Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HWE2_LEIIN

TriTrypDb:

LINF_150009400

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HWE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.637
CLV_C14_Caspase3-7	33	37	PF00656	0.708
CLV_C14_Caspase3-7	337	341	PF00656	0.518
CLV_C14_Caspase3-7	79	83	PF00656	0.717
CLV_NRD_NRD_1	111	113	PF00675	0.490
CLV_NRD_NRD_1	150	152	PF00675	0.676
CLV_NRD_NRD_1	219	221	PF00675	0.722
CLV_NRD_NRD_1	347	349	PF00675	0.522
CLV_NRD_NRD_1	439	441	PF00675	0.745
CLV_PCSK_KEX2_1	111	113	PF00082	0.490
CLV_PCSK_KEX2_1	150	152	PF00082	0.676
CLV_PCSK_KEX2_1	219	221	PF00082	0.769
CLV_PCSK_KEX2_1	347	349	PF00082	0.452
CLV_PCSK_KEX2_1	439	441	PF00082	0.745
CLV_PCSK_PC7_1	146	152	PF00082	0.598
CLV_PCSK_SKI1_1	6	10	PF00082	0.434
CLV_PCSK_SKI1_1	656	660	PF00082	0.604
DEG_SCF_FBW7_2	123	129	PF00400	0.571
DEG_SPOP_SBC_1	29	33	PF00917	0.704
DEG_SPOP_SBC_1	409	413	PF00917	0.590
DOC_CKS1_1	123	128	PF01111	0.594
DOC_CYCLIN_RxL_1	86	100	PF00134	0.655
DOC_CYCLIN_yCln2_LP_2	274	277	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.596
DOC_MAPK_gen_1	111	117	PF00069	0.471
DOC_MAPK_gen_1	227	237	PF00069	0.678
DOC_MAPK_gen_1	324	334	PF00069	0.592
DOC_MAPK_gen_1	609	616	PF00069	0.447
DOC_MAPK_MEF2A_6	102	110	PF00069	0.498
DOC_MAPK_MEF2A_6	609	616	PF00069	0.447
DOC_PP1_RVXF_1	90	97	PF00149	0.655
DOC_PP2B_LxvP_1	274	277	PF13499	0.491
DOC_PP2B_LxvP_1	8	11	PF13499	0.422
DOC_USP7_MATH_1	165	169	PF00917	0.622
DOC_USP7_MATH_1	307	311	PF00917	0.642
DOC_USP7_MATH_1	409	413	PF00917	0.586
DOC_USP7_MATH_1	46	50	PF00917	0.701
DOC_USP7_MATH_1	468	472	PF00917	0.501
DOC_USP7_MATH_1	498	502	PF00917	0.530
DOC_USP7_MATH_1	625	629	PF00917	0.597
DOC_USP7_MATH_1	63	67	PF00917	0.523
DOC_USP7_MATH_1	90	94	PF00917	0.680
DOC_USP7_MATH_1	97	101	PF00917	0.607
DOC_USP7_UBL2_3	428	432	PF12436	0.632
DOC_WW_Pin1_4	122	127	PF00397	0.604
DOC_WW_Pin1_4	209	214	PF00397	0.691
DOC_WW_Pin1_4	286	291	PF00397	0.739
DOC_WW_Pin1_4	312	317	PF00397	0.704
DOC_WW_Pin1_4	351	356	PF00397	0.556
DOC_WW_Pin1_4	423	428	PF00397	0.604
DOC_WW_Pin1_4	59	64	PF00397	0.696
LIG_14-3-3_CanoR_1	247	251	PF00244	0.539
LIG_14-3-3_CanoR_1	294	300	PF00244	0.637
LIG_14-3-3_CanoR_1	327	335	PF00244	0.581
LIG_14-3-3_CanoR_1	360	365	PF00244	0.605
LIG_14-3-3_CanoR_1	420	429	PF00244	0.469
LIG_14-3-3_CanoR_1	538	544	PF00244	0.504
LIG_AP2alpha_1	20	24	PF02296	0.471
LIG_APCC_ABBA_1	248	253	PF00400	0.415
LIG_APCC_ABBAyCdc20_2	247	253	PF00400	0.443
LIG_BRCT_BRCA1_1	204	208	PF00533	0.663
LIG_BRCT_BRCA1_1	92	96	PF00533	0.577
LIG_Clathr_ClatBox_1	505	509	PF01394	0.469
LIG_FHA_1	137	143	PF00498	0.595
LIG_FHA_1	291	297	PF00498	0.719
LIG_FHA_1	327	333	PF00498	0.598
LIG_FHA_1	414	420	PF00498	0.527
LIG_FHA_1	501	507	PF00498	0.454
LIG_FHA_1	519	525	PF00498	0.507
