RNA pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase - putative

Species:

Leishmania infantum

UniProt:

A4HWD8_LEIIN

TriTrypDb:

LINF_150009000

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HWD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HWD8

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	5
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009451	RNA modification	5	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0009982	pseudouridine synthase activity	4	5
GO:0016853	isomerase activity	2	5
GO:0016866	intramolecular transferase activity	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.363
CLV_NRD_NRD_1	109	111	PF00675	0.163
CLV_NRD_NRD_1	161	163	PF00675	0.293
CLV_NRD_NRD_1	338	340	PF00675	0.163
CLV_PCSK_KEX2_1	109	111	PF00082	0.163
CLV_PCSK_KEX2_1	293	295	PF00082	0.492
CLV_PCSK_KEX2_1	338	340	PF00082	0.245
CLV_PCSK_KEX2_1	39	41	PF00082	0.547
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.492
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.530
CLV_PCSK_SKI1_1	296	300	PF00082	0.285
CLV_PCSK_SKI1_1	36	40	PF00082	0.517
CLV_PCSK_SKI1_1	4	8	PF00082	0.646
CLV_PCSK_SKI1_1	42	46	PF00082	0.516
DEG_APCC_DBOX_1	171	179	PF00400	0.273
DEG_APCC_DBOX_1	380	388	PF00400	0.358
DEG_Nend_UBRbox_1	1	4	PF02207	0.506
DEG_SCF_FBW7_1	427	434	PF00400	0.381
DEG_SPOP_SBC_1	11	15	PF00917	0.489
DEG_SPOP_SBC_1	157	161	PF00917	0.341
DOC_CKS1_1	187	192	PF01111	0.381
DOC_CKS1_1	428	433	PF01111	0.376
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.243
DOC_MAPK_MEF2A_6	218	227	PF00069	0.327
DOC_MAPK_MEF2A_6	376	384	PF00069	0.371
DOC_MAPK_MEF2A_6	396	404	PF00069	0.384
DOC_PP2B_LxvP_1	154	157	PF13499	0.455
DOC_PP2B_LxvP_1	201	204	PF13499	0.497
DOC_USP7_MATH_1	11	15	PF00917	0.516
DOC_USP7_MATH_1	116	120	PF00917	0.421
DOC_USP7_MATH_1	157	161	PF00917	0.455
DOC_USP7_MATH_1	207	211	PF00917	0.571
DOC_USP7_MATH_1	431	435	PF00917	0.350
DOC_USP7_MATH_1	448	452	PF00917	0.385
DOC_USP7_MATH_1	510	514	PF00917	0.296
DOC_USP7_MATH_1	93	97	PF00917	0.358
DOC_WW_Pin1_4	148	153	PF00397	0.475
DOC_WW_Pin1_4	186	191	PF00397	0.361
DOC_WW_Pin1_4	240	245	PF00397	0.415
DOC_WW_Pin1_4	281	286	PF00397	0.442
DOC_WW_Pin1_4	427	432	PF00397	0.502
LIG_14-3-3_CanoR_1	109	115	PF00244	0.363
LIG_14-3-3_CanoR_1	196	204	PF00244	0.499
LIG_14-3-3_CanoR_1	218	226	PF00244	0.338
LIG_14-3-3_CanoR_1	270	275	PF00244	0.693
LIG_BIR_III_4	205	209	PF00653	0.506
LIG_BRCT_BRCA1_1	469	473	PF00533	0.442
LIG_Clathr_ClatBox_1	504	508	PF01394	0.291
LIG_eIF4E_1	499	505	PF01652	0.286
LIG_FHA_1	149	155	PF00498	0.468
LIG_FHA_1	302	308	PF00498	0.439
LIG_FHA_1	375	381	PF00498	0.436
LIG_FHA_1	60	66	PF00498	0.211
LIG_FHA_1	93	99	PF00498	0.416
LIG_LIR_Apic_2	239	244	PF02991	0.262
LIG_LIR_Gen_1	394	404	PF02991	0.308
LIG_LIR_Nem_3	394	400	PF02991	0.277
LIG_SH2_NCK_1	359	363	PF00017	0.363
LIG_SH2_NCK_1	495	499	PF00017	0.238
LIG_SH2_PTP2	397	400	PF00017	0.293
