ER membrane protein complex subunit 6

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWE4_LEIIN

TriTrypDb:

LINF_150009600

Length:

146

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HWE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.475
CLV_NRD_NRD_1	85	87	PF00675	0.689
CLV_PCSK_KEX2_1	130	132	PF00082	0.476
CLV_PCSK_KEX2_1	85	87	PF00082	0.671
CLV_PCSK_PC7_1	126	132	PF00082	0.496
CLV_PCSK_SKI1_1	131	135	PF00082	0.462
CLV_PCSK_SKI1_1	86	90	PF00082	0.625
DEG_Nend_UBRbox_3	1	3	PF02207	0.692
DOC_MAPK_DCC_7	60	70	PF00069	0.562
DOC_MAPK_RevD_3	72	86	PF00069	0.447
DOC_PP2B_PxIxI_1	65	71	PF00149	0.441
DOC_WW_Pin1_4	36	41	PF00397	0.754
DOC_WW_Pin1_4	90	95	PF00397	0.362
LIG_14-3-3_CanoR_1	130	139	PF00244	0.692
LIG_14-3-3_CanoR_1	85	95	PF00244	0.469
LIG_FHA_1	132	138	PF00498	0.692
LIG_FHA_1	87	93	PF00498	0.472
LIG_LIR_Gen_1	75	83	PF02991	0.480
LIG_LIR_Nem_3	75	81	PF02991	0.410
LIG_PCNA_PIPBox_1	48	57	PF02747	0.680
LIG_SH2_CRK	78	82	PF00017	0.462
LIG_SH2_STAT5	54	57	PF00017	0.616
LIG_SH3_2	5	10	PF14604	0.697
LIG_SH3_3	14	20	PF00018	0.669
LIG_SH3_3	2	8	PF00018	0.719
LIG_SH3_3	31	37	PF00018	0.798
LIG_SxIP_EBH_1	60	71	PF03271	0.558
LIG_TRAF2_1	24	27	PF00917	0.786
LIG_UBA3_1	51	60	PF00899	0.615
MOD_CK1_1	132	138	PF00069	0.673
MOD_CK2_1	21	27	PF00069	0.730
MOD_GlcNHglycan	2	5	PF01048	0.562
MOD_GSK3_1	86	93	PF00069	0.461
MOD_NEK2_1	72	77	PF00069	0.438
MOD_NEK2_1	88	93	PF00069	0.431
MOD_PIKK_1	22	28	PF00454	0.733
MOD_PIKK_1	46	52	PF00454	0.722
MOD_PIKK_1	60	66	PF00454	0.507
MOD_PKA_2	129	135	PF00069	0.695
MOD_Plk_1	46	52	PF00069	0.721
MOD_Plk_4	54	60	PF00069	0.631
MOD_Plk_4	72	78	PF00069	0.250
MOD_ProDKin_1	36	42	PF00069	0.752
MOD_ProDKin_1	90	96	PF00069	0.362
TRG_ENDOCYTIC_2	78	81	PF00928	0.398
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK1	Leptomonas seymouri	73%	100%
A0A0S4JX73	Bodo saltans	39%	100%
A0A1X0NVE4	Trypanosomatidae	45%	100%
A0A3R7RL81	Trypanosoma rangeli	44%	90%
A0A3S7WTD5	Leishmania donovani	99%	100%
A4H814	Leishmania braziliensis	81%	100%
C9ZNY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQ44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QFD8	Leishmania major	91%	100%