV_NRD_NRD_1	111	113	PF00675	0.656
CLV_NRD_NRD_1	196	198	PF00675	0.630
CLV_NRD_NRD_1	200	202	PF00675	0.663
CLV_PCSK_KEX2_1	196	198	PF00082	0.627
CLV_PCSK_KEX2_1	200	202	PF00082	0.667
CLV_PCSK_KEX2_1	258	260	PF00082	0.655
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.655
CLV_PCSK_PC7_1	196	202	PF00082	0.632
CLV_PCSK_SKI1_1	122	126	PF00082	0.646
CLV_PCSK_SKI1_1	133	137	PF00082	0.527
CLV_PCSK_SKI1_1	191	195	PF00082	0.633
CLV_PCSK_SKI1_1	201	205	PF00082	0.622
CLV_PCSK_SKI1_1	259	263	PF00082	0.594
DOC_MAPK_HePTP_8	126	138	PF00069	0.419
DOC_MAPK_MEF2A_6	129	138	PF00069	0.346
DOC_USP7_MATH_1	103	107	PF00917	0.494
DOC_USP7_MATH_1	164	168	PF00917	0.363
DOC_USP7_MATH_1	41	45	PF00917	0.477
DOC_WW_Pin1_4	142	147	PF00397	0.419
DOC_WW_Pin1_4	216	221	PF00397	0.549
DOC_WW_Pin1_4	49	54	PF00397	0.395
DOC_WW_Pin1_4	56	61	PF00397	0.376
LIG_14-3-3_CanoR_1	181	186	PF00244	0.492
LIG_14-3-3_CanoR_1	211	215	PF00244	0.487
LIG_14-3-3_CanoR_1	40	48	PF00244	0.430
LIG_14-3-3_CanoR_1	5	12	PF00244	0.654
LIG_AP2alpha_1	269	273	PF02296	0.423
LIG_BRCT_BRCA1_1	140	144	PF00533	0.419
LIG_FHA_1	150	156	PF00498	0.346
LIG_FHA_1	20	26	PF00498	0.471
LIG_FHA_1	221	227	PF00498	0.465
LIG_FHA_1	280	286	PF00498	0.463
LIG_FHA_2	225	231	PF00498	0.422
LIG_FHA_2	76	82	PF00498	0.544
LIG_LIR_Nem_3	264	269	PF02991	0.454
LIG_LIR_Nem_3	295	300	PF02991	0.420
LIG_LIR_Nem_3	49	54	PF02991	0.475
LIG_Pex14_2	144	148	PF04695	0.346
LIG_Pex14_2	159	163	PF04695	0.346
LIG_Pex14_2	269	273	PF04695	0.423
LIG_PTB_Apo_2	260	267	PF02174	0.390
LIG_SH2_SRC	252	255	PF00017	0.414
LIG_SH2_STAT5	137	140	PF00017	0.346
LIG_SH2_STAT5	156	159	PF00017	0.206
LIG_SH2_STAT5	252	255	PF00017	0.414
LIG_SH2_STAT5	268	271	PF00017	0.467
LIG_SH3_3	176	182	PF00018	0.355
LIG_SH3_3	308	314	PF00018	0.458
LIG_SH3_3	33	39	PF00018	0.505
LIG_SH3_3	54	60	PF00018	0.447
LIG_SH3_3	62	68	PF00018	0.424
LIG_SH3_3	97	103	PF00018	0.509
LIG_Sin3_3	315	322	PF02671	0.378
LIG_SUMO_SIM_anti_2	172	177	PF11976	0.419
LIG_SUMO_SIM_anti_2	282	287	PF11976	0.463
LIG_SUMO_SIM_anti_2	92	99	PF11976	0.435
LIG_SUMO_SIM_par_1	172	177	PF11976	0.419
LIG_TRAF2_1	227	230	PF00917	0.488
LIG_WRC_WIRS_1	156	161	PF05994	0.346
LIG_WRC_WIRS_1	48	53	PF05994	0.420
MOD_CK1_1	14	20	PF00069	0.411
MOD_CK1_1	49	55	PF00069	0.414
MOD_CK2_1	204	210	PF00069	0.573
MOD_CK2_1	224	230	PF00069	0.307
MOD_CK2_1	89	95	PF00069	0.425
MOD_GlcNHglycan	138	141	PF01048	0.546
MOD_GlcNHglycan	16	19	PF01048	0.513
MOD_GlcNHglycan	166	169	PF01048	0.530
MOD_GlcNHglycan	206	209	PF01048	0.721
MOD_GlcNHglycan	294	297	PF01048	0.627
MOD_GSK3_1	138	145	PF00069	0.419
MOD_GSK3_1	162	169	PF00069	0.310
MOD_GSK3_1	19	26	PF00069	0.503
MOD_GSK3_1	216	223	PF00069	0.526
MOD_LATS_1	56	62	PF00433	0.499
MOD_N-GLC_1	262	267	PF02516	0.593
MOD_NEK2_1	12	17	PF00069	0.455
MOD_NEK2_1	136	141	PF00069	0.346
MOD_NEK2_1	19	24	PF00069	0.478
MOD_NEK2_1	25	30	PF00069	0.224
MOD_NEK2_1	262	267	PF00069	0.393
MOD_NEK2_1	273	278	PF00069	0.429
MOD_NEK2_1	292	297	PF00069	0.333
MOD_PIKK_1	166	172	PF00454	0.330
MOD_PIKK_1	220	226	PF00454	0.486
MOD_PKA_2	210	216	PF00069	0.555
MOD_PKA_2	46	52	PF00069	0.424
MOD_Plk_1	262	268	PF00069	0.370
MOD_Plk_1	273	279	PF00069	0.427
MOD_Plk_4	155	161	PF00069	0.406
MOD_Plk_4	247	253	PF00069	0.463
MOD_Plk_4	27	33	PF00069	0.438
MOD_Plk_4	58	64	PF00069	0.496
MOD_ProDKin_1	142	148	PF00069	0.419
MOD_ProDKin_1	216	222	PF00069	0.547
MOD_ProDKin_1	49	55	PF00069	0.394
MOD_ProDKin_1	56	62	PF00069	0.377
TRG_DiLeu_BaEn_4	229	235	PF01217	0.445
TRG_ENDOCYTIC_2	156	159	PF00928	0.404
TRG_ENDOCYTIC_2	289	292	PF00928	0.379
TRG_ER_diArg_1	117	120	PF00400	0.423
TRG_ER_diArg_1	195	197	PF00400	0.416
TRG_ER_diArg_1	37	40	PF00400	0.451
TRG_ER_diArg_1	4	7	PF00400	0.652
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	40	45	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I7	Leptomonas seymouri	57%	100%
A0A3S5H6U6	Leishmania donovani	99%	100%
A4H830	Leishmania braziliensis	78%	100%
E9AQ55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFC7	Leishmania major	95%	100%