LIG_FHA_1	529	535	PF00498	0.520
LIG_FHA_1	567	573	PF00498	0.389
LIG_FHA_2	559	565	PF00498	0.456
LIG_FHA_2	628	634	PF00498	0.585
LIG_FHA_2	77	83	PF00498	0.784
LIG_Integrin_RGD_1	112	114	PF01839	0.477
LIG_LIR_Apic_2	305	309	PF02991	0.558
LIG_LIR_Nem_3	2	8	PF02991	0.468
LIG_LIR_Nem_3	22	27	PF02991	0.252
LIG_NRBOX	377	383	PF00104	0.691
LIG_Pex14_2	20	24	PF04695	0.382
LIG_Pex14_2	5	9	PF04695	0.553
LIG_SH2_CRK	306	310	PF00017	0.721
LIG_SH2_GRB2like	152	155	PF00017	0.580
LIG_SH2_NCK_1	152	156	PF00017	0.588
LIG_SH2_NCK_1	306	310	PF00017	0.566
LIG_SH2_NCK_1	662	666	PF00017	0.690
LIG_SH2_STAP1	256	260	PF00017	0.519
LIG_SH2_STAT5	198	201	PF00017	0.525
LIG_SH2_STAT5	236	239	PF00017	0.415
LIG_SH2_STAT5	256	259	PF00017	0.225
LIG_SH3_2	316	321	PF14604	0.544
LIG_SH3_3	270	276	PF00018	0.504
LIG_SH3_3	313	319	PF00018	0.674
LIG_SH3_3	355	361	PF00018	0.552
LIG_SH3_3	369	375	PF00018	0.418
LIG_SH3_3	569	575	PF00018	0.455
LIG_SH3_4	428	435	PF00018	0.643
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.475
LIG_SUMO_SIM_anti_2	340	346	PF11976	0.506
LIG_SUMO_SIM_anti_2	354	360	PF11976	0.565
LIG_SUMO_SIM_anti_2	470	476	PF11976	0.462
LIG_SUMO_SIM_anti_2	480	486	PF11976	0.465
LIG_SUMO_SIM_anti_2	503	510	PF11976	0.469
LIG_SUMO_SIM_par_1	503	510	PF11976	0.469
LIG_SUMO_SIM_par_1	523	528	PF11976	0.310
LIG_TRAF2_1	13	16	PF00917	0.499
LIG_TRAF2_1	442	445	PF00917	0.756
LIG_UBA3_1	481	486	PF00899	0.467
LIG_Vh1_VBS_1	548	566	PF01044	0.326
MOD_CDC14_SPxK_1	318	321	PF00782	0.525
MOD_CDK_SPK_2	423	428	PF00069	0.553
MOD_CDK_SPxK_1	315	321	PF00069	0.555
MOD_CK1_1	160	166	PF00069	0.733
MOD_CK1_1	207	213	PF00069	0.630
MOD_CK1_1	249	255	PF00069	0.470
MOD_CK1_1	289	295	PF00069	0.644
MOD_CK1_1	30	36	PF00069	0.629
MOD_CK1_1	315	321	PF00069	0.697
MOD_CK1_1	362	368	PF00069	0.609
MOD_CK1_1	376	382	PF00069	0.557
MOD_CK1_1	423	429	PF00069	0.495
MOD_CK1_1	433	439	PF00069	0.675
MOD_CK1_1	450	456	PF00069	0.425
MOD_CK1_1	480	486	PF00069	0.469
MOD_CK1_1	62	68	PF00069	0.706
MOD_CK2_1	223	229	PF00069	0.714
MOD_CK2_1	386	392	PF00069	0.731
MOD_CK2_1	439	445	PF00069	0.762
MOD_CK2_1	62	68	PF00069	0.682
MOD_CK2_1	627	633	PF00069	0.727
MOD_CK2_1	639	645	PF00069	0.621
MOD_GlcNHglycan	166	170	PF01048	0.738
MOD_GlcNHglycan	204	207	PF01048	0.568
MOD_GlcNHglycan	209	212	PF01048	0.640
MOD_GlcNHglycan	284	287	PF01048	0.545
MOD_GlcNHglycan	309	312	PF01048	0.691
MOD_GlcNHglycan	336	339	PF01048	0.496
MOD_GlcNHglycan	375	378	PF01048	0.613
MOD_GlcNHglycan	459	462	PF01048	0.557
MOD_GlcNHglycan	48	51	PF01048	0.711
MOD_GlcNHglycan	518	521	PF01048	0.413
MOD_GlcNHglycan	56	59	PF01048	0.699
MOD_GlcNHglycan	592	595	PF01048	0.602
MOD_GlcNHglycan	619	623	PF01048	0.650
MOD_GlcNHglycan	625	628	PF01048	0.614
MOD_GlcNHglycan	65	68	PF01048	0.547
MOD_GlcNHglycan	99	102	PF01048	0.631
