Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWE7_LEIIN

TriTrypDb:

LINF_150012200

Length:

861

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.537
CLV_C14_Caspase3-7	207	211	PF00656	0.746
CLV_C14_Caspase3-7	311	315	PF00656	0.723
CLV_C14_Caspase3-7	855	859	PF00656	0.574
CLV_NRD_NRD_1	131	133	PF00675	0.549
CLV_NRD_NRD_1	188	190	PF00675	0.783
CLV_NRD_NRD_1	381	383	PF00675	0.725
CLV_NRD_NRD_1	418	420	PF00675	0.580
CLV_NRD_NRD_1	473	475	PF00675	0.798
CLV_NRD_NRD_1	540	542	PF00675	0.604
CLV_NRD_NRD_1	666	668	PF00675	0.586
CLV_NRD_NRD_1	701	703	PF00675	0.615
CLV_NRD_NRD_1	777	779	PF00675	0.562
CLV_NRD_NRD_1	807	809	PF00675	0.609
CLV_PCSK_FUR_1	473	477	PF00082	0.785
CLV_PCSK_KEX2_1	124	126	PF00082	0.522
CLV_PCSK_KEX2_1	131	133	PF00082	0.542
CLV_PCSK_KEX2_1	381	383	PF00082	0.725
CLV_PCSK_KEX2_1	418	420	PF00082	0.580
CLV_PCSK_KEX2_1	472	474	PF00082	0.805
CLV_PCSK_KEX2_1	475	477	PF00082	0.750
CLV_PCSK_KEX2_1	540	542	PF00082	0.604
CLV_PCSK_KEX2_1	666	668	PF00082	0.586
CLV_PCSK_KEX2_1	701	703	PF00082	0.615
CLV_PCSK_KEX2_1	777	779	PF00082	0.562
CLV_PCSK_KEX2_1	807	809	PF00082	0.609
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.522
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.762
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.713
CLV_PCSK_SKI1_1	124	128	PF00082	0.521
CLV_PCSK_SKI1_1	194	198	PF00082	0.825
CLV_PCSK_SKI1_1	461	465	PF00082	0.590
CLV_PCSK_SKI1_1	529	533	PF00082	0.631
CLV_PCSK_SKI1_1	587	591	PF00082	0.744
DEG_COP1_1	556	565	PF00400	0.553
DEG_Nend_Nbox_1	1	3	PF02207	0.498
DEG_SPOP_SBC_1	10	14	PF00917	0.533
DOC_CKS1_1	562	567	PF01111	0.589
DOC_CYCLIN_RxL_1	189	198	PF00134	0.823
DOC_CYCLIN_RxL_1	584	591	PF00134	0.743
DOC_CYCLIN_RxL_1	641	653	PF00134	0.585
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.696
DOC_MAPK_gen_1	281	288	PF00069	0.716
DOC_MAPK_gen_1	472	483	PF00069	0.806
DOC_MAPK_gen_1	642	651	PF00069	0.587
DOC_MAPK_gen_1	701	707	PF00069	0.611
DOC_MAPK_gen_1	714	724	PF00069	0.490
DOC_MAPK_gen_1	804	813	PF00069	0.595
DOC_PP2B_LxvP_1	105	108	PF13499	0.501
DOC_PP4_FxxP_1	412	415	PF00568	0.698
DOC_USP7_MATH_1	10	14	PF00917	0.533
DOC_USP7_MATH_1	126	130	PF00917	0.520
DOC_USP7_MATH_1	183	187	PF00917	0.825
DOC_USP7_MATH_1	192	196	PF00917	0.687
DOC_USP7_MATH_1	293	297	PF00917	0.686
DOC_USP7_MATH_1	347	351	PF00917	0.651
DOC_USP7_MATH_1	366	370	PF00917	0.690
DOC_USP7_MATH_1	407	411	PF00917	0.619
DOC_USP7_MATH_1	423	427	PF00917	0.653
DOC_USP7_MATH_1	491	495	PF00917	0.574
DOC_USP7_MATH_1	566	570	PF00917	0.556
