LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HWF2_LEIIN
TriTrypDb:
LINF_150012700 *
Length:
413

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 2

Phosphorylation

Promastigote: 23, 306

Expansion

Sequence features

A4HWF2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWF2

Function

Biological processes
Term Name Level Count
GO:0003341 cilium movement 4 2
GO:0007017 microtubule-based process 2 2
GO:0007018 microtubule-based movement 3 2
GO:0009987 cellular process 1 2
GO:0016043 cellular component organization 3 2
GO:0022607 cellular component assembly 4 2
GO:0036158 outer dynein arm assembly 7 2
GO:0043933 protein-containing complex organization 4 2
GO:0065003 protein-containing complex assembly 5 2
GO:0070286 axonemal dynein complex assembly 6 2
GO:0071840 cellular component organization or biogenesis 2 2
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 134 138 PF00656 0.504
CLV_C14_Caspase3-7 264 268 PF00656 0.354
CLV_C14_Caspase3-7 83 87 PF00656 0.337
CLV_NRD_NRD_1 14 16 PF00675 0.489
CLV_NRD_NRD_1 164 166 PF00675 0.342
CLV_NRD_NRD_1 168 170 PF00675 0.335
CLV_NRD_NRD_1 398 400 PF00675 0.398
CLV_NRD_NRD_1 406 408 PF00675 0.410
CLV_PCSK_KEX2_1 13 15 PF00082 0.499
CLV_PCSK_KEX2_1 164 166 PF00082 0.342
CLV_PCSK_KEX2_1 168 170 PF00082 0.335
CLV_PCSK_KEX2_1 400 402 PF00082 0.403
CLV_PCSK_KEX2_1 406 408 PF00082 0.410
CLV_PCSK_PC1ET2_1 400 402 PF00082 0.403
CLV_PCSK_PC7_1 164 170 PF00082 0.339
CLV_PCSK_SKI1_1 169 173 PF00082 0.335
CLV_PCSK_SKI1_1 235 239 PF00082 0.419
CLV_PCSK_SKI1_1 46 50 PF00082 0.323
CLV_PCSK_SKI1_1 89 93 PF00082 0.333
DEG_APCC_DBOX_1 379 387 PF00400 0.409
DEG_Nend_UBRbox_3 1 3 PF02207 0.507
DEG_SCF_TRCP1_1 345 350 PF00400 0.501
DOC_CYCLIN_RxL_1 164 174 PF00134 0.339
DOC_CYCLIN_yCln2_LP_2 26 32 PF00134 0.373
DOC_MAPK_gen_1 164 172 PF00069 0.338
DOC_MAPK_gen_1 37 45 PF00069 0.334
DOC_MAPK_gen_1 62 71 PF00069 0.337
DOC_USP7_MATH_1 106 110 PF00917 0.367
DOC_USP7_MATH_1 353 357 PF00917 0.509
DOC_USP7_MATH_1 360 364 PF00917 0.489
DOC_USP7_MATH_1 91 95 PF00917 0.336
DOC_WW_Pin1_4 25 30 PF00397 0.394
DOC_WW_Pin1_4 259 264 PF00397 0.358
DOC_WW_Pin1_4 310 315 PF00397 0.523
DOC_WW_Pin1_4 320 325 PF00397 0.528
LIG_14-3-3_CanoR_1 18 27 PF00244 0.446
LIG_14-3-3_CanoR_1 235 244 PF00244 0.391
LIG_14-3-3_CanoR_1 3 8 PF00244 0.495
LIG_14-3-3_CanoR_1 340 349 PF00244 0.504
LIG_CtBP_PxDLS_1 324 328 PF00389 0.524
LIG_FHA_1 241 247 PF00498 0.350
LIG_FHA_1 320 326 PF00498 0.527
LIG_FHA_1 38 44 PF00498 0.336
LIG_FHA_2 72 78 PF00498 0.343