MOD_GSK3_1	202	209	PF00069	0.565
MOD_GSK3_1	23	30	PF00069	0.530
MOD_GSK3_1	252	259	PF00069	0.551
MOD_GSK3_1	282	289	PF00069	0.624
MOD_GSK3_1	359	366	PF00069	0.523
MOD_GSK3_1	376	383	PF00069	0.545
MOD_GSK3_1	397	404	PF00069	0.648
MOD_GSK3_1	40	47	PF00069	0.434
MOD_GSK3_1	409	416	PF00069	0.481
MOD_GSK3_1	423	430	PF00069	0.539
MOD_GSK3_1	446	453	PF00069	0.636
MOD_GSK3_1	455	462	PF00069	0.513
MOD_GSK3_1	523	530	PF00069	0.515
MOD_GSK3_1	54	61	PF00069	0.661
MOD_GSK3_1	554	561	PF00069	0.412
MOD_GSK3_1	623	630	PF00069	0.692
MOD_N-GLC_1	286	291	PF02516	0.682
MOD_NEK2_1	173	178	PF00069	0.737
MOD_NEK2_1	204	209	PF00069	0.614
MOD_NEK2_1	251	256	PF00069	0.531
MOD_NEK2_1	27	32	PF00069	0.638
MOD_NEK2_1	334	339	PF00069	0.509
MOD_NEK2_1	349	354	PF00069	0.381
MOD_NEK2_1	381	386	PF00069	0.668
MOD_NEK2_1	434	439	PF00069	0.711
MOD_NEK2_1	477	482	PF00069	0.501
MOD_NEK2_1	507	512	PF00069	0.436
MOD_NEK2_1	52	57	PF00069	0.545
MOD_NEK2_1	558	563	PF00069	0.462
MOD_NEK2_1	601	606	PF00069	0.615
MOD_NEK2_2	246	251	PF00069	0.536
MOD_PIKK_1	136	142	PF00454	0.657
MOD_PIKK_1	326	332	PF00454	0.604
MOD_PIKK_1	386	392	PF00454	0.669
MOD_PIKK_1	500	506	PF00454	0.480
MOD_PK_1	439	445	PF00069	0.764
MOD_PKA_1	150	156	PF00069	0.696
MOD_PKA_1	439	445	PF00069	0.764
MOD_PKA_2	150	156	PF00069	0.655
MOD_PKA_2	246	252	PF00069	0.536
MOD_PKA_2	326	332	PF00069	0.582
MOD_PKA_2	359	365	PF00069	0.590
MOD_PKA_2	439	445	PF00069	0.718
MOD_PKA_2	76	82	PF00069	0.677
MOD_PKB_1	418	426	PF00069	0.420
MOD_Plk_1	252	258	PF00069	0.502
MOD_Plk_1	40	46	PF00069	0.662
MOD_Plk_4	23	29	PF00069	0.509
MOD_Plk_4	246	252	PF00069	0.504
MOD_Plk_4	470	476	PF00069	0.468
MOD_Plk_4	477	483	PF00069	0.412
MOD_Plk_4	554	560	PF00069	0.462
MOD_ProDKin_1	122	128	PF00069	0.596
MOD_ProDKin_1	209	215	PF00069	0.692
MOD_ProDKin_1	286	292	PF00069	0.738
MOD_ProDKin_1	312	318	PF00069	0.692
MOD_ProDKin_1	351	357	PF00069	0.557
MOD_ProDKin_1	423	429	PF00069	0.613
MOD_ProDKin_1	59	65	PF00069	0.695
TRG_DiLeu_BaEn_3	666	672	PF01217	0.685
TRG_DiLeu_BaLyEn_6	653	658	PF01217	0.624
TRG_ER_diArg_1	110	112	PF00400	0.485
TRG_ER_diArg_1	132	135	PF00400	0.495
TRG_ER_diArg_1	150	152	PF00400	0.383
TRG_ER_diArg_1	218	220	PF00400	0.727
TRG_ER_diArg_1	346	348	PF00400	0.511
TRG_ER_diArg_1	417	420	PF00400	0.464
TRG_ER_diArg_1	535	538	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	585	590	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD21	Leptomonas seymouri	50%	100%
A0A0S4JR70	Bodo saltans	26%	100%
A0A1X0NU73	Trypanosomatidae	28%	100%
A0A3R7NGV0	Trypanosoma rangeli	27%	100%
A0A3S7WTC1	Leishmania donovani	99%	100%
A4H812	Leishmania braziliensis	71%	96%
E9AQ42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QFE0	Leishmania major	91%	100%
V5DCS7	Trypanosoma cruzi	28%	100%