LIG_SH2_SRC	499	502	PF00017	0.399
LIG_SH2_STAP1	495	499	PF00017	0.244
LIG_SH2_STAP1	81	85	PF00017	0.363
LIG_SH2_STAT5	165	168	PF00017	0.256
LIG_SH2_STAT5	343	346	PF00017	0.469
LIG_SH2_STAT5	397	400	PF00017	0.273
LIG_SH2_STAT5	495	498	PF00017	0.273
LIG_SH2_STAT5	81	84	PF00017	0.363
LIG_SH3_3	149	155	PF00018	0.494
LIG_SH3_3	224	230	PF00018	0.252
LIG_SH3_3	35	41	PF00018	0.661
LIG_SH3_3	425	431	PF00018	0.425
LIG_SH3_3	504	510	PF00018	0.294
LIG_SUMO_SIM_par_1	503	508	PF11976	0.291
LIG_TRAF2_1	15	18	PF00917	0.525
LIG_WW_1	78	81	PF00397	0.363
LIG_WW_2	152	155	PF00397	0.484
MOD_CK1_1	133	139	PF00069	0.737
MOD_CK1_1	191	197	PF00069	0.649
MOD_CK1_1	214	220	PF00069	0.543
MOD_CK1_1	272	278	PF00069	0.460
MOD_CK1_1	334	340	PF00069	0.363
MOD_CK1_1	349	355	PF00069	0.334
MOD_CK1_1	434	440	PF00069	0.349
MOD_CK2_1	12	18	PF00069	0.534
MOD_GlcNHglycan	135	138	PF01048	0.526
MOD_GlcNHglycan	148	151	PF01048	0.472
MOD_GlcNHglycan	209	212	PF01048	0.604
MOD_GlcNHglycan	214	217	PF01048	0.520
MOD_GlcNHglycan	219	222	PF01048	0.403
MOD_GlcNHglycan	274	277	PF01048	0.532
MOD_GlcNHglycan	317	320	PF01048	0.250
MOD_GlcNHglycan	348	351	PF01048	0.172
MOD_GlcNHglycan	417	420	PF01048	0.497
MOD_GlcNHglycan	455	458	PF01048	0.472
MOD_GlcNHglycan	69	72	PF01048	0.288
MOD_GlcNHglycan	95	98	PF01048	0.166
MOD_GSK3_1	104	111	PF00069	0.439
MOD_GSK3_1	191	198	PF00069	0.621
MOD_GSK3_1	207	214	PF00069	0.691
MOD_GSK3_1	236	243	PF00069	0.353
MOD_GSK3_1	268	275	PF00069	0.648
MOD_GSK3_1	327	334	PF00069	0.470
MOD_GSK3_1	415	422	PF00069	0.492
MOD_GSK3_1	427	434	PF00069	0.349
MOD_N-GLC_1	116	121	PF02516	0.298
MOD_N-GLC_1	140	145	PF02516	0.553
MOD_NEK2_1	269	274	PF00069	0.406
MOD_NEK2_1	333	338	PF00069	0.433
MOD_NEK2_1	441	446	PF00069	0.350
MOD_NEK2_1	473	478	PF00069	0.434
MOD_NEK2_1	66	71	PF00069	0.375
MOD_NEK2_2	343	348	PF00069	0.378
MOD_NEK2_2	79	84	PF00069	0.363
MOD_PIKK_1	191	197	PF00454	0.602
MOD_PKA_2	108	114	PF00069	0.358
MOD_PKA_2	195	201	PF00069	0.563
MOD_PKA_2	217	223	PF00069	0.392
MOD_PKA_2	269	275	PF00069	0.514
MOD_PKA_2	326	332	PF00069	0.414
MOD_PKA_2	66	72	PF00069	0.550
MOD_PKB_1	2	10	PF00069	0.503
MOD_PKB_1	294	302	PF00069	0.171
MOD_Plk_1	116	122	PF00069	0.363
MOD_Plk_1	363	369	PF00069	0.358
MOD_Plk_1	434	440	PF00069	0.349
MOD_Plk_1	49	55	PF00069	0.523
MOD_Plk_2-3	503	509	PF00069	0.287
MOD_Plk_4	236	242	PF00069	0.376
MOD_Plk_4	363	369	PF00069	0.405
MOD_ProDKin_1	148	154	PF00069	0.473
MOD_ProDKin_1	186	192	PF00069	0.373
MOD_ProDKin_1	240	246	PF00069	0.421
MOD_ProDKin_1	281	287	PF00069	0.434
MOD_ProDKin_1	427	433	PF00069	0.491
MOD_SUMO_rev_2	123	133	PF00179	0.720
TRG_ENDOCYTIC_2	397	400	PF00928	0.293
TRG_ER_diArg_1	338	340	PF00400	0.363
TRG_NLS_MonoExtN_4	291	297	PF00514	0.394
TRG_Pf-PMV_PEXEL_1	405	410	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NTP6	Trypanosomatidae	32%	78%
A0A422N3I8	Trypanosoma rangeli	35%	77%
V5BL50	Trypanosoma cruzi	33%	70%