LIG_GLEBS_BUB3_1 260 268 PF00400 0.352
LIG_IRF3_LxIS_1 210 217 PF10401 0.342
LIG_LIR_Gen_1 40 50 PF02991 0.327
LIG_LIR_Gen_1 94 103 PF02991 0.346
LIG_LIR_Nem_3 157 161 PF02991 0.406
LIG_LIR_Nem_3 40 45 PF02991 0.330
LIG_LIR_Nem_3 94 99 PF02991 0.347
LIG_NRBOX 195 201 PF00104 0.302
LIG_PDZ_Class_3 408 413 PF00595 0.451
LIG_SH2_CRK 158 162 PF00017 0.393
LIG_SH2_STAT5 209 212 PF00017 0.319
LIG_SH2_STAT5 42 45 PF00017 0.329
LIG_SH3_3 282 288 PF00018 0.433
LIG_SUMO_SIM_anti_2 243 248 PF11976 0.346
LIG_TRAF2_1 262 265 PF00917 0.361
LIG_TRAF2_1 408 411 PF00917 0.432
LIG_TYR_ITIM 156 161 PF00017 0.412
MOD_CK1_1 19 25 PF00069 0.451
MOD_CK1_1 225 231 PF00069 0.479
MOD_CK1_1 305 311 PF00069 0.530
MOD_CK1_1 323 329 PF00069 0.523
MOD_CK1_1 343 349 PF00069 0.498
MOD_CK1_1 387 393 PF00069 0.387
MOD_CK1_1 8 14 PF00069 0.500
MOD_CK2_1 259 265 PF00069 0.357
MOD_CK2_1 405 411 PF00069 0.422
MOD_CK2_1 71 77 PF00069 0.343
MOD_CK2_1 91 97 PF00069 0.340
MOD_GlcNHglycan 108 111 PF01048 0.362
MOD_GlcNHglycan 120 123 PF01048 0.399
MOD_GlcNHglycan 126 129 PF01048 0.466
MOD_GlcNHglycan 216 219 PF01048 0.394
MOD_GlcNHglycan 22 25 PF01048 0.439
MOD_GlcNHglycan 223 227 PF01048 0.476
MOD_GlcNHglycan 235 238 PF01048 0.420
MOD_GlcNHglycan 305 308 PF01048 0.526
MOD_GlcNHglycan 345 348 PF01048 0.499
MOD_GlcNHglycan 355 358 PF01048 0.504
MOD_GlcNHglycan 362 365 PF01048 0.483
MOD_GlcNHglycan 7 10 PF01048 0.503
MOD_GSK3_1 16 23 PF00069 0.466
MOD_GSK3_1 233 240 PF00069 0.426
MOD_GSK3_1 319 326 PF00069 0.530
MOD_GSK3_1 341 348 PF00069 0.502
MOD_LATS_1 231 237 PF00433 0.449
MOD_NEK2_1 214 219 PF00069 0.378
MOD_NEK2_1 71 76 PF00069 0.342
MOD_PIKK_1 194 200 PF00454 0.306
MOD_PIKK_1 225 231 PF00454 0.479
MOD_PIKK_1 235 241 PF00454 0.404
MOD_PK_1 3 9 PF00069 0.497
MOD_PKA_2 19 25 PF00069 0.451
MOD_PKA_2 405 411 PF00069 0.422
MOD_PKB_1 18 26 PF00069 0.453
MOD_PKB_1 44 52 PF00069 0.323
MOD_PKB_1 60 68 PF00069 0.333
MOD_Plk_1 46 52 PF00069 0.320
MOD_Plk_1 78 84 PF00069 0.339
MOD_Plk_4 22 28 PF00069 0.418
MOD_Plk_4 334 340 PF00069 0.516
MOD_ProDKin_1 25 31 PF00069 0.387
MOD_ProDKin_1 259 265 PF00069 0.357
MOD_ProDKin_1 310 316 PF00069 0.524
MOD_ProDKin_1 320 326 PF00069 0.527
MOD_SUMO_rev_2 376 386 PF00179 0.419
TRG_ENDOCYTIC_2 158 161 PF00928 0.405
TRG_ENDOCYTIC_2 42 45 PF00928 0.329
TRG_ER_diArg_1 13 15 PF00400 0.499
TRG_ER_diArg_1 168 170 PF00400 0.335
TRG_ER_diArg_1 43 46 PF00400 0.331
TRG_NLS_MonoExtN_4 397 403 PF00514 0.396
TRG_Pf-PMV_PEXEL_1 168 173 PF00026 0.336

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS