LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HWF4_LEIIN
TriTrypDb:
LINF_150012900
Length:
542

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWF4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWF4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 161 165 PF00656 0.670
CLV_C14_Caspase3-7 395 399 PF00656 0.536
CLV_NRD_NRD_1 139 141 PF00675 0.599
CLV_NRD_NRD_1 2 4 PF00675 0.576
CLV_NRD_NRD_1 242 244 PF00675 0.600
CLV_NRD_NRD_1 245 247 PF00675 0.540
CLV_NRD_NRD_1 341 343 PF00675 0.573
CLV_NRD_NRD_1 403 405 PF00675 0.560
CLV_NRD_NRD_1 537 539 PF00675 0.625
CLV_PCSK_FUR_1 243 247 PF00082 0.642
CLV_PCSK_KEX2_1 139 141 PF00082 0.523
CLV_PCSK_KEX2_1 242 244 PF00082 0.595
CLV_PCSK_KEX2_1 245 247 PF00082 0.544
CLV_PCSK_KEX2_1 341 343 PF00082 0.660
CLV_PCSK_KEX2_1 403 405 PF00082 0.560
CLV_PCSK_KEX2_1 500 502 PF00082 0.458
CLV_PCSK_KEX2_1 539 541 PF00082 0.627
CLV_PCSK_PC1ET2_1 500 502 PF00082 0.458
CLV_PCSK_PC1ET2_1 539 541 PF00082 0.512
CLV_PCSK_SKI1_1 139 143 PF00082 0.552
CLV_PCSK_SKI1_1 217 221 PF00082 0.607
CLV_PCSK_SKI1_1 296 300 PF00082 0.452
CLV_PCSK_SKI1_1 458 462 PF00082 0.421
CLV_PCSK_SKI1_1 48 52 PF00082 0.672
CLV_PCSK_SKI1_1 6 10 PF00082 0.531
DEG_APCC_DBOX_1 252 260 PF00400 0.479
DEG_APCC_KENBOX_2 492 496 PF00400 0.440
DEG_Nend_Nbox_1 1 3 PF02207 0.511
DEG_SPOP_SBC_1 143 147 PF00917 0.647
DEG_SPOP_SBC_1 195 199 PF00917 0.626
DEG_SPOP_SBC_1 233 237 PF00917 0.668
DEG_SPOP_SBC_1 529 533 PF00917 0.554
DOC_CYCLIN_yCln2_LP_2 210 216 PF00134 0.507
DOC_MAPK_gen_1 169 178 PF00069 0.465
DOC_MAPK_gen_1 3 12 PF00069 0.481
DOC_MAPK_gen_1 32 42 PF00069 0.548
DOC_MAPK_gen_1 403 409 PF00069 0.553
DOC_MAPK_MEF2A_6 3 12 PF00069 0.481
DOC_PP1_RVXF_1 515 521 PF00149 0.459
DOC_PP2B_LxvP_1 210 213 PF13499 0.517
DOC_PP2B_LxvP_1 409 412 PF13499 0.532
DOC_USP7_MATH_1 116 120 PF00917 0.441
DOC_USP7_MATH_1 143 147 PF00917 0.699
DOC_USP7_MATH_1 194 198 PF00917 0.630
DOC_USP7_MATH_1 414 418 PF00917 0.606
DOC_USP7_MATH_1 529 533 PF00917 0.706
DOC_USP7_MATH_1 86 90 PF00917 0.590
DOC_USP7_UBL2_3 179 183 PF12436 0.450
DOC_USP7_UBL2_3 51 55 PF12436 0.655
DOC_USP7_UBL2_3 99 103 PF12436 0.477
DOC_WW_Pin1_4 407 412 PF00397 0.686
LIG_14-3-3_CanoR_1 217 226 PF00244 0.527
LIG_14-3-3_CanoR_1 231 241 PF00244 0.598
LIG_14-3-3_CanoR_1 294 299 PF00244 0.445
LIG_BRCT_BRCA1_1 356 360 PF00533 0.574
LIG_Clathr_ClatBox_1 464 468 PF01394 0.471
LIG_FHA_1 129 135 PF00498 0.523
LIG_FHA_1 236 242 PF00498 0.669
LIG_FHA_1 31 37 PF00498 0.516
LIG_FHA_1 7 13 PF00498 0.518
LIG_FHA_2 309 315 PF00498 0.509
LIG_FHA_2 316 322 PF00498 0.592
LIG_FHA_2 531 537 PF00498 0.543
LIG_LIR_Gen_1 421 429 PF02991 0.535
LIG_LIR_Nem_3 379 385 PF02991 0.545
LIG_LIR_Nem_3 421 426 PF02991 0.530
LIG_PCNA_yPIPBox_3 112 121 PF02747 0.458
LIG_PCNA_yPIPBox_3 179 193 PF02747 0.409
LIG_SH2_CRK 382 386 PF00017 0.515
LIG_SH2_CRK 97 101 PF00017 0.444
LIG_SH2_GRB2like 308 311 PF00017 0.337
LIG_SH2_STAT5 308 311 PF00017 0.442
LIG_SH3_2 411 416 PF14604 0.533
LIG_SH3_3 238 244 PF00018 0.668
LIG_SH3_3 405 411 PF00018 0.603
LIG_SUMO_SIM_anti_2 173 180 PF11976 0.452
LIG_SUMO_SIM_par_1 173 180 PF11976 0.431
LIG_SUMO_SIM_par_1 463 468 PF11976 0.514