DOC_USP7_MATH_1	593	597	PF00917	0.715
DOC_USP7_MATH_1	668	672	PF00917	0.657
DOC_USP7_MATH_1	738	742	PF00917	0.630
DOC_USP7_MATH_1	746	750	PF00917	0.691
DOC_USP7_MATH_1	80	84	PF00917	0.521
DOC_USP7_UBL2_3	18	22	PF12436	0.553
DOC_WW_Pin1_4	13	18	PF00397	0.545
DOC_WW_Pin1_4	296	301	PF00397	0.851
DOC_WW_Pin1_4	317	322	PF00397	0.638
DOC_WW_Pin1_4	334	339	PF00397	0.651
DOC_WW_Pin1_4	376	381	PF00397	0.851
DOC_WW_Pin1_4	413	418	PF00397	0.756
DOC_WW_Pin1_4	419	424	PF00397	0.685
DOC_WW_Pin1_4	428	433	PF00397	0.590
DOC_WW_Pin1_4	561	566	PF00397	0.617
DOC_WW_Pin1_4	89	94	PF00397	0.506
DOC_WW_Pin1_4	99	104	PF00397	0.514
LIG_14-3-3_CanoR_1	125	134	PF00244	0.525
LIG_14-3-3_CanoR_1	156	161	PF00244	0.819
LIG_14-3-3_CanoR_1	367	376	PF00244	0.769
LIG_14-3-3_CanoR_1	442	450	PF00244	0.651
LIG_14-3-3_CanoR_1	540	544	PF00244	0.732
LIG_14-3-3_CanoR_1	667	676	PF00244	0.592
LIG_14-3-3_CanoR_1	701	707	PF00244	0.556
LIG_14-3-3_CanoR_1	714	724	PF00244	0.494
LIG_14-3-3_CanoR_1	9	17	PF00244	0.535
LIG_Actin_WH2_2	724	742	PF00022	0.573
LIG_BIR_III_4	53	57	PF00653	0.517
LIG_BRCT_BRCA1_1	408	412	PF00533	0.697
LIG_deltaCOP1_diTrp_1	815	821	PF00928	0.630
LIG_EH1_1	544	552	PF00400	0.680
LIG_FHA_1	393	399	PF00498	0.698
LIG_FHA_1	422	428	PF00498	0.702
LIG_FHA_1	578	584	PF00498	0.718
LIG_FHA_1	644	650	PF00498	0.583
LIG_FHA_1	743	749	PF00498	0.638
LIG_FHA_2	10	16	PF00498	0.535
LIG_FHA_2	464	470	PF00498	0.627
LIG_FHA_2	509	515	PF00498	0.508
LIG_FHA_2	562	568	PF00498	0.752
LIG_FHA_2	625	631	PF00498	0.594
LIG_FHA_2	673	679	PF00498	0.539
LIG_FHA_2	754	760	PF00498	0.749
LIG_GBD_Chelix_1	731	739	PF00786	0.651
LIG_Integrin_RGD_1	312	314	PF01839	0.618
LIG_LIR_Apic_2	316	321	PF02991	0.704
LIG_LIR_Apic_2	409	415	PF02991	0.697
LIG_LIR_Gen_1	652	662	PF02991	0.592
LIG_LIR_Nem_3	652	657	PF02991	0.597
LIG_LIR_Nem_3	819	824	PF02991	0.515
LIG_MYND_1	103	107	PF01753	0.504
LIG_MYND_1	838	842	PF01753	0.595
LIG_Pex14_1	818	822	PF04695	0.614
LIG_PTAP_UEV_1	338	343	PF05743	0.767
LIG_SH2_CRK	614	618	PF00017	0.643
LIG_SH2_NCK_1	430	434	PF00017	0.730
LIG_SH2_STAP1	110	114	PF00017	0.518
LIG_SH2_STAT5	378	381	PF00017	0.848
LIG_SH2_STAT5	430	433	PF00017	0.736
LIG_SH2_STAT5	822	825	PF00017	0.605
LIG_SH2_STAT5	87	90	PF00017	0.514
LIG_SH3_3	100	106	PF00018	0.507
LIG_SH3_3	287	293	PF00018	0.718
LIG_SH3_3	32	38	PF00018	0.506
LIG_SH3_3	336	342	PF00018	0.824
LIG_SH3_3	360	366	PF00018	0.751
LIG_SH3_3	480	486	PF00018	0.682
LIG_SH3_3	559	565	PF00018	0.647
LIG_SH3_3	569	575	PF00018	0.711
LIG_SH3_3	576	582	PF00018	0.624
LIG_SH3_3	656	662	PF00018	0.674
LIG_SH3_3	69	75	PF00018	0.513
LIG_SH3_3	839	845	PF00018	0.724
LIG_SH3_3	90	96	PF00018	0.506
LIG_SUMO_SIM_par_1	766	771	PF11976	0.423
LIG_SUMO_SIM_par_1	785	792	PF11976	0.607
LIG_TRAF2_1	511	514	PF00917	0.611
LIG_TRAF2_1	521	524	PF00917	0.498
LIG_TRAF2_1	546	549	PF00917	0.630
LIG_WW_1	107	110	PF00397	0.501
LIG_WW_2	103	106	PF00397	0.505
LIG_WW_2	74	77	PF00397	0.510
LIG_WW_3	153	157	PF00397	0.752
MOD_CDC14_SPxK_1	416	419	PF00782	0.709
MOD_CDK_SPK_2	13	18	PF00069	0.545
MOD_CDK_SPK_2	376	381	PF00069	0.762
MOD_CDK_SPK_2	413	418	PF00069	0.582
MOD_CDK_SPxK_1	376	382	PF00069	0.720
MOD_CDK_SPxK_1	413	419	PF00069	0.714
MOD_CDK_SPxxK_3	296	303	PF00069	0.744
MOD_CK1_1	13	19	PF00069	0.546
MOD_CK1_1	147	153	PF00069	0.648
MOD_CK1_1	195	201	PF00069	0.699
MOD_CK1_1	239	245	PF00069	0.823
MOD_CK1_1	296	302	PF00069	0.806
MOD_CK1_1	334	340	PF00069	0.827
MOD_CK1_1	405	411	PF00069	0.693
MOD_CK1_1	422	428	PF00069	0.637
MOD_CK1_1	596	602	PF00069	0.741
MOD_CK1_1	715	721	PF00069	0.657
MOD_CK1_1	742	748	PF00069	0.668
MOD_CK1_1	749	755	PF00069	0.671
MOD_CK1_1	83	89	PF00069	0.524
MOD_CK2_1	508	514	PF00069	0.512
MOD_CK2_1	561	567	PF00069	0.748
MOD_CK2_1	624	630	PF00069	0.581
MOD_CK2_1	672	678	PF00069	0.567
MOD_CK2_1	753	759	PF00069	0.768
MOD_CMANNOS	818	821	PF00535	0.619
MOD_GlcNHglycan	139	142	PF01048	0.616
MOD_GlcNHglycan	146	149	PF01048	0.728
MOD_GlcNHglycan	156	159	PF01048	0.787
MOD_GlcNHglycan	170	173	PF01048	0.602
MOD_GlcNHglycan	178	181	PF01048	0.712
MOD_GlcNHglycan	185	188	PF01048	0.540
MOD_GlcNHglycan	197	200	PF01048	0.675
MOD_GlcNHglycan	202	205	PF01048	0.588
MOD_GlcNHglycan	210	213	PF01048	0.615
MOD_GlcNHglycan	295	298	PF01048	0.599
MOD_GlcNHglycan	339	342	PF01048	0.647
MOD_GlcNHglycan	438	441	PF01048	0.648
MOD_GlcNHglycan	445	448	PF01048	0.650
MOD_GlcNHglycan	452	455	PF01048	0.679
MOD_GlcNHglycan	46	49	PF01048	0.537
MOD_GlcNHglycan	466	469	PF01048	0.579
MOD_GlcNHglycan	489	492	PF01048	0.694
MOD_GlcNHglycan	493	496	PF01048	0.714
MOD_GlcNHglycan	599	602	PF01048	0.664
MOD_GlcNHglycan	670	673	PF01048	0.672
MOD_GlcNHglycan	682	685	PF01048	0.574
MOD_GlcNHglycan	741	744	PF01048	0.621
MOD_GlcNHglycan	748	751	PF01048	0.620
MOD_GlcNHglycan	846	849	PF01048	0.663
MOD_GlcNHglycan	853	857	PF01048	0.620
MOD_GSK3_1	200	207	PF00069	0.775
MOD_GSK3_1	337	344	PF00069	0.725
MOD_GSK3_1	402	409	PF00069	0.604
MOD_GSK3_1	419	426	PF00069	0.768
MOD_GSK3_1	487	494	PF00069	0.696
MOD_GSK3_1	592	599	PF00069	0.726
MOD_GSK3_1	668	675	PF00069	0.489
MOD_GSK3_1	680	687	PF00069	0.566
MOD_GSK3_1	738	745	PF00069	0.677
MOD_GSK3_1	746	753	PF00069	0.676
MOD_GSK3_1	83	90	PF00069	0.522
MOD_GSK3_1	854	861	PF00069	0.759
MOD_GSK3_1	9	16	PF00069	0.533
MOD_LATS_1	130	136	PF00433	0.524
MOD_LATS_1	218	224	PF00433	0.840
MOD_N-GLC_1	18	23	PF02516	0.549
MOD_N-GLC_1	220	225	PF02516	0.754
MOD_N-GLC_1	405	410	PF02516	0.580
MOD_N-GLC_1	655	660	PF02516	0.488
MOD_NEK2_1	236	241	PF00069	0.818
MOD_NEK2_1	450	455	PF00069	0.588
MOD_NEK2_1	505	510	PF00069	0.471
MOD_NEK2_1	712	717	PF00069	0.725
MOD_NEK2_1	739	744	PF00069	0.682
MOD_NEK2_2	192	197	PF00069	0.782
MOD_NEK2_2	706	711	PF00069	0.530
MOD_PIKK_1	275	281	PF00454	0.841
MOD_PIKK_1	366	372	PF00454	0.764
MOD_PIKK_1	399	405	PF00454	0.730
MOD_PIKK_1	4	10	PF00454	0.506
MOD_PIKK_1	60	66	PF00454	0.512
MOD_PIKK_1	622	628	PF00454	0.697
MOD_PK_1	156	162	PF00069	0.660
MOD_PKA_2	10	16	PF00069	0.535
MOD_PKA_2	293	299	PF00069	0.724
MOD_PKA_2	366	372	PF00069	0.764
MOD_PKA_2	539	545	PF00069	0.734
MOD_PKA_2	593	599	PF00069	0.620
MOD_PKA_2	700	706	PF00069	0.644
MOD_PKA_2	713	719	PF00069	0.515
MOD_PKB_1	9	17	PF00069	0.535
MOD_Plk_1	655	661	PF00069	0.481
MOD_Plk_1	684	690	PF00069	0.531
MOD_Plk_4	139	145	PF00069	0.516
MOD_Plk_4	407	413	PF00069	0.616
MOD_Plk_4	568	574	PF00069	0.566
MOD_Plk_4	613	619	PF00069	0.649
MOD_Plk_4	706	712	PF00069	0.626
MOD_Plk_4	83	89	PF00069	0.524
MOD_ProDKin_1	13	19	PF00069	0.546
MOD_ProDKin_1	296	302	PF00069	0.850
MOD_ProDKin_1	317	323	PF00069	0.636
MOD_ProDKin_1	334	340	PF00069	0.653
MOD_ProDKin_1	376	382	PF00069	0.853
MOD_ProDKin_1	413	419	PF00069	0.756
MOD_ProDKin_1	428	434	PF00069	0.586
MOD_ProDKin_1	561	567	PF00069	0.623
MOD_ProDKin_1	89	95	PF00069	0.506
MOD_ProDKin_1	99	105	PF00069	0.512
TRG_ENDOCYTIC_2	614	617	PF00928	0.643
TRG_ER_diArg_1	131	133	PF00400	0.554
TRG_ER_diArg_1	280	283	PF00400	0.843
TRG_ER_diArg_1	380	382	PF00400	0.725
TRG_ER_diArg_1	417	419	PF00400	0.577
TRG_ER_diArg_1	473	476	PF00400	0.714
TRG_ER_diArg_1	517	520	PF00400	0.588
TRG_ER_diArg_1	527	530	PF00400	0.682
TRG_ER_diArg_1	665	667	PF00400	0.592
TRG_ER_diArg_1	776	778	PF00400	0.558
TRG_ER_diArg_1	806	808	PF00400	0.613
TRG_NLS_MonoCore_2	471	476	PF00514	0.761
TRG_NLS_MonoExtC_3	471	476	PF00514	0.761
TRG_NLS_MonoExtN_4	472	478	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.744
TRG_Pf-PMV_PEXEL_1	647	652	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC82	Leishmania donovani	97%	100%
A4H819	Leishmania braziliensis	54%	98%
E9AQ47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4QFD6	Leishmania major	88%	99%