LIG_TRAF2_1 28 31 PF00917 0.521
LIG_TRAF2_1 333 336 PF00917 0.447
LIG_WRC_WIRS_1 216 221 PF05994 0.466
LIG_WRC_WIRS_1 415 420 PF05994 0.525
MOD_CK1_1 147 153 PF00069 0.617
MOD_CK1_1 215 221 PF00069 0.520
MOD_CK1_1 232 238 PF00069 0.570
MOD_CK1_1 486 492 PF00069 0.552
MOD_CK1_1 532 538 PF00069 0.603
MOD_CK1_1 70 76 PF00069 0.622
MOD_CK2_1 194 200 PF00069 0.571
MOD_CK2_1 308 314 PF00069 0.441
MOD_CK2_1 315 321 PF00069 0.446
MOD_CK2_1 418 424 PF00069 0.552
MOD_CK2_1 528 534 PF00069 0.504
MOD_CK2_1 77 83 PF00069 0.714
MOD_GlcNHglycan 146 149 PF01048 0.655
MOD_GlcNHglycan 158 161 PF01048 0.584
MOD_GlcNHglycan 220 223 PF01048 0.573
MOD_GlcNHglycan 256 259 PF01048 0.559
MOD_GlcNHglycan 288 291 PF01048 0.548
MOD_GlcNHglycan 355 359 PF01048 0.658
MOD_GlcNHglycan 362 365 PF01048 0.570
MOD_GlcNHglycan 370 373 PF01048 0.436
MOD_GlcNHglycan 448 451 PF01048 0.498
MOD_GlcNHglycan 485 488 PF01048 0.595
MOD_GlcNHglycan 505 508 PF01048 0.308
MOD_GlcNHglycan 55 58 PF01048 0.705
MOD_GlcNHglycan 70 73 PF01048 0.550
MOD_GlcNHglycan 74 77 PF01048 0.704
MOD_GlcNHglycan 79 82 PF01048 0.550
MOD_GlcNHglycan 89 92 PF01048 0.421
MOD_GSK3_1 139 146 PF00069 0.564
MOD_GSK3_1 208 215 PF00069 0.692
MOD_GSK3_1 229 236 PF00069 0.615
MOD_GSK3_1 297 304 PF00069 0.476
MOD_GSK3_1 354 361 PF00069 0.568
MOD_GSK3_1 414 421 PF00069 0.595
MOD_GSK3_1 479 486 PF00069 0.721
MOD_GSK3_1 528 535 PF00069 0.648
MOD_GSK3_1 66 73 PF00069 0.710
MOD_GSK3_1 82 89 PF00069 0.483
MOD_N-GLC_1 67 72 PF02516 0.539
MOD_NEK2_1 12 17 PF00069 0.496
MOD_NEK2_1 177 182 PF00069 0.428
MOD_NEK2_1 286 291 PF00069 0.552
MOD_NEK2_1 313 318 PF00069 0.439
MOD_NEK2_1 360 365 PF00069 0.585
MOD_NEK2_1 418 423 PF00069 0.525
MOD_PIKK_1 12 18 PF00454 0.485
MOD_PIKK_1 30 36 PF00454 0.534
MOD_PKA_1 139 145 PF00069 0.509
MOD_PKA_2 139 145 PF00069 0.555
MOD_PKA_2 254 260 PF00069 0.478
MOD_PKA_2 286 292 PF00069 0.508
MOD_PKB_1 501 509 PF00069 0.423
MOD_Plk_1 6 12 PF00069 0.484
MOD_Plk_4 308 314 PF00069 0.452
MOD_Plk_4 486 492 PF00069 0.573
MOD_ProDKin_1 407 413 PF00069 0.683
MOD_SUMO_for_1 298 301 PF00179 0.446
MOD_SUMO_rev_2 124 134 PF00179 0.552
TRG_DiLeu_BaEn_1 133 138 PF01217 0.513
TRG_DiLeu_BaEn_1 173 178 PF01217 0.454
TRG_DiLeu_BaEn_4 173 179 PF01217 0.530
TRG_DiLeu_LyEn_5 133 138 PF01217 0.541
TRG_ENDOCYTIC_2 382 385 PF00928 0.559
TRG_ENDOCYTIC_2 423 426 PF00928 0.450
TRG_ENDOCYTIC_2 97 100 PF00928 0.446
TRG_ER_diArg_1 138 140 PF00400 0.710
TRG_ER_diArg_1 168 171 PF00400 0.507
TRG_ER_diArg_1 241 243 PF00400 0.605
TRG_ER_diArg_1 244 246 PF00400 0.558
TRG_ER_diArg_1 340 342 PF00400 0.669
TRG_ER_diArg_1 402 404 PF00400 0.559
TRG_NLS_MonoExtC_3 498 503 PF00514 0.415
TRG_NLS_MonoExtN_4 499 504 PF00514 0.416
TRG_Pf-PMV_PEXEL_1 118 122 PF00026 0.487
TRG_Pf-PMV_PEXEL_1 268 273 PF00026 0.483
TRG_Pf-PMV_PEXEL_1 420 424 PF00026 0.543
TRG_Pf-PMV_PEXEL_1 6 11 PF00026 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I948 Leptomonas seymouri 44% 87%
A0A3Q8IA19 Leishmania donovani 100% 100%
A4H828 Leishmania braziliensis 70% 100%
E9AQ53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QFC9 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS